Page last updated: 2024-11-06

reserpine and Allodynia

reserpine has been researched along with Allodynia in 26 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Research Excerpts

ExcerptRelevanceReference
" Mechanical hyperalgesia, thermal allodynia, depressive- and anxious-related behavior, and locomotor activity were evaluated after reserpine (0."8.12Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice. ( Baldasso, GM; Capasso, R; Cicco, P; de Assis, PM; Dutra, RC; Ferrarini, EG; Gouvêa, MC; Moreira, ELG; Paes, RS; Raposo, NRB, 2022)
" Here, we investigated the relationship between SERT occupancies and the analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine, which are both 5-HT and NE reuptake inhibitors (SNRIs), on muscular pain in reserpine-induced myalgia (RIM) rats, an animal model of FM-like chronic pain."7.81Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. ( Aoki, T; Fushiki, H; Honda, S; Irie, M; Iwashita, A; Murai, N; Murakami, Y; Nagakura, Y; Tamura, S, 2015)
"This study is to offer a clinical pain-depression dyad therapy of ferulic acid, the pain-depression dyad induced by reserpine was established and the dose-effect relationship of ferulic acid on ameliorating pain-depression dyad was explored."7.79[Influence of ferulic acid on the pain-depression dyad induced by reserpine]. ( Pan, JC; Shi, HM; Wang, QD; Zhang, L, 2013)
"The reserpine-induced myalgia (RIM) rat manifests fibromyalgia-like chronic pain symptoms."7.78Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats. ( Nagakura, Y; Noto, T; Oe, T; Sekizawa, T; Shimizu, Y; Takahashi, M; Tamaki, K; Yoshimi, E, 2012)
"Repeated reserpine injection induced hyperalgesia and depressive behaviors with decreased sucrose preference and horizontal movement distance, and increased immobility time in forced swimming test."5.72Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model. ( Du, Y; Gao, X; Li, L; Lu, Y; Shi, W; Wang, A; Wang, Y; Zhang, S; Zhao, J, 2022)
"Chronic widespread pain is a serious medical problem, yet the mechanisms of nociception and pain are poorly understood."5.42Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. ( Hayashi, K; Katanosaka, K; Kiyama, H; Mizumura, K; Taguchi, T; Wakatsuki, K; Yamanaka, A; Yamashita, M; Yasui, M, 2015)
"Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice."5.40Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014)
" Fibromyalgia was induced by three injections once a day of reserpine at the dose of 1 mg/kg."4.12Role of Etanercept and Infliximab on Nociceptive Changes Induced by the Experimental Model of Fibromyalgia. ( Cordaro, M; Cuzzocrea, S; D'Amico, R; Di Paola, D; Di Paola, R; Franco, G; Fusco, R; Genovese, T; Impellizzeri, D; Marino, Y; Siracusa, R, 2022)
" Mechanical hyperalgesia, thermal allodynia, depressive- and anxious-related behavior, and locomotor activity were evaluated after reserpine (0."4.12Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice. ( Baldasso, GM; Capasso, R; Cicco, P; de Assis, PM; Dutra, RC; Ferrarini, EG; Gouvêa, MC; Moreira, ELG; Paes, RS; Raposo, NRB, 2022)
" On the contrary, suppression of EEG delta power using a wake-promoting agent modafinil significantly attenuated mechanical allodynia."3.96High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice. ( Ge, J; Hong, ZY; Huang, ZL; Lazarus, M; Li, YD; Luo, YJ; Qu, WM; Wang, J; Xu, W, 2020)
" Here, we investigated the relationship between SERT occupancies and the analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine, which are both 5-HT and NE reuptake inhibitors (SNRIs), on muscular pain in reserpine-induced myalgia (RIM) rats, an animal model of FM-like chronic pain."3.81Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. ( Aoki, T; Fushiki, H; Honda, S; Irie, M; Iwashita, A; Murai, N; Murakami, Y; Nagakura, Y; Tamura, S, 2015)
"This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM)."3.80The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. ( Castro, CJ; da Costa Lopes, AM; da Silva, CA; da Silva, JF; de Souza, AH; Ferreira, J; Gomez, MV; Klein, CP; Pereira, EM, 2014)
