reserpine has been researched along with Allodynia in 26 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Excerpt | Relevance | Reference |
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" Mechanical hyperalgesia, thermal allodynia, depressive- and anxious-related behavior, and locomotor activity were evaluated after reserpine (0." | 8.12 | Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice. ( Baldasso, GM; Capasso, R; Cicco, P; de Assis, PM; Dutra, RC; Ferrarini, EG; Gouvêa, MC; Moreira, ELG; Paes, RS; Raposo, NRB, 2022) |
" Here, we investigated the relationship between SERT occupancies and the analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine, which are both 5-HT and NE reuptake inhibitors (SNRIs), on muscular pain in reserpine-induced myalgia (RIM) rats, an animal model of FM-like chronic pain." | 7.81 | Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. ( Aoki, T; Fushiki, H; Honda, S; Irie, M; Iwashita, A; Murai, N; Murakami, Y; Nagakura, Y; Tamura, S, 2015) |
"This study is to offer a clinical pain-depression dyad therapy of ferulic acid, the pain-depression dyad induced by reserpine was established and the dose-effect relationship of ferulic acid on ameliorating pain-depression dyad was explored." | 7.79 | [Influence of ferulic acid on the pain-depression dyad induced by reserpine]. ( Pan, JC; Shi, HM; Wang, QD; Zhang, L, 2013) |
"The reserpine-induced myalgia (RIM) rat manifests fibromyalgia-like chronic pain symptoms." | 7.78 | Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats. ( Nagakura, Y; Noto, T; Oe, T; Sekizawa, T; Shimizu, Y; Takahashi, M; Tamaki, K; Yoshimi, E, 2012) |
"Repeated reserpine injection induced hyperalgesia and depressive behaviors with decreased sucrose preference and horizontal movement distance, and increased immobility time in forced swimming test." | 5.72 | Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model. ( Du, Y; Gao, X; Li, L; Lu, Y; Shi, W; Wang, A; Wang, Y; Zhang, S; Zhao, J, 2022) |
"Chronic widespread pain is a serious medical problem, yet the mechanisms of nociception and pain are poorly understood." | 5.42 | Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. ( Hayashi, K; Katanosaka, K; Kiyama, H; Mizumura, K; Taguchi, T; Wakatsuki, K; Yamanaka, A; Yamashita, M; Yasui, M, 2015) |
"Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice." | 5.40 | Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014) |
" Fibromyalgia was induced by three injections once a day of reserpine at the dose of 1 mg/kg." | 4.12 | Role of Etanercept and Infliximab on Nociceptive Changes Induced by the Experimental Model of Fibromyalgia. ( Cordaro, M; Cuzzocrea, S; D'Amico, R; Di Paola, D; Di Paola, R; Franco, G; Fusco, R; Genovese, T; Impellizzeri, D; Marino, Y; Siracusa, R, 2022) |
" Mechanical hyperalgesia, thermal allodynia, depressive- and anxious-related behavior, and locomotor activity were evaluated after reserpine (0." | 4.12 | Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice. ( Baldasso, GM; Capasso, R; Cicco, P; de Assis, PM; Dutra, RC; Ferrarini, EG; Gouvêa, MC; Moreira, ELG; Paes, RS; Raposo, NRB, 2022) |
" On the contrary, suppression of EEG delta power using a wake-promoting agent modafinil significantly attenuated mechanical allodynia." | 3.96 | High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice. ( Ge, J; Hong, ZY; Huang, ZL; Lazarus, M; Li, YD; Luo, YJ; Qu, WM; Wang, J; Xu, W, 2020) |
" Here, we investigated the relationship between SERT occupancies and the analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine, which are both 5-HT and NE reuptake inhibitors (SNRIs), on muscular pain in reserpine-induced myalgia (RIM) rats, an animal model of FM-like chronic pain." | 3.81 | Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. ( Aoki, T; Fushiki, H; Honda, S; Irie, M; Iwashita, A; Murai, N; Murakami, Y; Nagakura, Y; Tamura, S, 2015) |
