| Assay ID | Title | Year | Journal | Article |
|---|
| AID1586074 | Inhibition of bovine brain tubulin polymerization measured every 30 secs for 30 mins by turbidimetric assay | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | 1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase. |
| AID1761114 | Inhibition of tubulin polymerization in human RKO cells assessed as fragmentation of microtubule at 1 uM measured 24 hrs by DAPI staining based immunoflourescence assay | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1175489 | Induction of apoptosis in human DU145 cells assessed as mitochondrial membrane potential drop measured as early apoptotic cells at 2 uM after 48 hrs using JC-1 staining-based flow cytometry (Rvb = 9.1%) | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID1761128 | Induction of cell cycle arrest in human SW-620 cells assessed as accumulation of cells in S phase at 1 uM measured after 24 hrs by PI staining based flow cytometry method (Rvb = 46.12%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1734477 | Antitumor activity against mouse B16-F10 cells xenografted in C57BL/6 mouse assessed as tumor volume at 50 mg/kg, sc administered from day 7 post-infection until day 14 and measured every 3 to 4 days (Rvb = 2400 +/- 310 mm3) | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity. |
| AID1450050 | Cell cycle arrest in human DU145 cells assessed as accumulation at G2/M phase at 5 uM after 48 hrs by propidium iodide staining based flow cytometric method (Rvb = 11.85%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1761104 | Antiproliferative activity against human RKO cells assessed as cell viability measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1586068 | Growth inhibition of human A549 cells after 48 hrs by SRB assay | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | 1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase. |
| AID1761135 | Induction of cell cycle arrest in human PANC-1 cells assessed as accumulation of cells in G2 phase at 1 uM measured after 24 hrs by PI staining based flow cytometry method (Rvb = 3.63%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID553915 | Cytotoxicity against human A2780 cells after 48 to 72 hrs by WAT-1 assay | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent. |
| AID1761156 | Induction of apoptosis in human SW-620 cells assessed as increase in Bax expression at 0.5 to 1 uM measured after 24 hrs by western blot assay | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1153428 | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID1153499 | Cell cycle arrest in human MCF7 cells assessed as accumulation at G2/M phase at 0.5 uM after 48 hrs using propidium iodide staining by flow cytometry | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID1627183 | Cytotoxicity against mouse P338 cells assessed as inhibition of cell growth after 3 days by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
| Synthesis and biological evaluation of N(9)-substituted harmine derivatives as potential anticancer agents. |
| AID677620 | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei 427 after 48 hrs by MTS assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
| Identification of selective tubulin inhibitors as potential anti-trypanosomal agents. |
| AID306373 | Inhibition of tubulin polymerization at 1 ug/ml | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Synthesis of novel diaryl ethers and their evaluation as antimitotic agents. |
| AID1628409 | Inhibition of porcine brain tubulin polymerization incubated for 60 mins by fluorescence-based assay | 2016 | Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11
| Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site. |
| AID1175481 | Induction of apoptosis in human DU145 cells assessed as viable cells at 2 uM after 48 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 97.12%) | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID1239252 | Cytotoxicity against human AsPC1 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay | 2015 | Journal of medicinal chemistry, Aug-27, Volume: 58, Issue:16
| N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling. |
| AID1450060 | Induction of apoptosis in human DU145 cells assessed as late apoptotic cells at 2.5 uM after 48 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometric method (Rvb = 9.88 to 9.9%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1761117 | Inhibition of N,N'-Ethylenebis(iodoacetamide) binding to beta tubulin in human SW-620 cells at 20 to 40 uM preincubated for 2 hrs followed by addition of EBI and measured after 2 hrs by western blot assay | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1153430 | Cytotoxicity against human ACHN cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID1450046 | Cell cycle arrest in human DU145 cells assessed as accumulation at G0/G1 phase at 5 uM after 48 hrs by propidium iodide staining based flow cytometric method (Rvb = 82.09%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1694904 | Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2020 | RSC medicinal chemistry, Mar-01, Volume: 11, Issue:3
| Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents. |
| AID1761129 | Induction of cell cycle arrest in human SW-620 cells assessed as accumulation of cells in G2 phase at 1 uM measured after 24 hrs by PI staining based flow cytometry method (Rvb = 13.83%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID219734 | Ratio between Tumor weight of treated mice and Tumor weight of control mice * 100 at the dose of 25 (mg/kg/day) | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| Novel sulfonamides as potential, systemically active antitumor agents. |