"This study is to offer a clinical pain-depression dyad therapy of ferulic acid, the pain-depression dyad induced by reserpine was established and the dose-effect relationship of ferulic acid on ameliorating pain-depression dyad was explored."3.79[Influence of ferulic acid on the pain-depression dyad induced by reserpine]. ( Pan, JC; Shi, HM; Wang, QD; Zhang, L, 2013)
"More studies are still warranted in similar rodent models of pain and depression, so, that the present findings can be further substantiated to establish the clinical effectiveness of berberine in a subset of patients suffering from pain as well as depression."3.79Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model. ( Arora, V; Chopra, K, 2013)
"The reserpine-induced myalgia (RIM) rat manifests fibromyalgia-like chronic pain symptoms."3.78Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats. ( Nagakura, Y; Noto, T; Oe, T; Sekizawa, T; Shimizu, Y; Takahashi, M; Tamaki, K; Yoshimi, E, 2012)
"Repeated reserpine injection induced hyperalgesia and depressive behaviors with decreased sucrose preference and horizontal movement distance, and increased immobility time in forced swimming test."1.72Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model. ( Du, Y; Gao, X; Li, L; Lu, Y; Shi, W; Wang, A; Wang, Y; Zhang, S; Zhao, J, 2022)
"Musculoskeletal pain is a widespread complex regional pain syndrome associated with altered emotional and cognitive functioning along with heightened physical disability that has become a global health concern."1.62Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin. ( Bhatti, R; Garg, S; Kaur, A; Kaur, H; Singh, L; Singh, N, 2021)
"Fibromyalgia is characterized by the amplification of central nervous system pain with concomitant fatigue, sleep, mood disorders, depression, and anxiety."1.62Phoneutria nigriventer Tx3-3 peptide toxin reduces fibromyalgia symptoms in mice. ( Antunes, FTT; Campos, MM; Correa, ÁP; de Oliveira, IB; de Souza, AH; do Nascimento Cordeiro, M; Gomez, MV; Klein, CP; Pedron, C; Rebelo, IN, 2021)
"Reserpine caused hyperalgesia on the mechanical and thermal hyperalgesia on the 4th day was reverted by recombinant Phα1β (0."1.62Effects of intravenous administration of recombinant Phα1β toxin in a mouse model of fibromyalgia. ( Assis Ferreira, LC; Carvalho Dos Santos, D; Garcia Mendes, MP; Gomez, MV; José de Castro Junior, C; Rezende, MJS; Rigo, FK, 2021)
"Fibromyalgia is a disease characterised as generalised chronic primary pain that causes functional disability and a reduction in patients' quality of life, without specific pathophysiology or appropriate treatment."1.51Kinins and their B ( Brusco, I; Cunha, TM; Ferreira, J; Fischer, S; Justino, AB; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Silva, CR, 2019)
"Chronic widespread pain is a serious medical problem, yet the mechanisms of nociception and pain are poorly understood."1.42Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. ( Hayashi, K; Katanosaka, K; Kiyama, H; Mizumura, K; Taguchi, T; Wakatsuki, K; Yamanaka, A; Yamashita, M; Yasui, M, 2015)
"Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice."1.40Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014)
"Fibromyalgia is a prevalent and burdensome disorder characterized by chronic widespread pain and complex comorbid symptoms."1.35Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia. ( Aoki, T; Matsuoka, N; Nagakura, Y; Oe, T, 2009)
"This hyperalgesia was antagonized by pretreatment with the N-methyl-D-aspartate (NMDA) receptor antagonist (+)-MK-801, suggesting involvement of NMDA receptors."1.29Noradrenaline but not dopamine involved in NMDA receptor-mediated hyperalgesia induced by theophylline in awake rats. ( Paalzow, GH, 1994)
"To clarify the mechanism of the hyperalgesia in SART mice and the mode of the antinociceptive action of neurotropin in this model, the influence of systemically administered neurotransmitter related drugs was studied."1.28Mechanism of hyperalgesia in SART stressed (repeated cold stress) mice: antinociceptive effect of neurotropin. ( Hata, T; Kawamura, M; Miura, T; Namimatsu, A; Ohara, H; Yoneda, R, 1991)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.85)18.7374
1990's2 (7.69)18.2507
2000's1 (3.85)29.6817
2010's14 (53.85)24.3611
2020's8 (30.77)2.80