"This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM)." | 3.80 | The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. ( Castro, CJ; da Costa Lopes, AM; da Silva, CA; da Silva, JF; de Souza, AH; Ferreira, J; Gomez, MV; Klein, CP; Pereira, EM, 2014) |
"This study is to offer a clinical pain-depression dyad therapy of ferulic acid, the pain-depression dyad induced by reserpine was established and the dose-effect relationship of ferulic acid on ameliorating pain-depression dyad was explored." | 3.79 | [Influence of ferulic acid on the pain-depression dyad induced by reserpine]. ( Pan, JC; Shi, HM; Wang, QD; Zhang, L, 2013) |
"More studies are still warranted in similar rodent models of pain and depression, so, that the present findings can be further substantiated to establish the clinical effectiveness of berberine in a subset of patients suffering from pain as well as depression." | 3.79 | Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model. ( Arora, V; Chopra, K, 2013) |
"The reserpine-induced myalgia (RIM) rat manifests fibromyalgia-like chronic pain symptoms." | 3.78 | Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats. ( Nagakura, Y; Noto, T; Oe, T; Sekizawa, T; Shimizu, Y; Takahashi, M; Tamaki, K; Yoshimi, E, 2012) |
"Repeated reserpine injection induced hyperalgesia and depressive behaviors with decreased sucrose preference and horizontal movement distance, and increased immobility time in forced swimming test." | 1.72 | Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model. ( Du, Y; Gao, X; Li, L; Lu, Y; Shi, W; Wang, A; Wang, Y; Zhang, S; Zhao, J, 2022) |
"Musculoskeletal pain is a widespread complex regional pain syndrome associated with altered emotional and cognitive functioning along with heightened physical disability that has become a global health concern." | 1.62 | Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin. ( Bhatti, R; Garg, S; Kaur, A; Kaur, H; Singh, L; Singh, N, 2021) |
"Fibromyalgia is characterized by the amplification of central nervous system pain with concomitant fatigue, sleep, mood disorders, depression, and anxiety." | 1.62 | Phoneutria nigriventer Tx3-3 peptide toxin reduces fibromyalgia symptoms in mice. ( Antunes, FTT; Campos, MM; Correa, ÁP; de Oliveira, IB; de Souza, AH; do Nascimento Cordeiro, M; Gomez, MV; Klein, CP; Pedron, C; Rebelo, IN, 2021) |
"Reserpine caused hyperalgesia on the mechanical and thermal hyperalgesia on the 4th day was reverted by recombinant Phα1β (0." | 1.62 | Effects of intravenous administration of recombinant Phα1β toxin in a mouse model of fibromyalgia. ( Assis Ferreira, LC; Carvalho Dos Santos, D; Garcia Mendes, MP; Gomez, MV; José de Castro Junior, C; Rezende, MJS; Rigo, FK, 2021) |
"Fibromyalgia is a disease characterised as generalised chronic primary pain that causes functional disability and a reduction in patients' quality of life, without specific pathophysiology or appropriate treatment." | 1.51 | Kinins and their B ( Brusco, I; Cunha, TM; Ferreira, J; Fischer, S; Justino, AB; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Silva, CR, 2019) |
"Chronic widespread pain is a serious medical problem, yet the mechanisms of nociception and pain are poorly understood." | 1.42 | Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. ( Hayashi, K; Katanosaka, K; Kiyama, H; Mizumura, K; Taguchi, T; Wakatsuki, K; Yamanaka, A; Yamashita, M; Yasui, M, 2015) |
"Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice." | 1.40 | Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014) |
"Fibromyalgia is a prevalent and burdensome disorder characterized by chronic widespread pain and complex comorbid symptoms." | 1.35 | Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia. ( Aoki, T; Matsuoka, N; Nagakura, Y; Oe, T, 2009) |
"This hyperalgesia was antagonized by pretreatment with the N-methyl-D-aspartate (NMDA) receptor antagonist (+)-MK-801, suggesting involvement of NMDA receptors." | 1.29 | Noradrenaline but not dopamine involved in NMDA receptor-mediated hyperalgesia induced by theophylline in awake rats. ( Paalzow, GH, 1994) |
"To clarify the mechanism of the hyperalgesia in SART mice and the mode of the antinociceptive action of neurotropin in this model, the influence of systemically administered neurotransmitter related drugs was studied." | 1.28 | Mechanism of hyperalgesia in SART stressed (repeated cold stress) mice: antinociceptive effect of neurotropin. ( Hata, T; Kawamura, M; Miura, T; Namimatsu, A; Ohara, H; Yoneda, R, 1991) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (3.85) | 18.7374 |
1990's | 2 (7.69) | 18.2507 |
2000's | 1 (3.85) | 29.6817 |
2010's | 14 (53.85) | 24.3611 |
2020's | 8 (30.77) | 2.80 |
Authors | Studies |
---|---|
Cordaro, M | 1 |
Siracusa, R | 1 |
D'Amico, R | 1 |
Genovese, T | 1 |
Franco, G | 1 |
Marino, Y | 1 |
Di Paola, D | 1 |
Cuzzocrea, S | 1 |
Impellizzeri, D | 1 |
Di Paola, R | 1 |
Fusco, R | 1 |
Zhao, J | 1 |
Shi, W | 1 |
Lu, Y | 1 |
Gao, X | 1 |
Wang, A | 1 |
Zhang, S | 1 |
Du, Y | 1 |
Wang, Y | 1 |
Li, L | 1 |
Ferrarini, EG | 1 |
Paes, RS | 1 |
Baldasso, GM | 1 |
de Assis, PM | 1 |
Gouvêa, MC | 1 |
Cicco, P | 1 |
Raposo, NRB | 1 |
Capasso, R | 1 |
Moreira, ELG | 1 |
Dutra, RC | 1 |
Álvarez-Pérez, B | 1 |
Bagó-Mas, A | 1 |
Deulofeu, M | 1 |
Vela, JM | 1 |
Merlos, M | 1 |
Verdú, E | 1 |
Boadas-Vaello, P | 1 |
Li, YD | 1 |
Ge, J | 1 |
Luo, YJ | 1 |
Xu, W | 1 |
Wang, J | 1 |
Lazarus, M | 1 |
Hong, ZY | 1 |
Qu, WM | 1 |
Huang, ZL | 1 |
Kaur, A | 1 |
Singh, L | 1 |
Garg, S | 1 |
Kaur, H | 1 |
Singh, N | 1 |
Bhatti, R | 1 |
Pedron, C | 1 |
Antunes, FTT | 1 |
Rebelo, IN | 1 |
Campos, MM | 1 |
Correa, ÁP | 1 |
Klein, CP | 2 |
de Oliveira, IB | 1 |
do Nascimento Cordeiro, M | 1 |
Gomez, MV | 3 |
de Souza, AH | 2 |
Garcia Mendes, MP | 1 |
Carvalho Dos Santos, D | 1 |
Rezende, MJS | 1 |
Assis Ferreira, LC | 1 |
Rigo, FK | 1 |
José de Castro Junior, C | 1 |
Hernandez-Leon, A | 1 |
Fernández-Guasti, A | 1 |
Martínez, A | 1 |
Pellicer, F | 1 |
González-Trujano, ME | 1 |
Siemian, JN | 1 |
Shang, L | 1 |
Seaman, RW | 1 |
Zhu, Q | 1 |
Zhang, Y | 1 |
Li, JX | 1 |
Uchida, M | 1 |
Kobayashi, O | 1 |
Yoshida, M | 1 |
Miwa, M | 1 |
Miura, R | 1 |
Saito, H | 1 |
Nagakura, Y | 5 |
De la Luz-Cuellar, YE | 1 |
Rodríguez-Palma, EJ | 1 |
Franco-Enzástiga, Ú | 1 |
Salinas-Abarca, AB | 1 |
Delgado-Lezama, R | 1 |
Granados-Soto, V | 1 |
Brusco, I | 1 |
Justino, AB | 1 |
Silva, CR | 1 |
Fischer, S | 1 |
Cunha, TM | 1 |
Scussel, R | 1 |
Machado-de-Ávila, RA | 1 |
Ferreira, J | 2 |
Oliveira, SM | 1 |
Zhang, L | 1 |
Wang, QD | 1 |
Shi, HM | 1 |
Pan, JC | 1 |
Ogino, S | 1 |
Tsukamoto, M | 1 |
Watabiki, T | 1 |
Ozawa, T | 1 |
Oe, T | 3 |
Shimizu, Y | 2 |
Ito, H | 1 |
Arora, V | 1 |
Chopra, K | 1 |
da Costa Lopes, AM | 1 |
Castro, CJ | 1 |
Pereira, EM | 1 |
da Silva, CA | 1 |
da Silva, JF | 1 |
Liu, SB | 1 |
Zhao, R | 1 |
Li, XS | 1 |
Guo, HJ | 1 |
Tian, Z | 1 |
Zhang, N | 1 |
Gao, GD | 1 |
Zhao, MG | 1 |
Murai, N | 1 |
Fushiki, H | 1 |
Honda, S | 1 |
Murakami, Y | 1 |
Iwashita, A | 1 |
Irie, M | 1 |
Tamura, S | 1 |
Aoki, T | 2 |
Taguchi, T | 1 |
Katanosaka, K | 1 |
Yasui, M | 1 |
Hayashi, K | 1 |
Yamashita, M | 1 |
Wakatsuki, K | 1 |
Kiyama, H | 1 |
Yamanaka, A | 1 |
Mizumura, K | 1 |
Wells, JA | 1 |
Shibata, S | 1 |
Fujikawa, A | 1 |
Takahashi, M | 2 |
Saga, T | 1 |
Aoki, I | 1 |
Matsuoka, N | 1 |
Noto, T | 1 |
Sekizawa, T | 1 |
Yoshimi, E | 1 |
Tamaki, K | 1 |
Kulkarni, SK | 1 |
Robert, RK | 1 |
Paalzow, GH | 1 |
Ohara, H | 1 |
Kawamura, M | 1 |
Namimatsu, A | 1 |
Miura, T | 1 |
Yoneda, R | 1 |
Hata, T | 1 |
26 other studies available for reserpine and Allodynia
Article | Year |
---|---|
Role of Etanercept and Infliximab on Nociceptive Changes Induced by the Experimental Model of Fibromyalgia.
