Muscular Dystrophy, Oculopharyngeal

An autosomal dominant hereditary disease that presents in late in life and is characterized by DYSPHAGIA and progressive ptosis of the eyelids. Mutations in the gene for POLY(A)-BINDING PROTEIN II have been associated with oculopharyngeal muscular dystrophy.

Synonym
Muscular Dystrophy, Oculopharyngeal

Excerpt	Reference
"Oculopharyngeal muscular dystrophy is a neuromuscular disease usually presenting in the 5th or 6th decades of life with a dominant inheritance pattern."	( Hildebrand, GD; Hilton-Jones, D; Mansfield, D; Marks, S; Mechan, D; Ramsay, J; Robinson, DO, 2011)
"Oculopharyngeal muscular dystrophy is a late-onset disease caused by an elongation of a natural 10-alanine segment within the N-terminal domain of the nuclear poly(A)-binding protein 1 (PABPN1) to maximally 17 alanines."	( Hause, G; Kühn, U; Schwarz, E; Winter, R, 2012)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	17 (31.48)	18.1394
2010's	31 (57.41)	28.8240
2020's	6 (11.11)	9.53

Drug	Relationship Strength	Studies	Trials
lactic acid	low	1	0
glycine	low	2	0
toluene	low	1	0
oxyquinoline	low	1	0
amantadine	low	1	0
cystamine	low	1	0
valproic acid	low	1	0
fluorouracil	low	1	0
ibuprofen	low	1	0
indomethacin	low	1	0
pifithrin	low	1	0
potassium chloride	low	1	0
fenofibrate	low	1	0
thalidomide	low	1	0
thymidine	low	9	0
alanine	low	12	0
tyrosine	low	1	0
arginine	low	1	0
2-naphthol	low	2	0
thiazoles	low	1	0
congo red	low	2	0
acetylcysteine	low	1	0
deoxycytidine	low	1	0
deoxyuridine	low	5	0
thioflavin t	low	1	0
zinc sulfate	low	1	0
atracurium	medium	1	1
capecitabine	low	1	0
dityrosine	low	1	0
6-aminophenanthridine	low	2	0
leupeptins	low	1	0
lithium chloride	low	1	0
resveratrol	low	1	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	low	1	0
isomethyleugenol	low	1	0
stilbenes	low	1	0
sirtinol	low	2	0
guanabenz	low	3	0
lactacystin	low	1	0
cytochrome c-t	low	1	0
minocycline	low	1	0
transforming growth factor beta	low	1	0
cyclosporine	low	1	0
exudates	low	1	0
n-(3-((2-hydroxynaphthalen-1-ylmethylene)amino)phenyl)-2-phenylpropionamide	low	1	0
eye	low	1	0