| AID1628410 | Displacement of [3H]colchicine from biotinylated porcine tubulin at 1 uM incubated for 2 hrs by competition scintillation proximity | 2016 | Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11
| Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site. |
| AID1450052 | Disruption of mitochondrial membrane potential in human DU145 cells assessed as intact mitochondrial membrane at 2.5 uM after 48 hrs by JC1 staining-based flow cytometric method (Rvb = 95.4%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1761101 | Antiproliferative activity against human HCCLM3 cells assessed as cell viability measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1761123 | Induction of cell cycle arrest in human RKO cells assessed as accumulation of cells in G2 phase at 1 uM measured after 24 hrs by PI staining based flow cytometry method (Rvb = 10.79%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID306371 | Inhibition of tubulin polymerization at 10 ug/ml | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Synthesis of novel diaryl ethers and their evaluation as antimitotic agents. |
| AID1761133 | Induction of cell cycle arrest in human PANC-1 cells assessed as accumulation of cells in G1 phase at 1 uM measured after 24 hrs by PI staining based flow cytometry method (Rvb = 31.35%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1450043 | Inhibition of colchicine binding to rat brain tubulin up to 20 uM measured after 60 mins by fluorescence assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID780985 | Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Furanylazaindoles: potent anticancer agents in vitro and in vivo. |
| AID52987 | In vitro antiproliferative activity (4 ug/mL) was measured against colon 38 cancer cell line using MTT colorimetric assay | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11
| A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors. |
| AID1761097 | Antiproliferative activity against human MCF7 cells assessed as cell viability at 10 uM measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1761144 | Induction of apoptosis in human RKO cells assessed as late apoptotic cells at 1 uM measured after 24 hrs by PI/Annexin V staining based flow cytometry assay (Rvb = 0.81%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1761151 | Induction of apoptosis in human SW-620 cells assessed as early apoptotic cells at 1 uM measured after 24 hrs by PI/Annexin V staining based flow cytometry assay (Rvb = 2.41%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1450041 | Growth inhibition of human DU145 cells after 48 hrs by SRB assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1175462 | Antiproliferative activity against human DU145 cells assessed as growth inhibition after 24 hrs by SRB assay | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID140226 | Ratio between dead mices and total mices at the dose of 12.5 (mg/kg/day.); 0/6 | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| Novel sulfonamides as potential, systemically active antitumor agents. |
| AID1761159 | Induction of apoptosis in human SW-620 cells assessed as increase in ROS levels at 0.5 uM measured after 24 hrs by DCFH-DA staining based flow cytometry method relative to control | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID677621 | Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
| Identification of selective tubulin inhibitors as potential anti-trypanosomal agents. |
| AID553907 | Cell cycle arrest in human Jurkat cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent. |
| AID780973 | Inhibition of bovine brain MAP-rich tubulin polymerization measured every 30 secs for 30 mins by turbidometric method | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Furanylazaindoles: potent anticancer agents in vitro and in vivo. |
| AID95349 | In vitro antiproliferative activity (4 ug/mL) was measured against KB cancer cell line using MTT colorimetric assay | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11
| A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors. |
| AID1761172 | Inhibition of tubulin polymerization in human RKO cells assessed as morphology changed to fusiform at 1 uM measured 24 hrs by DAPI staining based immunoflourescence assay | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1586076 | Displacement of [3H]-colchicine from bovine brain tubulin at 5 uM by scintillation proximity assay relative to control | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | 1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase. |
| AID214545 | Concentration inhibiting tubulin polymerization | 2001 | Bioorganic & medicinal chemistry letters, Jul-09, Volume: 11, Issue:13
| Novel sulfonate derivatives: potent antimitotic agents. |
| AID780976 | Cytotoxicity against human KB-S15 cells overexpressing P-gp170/MDR assessed as growth inhibition after 72 hrs by methylene blue staining-based assay | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Furanylazaindoles: potent anticancer agents in vitro and in vivo. |
| AID553904 | Cytotoxicity against human HeLa cells after 48 to 72 hrs by WAT-1 assay | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent. |
| AID1153432 | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID1175473 | Displacement of colchicine from tubulin (unknown origin) at 5 to 25 uM after 60 mins by competitive binding assay | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID1734478 | Toxicity in C57BL/6 mouse xenografted with mouse B16-F10 cells assessed as change in body weight at 5 mg/kg, sc administered administered from day 7 post-infection until day 14 | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity. |
| AID1761113 | Inhibition of pig tubulin polymerization at 10 uM measured every minute for 60 mins by microplate reader method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1450039 | Growth inhibition of human A549 cells after 48 hrs by SRB assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1627184 | Cytotoxicity against human HL60 cells assessed as inhibition of cell growth after 3 days by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
