| Assay ID | Title | Year | Journal | Article |
|---|
| AID1163510 | Cytotoxicity against human PANC1 cells under nutrient-deprived condition after 24 hrs by WST8 dye based assay | 2014 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 24, Issue:19
| Synthesis and biological evaluation of isoprenylated coumarins as potential anti-pancreatic cancer agents. |
| AID726205 | Inhibition of human recombinant DAO expressed in G418-resistant HEK293/NEO cells assessed as effect on D-alanine level at 83 uM incubated for 30 mins prior to D-alanine addition measured after 24 hrs by HPLC analysis relative to vehicle-treated control | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID726214 | Inhibition of human recombinant N-terminal His-tagged DAO Y224A mutant expressed in Escherichia coli BL21(DE3) using D-alanine as substrate after 10 mins by Lineweaver-Burk plot analysis | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID541494 | Inhibition of beta-glucosidase using salicin substrate | 2010 | Journal of medicinal chemistry, Dec-09, Volume: 53, Issue:23
| Hydroxycoumarin derivatives: novel and potent α-glucosidase inhibitors. |
| AID315168 | Induction of apoptosis in human U937 cells at 250 uM after 24 hrs | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
| Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells. |
| AID593513 | Binding affinity to corpus collosum myelin in central nervous system of mouse at 100 uM after 20 mins by fluorescent microscopy | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Design, synthesis, and evaluation of coumarin-based molecular probes for imaging of myelination. |
| AID726222 | Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by colorimetric assay | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID1171397 | Drug metabolism in mouse liver microsomes assessed as glucuronidation of compound measured as compound remaining after 30 mins by LC/MS analysis | 2014 | ACS medicinal chemistry letters, Nov-13, Volume: 5, Issue:11
| Structure-Metabolism Relationships in the Glucuronidation of d-Amino Acid Oxidase Inhibitors. |
| AID144377 | Ability to induce NAD(P)H quinone reductase activity in cultured Hepa 1c1c7 murine hepatoma cells. | 1998 | Journal of medicinal chemistry, Dec-17, Volume: 41, Issue:26
| Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers. |
| AID745618 | Binding affinity to human recombinant DAAO at 496 nm spectral modification by spectrophotometric analysis in presence of FAD | 2013 | Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
| Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules. |
| AID1105456 | Antifungal activity against Aspergillus flavus ATCC 16013 after 72 hr by broth microdilution method | 2013 | International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
| Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity. |
| AID726215 | Inhibition of human recombinant N-terminal His-tagged DAO Y224F mutant expressed in Escherichia coli BL21(DE3) using D-alanine as substrate after 10 mins by Lineweaver-Burk plot analysis | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID516863 | Inhibition kidney aldose reductase 2 by spectrophotometric analysis | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19
| 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. |
| AID1105460 | Antifungal activity against Aspergillus fumigatus IPP 210 after 72 hr by broth microdilution method | 2013 | International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
| Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity. |
| AID745647 | Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serine | 2013 | Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
| Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules. |
| AID1163511 | Cytotoxicity against human PANC1 cells under nutrient-rich condition after 24 hrs by WST8 dye based assay | 2014 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 24, Issue:19
| Synthesis and biological evaluation of isoprenylated coumarins as potential anti-pancreatic cancer agents. |
| AID726223 | Inhibition of human recombinant N-terminal His-tagged DDO expressed in Escherichia coli BL21(DE3) using D-aspartate as substrate by colorimetric assay | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID1105457 | Antifungal activity against Aspergillus flavus LM 247 after 72 hr by broth microdilution method | 2013 | International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
| Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity. |
| AID493454 | Inhibition of human CA1 by CO2 hydration assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15
| Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II. |
| AID294445 | Inhibition of xanthine oxidase | 2007 | European journal of medicinal chemistry, Jul, Volume: 42, Issue:7
| Relationship between quantum-chemical descriptors of proton dissociation and experimental acidity constants of various hydroxylated coumarins. Identification of the biologically active species for xanthine oxidase inhibition. |
| AID1265003 | Antioxidant activity assessed as DPPH radical scavenging activity | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model. |
| AID1105459 | Antifungal activity against Aspergillus fumigatus ATCC 46913 after 72 hr by broth microdilution method | 2013 | International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
| Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity. |
| AID726220 | Inhibition of human recombinant N-terminal His-tagged serine racemase expressed in Escherichia coli BL21(DE3) using L-serine as substrate after 10 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID726206 | Effect on L-alanine level in G418-resistant HEK293 cells at 17 uM by HPLC analysis relative to vehicle-treated control | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID726207 | Effect on L-alanine level in G418-resistant HEK293/NEO cells at 17 uM by HPLC analysis relative to vehicle-treated control | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID745649 | Binding affinity to human recombinant DAAO by stopped flow spectrophotometric analysis in presence of FAD | 2013 | Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
| Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules. |
| AID493457 | Inhibition of human CA12 by CO2 hydration assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15
| Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II. |
| AID516864 | Inhibition sorbitol dehydrogenase by spectrophotometric analysis | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19
| 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. |
| AID726221 | Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-alanine as substrate by colorimetric assay | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID726212 | Inhibition of N-terminal HA-tagged human recombinant DAO overexpressed in G418-resistant HEK293 cells assessed as increase in D-alanine levels at 83 uM incubated for 30 mins prior to D-alanine addition measured after 24 hrs by HPLC analysis relative to ve | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID315164 | Cytotoxicity against human U937 cells by trypan blue assay after 48 hrs | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
| Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells. |
| AID1717734 | Inhibition of human tyrosinase expressed in Escherichia coli | 2020 | Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22
| Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations. |
| AID726218 | Binding affinity to human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) at 40 uM after 2 to 30 mins by absorption spectra analysis | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID541341 | Inhibition of Aspergillus oryzae Beta-galactosidase | 2010 | Journal of medicinal chemistry, Dec-09, Volume: 53, Issue:23
| Hydroxycoumarin derivatives: novel and potent α-glucosidase inhibitors. |
| AID1171400 | Drug metabolism in mouse liver microsomes assessed as glucuronidation of compound measured as compound remaining after 60 mins by LC/MS analysis | 2014 | ACS medicinal chemistry letters, Nov-13, Volume: 5, Issue:11
| Structure-Metabolism Relationships in the Glucuronidation of d-Amino Acid Oxidase Inhibitors. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| AID493456 | Inhibition of human CA9 by CO2 hydration assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15
| Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II. |
| AID493455 | Inhibition of human CA2 by CO2 hydration assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15
| Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II. |
| AID745619 | Binding affinity to human recombinant DAAO at 443 nm spectral modification by spectrophotometric analysis in presence of FAD | 2013 | Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
| Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules. |
| AID541342 | Inhibition of Aspergillus oryzae Beta-galactosidase at 400 uM | 2010 | Journal of medicinal chemistry, Dec-09, Volume: 53, Issue:23
| Hydroxycoumarin derivatives: novel and potent α-glucosidase inhibitors. |
| AID516862 | Inhibition human recombinant aldose reductase 1 by spectrophotometric analysis | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19
| 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. |
| AID1105454 | Antifungal activity against Aspergillus flavus LM 26 after 72 hr by broth microdilution method | 2013 | International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
| Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity. |
| AID1105461 | Antifungal activity against Aspergillus fumigatus ATCC 16913 after 72 hr by broth microdilution method | 2013 | International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
| Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity. |
| AID726213 | Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by Lineweaver-Burk plot analysis | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID315165 | Growth inhibition of human U937 cells by [3H]thymidine incorporation assay | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
| Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells. |
| AID726211 | Effect on L-alanine level in G418-resistant HEK293/NEO cells at 83 uM by HPLC analysis relative to vehicle-treated control | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID745648 | Competitive inhibition of human recombinant DAAO after 1 hr by coupled enzyme assay in presence of D-serine | 2013 | Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
| Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules. |
| AID726216 | Competitive inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-alanine as substrate by Lineweaver-Burk plot analysis | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID1105455 | Antifungal activity against Aspergillus flavus LM 210 after 72 hr by broth microdilution method | 2013 | International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
| Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity. |
| AID726210 | Effect on L-alanine level in G418-resistant HEK293 cells at 83 uM by HPLC analysis relative to vehicle-treated control | 2013 | Journal of medicinal chemistry, Mar-14, Volume: 56, Issue:5
| Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. |
| AID1105458 | Antifungal activity against Aspergillus fumigatus ATCC 40640 after 72 hr by broth microdilution method | 2013 | International journal of molecular sciences, Jan-10, Volume: 14, Issue:1
| Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity. |
| AID516866 | Selectivity index, ratio of IC50 for human recombinant aldose reductase 1 to IC50 for kidney aldose reductase 2 | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19
| 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| AID516865 | Selectivity index, ratio of IC50 for sorbitol dehydrogenase to IC50 for kidney aldose reductase 2 | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19
| 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. |
| AID541338 | Inhibition of alpha-glucosidase using para-nitrophenyl substrate | 2010 | Journal of medicinal chemistry, Dec-09, Volume: 53, Issue:23
| Hydroxycoumarin derivatives: novel and potent α-glucosidase inhibitors. |
| AID1265014 | Activation of Nrf2 in human HSC3-ARE9 cells assessed as increase of ARE-mediated luciferase expression at 50 uM after 24 hrs relative to control | 2015 | European journal of medicinal chemistry, Dec-01, Volume: 106 | Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11
| 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |