Page last updated: 2024-09-27

Aggressive Natural Killer Cell Leukemia

Synonyms(19)

Synonym
Large Granular Lymphocyte Leukemia
Leukemia, T-LGL
Leukemia, T-Cell Large Granular Lymphocytic
Leukemia, NK-LGL
Leukemia, Natural Killer Cell Large Granular Lymphocytic
Leukemia, LGL
LGL Leukemia
Aggressive NK Cell Leukemia
Aggressive Natural Killer Cell Leukemia
T-Cell Large Granular Lymphocyte Leukemia
T-Cell Large Granular Lymphocytic Leukemia
Natural Killer Cell Large Granular Lymphocytic Leukemia
T-LGL Leukemia
Lymphoproliferative Disease of Granular Lymphocytes
NK-LGL Leukemia
Large Granular Lymphocytosis
Leukemia, Lymphocytic, Large Granular
NK-Cell Large Granular Lymphocytic Leukemia
Lymphoproliferative Disease of Large Granular Lymphocytes

Research Excerpts

Overview

ExcerptReference
"T-LGL leukemia is associated with immunological abnormalities: rheumatoid factor with or without rheumatoid arthritis (RA), Coombs positive hemolytic anemia, idiopathic thrombocytopenic purpura (ITP), pure red cell aplasia (PRCA), positive anti-nuclear antibodies (ANA), anti-neutrophil cytoplasmic antibodies (ANCA), hypogammaglobulinemia, and polyclonal hypergammaglobulinemia."( Antic, D; Gotic, M; Jakovic, L; Jankovic, S; Mihaljevic, B; Perunicic-Jovanovic, M; Sretenovic, A, 2010)
"Treatment of LGL leukemia is based on a low-dose immunosuppressive regimen using methotrexate or cyclophosphamide."( Leblanc, F; Liu, X; Loughran, TP; Zhang, D, 2012)
"LGL leukemia is thought to arise from chronic antigenic stimulation, with the long-term survival of LGL being promoted by constitutive activation of multiple survival signaling pathways, such as the JAK/STAT3, sphingolipid, and Ras/MEK/ERK pathways."( Loughran, TP; Zhang, D, 2012)
"Large granular lymphocyte leukemia is rare, mainly chronic disease."( Adamkovich, N; Bagdi, E; Borbényi, Z; Kispál, M; Krenács, L, 2014)
"T-LGL leukemia is characterized by CD3+ T-cell phenotype and TCR gene rearrangement (T lymphocyte receptor)."( Benmoussa, A; Oussaih, L; Tazi, I, 2019)

Treatment

ExcerptReference
"One patient died due to T-LGL leukemia in first year after diagnosis, one patient died 4 years after diagnosis, two patients interrupted their treatment, and two patients are still alive."( Antic, D; Gotic, M; Jakovic, L; Jankovic, S; Mihaljevic, B; Perunicic-Jovanovic, M; Sretenovic, A, 2010)
"The majority of LGL leukemia patients eventually need treatment."( Loughran, TP; Zhang, D, 2012)
"This first prospective trial in LGL leukemia was a multicenter, phase 2 clinical trial evaluating methotrexate (MTX) at 10 mg/m(2) orally weekly as initial therapy (step 1)."( Bennett, JM; Evens, AM; Hasanali, Z; Lazarus, HM; Litzow, MR; Loughran, TP; Mustjoki, S; Olson, TL; Rajala, HL; Tallman, MS; Wang, V; Zhang, D; Zickl, L, 2015)
"Although most cases of T-LGL leukemia are indolent and asymptomatic during the course of the disease, some present with pure red cell aplasia (PRCA) and require therapy."( Tabata, C; Tabata, R, 2014)

Research

Studies (91)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's6 (6.59)18.1394
2010's64 (70.33)28.8240
2020's21 (23.08)9.53
DrugIndicatedRelationship StrengthStudiesTrials
cytosine0low10
azathioprine0low10
1-phenyl-2-palmitoylamino-3-morpholino-1-propanol0low10
hydroxychloroquine0low10
hydroxyurea0low10
ifosfamide0low10
pd 980590low10
vorinostat0low10
thalidomide0low20
prednisolone0low40
prednisone0low80
carbostyril0low20
cytarabine0low10
methylprednisolone0low20
pyrroles0low10
adamantane0low10
thiazoles0low10
pyrazines0low20
hydrazine0low10
alpha-aminopyridine0low10
arsenic trioxide0low10
cladribine0low20
vidarabine0low20
cetylpyridinium chloride anhydrous0low10
etoposide0low20
vindesine0low10
imiquimod0low10
fluorodeoxyglucose f180low10
voriconazole0low10
bendamustine hydrochloride0low20
fibrinogen0low10
imatinib mesylate0low30
methotrexate0medium251
tipifarnib0low20
lenalidomide0low20
bortezomib0low40
pentostatin0low30
tretinoin0low10
resveratrol0low10
melphalan0low10
stilbenes0low10
fludarabine0low20
dasatinib0medium41
sphingosine0low10
calcitriol0low20
amphotericin b0low10
sphingosine 1-phosphate0low10
sirolimus0low30
arsenic0low10
abscisic acid0low20
belinostat0low10
tofacitinib0low10
losartan potassium0low10
indocyanine green0low10
sphingosine kinase0low20
incb-0184240low10
piperidines0low10
interleukin-80low10
3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide0low10
cyclosporine0medium201

Protein Targets (1,256)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
AR protein240024
retinoic acid nuclear receptor alpha variant 1170017
estrogen nuclear receptor alpha230023
thyroid stimulating hormone receptor7007
thyroid hormone receptor beta isoform 2180018
Voltage-dependent calcium channel gamma-2 subunit150015
Heat shock protein HSP 90-alpha0112
Botulinum neurotoxin type A 0101
Neutrophil cytosol factor 10202
Glutamate receptor 2150015
Nitric oxide synthase, endothelial0101
Nitric oxide synthase, brain0101
Nitric oxide synthase, brain 0101
Nitric oxide synthase, inducible0101
Kappa-type opioid receptor0022
Phosphatidylinositol 4-kinase alpha0101
Mu-type opioid receptor0011
Tyrosine-protein kinase 0011
Phosphatidylinositol 4-kinase type 2-beta0101
Phosphatidylinositol 4-kinase type 2-alpha0101
Phosphatidylinositol 4-kinase beta0134
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, Cruzipain3003
interleukin 82002
phosphopantetheinyl transferase7007
GLS protein7007
glucocorticoid receptor [Homo sapiens]150015
farnesoid X nuclear receptor130013
peroxisome proliferator-activated receptor delta120012
vitamin D (1,25- dihydroxyvitamin D3) receptor100010
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA7007
nuclear factor erythroid 2-related factor 2 isoform 1170017
peripheral myelin protein 22100010
lamin isoform A-delta10120012
Cytochrome P450 1A20416
Cytochrome P450 3A4013117
Cytochrome P450 2D60516
Cytochrome P450 2C9 09111
Cytochrome P450 2C190819
Nuclear receptor ROR-gamma5117
Potassium voltage-gated channel subfamily H member 20606
Aurora kinase B0246
Broad substrate specificity ATP-binding cassette transporter ABCG20304
TDP1 protein230023
peroxisome proliferator activated receptor gamma100010
nuclear receptor subfamily 1, group I, member 25005
Cellular tumor antigen p53180018
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE7007
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Ferritin light chain6006
acetylcholinesterase6006
thioredoxin reductase100010
RAR-related orphan receptor gamma140014
SMAD family member 25005
ATAD5 protein, partial5005
Fumarate hydratase8008
SMAD family member 35005
GLI family zinc finger 3170017
Microtubule-associated protein tau8008
thioredoxin glutathione reductase5005
nuclear receptor subfamily 1, group I, member 3170017
EWS/FLI fusion protein200020
retinoid X nuclear receptor alpha140014
estrogen-related nuclear receptor alpha190019
pregnane X nuclear receptor160016
G100010
polyprotein8008
P532002
arylsulfatase A4004
IDH19009
euchromatic histone-lysine N-methyltransferase 2100010
aryl hydrocarbon receptor9009
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a140014
activating transcription factor 65005
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x100010
Bloom syndrome protein isoform 18008
peripheral myelin protein 22 isoform 14004
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a5005
heat shock protein beta-15005
DNA polymerase iota isoform a (long)8008
geminin210021
survival motor neuron protein isoform d8008
cytochrome P450 3A4 isoform 16006
M-phase phosphoprotein 84004
muscleblind-like protein 1 isoform 16006
muscarinic acetylcholine receptor M12002
Gamma-aminobutyric acid receptor subunit pi6006
ATP-binding cassette sub-family C member 3020020
Multidrug resistance-associated protein 4020021
Bile salt export pump0202
Bile salt export pump023023
Interferon beta160016
HLA class I histocompatibility antigen, B alpha chain 100010
Gamma-aminobutyric acid receptor subunit beta-16006
Gamma-aminobutyric acid receptor subunit delta6006
Gamma-aminobutyric acid receptor subunit gamma-26006
Gamma-aminobutyric acid receptor subunit alpha-56006
Gamma-aminobutyric acid receptor subunit alpha-36006
Gamma-aminobutyric acid receptor subunit gamma-16006
Gamma-aminobutyric acid receptor subunit alpha-26006
Gamma-aminobutyric acid receptor subunit alpha-46006
Gamma-aminobutyric acid receptor subunit gamma-36006
Gamma-aminobutyric acid receptor subunit alpha-66006
Gamma-aminobutyric acid receptor subunit alpha-16006
Gamma-aminobutyric acid receptor subunit beta-36006
Gamma-aminobutyric acid receptor subunit beta-26006
GABA theta subunit6006
Inositol hexakisphosphate kinase 1100010
Canalicular multispecific organic anion transporter 1020021
ATPase family AAA domain-containing protein 5140014
Ataxin-2160016
Gamma-aminobutyric acid receptor subunit epsilon6006
Protein-arginine deiminase type-40202
cytochrome P450 2C9, partial100010
PPM1D protein8008
cytochrome P450 family 3 subfamily A polypeptide 4120012
cytochrome P450 2D67007
Histone deacetylase 305210
Bromodomain-containing protein 40303
Leukotriene A-4 hydrolase0303
Cytochrome P450 3A50102
Histone deacetylase 40429
Spike glycoprotein80210
Aspartyl/asparaginyl beta-hydroxylase0101
Histone deacetylase 105311
Histone deacetylase 704310
Histone deacetylase 205311
Polyamine deacetylase HDAC100429
Histone deacetylase 11 0429
Histone deacetylase 805311
Histone deacetylase 606312
Histone deacetylase 90429
Histone deacetylase 50429
Histone deacetylase 0202
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Proteasome subunit beta type-110101
caspase 7, apoptosis-related cysteine protease7007
estrogen receptor 2 (ER beta)100010
progesterone receptor120012
caspase-37007
Caspase-74004
caspase-34004
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70101
26S proteasome non-ATPase regulatory subunit 30101
Carbonic anhydrase 120303
Prothrombin0102
Chymotrypsinogen A0101
Carbonic anhydrase 10303
Carbonic anhydrase 20416
Carbonic anhydrase 30303
Cathepsin B0101
Neutrophil elastase0101
Cathepsin G0202
Lysosomal protective protein0101
Chymotrypsinogen B0101
26S proteasome regulatory subunit 6A0101
Nuclear factor NF-kappa-B p105 subunit0202
Proteasome subunit beta type-10102
Carbonic anhydrase 40404
Carbonic anhydrase 60303
Chymase0101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50304
Carbonic anhydrase 5A, mitochondrial0404
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
Proteasome subunit beta type-100101
Carbonic anhydrase 70303
26S proteasome regulatory subunit 6B0145
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20102
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Beta-carbonic anhydrase 10101
Nuclear factor NF-kappa-B p100 subunit 0202
Transcription factor p650202
26S proteasome non-ATPase regulatory subunit 20101
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
Carbonic anhydrase 90405
ATP-dependent Clp protease proteolytic subunit0112
Carbonic anhydrase 130303
NACHT, LRR and PYD domains-containing protein 3 0101
Proteasome subunit alpha-type 80101
Proteasome subunit beta type-70101
26S proteasome non-ATPase regulatory subunit 10101
Carbonic anhydrase 150202
Carbonic anhydrase 140303
26S proteasome non-ATPase regulatory subunit 130101
Carbonic anhydrase 5B, mitochondrial0303
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Beta-lactamase5005
Vitamin D3 receptor0011
USP1 protein, partial8008
mitogen-activated protein kinase 15005
nuclear receptor ROR-gamma isoform 19009
Vitamin D-binding protein0011
Androgen receptor0303
Vitamin D3 receptor0124
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0235
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0101
Vitamin D3 receptor A0022
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, serum paraoxonase0101
DNA polymerase kappa isoform 14004
Poly [ADP-ribose] polymerase tankyrase-20101
hypoxia-inducible factor 1 alpha subunit5005
67.9K protein100010
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
thyrotropin-releasing hormone receptor2002
Caspase-20011
Inositol monophosphatase 13003
Chain A, BCL-2-RELATED PROTEIN A10011
glp-1 receptor, partial6006
Smad37007
nuclear factor erythroid 2-related factor 2 isoform 29009
huntingtin isoform 23003
tyrosine-protein kinase Yes4004
urokinase-type plasminogen activator precursor9009
plasminogen precursor9009
urokinase plasminogen activator surface receptor precursor9009
relaxin receptor 1 isoform 11001
bcl-2-like protein 11 isoform 10011
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Integrin beta-34004
Integrin alpha-IIb4004
Deoxycytidine kinase0046
Adenosine receptor A30202
Rap guanine nucleotide exchange factor 42002
endonuclease IV2002
LMP1 [Human herpesvirus 4]0003
chromobox protein homolog 19009
thyroid hormone receptor beta isoform a5005
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0303
serine/threonine-protein kinase mTOR isoform 14004
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
transactivating tegument protein VP16 [Human herpesvirus 1]0303
nuclear receptor coactivator 3 isoform a0303
Thymidine kinase 2, mitochondrial0101
Thymidine kinase, cytosolic0102
Thymidine kinase0101
Thymidylate synthase0203
Thymidine kinase0101
Probable deoxycytidylate deaminase0001
Cytidine deaminase0102
D(1A) dopamine receptor2002
E3 ubiquitin-protein ligase Mdm20202
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Thymidine kinase0101
Deoxynucleoside kinase0101
ATP-dependent phosphofructokinase6006
Deoxycytidine kinase0001
Leukotriene C4 synthase0033
GALC protein2002
Spike glycoprotein0022
Replicase polyprotein 1ab0022
Bone morphogenetic protein receptor type-1B0044
Membrane-associated progesterone receptor component 10022
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0134
Serine/threonine-protein kinase PLK40044
Serine/threonine-protein kinase 250033
ATP-dependent RNA helicase DDX3X0044
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0033
Pyridoxal kinase0044
Citron Rho-interacting kinase0044
Serine/threonine-protein kinase RIO30033
Dual specificity mitogen-activated protein kinase kinase 70134
Serine/threonine-protein kinase Chk10145
Inhibitor of nuclear factor kappa-B kinase subunit beta0134
Peripheral plasma membrane protein CASK0033
Aurora kinase A0145
Cyclin-G-associated kinase0145
Serine/threonine-protein kinase DCLK10033
Inhibitor of nuclear factor kappa-B kinase subunit alpha0134
Muscle, skeletal receptor tyrosine-protein kinase0033
Ephrin type-B receptor 60044
Peroxisomal acyl-coenzyme A oxidase 30044
Mitogen-activated protein kinase 130235
Transmembrane protease serine 20022
3-phosphoinositide-dependent protein kinase 10033
Mitogen-activated protein kinase kinase kinase 130033
Death-associated protein kinase 30033
Mitogen-activated protein kinase kinase kinase 70033
Receptor-interacting serine/threonine-protein kinase 20246
Mitotic checkpoint serine/threonine-protein kinase BUB10044
NUAK family SNF1-like kinase 10033
Dynamin-like 120 kDa protein, mitochondrial0044
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0033
Tyrosine-protein kinase JAK206614
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Eukaryotic translation initiation factor 5B0033
Rho-associated protein kinase 20145
Serine/threonine-protein kinase ULK10044
Serine/threonine-protein kinase/endoribonuclease IRE10044
Ribosomal protein S6 kinase alpha-50145
U5 small nuclear ribonucleoprotein 200 kDa helicase0044
Ribosomal protein S6 kinase alpha-40044
Serine/threonine-protein kinase 160044
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0033
Serine/threonine-protein kinase PAK 30033
Cyclin-dependent kinase-like 50044
Serine/threonine-protein kinase 17B0033
Serine/threonine-protein kinase 100044
Serine/threonine-protein kinase D30044
Cyclin-dependent kinase 140033
Structural maintenance of chromosomes protein 20033
Mitogen-activated protein kinase kinase kinase 60044
Serine/threonine-protein kinase OSR10033
Mitogen-activated protein kinase kinase kinase kinase 40044
Serine/threonine-protein kinase LATS10044
Serine/threonine-protein kinase PAK 40044
Serine/threonine-protein kinase Chk20033
Tyrosine-protein kinase ABL106716
Tyrosine-protein kinase ABL10101
Proto-oncogene tyrosine-protein kinase Src0112
Epidermal growth factor receptor0347
Transthyretin0022
RAF proto-oncogene serine/threonine-protein kinase0235
Receptor tyrosine-protein kinase erbB-20235
High affinity nerve growth factor receptor0044
Guanine nucleotide-binding protein G(i) subunit alpha-20022
ADP/ATP translocase 20044
Neuronal proto-oncogene tyrosine-protein kinase Src 0001
Protein kinase C beta type0044
Insulin receptor0246
Tyrosine-protein kinase Lck0549
Proto-oncogene tyrosine-protein kinase LCK 0202
Tyrosine-protein kinase Fyn0246
Cyclin-dependent kinase 10044
Glycogen phosphorylase, liver form0044
Tyrosine-protein kinase Fes/Fps0044
Macrophage colony-stimulating factor 1 receptor0235
Procathepsin L0022
Adenine phosphoribosyltransferase0022
Tyrosine-protein kinase Yes0145
Tyrosine-protein kinase Lyn0145
Proto-oncogene tyrosine-protein kinase receptor Ret0145
Insulin-like growth factor 1 receptor0145
Signal recognition particle receptor subunit alpha0033
Cytochrome c1, heme protein, mitochondrial0044
Hepatocyte growth factor receptor0044
Tyrosine-protein kinase HCK0246
Proto-oncogene tyrosine-protein kinase ROS0033
Platelet-derived growth factor receptor beta0246
Tyrosine-protein kinase Fgr0044
Quinolone resistance protein NorA0101
Wee1-like protein kinase 20033
Uncharacterized serine/threonine-protein kinase SBK30033
Replicase polyprotein 1a0022
Replicase polyprotein 1ab0022
Replicase polyprotein 1ab0123
Replicase polyprotein 1ab0123
Serine/threonine-protein kinase A-Raf0044
Mast/stem cell growth factor receptor Kit0246
Glycogen phosphorylase, brain form0044
Breakpoint cluster region protein03612
Serine/threonine-protein kinase pim-10044
Fibroblast growth factor receptor 10145
Cytochrome P450 2A60202
Myosin light chain kinase, smooth muscle0022
Cyclin-dependent kinase 40044
ADP/ATP translocase 30044
Inosine-5'-monophosphate dehydrogenase 20033
Angiotensin-converting enzyme 0101
Proto-oncogene tyrosine-protein kinase Src0347
cAMP-dependent protein kinase type II-alpha regulatory subunit0033
Insulin receptor-related protein0033
Serine/threonine-protein kinase B-raf0044
Potassium voltage-gated channel subfamily E member 10101
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0044
Ribosyldihydronicotinamide dehydrogenase [quinone]0257
Platelet-derived growth factor receptor alpha0347
Tyrosine-protein kinase Blk0101
Tyrosine-protein kinase Fer0044
Protein kinase C alpha type0257
cAMP-dependent protein kinase catalytic subunit alpha0044
Vascular endothelial growth factor receptor 1 0033
General transcription and DNA repair factor IIH helicase subunit XPD0044
Interferon-induced, double-stranded RNA-activated protein kinase0033
Casein kinase II subunit alpha'0044
Ras-related protein Rab-6A0033
Serine/threonine-protein kinase MAK0033
Cytochrome P450 2B60202
Cyclin-dependent kinase 11B0033
Ephrin type-A receptor 10044
Fibroblast growth factor receptor 20033
Receptor tyrosine-protein kinase erbB-30033
Multifunctional protein ADE20044
Fibroblast growth factor receptor 40033
Fibroblast growth factor receptor 30033
cAMP-dependent protein kinase catalytic subunit gamma0033
cAMP-dependent protein kinase catalytic subunit beta0044
Ferrochelatase, mitochondrial0044
Ribosomal protein S6 kinase beta-10145
Tyrosine-protein kinase JAK105613
Protein kinase C eta type0033
Cyclin-dependent kinase 20257
Beta-adrenergic receptor kinase 10044
Probable ATP-dependent RNA helicase DDX60044
Activin receptor type-2A0033
Mitogen-activated protein kinase 3 0045
MAP/microtubule affinity-regulating kinase 30044
Mitogen-activated protein kinase 10246
Ephrin type-A receptor 20145
Ephrin type-A receptor 30033
Ephrin type-A receptor 80033
Ephrin type-B receptor 20145
Leukocyte tyrosine kinase receptor0033
Non-receptor tyrosine-protein kinase TYK205613
UMP-CMP kinase 0022
Phosphatidylethanolamine-binding protein 10033
Wee1-like protein kinase0044
Heme oxygenase 20044
Tyrosine-protein kinase receptor UFO0033
Mitogen-activated protein kinase 40033
S-adenosylmethionine synthase isoform type-20044
DnaJ homolog subfamily A member 10044
RAC-alpha serine/threonine-protein kinase0246
RAC-beta serine/threonine-protein kinase0145
G protein-coupled receptor kinase 40033
Dual specificity protein kinase TTK0044
DNA replication licensing factor MCM40033
Prostaglandin G/H synthase 20336
Tyrosine-protein kinase receptor Tie-10033
Vascular endothelial growth factor receptor 30033
Vascular endothelial growth factor receptor 20235
Dual specificity mitogen-activated protein kinase kinase 20145
Receptor-type tyrosine-protein kinase FLT30246
Bone morphogenetic protein receptor type-1A0044
Activin receptor type-1B0044
TGF-beta receptor type-10044
Serine/threonine-protein kinase receptor R30044
TGF-beta receptor type-20044
Electron transfer flavoprotein subunit beta0033
Tyrosine-protein kinase CSK0246
Glycine--tRNA ligase0044
Protein kinase C iota type0044
Exosome RNA helicase MTR40044
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0336
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0134
Serine/threonine-protein kinase mTOR0246
Megakaryocyte-associated tyrosine-protein kinase0033
Tyrosine-protein kinase Tec0246
Tyrosine-protein kinase TXK0235
Tyrosine-protein kinase ABL20044
Tyrosine-protein kinase FRK0044
G protein-coupled receptor kinase 60022
Tyrosine-protein kinase ZAP-700033
Tyrosine-protein kinase SYK0145
Mitogen-activated protein kinase 80145
Mitogen-activated protein kinase 90044
Dual specificity mitogen-activated protein kinase kinase 40033
Dual specificity mitogen-activated protein kinase kinase 30044
Casein kinase I isoform alpha0145
Casein kinase I isoform delta0044
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0134
MAP kinase-activated protein kinase 20246
Cyclin-dependent kinase 80033
Elongation factor Tu, mitochondrial0044
Choline-phosphate cytidylyltransferase A0022
Cysteine--tRNA ligase, cytoplasmic0044
Casein kinase I isoform epsilon0044
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0044
Dual specificity protein kinase CLK10044
Dual specificity protein kinase CLK20044
Dual specificity protein kinase CLK30044
Glycogen synthase kinase-3 alpha0044
Glycogen synthase kinase-3 beta0145
Cyclin-dependent kinase 70044
Cyclin-dependent kinase 90044
Ras-related protein Rab-27A0033
Tyrosine-protein kinase Blk0235
Interleukin-1 receptor-associated kinase 10044
Potassium voltage-gated channel subfamily KQT member 10101
Ribosomal protein S6 kinase alpha-30246
Cytoplasmic tyrosine-protein kinase BMX0134
cAMP-dependent protein kinase catalytic subunit PRKX0033
Serine/threonine-protein kinase Nek20044
Serine/threonine-protein kinase Nek30044
Serine/threonine-protein kinase Nek40033
Tyrosine-protein kinase JAK305412
Dual specificity mitogen-activated protein kinase kinase 60044
Serine/threonine-protein kinase PLK10044
Death-associated protein kinase 10033
LIM domain kinase 10145
LIM domain kinase 20145
Mitogen-activated protein kinase 120235
Mitogen-activated protein kinase 100044
Tyrosine--tRNA ligase, cytoplasmic0044
5'-AMP-activated protein kinase subunit gamma-10044
5'-AMP-activated protein kinase catalytic subunit alpha-20033
Ephrin type-B receptor 30044
Ephrin type-A receptor 50044
Ephrin type-B receptor 40145
Ephrin type-B receptor 10033
Ephrin type-A receptor 40044
Adenylate kinase 2, mitochondrial0044
Adenosine kinase0044
Hormonally up-regulated neu tumor-associated kinase0033
Serine/threonine-protein kinase SIK10235
Receptor-interacting serine/threonine-protein kinase 40033
Ras-related protein Rab-100044
Cell division control protein 2 homolog0033
Actin-related protein 30044
Actin-related protein 20033
Calcium-dependent protein kinase 10033
GTP-binding nuclear protein Ran0044
Tubulin alpha-1A chain0022
Casein kinase II subunit alpha0033
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0033
SRSF protein kinase 20033
Casein kinase I isoform gamma-20044
DNA-dependent protein kinase catalytic subunit0101
Mitogen-activated protein kinase kinase kinase 90033
Serine/threonine-protein kinase PknB0033
Cyclin-dependent kinase 30033
Cyclin-dependent kinase-like 10033
Cyclin-dependent kinase 60044
Cyclin-dependent-like kinase 5 0145
Cyclin-dependent kinase 160044
Cyclin-dependent kinase 170044
Myelin transcription factor 10101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
ATP-dependent 6-phosphofructokinase, platelet type0044
Protein kinase C epsilon type0033
Dual specificity mitogen-activated protein kinase kinase 10246
Angiopoietin-1 receptor0033
Mitogen-activated protein kinase kinase kinase 100033
DNA topoisomerase 2-beta01512
Protein kinase C theta type0044
Activin receptor type-10044
Macrophage-stimulating protein receptor0044
Focal adhesion kinase 10145
Protein kinase C zeta type0123
Protein kinase C delta type0145
Tyrosine-protein kinase BTK0347
Tyrosine-protein kinase receptor TYRO30033
Cyclin-dependent kinase 180044
Activated CDC42 kinase 10145
Epithelial discoidin domain-containing receptor 10347
Tyrosine-protein kinase ITK/TSK0235
Myotonin-protein kinase0033
Mitogen-activated protein kinase kinase kinase kinase 20044
Mitogen-activated protein kinase kinase kinase 120033
Tyrosine-protein kinase Mer0044
Serine/threonine-protein kinase 40044
5'-AMP-activated protein kinase catalytic subunit alpha-10044
Serine/threonine-protein kinase PAK 10134
Dual specificity mitogen-activated protein kinase kinase 50044
Mitogen-activated protein kinase 70044
Serine/threonine-protein kinase PAK 20044
Serine/threonine-protein kinase 30044
Mitogen-activated protein kinase kinase kinase 10044
cGMP-dependent protein kinase 20033
Integrin-linked protein kinase0044
Rho-associated protein kinase 10044
Non-receptor tyrosine-protein kinase TNK10044
Serine/threonine-protein kinase PRP4 homolog0033
Receptor-interacting serine/threonine-protein kinase 10033
Calcium/calmodulin-dependent protein kinase type II subunit beta0033
Calcium/calmodulin-dependent protein kinase type II subunit gamma0044
Calcium/calmodulin-dependent protein kinase type II subunit delta0044
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0044
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Activin receptor type-2B0044
Bone morphogenetic protein receptor type-20044
Protein-tyrosine kinase 60145
Voltage-dependent L-type calcium channel subunit alpha-1C0202
cGMP-dependent protein kinase 1 0044
Cyclin-dependent kinase 130044
Calcium/calmodulin-dependent protein kinase type 10033
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0044
Protein-tyrosine kinase 2-beta0044
Sodium channel protein type 5 subunit alpha0101
Maternal embryonic leucine zipper kinase0044
Structural maintenance of chromosomes protein 1A0033
Chromodomain-helicase-DNA-binding protein 40044
Peroxisomal acyl-coenzyme A oxidase 10033
Serine/threonine-protein kinase D10033
Serine/threonine-protein kinase 380033
Receptor tyrosine-protein kinase erbB-40134
Ribosomal protein S6 kinase alpha-20033
Ephrin type-A receptor 70033
Delta(24)-sterol reductase0033
Ribosomal protein S6 kinase alpha-10145
Dual specificity testis-specific protein kinase 10044
Myosin light chain kinase, smooth muscle0044
Mitogen-activated protein kinase 110246
Serine/threonine-protein kinase STK110044
Rhodopsin kinase GRK10033
NT-3 growth factor receptor0033
Serine/threonine-protein kinase N10044
Serine/threonine-protein kinase N20044
Mitogen-activated protein kinase 140257
Calcium/calmodulin-dependent protein kinase type IV0044
Mitogen-activated protein kinase kinase kinase 110044
BDNF/NT-3 growth factors receptor0033
Mitogen-activated protein kinase 60033
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0033
Discoidin domain-containing receptor 20246
AP2-associated protein kinase 10145
Myosin light chain kinase 30044
Uncharacterized aarF domain-containing protein kinase 50033
Serine/threonine-protein kinase SBK10033
Mitogen-activated protein kinase kinase kinase 190033
Putative heat shock protein HSP 90-beta 20044
Serine/threonine-protein kinase TNNI3K0033
Leucine-rich repeat serine/threonine-protein kinase 20033
Serine/threonine-protein kinase MRCK alpha0044
Serine/threonine-protein kinase MRCK gamma0044
Acyl-CoA dehydrogenase family member 100044
Serine/threonine-protein kinase Nek50033
Serine/threonine-protein kinase N30033
Breakpoint cluster region protein0101
Serine/threonine-protein kinase ULK30044
Dual serine/threonine and tyrosine protein kinase0033
Mitogen-activated protein kinase kinase kinase 150033
Uncharacterized protein FLJ452520044
Acyl-CoA dehydrogenase family member 110033
Serine/threonine-protein kinase/endoribonuclease IRE20044
Serine/threonine-protein kinase MARK20044
Serine/threonine-protein kinase TAO10044
STE20-related kinase adapter protein alpha0044
Myosin-140044
AarF domain-containing protein kinase 10044
Serine/threonine-protein kinase tousled-like 20033
Serine/threonine-protein kinase 32C0033
Serine/threonine-protein kinase pim-30033
ATP-dependent RNA helicase DDX420011
Serine/threonine-protein kinase VRK20033
Myosin light chain kinase family member 40033
Homeodomain-interacting protein kinase 10033
Calcium/calmodulin-dependent protein kinase type 1D0033
Mitogen-activated protein kinase kinase kinase kinase 30044
Cyclin-dependent kinase-like 30033
MAP kinase-activated protein kinase 50145
Serine/threonine-protein kinase BRSK20033
Serine/threonine-protein kinase NIM10033
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0022
Serine/threonine-protein kinase ULK20033
Misshapen-like kinase 10044
Serine/threonine-protein kinase DCLK20033
Calcium/calmodulin-dependent protein kinase kinase 10033
Casein kinase I isoform alpha-like0033
Homeodomain-interacting protein kinase 40033
Myosin-IIIa0033
Ankyrin repeat and protein kinase domain-containing protein 10033
Serine/threonine-protein kinase Nek110033
Atypical kinase COQ8A, mitochondrial0044
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0044
Mitogen-activated protein kinase 150044
Serine/threonine-protein kinase Nek90044
Serine/threonine-protein kinase BRSK10033
Serine/threonine-protein kinase 350033
Serine/threonine-protein kinase Nek70033
Rhodopsin kinase GRK70033
Serine/threonine-protein kinase 32A0033
Myosin-IIIb0033
ATP-dependent RNA helicase DDX10044
Dual specificity tyrosine-phosphorylation-regulated kinase 20033
Cyclin-dependent kinase-like 20033
Mitogen-activated protein kinase kinase kinase kinase 10044
Serine/threonine-protein kinase Sgk30033
Atypical kinase COQ8B, mitochondrial0033
MAP/microtubule affinity-regulating kinase 40044
Calcium/calmodulin-dependent protein kinase type 1G0044
Serine/threonine-protein kinase Nek10044
Cyclin-dependent kinase 150033
PAS domain-containing serine/threonine-protein kinase0044
Calcium/calmodulin-dependent protein kinase kinase 20044
EKC/KEOPS complex subunit TP53RK0044
Dual specificity testis-specific protein kinase 20033
SRSF protein kinase 10033
Protein cereblon04311
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0246
Mitogen-activated protein kinase kinase kinase 50044
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0033
Mitogen-activated protein kinase kinase kinase 30044
Eukaryotic translation initiation factor 2-alpha kinase 10044
Serine/threonine-protein kinase RIO10033
MAP kinase-interacting serine/threonine-protein kinase 10033
Serine/threonine-protein kinase RIO20033
Cyclin-dependent kinase 190033
Transient receptor potential cation channel subfamily M member 60033
Testis-specific serine/threonine-protein kinase 10033
Angiotensin-converting enzyme 2 0022
Serine/threonine-protein kinase 330033
Nucleolar GTP-binding protein 10044
Serine/threonine-protein kinase D20044
Serine/threonine-protein kinase DCLK30033
NUAK family SNF1-like kinase 20033
RNA cytidine acetyltransferase0044
Serine/threonine-protein kinase SIK20145
Myosin light chain kinase 2, skeletal/cardiac muscle0033
STE20-like serine/threonine-protein kinase 0044
Serine/threonine-protein kinase TAO30044
Homeodomain-interacting protein kinase 20033
Tyrosine-protein kinase Srms0033
Homeodomain-interacting protein kinase 30033
Serine/threonine-protein kinase PLK30033
dCTP pyrophosphatase 10044
Dual specificity protein kinase CLK40044
MAP kinase-interacting serine/threonine-protein kinase 20033
Serine/threonine-protein kinase Nek60033
Casein kinase I isoform gamma-10044
Serine/threonine-protein kinase PAK 60033
SNF-related serine/threonine-protein kinase0033
Serine/threonine-protein kinase LATS20033
Serine/threonine-protein kinase 360033
Phenylalanine--tRNA ligase beta subunit0044
Isoleucine--tRNA ligase, mitochondrial0033
BMP-2-inducible protein kinase0044
Obg-like ATPase 10022
Midasin0044
Interleukin-1 receptor-associated kinase 40044
Serine/threonine-protein kinase 32B0033
Mitogen-activated protein kinase kinase kinase 200044
Cyclin-dependent kinase 120044
Serine/threonine-protein kinase PLK20033
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130033
Serine/threonine-protein kinase MARK10033
Serine/threonine-protein kinase pim-20033
Serine/threonine-protein kinase PAK 50033
Serine/threonine-protein kinase 260044
eIF-2-alpha kinase GCN20033
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0044
Serine/threonine-protein kinase NLK0044
Serine/threonine-protein kinase 17A0033
STE20/SPS1-related proline-alanine-rich protein kinase0033
Ephrin type-A receptor 60033
5'-AMP-activated protein kinase subunit gamma-20044
Serine/threonine-protein kinase TBK10145
Septin-90044
Death-associated protein kinase 20033
Potassium voltage-gated channel subfamily D member 30101
Ribosomal protein S6 kinase alpha-60044
TRAF2 and NCK-interacting protein kinase0044
Serine/threonine-protein kinase tousled-like 10033
Serine/threonine-protein kinase TAO20044
Long-chain-fatty-acid--CoA ligase 50022
ALK tyrosine kinase receptor0033
SRSF protein kinase 30033
Serine/threonine-protein kinase ICK0044
Cyclin-dependent kinase 11A0033
Aurora kinase C0033
Calcium/calmodulin-dependent protein kinase type II subunit alpha0033
RAC-gamma serine/threonine-protein kinase0145
Serine/threonine-protein kinase 38-like0033
Microtubule-associated serine/threonine-protein kinase 10033
Serine/threonine-protein kinase SIK30145
Mitogen-activated protein kinase kinase kinase 20044
Thyroid hormone receptor-associated protein 30044
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0044
Mitogen-activated protein kinase kinase kinase kinase 50044
Receptor-interacting serine/threonine-protein kinase 30044
Serine/threonine-protein kinase MRCK beta0044
Interleukin-1 receptor-associated kinase 30044
Serine/threonine-protein kinase 240044
NF-kappa-B essential modulator0101
Casein kinase I isoform gamma-30044
Mitogen-activated protein kinase kinase kinase 40044
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
Regulatory protein E20011
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10406
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0139
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0001
Serum paraoxonase/arylesterase 10202
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0203