| Synthesis and biological evaluation of N(9)-substituted harmine derivatives as potential anticancer agents. |
| AID152343 | In vitro antiproliferative activity (4 ug/mL) was measured against P388 cancer cell line using MTT colorimetric assay | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11
| A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors. |
| AID1662437 | Anticancer activity against human NSCLC cells | 2020 | Journal of medicinal chemistry, 09-24, Volume: 63, Issue:18
| p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. |
| AID1545841 | Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships. |
| AID1450048 | Cell cycle arrest in human DU145 cells assessed as accumulation at S phase at 5 uM after 48 hrs by propidium iodide staining based flow cytometric method (Rvb = 3.04%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1175467 | Cell cycle arrest in human DU145 cells assessed as cells accumulation at S phase at 2 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 4.18%) | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID1761155 | Induction of apoptosis in human RKO cells assessed as increase in cleaved PARP levels at 0.5 to 1 uM measured after 24 hrs by western blot assay | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID213859 | Compound was tested against bovine brain tubulin polymerization | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11
| A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors. |
| AID1153431 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID143206 | Antiproliferative activity against human lung carcinoma NCI-H460 cell line (MDR(+)) | 2001 | Bioorganic & medicinal chemistry letters, Jul-09, Volume: 11, Issue:13
| Novel sulfonate derivatives: potent antimitotic agents. |
| AID780971 | Displacement of [3H]-colchicine from biotin-labeled tubulin (unknown origin) at 5 uM after 2 hrs by scintillation proximity assay relative to control | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Furanylazaindoles: potent anticancer agents in vitro and in vivo. |
| AID1761122 | Induction of cell cycle arrest in human RKO cells assessed as accumulation of cells in S phase at 1 uM measured after 24 hrs by PI staining based flow cytometry method (Rvb = 49.66%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1761102 | Antiproliferative activity against human BT-474 cells assessed as cell viability measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID155048 | Effect on the cell cycle progression using P388 cells at 4.0 ug/mL for 24 hr; G2/M arrest | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11
| A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors. |
| AID1761174 | Induction of cell cycle arrest in human SW-620 cells assessed as reduction in Cyclin B1 expression at 0.5 to 1 uM measured after 24 hrs by western blot assay | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID725351 | Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives. |
| AID1315699 | Tmax in human at 250 mg, po qd regimen measured on day 7 post dose by LC-MS analysis | 2016 | Journal of medicinal chemistry, 10-13, Volume: 59, Issue:19
| Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth. |
| AID1450056 | Induction of apoptosis in human DU145 cells assessed as live cells at 2.5 uM after 48 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometric method (Rvb = 86.77%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1637514 | Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18
| Design and synthesis of cis-restricted benzimidazole and benzothiazole mimics of combretastatin A-4 as antimitotic agents with apoptosis inducing ability. |
| AID1545858 | Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships. |
| AID1761110 | Antiproliferative activity against human SGC-7901 cells assessed as cell viability measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1175471 | Inhibition of tubulin polymerization (unknown origin) at 3 uM after 1 hr by fluorescence analysis | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID780965 | Induction of vascular disrupting activity in HUVEC assessed as VEGF-induced tube formation at 100 to 1000 nM after 4 hrs by microscopic analysis | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Furanylazaindoles: potent anticancer agents in vitro and in vivo. |
| AID1734420 | Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity. |
| AID1691060 | Induction of apoptosis in human KB7D cells assessed as increase in activated gammaH2AX expression at 0.1 uM measured after 24 hrs by Western blot analysis | | | |
| AID780977 | Cytotoxicity against human KB-VIN10 cells overexpressing P-gp170/MDR assessed as growth inhibition after 72 hrs by methylene blue staining-based assay | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Furanylazaindoles: potent anticancer agents in vitro and in vivo. |
| AID1450038 | Inhibition of bovine brain tubulin polymerization at 3 uM measured for 1 hr relative to control | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID234910 | Relative resistance value as the ratio of IC50 for the resistant cell line to that of parental cell line. | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22
| Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide. |
| AID1761165 | Antitumour activity against human SW-620 cells xenografted in Athymic nude mouse assessed as decrease in tumour growth at 25 mg/kg per two days, po measured after 20 days | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1761105 | Antiproliferative activity against human SW-620 cells assessed as cell viability measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1450058 | Induction of apoptosis in human DU145 cells assessed as early apoptotic cells at 2.5 uM after 48 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometric method (Rvb = 3.2 to 3.21%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1637517 | Antiproliferative activity against human DU145 cells after 48 hrs by sulforhodamine B assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18
| Design and synthesis of cis-restricted benzimidazole and benzothiazole mimics of combretastatin A-4 as antimitotic agents with apoptosis inducing ability. |
| AID780983 | Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Furanylazaindoles: potent anticancer agents in vitro and in vivo. |
| AID1175469 | Cell cycle arrest in human DU145 cells assessed as cells accumulation at G2/M phase at 2 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 6.81%) | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID1450040 | Growth inhibition of human MCF7 cells after 48 hrs by SRB assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1175460 | Antiproliferative activity against human A549 cells assessed as growth inhibition after 24 hrs by SRB assay | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID140229 | Ratio between dead mices and total mices at the dose of 25 (mg/kg/day.); 0/6 | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| Novel sulfonamides as potential, systemically active antitumor agents. |
| AID1729878 | Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth after 72 hrs by XTT assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents. |
| AID1761098 | Antiproliferative activity against human SK-HEP1 cells assessed as cell viability at 10 uM measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1175483 | Induction of apoptosis in human DU145 cells assessed as early apoptotic cells at 2 uM after 48 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 0.71%) | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID219728 | In vitro inhibitory activity against colon 38 cell proliferation | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| Novel sulfonamides as potential, systemically active antitumor agents. |
| AID1761145 | Induction of apoptosis in human RKO cells assessed as necrotic cells at 1 uM measured after 24 hrs by PI/Annexin V staining based flow cytometry assay (Rvb = 0.01%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1175486 | Induction of apoptosis in human DU145 cells assessed as mitochondrial membrane potential drop measured as necrotic cells at 2 uM after 48 hrs using JC-1 staining-based flow cytometry (Rvb = 0%) | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID1628400 | Growth inhibition of human PC3 cells incubated for 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11
| Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site. |
| AID1153505 | Induction of apoptosis in human MCF7 cells assessed as activation of caspase-9 at 2 uM after 48 hrs relative to control | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID1175465 | Cell cycle arrest in human DU145 cells assessed as cells accumulation at G0/G1 phase at 2 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 84.75%) | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID1761164 | Cytotoxicity against human HUVEC cells assessed as inhibition of cell proliferation measured after 24 hrs by MTS assay | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID81720 | Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 cell line | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22
| Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide. |
| AID1628411 | Displacement of [3H]colchicine from biotinylated porcine tubulin at 5 uM incubated for 2 hrs by competition scintillation proximity | 2016 | Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11
| Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site. |
| AID96007 | Antiproliferative activity against KB human nasopharynx carcinoma in vitro | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle. |
| AID780982 | Cytotoxicity against human H460 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Furanylazaindoles: potent anticancer agents in vitro and in vivo. |
| AID1586075 | Displacement of [3H]-colchicine from bovine brain tubulin at 1 uM by scintillation proximity assay relative to control | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | 1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase. |
| AID1153502 | Inhibition of tubulin (unknown origin) polymerization at 3 uM after 1 hr by fluorescence assay | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID1175472 | Inhibition of tubulin polymerization (unknown origin) after 1 hr by fluorescence analysis | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID1694905 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2020 | RSC medicinal chemistry, Mar-01, Volume: 11, Issue:3
| Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents. |
| AID1761134 | Induction of cell cycle arrest in human PANC-1 cells assessed as accumulation of cells in S phase at 1 uM measured after 24 hrs by PI staining based flow cytometry method (Rvb = 65%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID725350 | Inhibition of bovine tubulin polymerization after 1 hr | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives. |
| AID152704 | Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388 cell line | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22
| Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide. |
| AID1628399 | Growth inhibition of human HeLa cells incubated for 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11
| Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site. |
| AID140231 | Ratio between dead mices and total mices at the dose of 50 (mg/kg/day.); 0/6 | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| Novel sulfonamides as potential, systemically active antitumor agents. |
| AID1175488 | Induction of apoptosis in human DU145 cells assessed as mitochondrial membrane potential drop measured as viable cells at 2 uM after 48 hrs using JC-1 staining-based flow cytometry (Rvb = 0%) | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID1761107 | Antiproliferative activity against human A549 cells assessed as cell viability measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1761127 | Induction of cell cycle arrest in human SW-620 cells assessed as accumulation of cells in G1 phase at 1 uM measured after 24 hrs by PI staining based flow cytometry method (Rvb = 40.06%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1153493 | Cell cycle arrest in human MCF7 cells assessed as accumulation at sub-G1 phase at 0.5 uM after 48 hrs using propidium iodide staining by flow cytometry | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID1153429 | Cytotoxicity against human DU145 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID1734475 | Anti-angiogenesis activity in mouse B16-F10 cells xenografted in C57BL/6 mouse assessed as reduction in microvessel number at 5 mg/kg, sc administered from day 7 post-infection until day 14 by immunohistochemistry | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity. |
| AID1450044 | Cell cycle arrest in human DU145 cells assessed as accumulation at sub G1 phase at 5 uM after 48 hrs by propidium iodide staining based flow cytometric method (Rvb = 0.68%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1586069 | Growth inhibition of human MKN45 cells after 48 hrs by SRB assay | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | 1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase. |
| AID1761161 | Induction of apoptosis in human RKO cells assessed as increase in ROS levels at 0.5 uM measured after 24 hrs by DCFH-DA staining based flow cytometry method relative to control | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID219731 | Ratio between Tumor weight of treated mice and Tumor weight of control mice * 100 at the dose of 12.5 (mg/kg/day) | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| Novel sulfonamides as potential, systemically active antitumor agents. |
| AID219736 | Ratio between Tumor weight of treated mice and Tumor weight of control mice * 100 at the dose of 50 (mg/kg/day) | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| Novel sulfonamides as potential, systemically active antitumor agents. |
| AID1628398 | Growth inhibition of human HepG2 cells incubated for 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11
| Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site. |
| AID1450042 | Growth inhibition of human MRC5 cells after 48 hrs by SRB assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID780970 | Displacement of [3H]-colchicine from biotin-labeled tubulin (unknown origin) after 2 hrs by scintillation proximity assay | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Furanylazaindoles: potent anticancer agents in vitro and in vivo. |
| AID1153495 | Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 0.5 uM after 48 hrs using propidium iodide staining by flow cytometry | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID1175479 | Induction of apoptosis in human DU145 cells assessed as late apoptotic cells at 2 uM after 48 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 1.96%) | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID1691036 | Antiproliferative activity against human KB7D cells incubated for 48 hrs by SRB assay | | | |
| AID1175463 | Cell cycle arrest in human DU145 cells assessed as cells accumulation at SubG1 phase at 2 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 3.52%) | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID306370 | Antiproliferative activity against human HL60 cells | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Synthesis of novel diaryl ethers and their evaluation as antimitotic agents. |
| AID1761099 | Antiproliferative activity against human RKO cells assessed as cell viability at 10 uM measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1691035 | Antiproliferative activity against human KB-VIN cells incubated for 48 hrs by SRB assay | | | |
| AID153385 | Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388/4.0 r-M cell line | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22
| Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide. |
| AID1239253 | Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay | 2015 | Journal of medicinal chemistry, Aug-27, Volume: 58, Issue:16
| N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling. |
| AID306374 | Inhibition of tubulin polymerization at 3 ug/ml | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Synthesis of novel diaryl ethers and their evaluation as antimitotic agents. |
| AID52986 | In vitro antiproliferative activity against colon 38 murine adenocarcinoma | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle. |
| AID1153497 | Cell cycle arrest in human MCF7 cells assessed as accumulation at S phase at 0.5 uM after 48 hrs using propidium iodide staining by flow cytometry | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID1153500 | Cell cycle arrest in human MCF7 cells assessed as accumulation at G2/M phase at 1 uM after 48 hrs using propidium iodide staining by flow cytometry | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID140225 | Ratio between dead mices and total mices at the dose of 100 (mg/kg/day.); 0/6 | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| Novel sulfonamides as potential, systemically active antitumor agents. |
| AID1153501 | Inhibition of tubulin (unknown origin) polymerization by fluorescence assay | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID553905 | Cytotoxicity against human NCI-ADR-RES expressing MDR1 cells after 48 to 72 hrs by WAT-1 assay | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent. |
| AID1761109 | Antiproliferative activity against human PANC-1 cells assessed as cell viability measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID219729 | Ratio between Tumor weight of treated mice and Tumor weight of control mice * 100 at the dose of 100 (mg/kg/day) | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| Novel sulfonamides as potential, systemically active antitumor agents. |
| AID1761154 | Induction of apoptosis in human RKO cells assessed as increase in Bax expression at 0.5 to 1 uM measured after 24 hrs by western blot assay | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1545838 | Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships. |
| AID1175461 | Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 24 hrs by SRB assay | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID1153496 | Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 1 uM after 48 hrs using propidium iodide staining by flow cytometry | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID780975 | Cytotoxicity against human KB-7d cells overexpressing MRP assessed as growth inhibition after 72 hrs by methylene blue staining-based assay | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Furanylazaindoles: potent anticancer agents in vitro and in vivo. |
| AID1637515 | Antiproliferative activity against human HepG2 cells after 48 hrs by sulforhodamine B assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18
| Design and synthesis of cis-restricted benzimidazole and benzothiazole mimics of combretastatin A-4 as antimitotic agents with apoptosis inducing ability. |
| AID780984 | Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Furanylazaindoles: potent anticancer agents in vitro and in vivo. |
| AID1153498 | Cell cycle arrest in human MCF7 cells assessed as accumulation at S phase at 1 uM after 48 hrs using propidium iodide staining by flow cytometry | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID1761166 | Toxicity against Athymic nude mouse xenografted with SW-620 cells assessed as changes in body weight at 25 mg/kg per two days, po measured after 20 days | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1153494 | Cell cycle arrest in human MCF7 cells assessed as accumulation at sub-G1 phase at 1 uM after 48 hrs using propidium iodide staining by flow cytometry | 2014 | Bioorganic & medicinal chemistry, Jul-01, Volume: 22, Issue:13
| Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization. |
| AID1450062 | Induction of apoptosis in human DU145 cells assessed as necrotic cells at 2.5 uM after 48 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometric method (Rvb = 0.1 to 0.14%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1239254 | Cytotoxicity against human Hep3B cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay | 2015 | Journal of medicinal chemistry, Aug-27, Volume: 58, Issue:16
| N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling. |
| AID1761150 | Induction of apoptosis in human SW-620 cells assessed as viable cells at 1 uM measured after 24 hrs by PI/Annexin V staining based flow cytometry assay (Rvb = 93.89%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID414628 | Drug level in rhesus monkey cerebrospinal fluid at 7.5 mg/kg, iv after 24 hrs | 2009 | Journal of medicinal chemistry, Apr-23, Volume: 52, Issue:8
| Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. |
| AID81721 | Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 -C1cell line | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22
| Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide. |
| AID780972 | Displacement of [3H]-colchicine from biotin-labeled tubulin (unknown origin) at 1 uM after 2 hrs by scintillation proximity assay relative to control | 2013 | Journal of medicinal chemistry, Oct-24, Volume: 56, Issue:20
| Furanylazaindoles: potent anticancer agents in vitro and in vivo. |
| AID1450054 | Disruption of mitochondrial membrane potential in human DU145 cells assessed as collapse of the mitochondrial membrane potential at 2.5 uM after 48 hrs by JC1 staining-based flow cytometric method (Rvb = 4%) | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1761153 | Induction of apoptosis in human SW-620 cells assessed as necrotic cells at 1 uM measured after 24 hrs by PI/Annexin V staining based flow cytometry assay (Rvb = 0.03%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1761100 | Antiproliferative activity against human PLC-PRF-5 cells assessed as cell viability measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1761121 | Induction of cell cycle arrest in human RKO cells assessed as accumulation of cells in G1 phase at 1 uM measured after 24 hrs by PI staining based flow cytometry method (Rvb = 39.54%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1761103 | Antiproliferative activity against human SK-BR-3 cells assessed as cell viability measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1628401 | Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11
| Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site. |
| AID1761163 | Anti-vascular activity against human HUVEC cells assessed as wound closure at 1 uM measured after 24 hrs by wound closure assay (Rvb = 71.8%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1545839 | Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships. |
| AID1729880 | Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by XTT assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents. |
| AID78621 | Antiproliferative activity against human colon carcinoma HCT-15 cell line(MDR(-)) | 2001 | Bioorganic & medicinal chemistry letters, Jul-09, Volume: 11, Issue:13
