thiophenes has been researched along with Allodynia in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.92) | 18.2507 |
| 2000's | 11 (21.15) | 29.6817 |
| 2010's | 36 (69.23) | 24.3611 |
| 2020's | 4 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Garrett, TJ; Giancotti, LA; Harada, CM; Harmon, TA; Kolar, G; Lauro, F; Salvemini, D | 1 |
| Chai, XQ; Gao, W; Hu, SS; Long, DD; Pan, TT; Shen, L; Wang, D | 1 |
| François-Moutal, L; Khanna, M; Khanna, R; Madura, CL; Miranda, VG; Moutal, A; Shan, Z | 1 |
| Fu, F; Li, T; Liu, R; Wang, L; Wang, T; Zhai, R; Zhang, L | 1 |
| Baudouin, C; Fakih, D; Mélik Parsadaniantz, S; Réaux-Le Goazigo, A | 1 |
| Cartágenes, MSS; Garcia, JBS; Nunes, IDP; Rodrigues, TA; Sampaio, AJB | 1 |
| Araldi, D; Ferrari, LF; Levine, JD | 1 |
| Hisaoka-Nakashima, K; Kodama, K; Morioka, N; Nakamura, Y; Nakata, Y; Saeki, M; Tomori, M; Yoshikawa, K; Zhang, FF | 1 |
| Chen, Z; Doyle, TM; Durante, M; Salvemini, D | 1 |
| Aira, Z; Azkue, JJ; Bilbao, J; Buesa, I; Doñate, F; García Del Caño, G; Zimmermann, M | 1 |
| Cui, JH; Ju, J; Yoon, MH | 1 |
| Aoki, T; Hamakawa, N; Matsuoka, N; Murai, N; Tamura, S; Yamamoto, H | 1 |
| Baraldi, PG; Borea, PA; Gessi, S; Merighi, S; Romagnoli, R; Targa, M; Varani, K; Vincenzi, F | 1 |
| Authier, N; Balayssac, D; Eschalier, A; Ferrier, J; Ling, B; Pereira, B | 1 |
| Dong, YL; Hu, W; Li, HS; Lu, GJ; Sun, YH; Wu, SX; Yang, J; Zhao, GL; Zhu, C | 1 |
| Aoki, T; Matsuoka, N; Murai, N; Tamura, S; Tsukamoto, M | 1 |
| Castagné, V; Le Cudennec, C | 1 |
| Filipek, B; Sałat, K | 1 |
| Russell, G; Strichartz, GR; Wang, CF; Wang, GK | 1 |
| Bhola, RF; Christie, MJ; Christopoulos, A; Imlach, WL; May, LT | 1 |
| Hoshino, H; Obata, H; Saito, S | 1 |
| Davis, SF; Fairchild, DD; Hain, HS; Hanania, T; Henry, MA; Hu, A; Malekiani, SA; Nix, D; Patil, MJ; Sucholeiki, I; Sucholeiki, R | 1 |
| Bellucci, F; Buéno, L; Bugianesi, R; Crea, A; D'Aranno, V; Maggi, CA; Meini, S; Santicioli, P; Tramontana, M | 1 |
| Authier, N; Bertrand, M; Chapuy, E; Chenaf, C; Courteix, C; Eschalier, A; Gabriel, C; Libert, F; Marchand, F; Mocaër, E | 1 |
| Bishnoi, M; Chopra, K; Kuhad, A | 1 |
| Goforth, PB; Lynch, KR; Macdonald, TL; Mba, MU; Milstien, S; Satin, LS; Selley, DE; Sim-Selley, LJ; Spiegel, S; Welch, SP | 1 |
| Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT | 1 |
| Aquino, M; Bruno, I; Guerrero, MD; Payá, M; Riccio, R; Terencio, MC | 1 |
| Dubner, R; Guo, W; Ren, K; Wang, H; Wei, F; Zou, S | 1 |
| Dijkgraaf, MGW; Heesen, M; Hollmann, MW; Kruis, MR; Pijl, AJ; van der Vegt, MH; Vos, K; Vranken, JH | 1 |
| Chen, Z; Doyle, T; Finley, A; Salvemini, D | 1 |
| Courteix, C; Eschalier, A; Fialip, J; Libert, F; Loiodice, S; Privat, AM; Wattiez, AS | 1 |
| Jolivalt, CG; Mixcoatl-Zecuatl, T | 1 |
| Chen, Z; Doyle, T; Muscoli, C; Obeid, LM; Salvemini, D | 1 |
| Andrews, JS; Annedi, SC; Bunton, D; Christie, L; Lee, DK; Maddaford, SP; Mladenova, G; Porreca, F; Rakhit, S; Ramnauth, J; Zhang, D | 1 |
| Bannon, AW; Decker, MW; Gauvin, D; Hsieh, GC; Joshi, SK; Lee, CH; Lewis, LG; Mikusa, J; Mills, CD; Rueter, LE; Zhong, C; Zhu, CZ | 1 |
| Dyhr, H; Erichsen, HK; Hansen, MK; Marcher, L; Munro, G; Sheykhzade, M; Storm, A | 1 |
| Carroll, WA; Chandran, P; Dart, MJ; Daza, AV; El-Kouhen, OF; Fan, Y; Florjancic, AS; Frost, JM; Garrison, TR; Grayson, GK; Hooker, BA; Hsieh, GC; Meyer, MD; Nelson, DW; Pai, M; Ryther, K; Tietje, KR; Yao, B; Zhu, C | 1 |
| Miyazaki, R; Yamamoto, T | 1 |
| Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y | 1 |
| Christensen, J; Erichsen, H; Hansen, H; Hansen, R; Munro, G; Timmermann, D | 1 |
| Borrelli, G; Borsini, F; Brindisi, M; Butini, S; Cabri, W; Campiani, G; Caprioli, A; Di Serio, S; Fezza, F; Gallo, G; Gemma, S; Maccarrone, M; Maramai, S; Minetti, P; Ros, S; Stasi, MA; Talamonti, E; Vincenti, S | 1 |
| Bannon, AW; Gauvin, DM; Gomez, EJ; Mikusa, J; Mills, CD; Nguyen, T; Salyers, AK; Tanga, FY; Zhong, C | 1 |
| Lluch Girbés, E; López Cubas, C; Nijs, J; Torres-Cueco, R | 1 |
| Buursma, AR; de Vries, EF; Vaalburg, W; van Waarde, A | 1 |
| Andre, N; Bellot, I; Bresson, Y; Deschamps, C; Pastoureau, P; Tordjman, C; Wierzbicki, M | 1 |
| Eisenach, JC; Li, X; Obata, H | 1 |
| Jones, CK; Peters, SC; Shannon, HE | 2 |
| Berrino, L; de Novellis, V; Maione, S; Marabese, I; Mariani, L; Oliva, P; Palazzo, E; Rossi, F; Scafuro, M; Siniscalco, D | 1 |
| Eastwood, BJ; Jones, CK; Need, AB; Shannon, HE | 1 |
| de Belleroche, J; Hay, C | 1 |
1 trial(s) available for thiophenes and Allodynia
| Article | Year |
|---|---|
Duloxetine in patients with central neuropathic pain caused by spinal cord injury or stroke: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Disability Evaluation; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Outcome Assessment, Health Care; Pain Measurement; Pain Threshold; Placebo Effect; Spinal Cord Injuries; Stroke; Thiophenes; Treatment Outcome | 2011 |
51 other study(ies) available for thiophenes and Allodynia
| Article | Year |
|---|---|
Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities.
Topics: Adenosine; Adenosine Kinase; Animals; Hyperalgesia; Inflammasomes; Interleukin-1beta; NLR Proteins; Oxadiazoles; Rats; Rats, Sprague-Dawley; Sphingosine-1-Phosphate Receptors; Spinal Cord Dorsal Horn; Thiophenes | 2022 |
Angiotensin II type 2 receptor pharmacological agonist, C21, reduces the inflammation and pain hypersensitivity in mice with joint inflammatory pain.
Topics: Animals; Arthritis; Hyperalgesia; Imidazoles; Inflammation; Mice; Microglia; Pain; Receptor, Angiotensin, Type 2; Spinal Cord; Sulfonamides; Thiophenes | 2022 |
Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief.
Topics: Animals; Calcium; Drug Evaluation, Preclinical; Female; Ganglia, Spinal; Humans; Hyperalgesia; Intercellular Signaling Peptides and Proteins; Male; Maleates; Nerve Tissue Proteins; Phosphorylation; Thiophenes | 2019 |
Antinociceptive effects of rotigotine-loaded microspheres and its synergistic interactions with analgesics in inflammatory pain in rats.
Topics: Acetaminophen; Analgesics; Animals; Behavior, Animal; Carrageenan; Delayed-Action Preparations; Disease Models, Animal; Drug Compounding; Drug Synergism; Drug Therapy, Combination; Hyperalgesia; Locomotion; Male; Microspheres; Nociceptive Pain; Open Field Test; Pain Threshold; Rats, Sprague-Dawley; Tetrahydronaphthalenes; Thiophenes; Tramadol | 2021 |
TRPM8: A Therapeutic Target for Neuroinflammatory Symptoms Induced by Severe Dry Eye Disease.
Topics: Administration, Ophthalmic; Animals; Anti-Inflammatory Agents; Chemokine CCL2; Cold Temperature; Cornea; CX3C Chemokine Receptor 1; Disease Models, Animal; Dry Eye Syndromes; Evoked Potentials, Somatosensory; Ganglia, Parasympathetic; Gene Expression Regulation; Harderian Gland; Hyperalgesia; Interleukin-18; Interleukin-1beta; Lacrimal Apparatus; Male; Mice; Mice, Inbred C57BL; Neuralgia; Nicotinic Acids; Prostaglandin-E Synthases; Thiophenes; Trigeminal Ganglion; TRPM Cation Channels | 2020 |
Effect of strontium ranelate on pain behavior in an experimental model of osteoarthritis.
Topics: Animals; Bone Density Conservation Agents; Disease Models, Animal; Hyperalgesia; Male; Osteoarthritis, Knee; Rats; Rats, Wistar; Thiophenes | 2017 |
Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat.
Topics: Analgesics, Opioid; Animals; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Intradermal; Male; Nociception; Pain Threshold; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spiro Compounds; Thiophenes; Urea | 2018 |
Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice.
Topics: Animals; Astrocytes; Cytokines; Female; Glial Fibrillary Acidic Protein; Glycine; Hyperalgesia; Inflammation; Interleukin-6; Male; Mice; Neuralgia; Nociceptors; Nuclear Receptor Subfamily 1, Group D, Member 1; Primary Cell Culture; Pyrrolidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Spinal Cord; Spinal Cord Dorsal Horn; Thiophenes; Tumor Necrosis Factor-alpha | 2019 |
Activation of Sphingosine-1-Phosphate Receptor 1 in the Spinal Cord Produces Mechanohypersensitivity Through the Activation of Inflammasome and IL-1β Pathway.
Topics: Animals; Astrocytes; Caspase 1; Hyperalgesia; Inflammasomes; Interleukin-1beta; Male; Mice; Mice, Transgenic; NLR Family, Pyrin Domain-Containing 3 Protein; Oxadiazoles; Pain Measurement; Pain Threshold; Rats, Sprague-Dawley; Signal Transduction; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Spinal Cord; Thiophenes | 2019 |
Transient, 5-HT2B receptor-mediated facilitation in neuropathic pain: Up-regulation of PKCγ and engagement of the NMDA receptor in dorsal horn neurons.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Evoked Potentials; Excitatory Amino Acid Antagonists; HEK293 Cells; Humans; Hyperalgesia; Indoles; Male; Nerve Fibers, Unmyelinated; Neuralgia; Neurons; Physical Stimulation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists; Spinal Nerve Roots; Spinal Nerves; Subcellular Fractions; Thiophenes; Time Factors; Up-Regulation | 2013 |
Pharmacology of cannabinoid receptor agonists and a cyclooxygenase-2 inhibitor in rat bone tumor pain.
Topics: Animals; Arachidonic Acids; Bone Neoplasms; Cannabinoid Receptor Agonists; Cannabinoids; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Hyperalgesia; Pain; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Spinal Cord; Thiophenes; Tibia | 2013 |
AS1069562, the (+)-isomer of indeloxazine, but not duloxetine has a curative-like analgesic effect in a rat model of streptozotocin-induced diabetic neuropathy.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Duloxetine Hydrochloride; Fibroblast Growth Factor 2; Ganglia, Spinal; Hyperalgesia; Insulin-Like Growth Factor I; Male; Morpholines; Neural Conduction; Neurotransmitter Uptake Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Streptozocin; Thiophenes; Time Factors | 2014 |
TRR469, a potent A(1) adenosine receptor allosteric modulator, exhibits anti-nociceptive properties in acute and neuropathic pain models in mice.
Topics: Acetic Acid; Allosteric Regulation; Analgesics; Animals; Catalepsy; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Motor Activity; Neuralgia; Pain Measurement; Pain Threshold; Piperazines; Protein Binding; Purinergic Agents; Thiophenes | 2014 |
Assessment of thermal sensitivity in rats using the thermal place preference test: description and application in the study of oxaliplatin-induced acute thermal hypersensitivity and inflammatory pain models.
Topics: Analgesics; Analgesics, Opioid; Animals; Carrageenan; Cold Temperature; Conditioning, Psychological; Disease Models, Animal; Duloxetine Hydrochloride; Hot Temperature; Hyperalgesia; Male; Morphine; Organoplatinum Compounds; Oxaliplatin; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Space Perception; Temperature; Thiophenes | 2014 |
The analgesia effect of duloxetine on post-operative pain via intrathecal or intraperitoneal administration.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Duloxetine Hydrochloride; Hyperalgesia; Idazoxan; Injections, Intraperitoneal; Injections, Spinal; Ketanserin; Male; Microdialysis; Norepinephrine; Pain, Postoperative; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Spinal Cord; Thiophenes | 2014 |
Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Hyperalgesia; Injections, Spinal; Male; Mice, Inbred ICR; Morpholines; Neuralgia; Prostaglandins; Spinal Cord; Stereoisomerism; Thiophenes | 2014 |
Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine.
Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Male; Neuralgia; Physical Stimulation; Pregabalin; Rats, Wistar; Sciatic Nerve; Thiophenes; Tramadol | 2014 |
Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
Topics: Acetanilides; Analgesics; Animals; Benzamides; Capsaicin; Cold Temperature; Disease Models, Animal; Formaldehyde; Hyperalgesia; Isothiocyanates; Male; Mice; Neuralgia; Oximes; Paclitaxel; Pain Measurement; Purines; Thiophenes; Touch; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels | 2015 |
The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model.
Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Animals; Bupivacaine; Cells, Cultured; Dermatologic Surgical Procedures; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Hyperalgesia; Injections, Intraperitoneal; Male; Pain Measurement; Pain, Postoperative; Pituitary Gland; Rats, Sprague-Dawley; Sciatic Nerve; Sodium Channel Blockers; Sodium Channels; Thiophenes; Time Factors | 2015 |
A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model.
Topics: Adenosine A1 Receptor Agonists; Allosteric Regulation; Animals; Excitatory Postsynaptic Potentials; Hyperalgesia; Male; Neuralgia; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Thiophenes; Xanthines | 2015 |
Antihyperalgesic effect of duloxetine and amitriptyline in rats after peripheral nerve injury: Influence of descending noradrenergic plasticity.
Topics: Amitriptyline; Analgesics; Animals; Duloxetine Hydrochloride; Hyperalgesia; Lumbosacral Region; Male; Neuronal Plasticity; Norepinephrine; Rats, Sprague-Dawley; Serotonin; Spinal Cord Dorsal Horn; Spinal Nerves; Thiophenes; Time Factors | 2015 |
Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain.
Topics: Administration, Oral; Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Indoles; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neuralgia; Propionates; Rats; Rats, Sprague-Dawley; Spinal Nerves; Thiophenes; Trigeminal Nerve | 2015 |
Gender-related differential effect of tachykinin NK2 receptor-mediated visceral hyperalgesia in guinea pig colon.
Topics: Animals; Colitis; Colon; Dipeptides; Disease Models, Animal; Female; Guinea Pigs; Hyperalgesia; Male; Receptors, Neurokinin-2; Sex Characteristics; Thiophenes; Trinitrobenzenesulfonic Acid; Visceral Pain | 2016 |
Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence.
Topics: Acetamides; Adrenergic alpha-2 Receptor Antagonists; Amines; Animals; Antineoplastic Agents; Constriction, Pathologic; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Hypnotics and Sedatives; Idazoxan; Male; Motor Activity; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes | 2017 |
Anti-nociceptive effect of duloxetine in mouse model of diabetic neuropathic pain.
Topics: Adenosine; Animals; Cerebral Cortex; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred Strains; Pain Measurement; Pain Threshold; Selective Serotonin Reuptake Inhibitors; Streptozocin; Thiophenes; Touch | 2009 |
Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS.
Topics: Animals; Animals, Newborn; Binding, Competitive; Cannabinoids; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Lysophospholipids; Neurons; Oxadiazoles; Patch-Clamp Techniques; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Receptors, Neurotransmitter; Signal Transduction; Sphingosine; Sulfur Radioisotopes; Synaptic Transmission; Thiophenes | 2009 |
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.
Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan; Cyclohexanecarboxylic Acids; Duloxetine Hydrochloride; Edema; Freund's Adjuvant; Gabapentin; Gait; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Indomethacin; Inflammation; Male; Morphine; Neuralgia; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Thiophenes | 2009 |
Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression.
Topics: 4-Butyrolactone; Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Behavior, Animal; Blood Platelets; Cattle; Chronic Disease; Gene Expression Regulation, Enzymologic; Humans; Hyperalgesia; Inflammation; Intramolecular Oxidoreductases; Leukotriene B4; Male; Mice; Neutrophils; Prostaglandin-E Synthases; Thiophenes; Thromboxane B2 | 2009 |
Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: a model of myogenic orofacial pain.
Topics: Adrenergic Uptake Inhibitors; Analgesics; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Facial Pain; Hyperalgesia; Ligation; Male; Masseter Muscle; Neuroglia; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tendons; Thiophenes; Trigeminal Nucleus, Spinal | 2010 |
Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats.
Topics: Acetophenones; Anilides; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Hyperalgesia; Lysophospholipids; Male; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Organophosphonates; Oxadiazoles; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Time Factors | 2011 |
Evidence for a differential opioidergic involvement in the analgesic effect of antidepressants: prediction for efficacy in animal models of neuropathic pain?
Topics: Analgesics; Animals; Antidepressive Agents; Clomipramine; Cyclopropanes; Diabetes Mellitus, Experimental; Disease Models, Animal; Duloxetine Hydrochloride; Hyperalgesia; Male; Milnacipran; Naloxone; Neuralgia; Rats; Rats, Sprague-Dawley; Thiophenes | 2011 |
A spinal mechanism of action for duloxetine in a rat model of painful diabetic neuropathy.
Topics: Amphetamines; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; Hyperalgesia; Ketanserin; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Thiophenes | 2011 |
Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway.
Topics: Animals; Antibodies, Monoclonal; Ceramides; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Extremities; Hot Temperature; Hyperalgesia; Imidazoles; Injections; Male; Models, Biological; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiophenes; Touch | 2011 |
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
Topics: Analgesics; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Hot Temperature; Humans; Hyperalgesia; Indoles; Ligation; Neuralgia; Nitric Oxide Synthase Type I; Pain; Pyridines; Spinal Nerves; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Vascular Resistance; Vasoconstriction | 2011 |
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Central Nervous System Stimulants; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Ibuprofen; Lameness, Animal; Male; Morphine; Motor Activity; Neuritis; Rats; Rats, Sprague-Dawley; Thiophenes | 2012 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Locomotion; Male; Morphine; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes | 2012 |
Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB₂ receptor agonists for pain management.
Topics: Amides; Analgesics; Animals; Biological Availability; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Neuralgia; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship; Thiophenes | 2012 |
The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model.
Topics: Administration, Oral; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Morphine; Neuralgia; Neuroma; Pain Measurement; Pain Threshold; Pregabalin; Rats; Rats, Sprague-Dawley; Thiophenes; Time Factors | 2012 |
Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Drug Interactions; Duloxetine Hydrochloride; Etodolac; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mexiletine; Mice; Paclitaxel; Peripheral Nervous System Diseases; Pregabalin; Thiophenes; Tissue Distribution | 2012 |
The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azabicyclo Compounds; Carrageenan; Cytokines; Diclofenac; Freund's Adjuvant; Gene Expression Regulation; Hyperalgesia; Inflammation; Isoxazoles; Male; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thiophenes | 2012 |
Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.
Topics: Amidohydrolases; Analgesics; Animals; Brain; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Furans; Humans; Hyperalgesia; Maze Learning; Mice; Models, Molecular; Pain Threshold; Pyrroles; Rats; Recombinant Proteins; Stereotyped Behavior; Structure-Activity Relationship; Thiophenes | 2012 |
Characterization of nerve growth factor-induced mechanical and thermal hypersensitivity in rats.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diclofenac; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Nerve Growth Factor; Pain Threshold; Physical Stimulation; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones; Thiophenes; TRPV Cation Channels | 2013 |
Pain treatment for patients with osteoarthritis and central sensitization.
Topics: Brain Mapping; Cognitive Behavioral Therapy; Duloxetine Hydrochloride; Exercise Therapy; Humans; Hyperalgesia; Magnetic Resonance Imaging; Neuralgia; Neuroglia; Nociception; Osteoarthritis; Pain Management; Physical Therapy Modalities; Selective Serotonin Reuptake Inhibitors; Thiophenes | 2013 |
Synthesis and in vivo evaluation of 18F-desbromo-DuP-697 as a PET tracer for cyclooxygenase-2 expression.
Topics: Animals; Brain; Cyclooxygenase 2; Fluorine Radioisotopes; Hyperalgesia; Isoenzymes; Isotope Labeling; Male; Organ Specificity; Prostaglandin-Endoperoxide Synthases; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Thiophenes; Tissue Distribution | 2003 |
General pharmacology of the butanamide derivative S 19812, a new dual inhibitor of cyclooxygenase and lipoxygenase pathways.
Topics: Acetic Acid; Air; Amides; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Hot Temperature; Hyperalgesia; Lipoxygenase Inhibitors; Male; Mice; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Reaction Time; Stomach Diseases; Thiophenes | 2003 |
Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Hyperalgesia; Male; Pain Threshold; Postoperative Care; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Spinal Cord; Thiophenes | 2004 |
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Ibuprofen; Inflammation; Male; Mice; Morphine; Norepinephrine; Pain; Pain Measurement; Postural Balance; Rats; Rats, Sprague-Dawley; Reaction Time; Selective Serotonin Reuptake Inhibitors; Thiophenes | 2005 |
Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia.
Topics: Acetates; Acrylamides; Animals; Benzyl Compounds; Dimethyl Sulfoxide; Extracellular Fluid; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Injections, Intraventricular; Male; Mice; Microdialysis; Misoprostol; Naphthalenes; Pain Measurement; Periaqueductal Gray; Prostaglandin Antagonists; Receptors, Prostaglandin E; Thiophenes; Triazoles; Xanthones | 2006 |
Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents.
Topics: Acetic Acid; Adrenergic Uptake Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Drug Synergism; Duloxetine Hydrochloride; Hyperalgesia; Ibuprofen; Inflammation; Male; Mice; Mice, Inbred Strains; Norepinephrine; Pain; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiophenes | 2007 |
Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: evidence for synergism between serotonergic and noradrenergic reuptake inhibition.
Topics: Adrenergic Uptake Inhibitors; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Chemistry; Carrageenan; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Duloxetine Hydrochloride; Edema; Fluoxetine; Hot Temperature; Hyperalgesia; Male; Norepinephrine; Paroxetine; Pressure; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Sertraline; Thiophenes; Venlafaxine Hydrochloride | 2006 |
Carrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord.
Topics: Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Hyperalgesia; Isoenzymes; Lumbosacral Region; Male; Prostaglandin-Endoperoxide Synthases; Rats; Spinal Cord; Stress, Mechanical; Thiophenes | 1997 |