Authors

AuthorsStudies
Cordaro, M1
Siracusa, R1
D'Amico, R1
Genovese, T1
Franco, G1
Marino, Y1
Di Paola, D1
Cuzzocrea, S1
Impellizzeri, D1
Di Paola, R1
Fusco, R1
Zhao, J1
Shi, W1
Lu, Y1
Gao, X1
Wang, A1
Zhang, S1
Du, Y1
Wang, Y1
Li, L1
Ferrarini, EG1
Paes, RS1
Baldasso, GM1
de Assis, PM1
Gouvêa, MC1
Cicco, P1
Raposo, NRB1
Capasso, R1
Moreira, ELG1
Dutra, RC1
Álvarez-Pérez, B1
Bagó-Mas, A1
Deulofeu, M1
Vela, JM1
Merlos, M1
Verdú, E1
Boadas-Vaello, P1
Li, YD1
Ge, J1
Luo, YJ1
Xu, W1
Wang, J1
Lazarus, M1
Hong, ZY1
Qu, WM1
Huang, ZL1
Kaur, A1
Singh, L1
Garg, S1
Kaur, H1
Singh, N1
Bhatti, R1
Pedron, C1
Antunes, FTT1
Rebelo, IN1
Campos, MM1
Correa, ÁP1
Klein, CP2
de Oliveira, IB1
do Nascimento Cordeiro, M1
Gomez, MV3
de Souza, AH2
Garcia Mendes, MP1
Carvalho Dos Santos, D1
Rezende, MJS1
Assis Ferreira, LC1
Rigo, FK1
José de Castro Junior, C1
Hernandez-Leon, A1
Fernández-Guasti, A1
Martínez, A1
Pellicer, F1
González-Trujano, ME1
Siemian, JN1
Shang, L1
Seaman, RW1
Zhu, Q1
Zhang, Y1
Li, JX1
Uchida, M1
Kobayashi, O1
Yoshida, M1
Miwa, M1
Miura, R1
Saito, H1
Nagakura, Y5
De la Luz-Cuellar, YE1
Rodríguez-Palma, EJ1
Franco-Enzástiga, Ú1
Salinas-Abarca, AB1
Delgado-Lezama, R1
Granados-Soto, V1
Brusco, I1
Justino, AB1
Silva, CR1
Fischer, S1
Cunha, TM1
Scussel, R1
Machado-de-Ávila, RA1
Ferreira, J2
Oliveira, SM1
Zhang, L1
Wang, QD1
Shi, HM1
Pan, JC1
Ogino, S1
Tsukamoto, M1
Watabiki, T1
Ozawa, T1
Oe, T3
Shimizu, Y2
Ito, H1
Arora, V1
Chopra, K1
da Costa Lopes, AM1
Castro, CJ1
Pereira, EM1
da Silva, CA1
da Silva, JF1
Liu, SB1
Zhao, R1
Li, XS1
Guo, HJ1
Tian, Z1
Zhang, N1
Gao, GD1
Zhao, MG1
Murai, N1
Fushiki, H1
Honda, S1
Murakami, Y1
Iwashita, A1
Irie, M1
Tamura, S1
Aoki, T2
Taguchi, T1
Katanosaka, K1
Yasui, M1
Hayashi, K1
Yamashita, M1
Wakatsuki, K1
Kiyama, H1
Yamanaka, A1
Mizumura, K1
Wells, JA1
Shibata, S1
Fujikawa, A1
Takahashi, M2
Saga, T1
Aoki, I1
Matsuoka, N1
Noto, T1
Sekizawa, T1
Yoshimi, E1
Tamaki, K1
Kulkarni, SK1
Robert, RK1
Paalzow, GH1
Ohara, H1
Kawamura, M1
Namimatsu, A1
Miura, T1
Yoneda, R1
Hata, T1

Other Studies

26 other studies available for reserpine and Allodynia

ArticleYear
Role of Etanercept and Infliximab on Nociceptive Changes Induced by the Experimental Model of Fibromyalgia.
    International journal of molecular sciences, 2022, May-30, Volume: 23, Issue:11

    Topics: Animals; Etanercept; Fibromyalgia; Hyperalgesia; Infliximab; Models, Theoretical; Nociception; p38 M

2022
Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model.
    BMC psychiatry, 2022, 06-22, Volume: 22, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Comorbidity; Cytokines; Depression; Hydrocortisone; Hyperalges

2022
Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 154

    Topics: Analgesics; Animals; Cannabis; Disease Models, Animal; Dronabinol; Fibromyalgia; Hyperalgesia; Mice;

2022
Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models.
    International journal of molecular sciences, 2022, Oct-08, Volume: 23, Issue:19

    Topics: Analgesics; Animals; Chronic Pain; Disease Models, Animal; Female; Fibromyalgia; Gliosis; Hyperalges

2022
High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice.
    Pain, 2020, Volume: 161, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Animals; Cerebral Cortex; Cholinergic Antagonists; Cortical Synchroniz

2020
Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin.
    Journal of molecular neuroscience : MN, 2021, Volume: 71, Issue:2

    Topics: Analgesics; Animals; Anxiety; Brain Chemistry; Cognition Disorders; Cytokines; Drug Evaluation, Prec

2021
Phoneutria nigriventer Tx3-3 peptide toxin reduces fibromyalgia symptoms in mice.
    Neuropeptides, 2021, Volume: 85