| Novel sulfonate derivatives: potent antimitotic agents. |
| AID1734421 | Inhibition of bovine tubulin polymerization incubated for 1 hr in presence of GTP by fluorescence spectroscopy | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity. |
| AID1691034 | Antiproliferative activity against human KB cells incubated for 48 hrs by SRB assay | | | |
| AID214028 | Inhibitory activity against tubulin polymerization. | 2002 | Journal of medicinal chemistry, Oct-24, Volume: 45, Issue:22
| Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide. |
| AID1761142 | Induction of apoptosis in human RKO cells assessed as viable cells at 1 uM measured after 24 hrs by PI/Annexin V staining based flow cytometry assay (Rvb = 96.6%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1239255 | Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay | 2015 | Journal of medicinal chemistry, Aug-27, Volume: 58, Issue:16
| N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling. |
| AID95684 | In vitro inhibitory activity against KB (human carcinoma of the nasopharynx) cell proliferation. | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| Novel sulfonamides as potential, systemically active antitumor agents. |
| AID1761108 | Antiproliferative activity against human NCI-H460 cells assessed as cell viability measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1761152 | Induction of apoptosis in human SW-620 cells assessed as late apoptotic cells at 1 uM measured after 24 hrs by PI/Annexin V staining based flow cytometry assay (Rvb = 3.66%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1729877 | Inhibition of bovine brain tubulin polymerization incubated for 30 mins by turbidimetric assay | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents. |
| AID1761157 | Induction of apoptosis in human SW-620 cells assessed as increase in cleaved PARP levels at 0.5 to 1 uM measured after 24 hrs by western blot assay | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1450037 | Inhibition of bovine brain tubulin polymerization measured for 1 hr | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents. |
| AID1637516 | Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay | 2016 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18
| Design and synthesis of cis-restricted benzimidazole and benzothiazole mimics of combretastatin A-4 as antimitotic agents with apoptosis inducing ability. |
| AID1761143 | Induction of apoptosis in human RKO cells assessed as early apoptotic cells at 1 uM measured after 24 hrs by PI/Annexin V staining based flow cytometry assay (Rvb = 2.58%) | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID1175477 | Induction of apoptosis in human DU145 cells assessed as necrotic cells at 2 uM after 48 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 0.22%) | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID1175487 | Induction of apoptosis in human DU145 cells assessed as mitochondrial membrane potential drop measured as late apoptotic cells at 2 uM after 48 hrs using JC-1 staining-based flow cytometry (Rvb = 90.9%) | 2014 | Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
| Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents. |
| AID1761106 | Antiproliferative activity against human SW480 cells assessed as cell viability measured after 72 hrs by MTS method | 2021 | European journal of medicinal chemistry, Feb-05, Volume: 211 | Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities. |
| AID150686 | Antiproliferative activity against P388 murine leukemia in vitro | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle. |
| AID553914 | Cytotoxicity against human SW620 cells after 48 to 72 hrs by WAT-1 assay | 2011 | Journal of medicinal chemistry, Jan-13, Volume: 54, Issue:1
| Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent. |
| AID1586067 | Growth inhibition of human KB cells after 48 hrs by SRB assay | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | 1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase. |
| AID1347122 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347123 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347139 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347137 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for Daoy cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347119 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347129 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347136 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347125 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347118 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347115 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347127 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347117 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347113 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347141 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347110 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347121 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347128 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347135 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347116 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347138 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D caspase screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347109 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347111 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347114 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347124 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347140 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347126 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347112 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |