positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
Definition
Target type: biologicalprocess
Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]
The intrinsic apoptotic signaling pathway, also known as the mitochondrial pathway, is a critical mechanism for eliminating damaged or unwanted cells. It is tightly regulated by the tumor suppressor protein p53, which plays a crucial role in maintaining cellular homeostasis. p53, a transcription factor, responds to various cellular stresses, such as DNA damage, hypoxia, and oncogene activation, by triggering a cascade of events leading to apoptosis.
The p53 protein acts as a class mediator by directly activating the expression of pro-apoptotic genes, including Bax, Puma, and Noxa. These genes encode proteins that promote the permeabilization of the mitochondrial outer membrane, leading to the release of cytochrome c and other apoptotic factors into the cytosol.
Once in the cytosol, cytochrome c binds to the apoptotic protease-activating factor 1 (Apaf-1), forming the apoptosome. The apoptosome activates caspase-9, initiating a caspase cascade that culminates in the activation of effector caspases such as caspase-3 and caspase-7. These effector caspases cleave cellular substrates, leading to the dismantling of the cell and its eventual demise.
Therefore, p53, acting as a class mediator, positively regulates the intrinsic apoptotic signaling pathway by inducing the expression of pro-apoptotic genes, ultimately leading to the activation of caspases and the execution of apoptosis. This process is critical for eliminating damaged or unwanted cells and preventing uncontrolled cell growth and tumorigenesis.'
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Proteins (3)
| Protein | Definition | Taxonomy |
|---|---|---|
| Myc proto-oncogene protein | A c-myc protein that is encoded in the genome of chicken. [OMA:P01109, PRO:DNx] | Gallus gallus (chicken) |
| 40S ribosomal protein S7 | A small ribosomal subunit protein eS7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62081] | Homo sapiens (human) |
| Myc proto-oncogene protein | A c-myc protein that is encoded in the genome of human. [PRO:CNA, UniProtKB:P01106] | Homo sapiens (human) |
Compounds (12)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| aurintricarboxylic acid | aurintricarboxylic acid : A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'. Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues. | monohydroxybenzoic acid; quinomethanes; tricarboxylic acid | fluorochrome; histological dye; insulin-like growth factor receptor 1 antagonist |
| mefenamic acid | mefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis. Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase. | aminobenzoic acid; secondary amino compound | analgesic; antipyretic; antirheumatic drug; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; non-steroidal anti-inflammatory drug; xenobiotic |
| methyl red | methyl red : An azo dye consisting of benzoic acid substituted at position 2 by a 4-[(dimethylamino)phenyl]diazenyl group. methyl red: RN given refers to parent cpd; structure | ||
| 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine | 1,2,4-triazines | ||
| avasimibe | monoterpenoid | ||
| resveratrol | trans-resveratrol : A resveratrol in which the double bond has E configuration. | resveratrol | antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger |
| 10074-g5 | 10074-G5: structure in first source | ||
| tws 119 | pyrroles | ||
| gentamicin sulfate | |||
| sgi-1027 | SGI-1027: inhibits DNA methyltransferase 1; structure in first source | ||
| kj-pyr-9 | KJ-Pyr-9: antineoplastic; structure in first source | ||
| PF-06446846 | PF-06446846 : A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9. PF-06446846: inhibits translation of PCSK9 ;structure in first source | benzamides; monochloropyridine; piperidines; tertiary carboxamide; triazolopyridine | antilipemic drug; EC 3.4.21.61 (kexin) inhibitor |