    Topics: Analgesics; Anesthetics; Animals; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Male; Mice; Ne

2021
Effects of intravenous administration of recombinant Phα1β toxin in a mouse model of fibromyalgia.
    Toxicon : official journal of the International Society on Toxinology, 2021, Volume: 195

    Topics: Administration, Intravenous; Analgesics; Animals; Disease Models, Animal; Fibromyalgia; Hyperalgesia

2021
Sleep architecture is altered in the reserpine-induced fibromyalgia model in ovariectomized rats.
    Behavioural brain research, 2019, 05-17, Volume: 364

    Topics: Animals; Disease Models, Animal; Female; Fibromyalgia; Fluoxetine; Hyperalgesia; Ovariectomy; Pain;

2019
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
    Behavioural pharmacology, 2019, Volume: 30, Issue:5

    Topics: Analgesics; Animals; Benzofurans; Depression; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Id

2019
Coexistence of Alterations of Gastrointestinal Function and Mechanical Allodynia in the Reserpine-Induced Animal Model of Fibromyalgia.
    Digestive diseases and sciences, 2019, Volume: 64, Issue:9

    Topics: Animals; Body Temperature; Colon; Disease Models, Animal; Feces; Fibromyalgia; Gastric Emptying; Gas

2019
Blockade of spinal α
    European journal of pharmacology, 2019, Sep-05, Volume: 858

    Topics: Animals; Astrocytes; Female; Fibromyalgia; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia

2019
Kinins and their B
    Biochemical pharmacology, 2019, Volume: 168

    Topics: Animals; Behavior, Animal; Bradykinin; Disease Models, Animal; Fibromyalgia; Gene Knockout Technique

2019
[Influence of ferulic acid on the pain-depression dyad induced by reserpine].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2013, Volume: 48, Issue:1

    Topics: Animals; Antidepressive Agents; Coumaric Acids; Depression; Dopamine; Dose-Response Relationship, Dr

2013
Systemic administration of 5-HT(2C) receptor agonists attenuates muscular hyperalgesia in reserpine-induced myalgia model.
    Pharmacology, biochemistry, and behavior, 2013, Volume: 108

    Topics: Animals; Hyperalgesia; Locomotion; Microdialysis; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Rece

2013
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
    Journal of affective disorders, 2013, Volume: 151, Issue:3

    Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippoc

2013
The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model.
    Toxicon : official journal of the International Society on Toxinology, 2014, Volume: 81

    Topics: Animals; Brain; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dopamine; Fibromyalgia

2014
Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice.
    Neuromolecular medicine, 2014, Volume: 16, Issue:2

    Topics: Amygdala; Analgesics; Animals; Biogenic Amines; Brain Chemistry; Caspase 3; Chronic Pain; Depression

2014
Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats.
    Neuroscience, 2015, Mar-19, Volume: 289

    Topics: Analgesics; Animals; Brain; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug;

2015
Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model.
    Pain, 2015, Volume: 156, Issue:3

    Topics: Acid Sensing Ion Channels; Action Potentials; Analysis of Variance; Animals; Antihypertensive Agents

2015
Functional MRI of the Reserpine-Induced Putative Rat Model of Fibromyalgia Reveals Discriminatory Patterns of Functional Augmentation to Acute Nociceptive Stimuli.
    Scientific reports, 2017, 01-12, Volume: 7

    Topics: Animals; Biogenic Amines; Brain; Brain Mapping; Disease Models, Animal; Electric Stimulation; Fibrom

2017
Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia.
    Pain, 2009, Volume: 146, Issue:1-2

    Topics: Adrenergic Uptake Inhibitors; Animals; Biogenic Amines; Central Nervous System; Depressive Disorder;

2009
Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats.
    Behavioural brain research, 2012, Jan-01, Volume: 226, Issue:1

    Topics: Animals; Chronic Pain; Constriction; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Male; Neura

2012
Reversal by serotonergic agents of reserpine-induced hyperalgesia in rats.
    European journal of pharmacology, 1982, Sep-24, Volume: 83, Issue:3-4

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents, Tricyclic; Female; Hyperalgesia; Hyperesthesia;

1982
Noradrenaline but not dopamine involved in NMDA receptor-mediated hyperalgesia induced by theophylline in awake rats.
    European journal of pharmacology, 1994, Jan-24, Volume: 252, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenergic alpha-Agonists; Adrenergic alpha-Antagonist

1994
Mechanism of hyperalgesia in SART stressed (repeated cold stress) mice: antinociceptive effect of neurotropin.
    Japanese journal of pharmacology, 1991, Volume: 57, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Cold Temperature; Drug Interactions; Fenclonine; Haloperidol; Hyperalg

1991