positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]

The intrinsic apoptotic signaling pathway, also known as the mitochondrial pathway, is a critical mechanism for eliminating damaged or unwanted cells. It is tightly regulated by the tumor suppressor protein p53, which plays a crucial role in maintaining cellular homeostasis. p53, a transcription factor, responds to various cellular stresses, such as DNA damage, hypoxia, and oncogene activation, by triggering a cascade of events leading to apoptosis.

The p53 protein acts as a class mediator by directly activating the expression of pro-apoptotic genes, including Bax, Puma, and Noxa. These genes encode proteins that promote the permeabilization of the mitochondrial outer membrane, leading to the release of cytochrome c and other apoptotic factors into the cytosol.

Once in the cytosol, cytochrome c binds to the apoptotic protease-activating factor 1 (Apaf-1), forming the apoptosome. The apoptosome activates caspase-9, initiating a caspase cascade that culminates in the activation of effector caspases such as caspase-3 and caspase-7. These effector caspases cleave cellular substrates, leading to the dismantling of the cell and its eventual demise.

Therefore, p53, acting as a class mediator, positively regulates the intrinsic apoptotic signaling pathway by inducing the expression of pro-apoptotic genes, ultimately leading to the activation of caspases and the execution of apoptosis. This process is critical for eliminating damaged or unwanted cells and preventing uncontrolled cell growth and tumorigenesis.'
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Proteins (3)

Compounds (12)