Protein Targets (601)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Luciferase	9	0	0	9
RAR-related orphan receptor gamma	12	0	0	12
GLI family zinc finger 3	8	0	0	8
AR protein	15	0	0	15
estrogen receptor 2 (ER beta)	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
progesterone receptor	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
retinoid X nuclear receptor alpha	9	0	0	9
pregnane X nuclear receptor	4	0	0	4
estrogen nuclear receptor alpha	17	0	0	17
peroxisome proliferator-activated receptor delta	6	0	0	6
aryl hydrocarbon receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	5	0	0	5
thyroid hormone receptor beta isoform 2	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
DNA repair and recombination protein RadA	0	0	1	1
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Cellular tumor antigen p53	8	0	0	8
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 2A6	0	2	0	2
Sulfotransferase 1A1	0	0	0	1
Glutamate receptor 2	7	0	0	7
Cytochrome P450 2A5	0	1	0	1
Sulfotransferase 1E1	0	0	0	1
Sulfotransferase 1A1	0	0	0	1
Sulfotransferase 2A1	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
acetylcholinesterase	7	0	0	7
dopamine D1 receptor	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	3	0	0	3
phosphopantetheinyl transferase	3	0	0	3
USP1 protein, partial	3	0	0	3
NFKB1 protein, partial	4	0	0	4
Microtubule-associated protein tau	5	0	0	5
Thrombopoietin	3	0	0	3
regulator of G-protein signaling 4	5	0	0	5
glucocorticoid receptor [Homo sapiens]	8	0	0	8
farnesoid X nuclear receptor	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
arylsulfatase A	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
Bloom syndrome protein isoform 1	3	0	0	3
D(1A) dopamine receptor	3	0	0	3
thyroid hormone receptor beta isoform a	6	0	0	6
heat shock protein beta-1	4	0	0	4
flap endonuclease 1	4	0	0	4
geminin	6	0	0	6
peripheral myelin protein 22	5	0	0	5
survival motor neuron protein isoform d	6	0	0	6
muscarinic acetylcholine receptor M1	4	0	0	4
Histone deacetylase 3	0	5	0	5
Solute carrier family 22 member 6	0	3	0	3
Histone deacetylase 4	0	4	0	4
Guanine nucleotide-binding protein G	2	0	0	2
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	4	0	4
Ataxin-2	6	0	0	6
Histone deacetylase 8	0	4	1	5
Histone deacetylase 6	0	5	0	5
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
ATP-dependent phosphofructokinase	6	0	0	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Carbonic anhydrase 1	0	2	0	4
Carbonic anhydrase 2	0	2	0	4
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	4	1	6
Proton-coupled amino acid transporter 1	0	2	0	2
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	1
thioredoxin reductase	5	0	0	5
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
thyroid stimulating hormone receptor	8	0	0	8
EWS/FLI fusion protein	6	0	0	6
putative alpha-glucosidase	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
lamin isoform A-delta10	6	0	0	6
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 1	0	1	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Spike glycoprotein	4	0	0	4
Glutamate receptor ionotropic, NMDA 2A	0	3	1	5
Glutamate receptor ionotropic, NMDA 2B	0	3	1	5
Glutamate receptor ionotropic, NMDA 2C	0	3	1	5
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	1	5
Solute carrier family 22 member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	1	5
Multidrug and toxin extrusion protein 1	0	2	0	2
Solute carrier family 22 member 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	1	5
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
GLS protein	7	0	0	7
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
chromobox protein homolog 1	5	0	0	5
DNA polymerase iota isoform a (long)	3	0	0	3
lethal factor (plasmid)	4	0	0	4
Cytochrome P450 3A4	0	2	0	3
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	2	0	3
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
NPYLR7B	0	0	1	1
Amine oxidase [flavin-containing] A	0	0	1	1
Small conductance calcium-activated potassium channel protein 3	0	1	1	2
Proteasome subunit beta type-11	0	2	0	2
Fumarate hydratase	2	0	0	2
PPM1D protein	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
polyprotein	2	0	0	2
vitamin D3 receptor isoform VDRA	4	0	0	4
Calpain-9	0	1	0	1
Proteasome subunit alpha type-7	0	2	0	2
Interferon beta	4	0	0	4
Cathepsin B	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Aromatase	0	4	0	4
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Calpain-2 catalytic subunit	0	1	0	1
Proteasome subunit beta type-1	0	3	0	3
Proteasome subunit alpha type-1	0	2	0	2
Proteasome subunit alpha type-2	0	2	0	2
Proteasome subunit alpha type-3	0	2	0	2
Proteasome subunit alpha type-4	0	2	0	2
NF-kappa-B inhibitor alpha	0	0	1	1
Proteasome subunit beta type-8	0	2	0	2
Proteasome subunit beta type-9	0	2	0	2