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0202
Integrase 0101
Similar to alpha-tubulin isoform 1 0202
Similar to alpha-tubulin isoform 1 0202
Glutamate receptor ionotropic, NMDA 3B0001
Solute carrier organic anion transporter family member 1B30203
Glutamate receptor ionotropic, NMDA 3A0001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)6006
corticotropin-releasing hormone receptor 20112
corticotropin releasing factor-binding protein0112
glycogen synthase kinase-3 beta isoform 10022
5'-nucleotidase0101
Adenosine deaminase 0103
Genome polyprotein 0101
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0101
Muscarinic acetylcholine receptor M10101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Muscarinic acetylcholine receptor M30101
Alpha-1D adrenergic receptor0404
Sigma intracellular receptor 20101
Cyclic GMP-AMP synthase0101
Sigma non-opioid intracellular receptor 10101
Toll-like receptor 90101
Toll-like receptor 70112
NFKB1 protein, partial1001
thyroid stimulating hormone receptor2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Stromelysin-10011
Gamma-aminobutyric acid receptor subunit alpha-10101
Urease subunit alpha0101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Ribonucleoside-diphosphate reductase large subunit0101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Urease subunit beta0101
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit theta0101
Luciferase6006
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
DNA repair protein RAD52 homolog isoform a0001
Cytochrome P450 2C80203
DNA polymerase beta4004
Histamine H2 receptor0202
Adenosine receptor A2a0202
7,8-dihydro-8-oxoguanine triphosphatase0101
Toll-like receptor 80011
Cell division cycle 7-related protein kinase0022
Myosin-100022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0022
Oxysterols receptor LXR-beta0101
Tyrosine-protein kinase JAK2 0011
Cereblon isoform 40303
DNA-binding protein Ikaros0014
DNA damage-binding protein 10213
Zinc finger protein Aiolos0011
Type-1A angiotensin II receptor 0101
Type-1B angiotensin II receptor0202
Type-2 angiotensin II receptor0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
5-hydroxytryptamine receptor 1A0101
Type-1 angiotensin II receptor0101
15-lipoxygenase, partial3003
aldehyde dehydrogenase 1 family, member A18008
glucocerebrosidase3003
potassium voltage-gated channel subfamily H member 2 isoform d2002
importin subunit beta-1 isoform 12002
snurportin-12002
TAR DNA-binding protein 432002
Large neutral amino acids transporter small subunit 1 0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, 2-oxoglutarate Oxygenase3003
acid sphingomyelinase2002
dopamine D1 receptor1001
ClpP2002
Thymidylate synthase 0101
alpha-galactosidase2002
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
transcriptional regulator ERG isoform 31001
flap endonuclease 11001
DNA polymerase eta isoform 12002
histone acetyltransferase KAT2A isoform 12002
caspase-1 isoform alpha precursor1001
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
nonstructural protein 13003
bromodomain adjacent to zinc finger domain 2B2002
Nuclear receptor subfamily 1 group I member 20033
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Androgen receptor0404
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Nuclear receptor subfamily 1 group I member 20022
Thrombopoietin1001
regulator of G-protein signaling 43003
Parkin3003
pyruvate kinase2002
cytochrome P450 2D6 isoform 11001
NPC intracellular cholesterol transporter 1 precursor2002
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
atrial natriuretic peptide receptor 2 precursor2002
ras-related protein Rab-9A2002
lethal factor (plasmid)1001
pyruvate kinase PKM isoform b1001
Luciferin 4-monooxygenase0202
Ornithine decarboxylase1002
Amine oxidase [flavin-containing] B0101
Prostaglandin G/H synthase 10202
Dual specificity mitogen-activated protein kinase kinase 2 0101
Histamine H2 receptor2103
Dual specificity mitogen-activated protein kinase kinase 1 0101
Adenosine deaminase0101
Adenosine deaminase 0101
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0303
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Histamine H1 receptor0022
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
pregnane X receptor2002
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
BRCA11001
M18 aspartyl aminopeptidase0101
cathepsin L10101
lysosomal alpha-glucosidase preproprotein1001
hexokinase-4 isoform 11001
histone deacetylase 9 isoform 33003
glucokinase regulatory protein1001
nuclear factor NF-kappa-B p105 subunit isoform 10011
FAD-linked sulfhydryl oxidase ALR0001
Vif0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
transcription factor p65 isoform 10011
serine/threonine-protein kinase 33 isoform a0011
POsterior Segregation0011
Aryl hydrocarbon receptor0101
Estrogen receptor beta0011
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Acetylcholinesterase0101
Polyphenol oxidase 20101
Lysine-specific histone demethylase 1A0202
Transient receptor potential cation channel subfamily A member 10112
Myc proto-oncogene protein0102
Cytochrome P450 1A10101
Amyloid-beta precursor protein0314
Prostaglandin G/H synthase 10213
Cholinesterase0101
Cathepsin D0101
Aldo-keto reductase family 1 member B10202
Neuronal acetylcholine receptor subunit alpha-40101
DNA polymerase alpha catalytic subunit0101
Polyunsaturated fatty acid 5-lipoxygenase0102
Tyrosinase0303
Aromatase0202
Ornithine decarboxylase0101
Neuronal acetylcholine receptor subunit beta-20101
Tyrosinase0101
Tyrosine-protein phosphatase non-receptor type 10101
5-hydroxytryptamine receptor 1A0304
Estrogen receptor0011
Amine oxidase [flavin-containing] A0202
Endothelin receptor type B1001
Acetylcholinesterase0101
Sucrase-isomaltase, intestinal0101
Sodium-dependent noradrenaline transporter 0213
Endothelin-1 receptor1001
Amine oxidase [flavin-containing] B0202
Dipeptidyl peptidase 40202
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10101
Nitric oxide synthase, inducible0101
Cannabinoid receptor 10101
Alpha-glucosidase MAL120101
Prostaglandin G/H synthase 20202
Cholinesterase0101
Squalene synthase0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0102
Bcl-2-like protein 10101
Nuclear factor erythroid 2-related factor 20012
Cytochrome P450 1B10202
N1L 0101
NAD(P)H dehydrogenase [quinone] 10003
Lysosomal alpha-glucosidase0101
Transient receptor potential cation channel subfamily A member 10101
NAD-dependent protein deacetylase sirtuin-20011
NAD-dependent protein deacetylase sirtuin-10013
Prenyltransferase homolog0001
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Zinc finger protein mex-50011
large T antigen0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Eukaryotic translation initiation factor 4E0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Alpha-synuclein1102
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Peptidyl-prolyl cis-trans isomerase FKBP50101
Programmed cell death protein 40011
ATP-dependent RNA helicase DHX300022
Regulatory-associated protein of mTOR0101
Target of rapamycin complex subunit LST80101
Serine/threonine-protein kinase mTOR 0101
Solute carrier organic anion transporter family member 1B10101
apical membrane antigen 1, AMA11001
C-X-C chemokine receptor type 5 isoform 10101
ubiquitin-conjugating enzyme E2 N0101
C-C chemokine receptor type 60101
apelin receptor0101
bcl-2-related protein A10101
streptokinase A precursor0011
Endoglycoceramidase II 0001
Protein kinase C alpha type0101
Estrogen receptor0011
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
cAMP-dependent protein kinase catalytic subunit alpha 0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Estrogen receptor beta0011
Protein kinase C eta type0101
Sphingosine kinase 20101
Sphingosine kinase 10101
Protein kinase C theta type0101
Sphingosine 1-phosphate receptor 20112
Sphingosine 1-phosphate receptor 40112
Sphingosine 1-phosphate receptor 10112
Sodium-dependent serotonin transporter0112
Sphingosine 1-phosphate receptor 30112
Sphingosine 1-phosphate receptor 50112
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain B, Protein farnesyltransferase beta subunit0101
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha0101
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha0101
Protein farnesyltransferase subunit beta0101
Protein farnesyltransferase subunit beta0101
Geranylgeranyl transferase type-1 subunit beta0101
Geranylgeranyl transferase type-1 subunit beta0101
Protein farnesyltransferase alpha subunit0101
CAAX farnesyltransferase subunit beta 0101
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha0011
Protein farnesyltransferase subunit beta0011
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase JAK20101
Serine/threonine-protein kinase Sgk10101
Serine/threonine-protein kinase ATR0011
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
Rab-like protein 30011
Sigma intracellular receptor 20101
Tyrosine-protein kinase JAK30101
Tyrosine-protein kinase JAK20101
Tyrosine-protein kinase JAK30101
Chain A, Nuclear Receptor ROR-beta0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Ornithine decarboxylase0001
60 kDa chaperonin0101
Adenosine receptor A30202
Retinoic acid receptor alpha0227
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Alpha-1B adrenergic receptor0303
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Alpha-1D adrenergic receptor0202
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0303
Retinoic acid receptor RXR-gamma0224
10 kDa heat shock protein, mitochondrial0101
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
Adenosylhomocysteinase0101
RNA-directed RNA polymerase 0112
Sterol 14-alpha-demethylase0011
14-alpha sterol demethylase 0011
Cholesterol side-chain cleavage enzyme, mitochondrial 0011
Lanosterol 14-alpha demethylase0011
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Sterol 14-alpha demethylase0011
14-alpha sterol demethylase 0011
14-alpha sterol demethylase 0011
Cholesterol 24-hydroxylase0213
Chain A, Histone deacetylase-like amidohydrolase0101
Chain A, Histone deacetylase-like amidohydrolase0101
Histone deacetylase 80101
Nrf21001
PAX80001
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 70001
Histone deacetylase 0101
Lysine-specific demethylase 4E0101
Gli10101
nuclear receptor subfamily 0 group B member 10101
cystic fibrosis transmembrane conductance regulator0101
steroidogenic factor 10101
protein Wnt-3a precursor0101
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Histone deacetylase 10202
Transient receptor potential cation channel subfamily V member 10101
Nuclear receptor corepressor 10202
Tubulin alpha-1A chain0101
Tubulin beta chain0101
Albumin0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Protein Tat0011
Aminopeptidase N0101
Polyunsaturated fatty acid lipoxygenase ALOX150001
Polyunsaturated fatty acid lipoxygenase ALOX120001
Cannabinoid receptor 10101
Leukotriene A-4 hydrolase0101
DNA (cytosine-5)-methyltransferase 10101
Phosphatidylinositol 3-kinase regulatory subunit alpha0101
Delta-type opioid receptor0101
Apoptosis regulator BAX 0011
Platelet-activating factor acetylhydrolase0101
Histone deacetylase 10101
Histone deacetylase 0101
Sigma non-opioid intracellular receptor 10101
Renin0101
Histone deacetylase 30101
Histone deacetylase-like amidohydrolase0213
Histone deacetylase 0101
HD2 type histone deacetylase HDA106 0202
Carboxypeptidase B20101
Histone-lysine N-methyltransferase EHMT20101
Histone deacetylase 70101
Histone deacetylase 6 0101
Histone deacetylase 40101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
REST corepressor 30101
Nuclear receptor corepressor 20202
Histone deacetylase 60101
Histone deacetylase 0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]