Topics: Animals; Etanercept; Fibromyalgia; Hyperalgesia; Infliximab; Models, Theoretical; Nociception; p38 M | 2022 |
Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model.
Topics: Adrenocorticotropic Hormone; Animals; Comorbidity; Cytokines; Depression; Hydrocortisone; Hyperalges | 2022 |
Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice.
Topics: Analgesics; Animals; Cannabis; Disease Models, Animal; Dronabinol; Fibromyalgia; Hyperalgesia; Mice; | 2022 |
Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models.
Topics: Analgesics; Animals; Chronic Pain; Disease Models, Animal; Female; Fibromyalgia; Gliosis; Hyperalges | 2022 |
High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Cerebral Cortex; Cholinergic Antagonists; Cortical Synchroniz | 2020 |
Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin.
Topics: Analgesics; Animals; Anxiety; Brain Chemistry; Cognition Disorders; Cytokines; Drug Evaluation, Prec | 2021 |
Phoneutria nigriventer Tx3-3 peptide toxin reduces fibromyalgia symptoms in mice.
Topics: Analgesics; Anesthetics; Animals; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Male; Mice; Ne | 2021 |
Effects of intravenous administration of recombinant Phα1β toxin in a mouse model of fibromyalgia.
Topics: Administration, Intravenous; Analgesics; Animals; Disease Models, Animal; Fibromyalgia; Hyperalgesia | 2021 |
Sleep architecture is altered in the reserpine-induced fibromyalgia model in ovariectomized rats.
Topics: Animals; Disease Models, Animal; Female; Fibromyalgia; Fluoxetine; Hyperalgesia; Ovariectomy; Pain; | 2019 |
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
Topics: Analgesics; Animals; Benzofurans; Depression; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Id | 2019 |
Coexistence of Alterations of Gastrointestinal Function and Mechanical Allodynia in the Reserpine-Induced Animal Model of Fibromyalgia.
Topics: Animals; Body Temperature; Colon; Disease Models, Animal; Feces; Fibromyalgia; Gastric Emptying; Gas | 2019 |
Blockade of spinal α
Topics: Animals; Astrocytes; Female; Fibromyalgia; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia | 2019 |
Kinins and their B
Topics: Animals; Behavior, Animal; Bradykinin; Disease Models, Animal; Fibromyalgia; Gene Knockout Technique | 2019 |
[Influence of ferulic acid on the pain-depression dyad induced by reserpine].
Topics: Animals; Antidepressive Agents; Coumaric Acids; Depression; Dopamine; Dose-Response Relationship, Dr | 2013 |
Systemic administration of 5-HT(2C) receptor agonists attenuates muscular hyperalgesia in reserpine-induced myalgia model.
Topics: Animals; Hyperalgesia; Locomotion; Microdialysis; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Rece | 2013 |
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippoc | 2013 |
The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model.
Topics: Animals; Brain; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dopamine; Fibromyalgia | 2014 |
Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice.
Topics: Amygdala; Analgesics; Animals; Biogenic Amines; Brain Chemistry; Caspase 3; Chronic Pain; Depression | 2014 |
Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats.
Topics: Analgesics; Animals; Brain; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; | 2015 |
Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model.
Topics: Acid Sensing Ion Channels; Action Potentials; Analysis of Variance; Animals; Antihypertensive Agents | 2015 |
Functional MRI of the Reserpine-Induced Putative Rat Model of Fibromyalgia Reveals Discriminatory Patterns of Functional Augmentation to Acute Nociceptive Stimuli.
Topics: Animals; Biogenic Amines; Brain; Brain Mapping; Disease Models, Animal; Electric Stimulation; Fibrom | 2017 |
Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia.
Topics: Adrenergic Uptake Inhibitors; Animals; Biogenic Amines; Central Nervous System; Depressive Disorder; | 2009 |
Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats.
Topics: Animals; Chronic Pain; Constriction; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Male; Neura | 2012 |
Reversal by serotonergic agents of reserpine-induced hyperalgesia in rats.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents, Tricyclic; Female; Hyperalgesia; Hyperesthesia; | 1982 |
Noradrenaline but not dopamine involved in NMDA receptor-mediated hyperalgesia induced by theophylline in awake rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenergic alpha-Agonists; Adrenergic alpha-Antagonist | 1994 |
Mechanism of hyperalgesia in SART stressed (repeated cold stress) mice: antinociceptive effect of neurotropin.
Topics: 5-Hydroxytryptophan; Animals; Cold Temperature; Drug Interactions; Fenclonine; Haloperidol; Hyperalg | 1991 |