Proteasome subunit alpha type-5	0	2	0	2
Proteasome subunit beta type-4	0	2	0	2
Proteasome subunit beta type-6	0	2	0	2
Proteasome subunit beta type-5	0	3	0	3
Proteasome subunit beta type-10	0	2	0	2
Cathepsin K	0	1	0	1
Proteasome subunit beta type-3	0	2	0	2
Proteasome subunit beta type-2	0	3	0	3
Proteasome subunit alpha type-6	0	2	0	2
Proteasome subunit alpha-type 8	0	2	0	2
Proteasome subunit beta type-7	0	2	0	2
Gamma-secretase subunit PEN-2	0	1	0	1
TDP1 protein	10	0	0	10
Liver carboxylesterase 1	0	1	0	2
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
estrogen-related nuclear receptor alpha	12	0	0	12
peroxisome proliferator activated receptor gamma	7	0	0	7
thyroid stimulating hormone receptor	4	0	0	4
activating transcription factor 6	2	0	0	2
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Chymotrypsinogen A	0	0	0	1
Beta-lactamase	0	1	0	1
Amyloid-beta precursor protein	1	4	1	6
Beta-lactamase	0	0	0	1
5-hydroxytryptamine receptor 2A	0	0	0	1
Beta-galactosidase	0	1	0	2
5-hydroxytryptamine receptor 1A	0	3	0	4
Choline O-acetyltransferase	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	1
AAA family ATPase	0	0	0	1
Reverse transcriptase/RNaseH	0	0	1	1
Chain A, Dutpase	0	0	1	1
Chain A, Dutpase	0	0	1	1
Chain B, Dutpase	0	0	1	1
Chain A, Dutpase	0	0	1	1
Chain B, Dutpase	0	0	1	1
Thymidine kinase, cytosolic	0	2	0	5
Thymidine phosphorylase	0	0	0	2
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
glucocerebrosidase	4	0	0	4
cytochrome P450 2C9 precursor	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
NAD-dependent histone deacetylase SIR2	0	2	0	4
Histamine H2 receptor	3	0	0	3
NAD-dependent protein deacetylase HST2	0	2	0	2
NAD-dependent protein deacetylase sirtuin-2	0	3	1	4
NAD-dependent protein deacetylase sirtuin-1	0	3	1	6
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	3	0	3
Histone deacetylase	0	1	0	1
Nuclear receptor corepressor 2	0	2	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
interleukin 8	3	0	0	3
endonuclease IV	1	0	0	1
glp-1 receptor, partial	2	0	0	2
Skn7p	0	0	0	1
ATAD5 protein, partial	4	0	0	4
nonstructural protein 1	3	0	0	3
67.9K protein	4	0	0	4
IDH1	3	0	0	3
peripheral myelin protein 22 isoform 1	3	0	0	3
hemoglobin subunit beta	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
huntingtin isoform 2	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Vpr	1	0	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	2
Solute carrier family 22 member 8	0	0	0	1
Bile salt export pump	0	7	0	7
Epidermal growth factor receptor	0	3	0	3
Thymidylate synthase	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	2	0	2
ATPase family AAA domain-containing protein 5	4	0	0	4
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
cytochrome P450 2D6	4	0	0	4
interferon gamma precursor	0	0	0	1
guanine nucleotide-binding protein subunit alpha-15	0	1	1	2
trace amine-associated receptor 1	0	1	1	2
5-hydroxytryptamine receptor 4	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Amine oxidase [flavin-containing] A	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Nischarin	0	1	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
DNA polymerase kappa isoform 1	3	0	0	3
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	3
Prostaglandin G/H synthase 2	0	2	0	3
Bile salt export pump	0	2	0	2
Fatty acid-binding protein, liver	0	1	0	1
Albumin	0	2	3	5
Albumin	0	1	0	1
Albumin	0	0	1	1
Prostaglandin G/H synthase 1	0	6	1	8
Cholinesterase	0	4	0	4
Cytochrome P450 2C9	0	4	0	4
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	4
UDP-glucuronosyltransferase 2B7	0	1	0	3
Acetylcholinesterase	0	4	0	4
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Adenosine receptor A1	0	2	0	3
Caspase-1	0	1	0	2
Adenosine receptor A2a	0	2	0	3
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	4	1	5
Prostaglandin G/H synthase 2	0	2	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	3	0	3
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	6	0	6
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	3
TAR DNA-binding protein 43	1	0	0	1
Solute carrier family 22 member 6	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	3
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, Cruzipain	1	0	0	1
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
G	2	0	0	2
Parkin	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
cytochrome P450 2D6 isoform 1	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
nuclear receptor ROR-gamma isoform 1	5	0	0	5
M-phase phosphoprotein 8	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Procathepsin L	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Interleukin-8	0	1	0	1
Androgen receptor	0	0	1	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
cytochrome P450 2C9, partial	2	0	0	2
Splicing factor 3B subunit 3	0	1	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	3	0	0	3
inositol monophosphatase 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit delta	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	3	0	0	3
Cholecystokinin receptor type A	1	0	0	1
Gastrin/cholecystokinin type B receptor	1	0	0	1
Glycogen synthase kinase-3 beta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	3	0	0	3
GABA theta subunit	3	0	0	3
Gamma-aminobutyric acid receptor subunit epsilon	3	0	0	3
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	2	0	2
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	1	2
Chain A, Bacterial leucyl aminopeptidase	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
GALC protein	1	0	0	1
Smad3	1	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
thyrotropin-releasing hormone receptor	1	0	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	1	0	2
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Thermolysin	0	2	0	3
72 kDa type IV collagenase	0	1	0	1
Botulinum neurotoxin type A	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Alpha-synuclein	1	0	0	1
Methionine aminopeptidase 2	0	1	0	1
Methionine aminopeptidase 1	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
luciferase	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
Luciferin 4-monooxygenase	0	2	0	2
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Carbonic anhydrase 9	0	2	0	3
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	2
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
Chain A, Beta-lactamase	1	0	0	1
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
BRCA1	1	0	0	1
ClpP	1	0	0	1
P53	1	0	0	1
pyruvate kinase	1	0	0	1
M18 aspartyl aminopeptidase	0	1	0	1
cathepsin L1	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
histone deacetylase 9 isoform 3	2	0	0	2
glucokinase regulatory protein	1	0	0	1
DNA polymerase beta	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	0	0	1	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Vif	0	1	0	1
transcription factor p65 isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
POsterior Segregation	0	0	1	1
Aryl hydrocarbon receptor	0	1	0	1
Estrogen receptor beta	0	0	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Acetylcholinesterase	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
Carbonic anhydrase 12	0	1	0	2
Lysine-specific histone demethylase 1A	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Tyrosine-protein kinase ABL1	0	1	0	2
Myc proto-oncogene protein	0	1	0	2
Transthyretin	0	0	1	1
Estrogen receptor	0	1	0	1
Cytochrome P450 1A1	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Cathepsin D	0	1	0	1
Carbonic anhydrase 3	0	1	0	2
Aldo-keto reductase family 1 member B1	0	3	0	3
DNA polymerase alpha catalytic subunit	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Leukotriene A-4 hydrolase	0	1	0	1
Breakpoint cluster region protein	0	1	0	2
Tyrosinase	0	3	0	3
Ornithine decarboxylase	0	1	0	1
Tyrosinase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	1	3
Protein kinase C alpha type	0	0	1	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Estrogen receptor	0	0	1	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Endothelin receptor type B	1	0	0	1
Carbonic anhydrase 6	0	1	0	2
Sucrase-isomaltase, intestinal	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	1	3
Endothelin-1 receptor	1	0	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Carbonic anhydrase 7	0	1	0	2
Cannabinoid receptor 1	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Alpha-glucosidase MAL12	0	1	0	1
Cholinesterase	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Squalene synthase	0	1	0	1
Transcription factor p65	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	2
Bcl-2-like protein 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Nuclear factor erythroid 2-related factor 2	0	0	1	2
Cytochrome P450 1B1	0	2	0	2
N1L	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	3
Tubulin beta-2B chain	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Carbonic anhydrase 15	0	1	0	2
Prenyltransferase homolog	0	0	0	1
Carbonic anhydrase 14	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
large T antigen	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Endolysin	0	0	1	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with trehalose	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with cellobiose	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with maltose	0	1	0	1
Trehalose-phosphatase	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Muscular Dystrophy, Oculopharyngeal

Synonyms(1)

Research Excerpts

Overview

Research

Studies (54)

Protein Targets (601)

Muscular Dystrophy, Oculopharyngeal

Synonyms(1)

Research Excerpts

Overview

Research

Studies (54)

Drugs Studied (52)

Protein Targets (601)