2-bromopropane: used as a substitute for freon [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 6358 |
| CHEMBL ID | 451810 |
| SCHEMBL ID | 10251 |
| MeSH ID | M0271148 |
| Synonym |
|---|
| isopropyl bromide |
| isopropylbromide |
| propane, 2-bromo- |
| inchi=1/c3h7br/c1-3(2)4/h3h,1-2h |
| 2-bromopropane |
| 2-bromo-propane |
| 75-26-3 |
| NCGC00091451-01 |
| ai3-18127 |
| hsdb 623 |
| einecs 200-855-1 |
| ccris 7919 |
| un2344 |
| 2-bromopropane, 99% |
| 2-bromopropane [un2344] [flammable liquid] |
| B0639 |
| CHEMBL451810 |
| AKOS000119846 |
| A838364 |
| 2-bromanylpropane |
| NCGC00091451-02 |
| BR1118 |
| NCGC00257910-01 |
| cas-75-26-3 |
| tox21_200356 |
| dtxsid7030197 , |
| dtxcid5010197 |
| STL146524 |
| unii-r651xov97z |
| ec 200-855-1 |
| r651xov97z , |
| FT-0611602 |
| un-2344 |
| isopropyl bromide [mi] |
| sec-propyl bromide |
| BBL027287 |
| SCHEMBL10251 |
| 2-bromo propane |
| i-prbr |
| 1-isopropylbromide |
| 1-bromo-1-methylethane |
| iso-propyl bromide |
| i-propyl bromide |
| i-propylbromide |
| iso-propylbromide |
| 2-propyl bromide |
| iso-c3h7br |
| J-508539 |
| F0001-1897 |
| 2-bromopropane, analytical standard |
| mfcd00000147 |
| 2-bromopropane, purum, >=99.0% (gc) |
| 2-bromopropane, >=99% |
| 2-bromopropane-d6 |
| VS-08520 |
| Q209323 |
| AMY37129 |
| D87619 |
| EN300-20069 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Recently, health effects of HCFC 123, including toxic hepatitis, have been reported by several authors." | ( Hematopoietic and reproductive toxicity of 2-bromopropane, a recently introduced substitute for chlorofluorocarbons. Kim, Y; Moon, Y; Park, J, 1999) | 0.57 |
| " The no observed adverse effect level (NOAEL) in this study could be estimated to be lower than 200 mg/kg/b." | ( Male reproductive toxicity and beta-luteinizing hormone gene expression in sexually mature and immature rats exposed to 2-bromopropane. Chahoud, I; Ding, X; Faqi, AS; Jiang, X; Wu, X; Yang, J, 1999) | 0.51 |
| " In conclusion, 2-BP is neurotoxic to the peripheral nerves in addition to its toxic effects on the reproductive and hematopoietic systems at 1000 ppm." | ( Neurotoxicity of 2-bromopropane and 1-bromopropane, alternative solvents for chlorofluorocarbons. Ichihara, G; Kamijima, M; Kitoh, J; Shibata, E; Takeuchi, Y; Xie, Z; Yu, X, 2001) | 0.65 |
| " Further studies should focus more on the differences and commonality between animals and humans in response to toxic agents." | ( [Investigation of toxicity through human cases and animal experiments--study of bromopropanes]. Ichihara, G, 2005) | 0.33 |
| "To study the reproductive toxicity of male rats exposed to 1-bromopropane and 2-bromopropane and to explore the toxic mechanism of two isomers." | ( [Reproductive toxicity of male rats exposed to two isomers of bromopropanes]. Huang, F; Song, X; Wang, H; Xin, Q; Ye, D; Zhang, W, 2010) | 0.59 |
| "This study indicates that bromopropanes can cause reproductive disorder in male rats, the rats treatment with 2-BP had more toxicity than that with 1-BP, and it might have different toxic mechanism between two isomers." | ( [Reproductive toxicity of male rats exposed to two isomers of bromopropanes]. Huang, F; Song, X; Wang, H; Xin, Q; Ye, D; Zhang, W, 2010) | 0.36 |
| " Taken together, this study indicated that those two isomers both have toxicity in male rats, however, the testicular toxicity and the role of apoptosis in the toxic mechanism induced by 1-BP and 2-BP may be different." | ( Apoptosis contributes to testicular toxicity induced by two isomers of bromopropanes. Xin, QQ; Ye, DQ; Zhang, WJ, 2010) | 0.36 |
| " While current animal models are available, understanding of the reproductive toxic effects on human fertility requires a more robust model system." | ( Assessing reproductive toxicity of two environmental toxicants with a novel in vitro human spermatogenic model. Bradner, JM; Caudle, WM; Easley, CA; Hansen, JM; McEachin, ZT; Merritt, MM; Moser, A; Rickman, CA, 2015) | 0.42 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " (2) Exposure paradigms: extrapolating dosing in animals to exposures in humans becomes complex." | ( Reproductive toxicology: current and future directions. Hoyer, PB, 2001) | 0.31 |
| " The dose-response of bromopropanes in humans and mechanism(s) underlying the differences in the toxic effects of the two bromopropanes remain to be determined." | ( Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane. Ichihara, G, 2005) | 0.58 |
| " Thus, these serial studies revealed that 1-bromopropane is neurotoxic, but its dose-response relationship in humans remains unknown." | ( [Investigation of toxicity through human cases and animal experiments--study of bromopropanes]. Ichihara, G, 2005) | 0.33 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 27.3616 | 0.0002 | 21.2231 | 8,912.5098 | AID1259243; AID1259247 |
| progesterone receptor | Homo sapiens (human) | Potency | 24.3860 | 0.0004 | 17.9460 | 75.1148 | AID1346795 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 0.1585 | 0.0002 | 14.3764 | 60.0339 | AID588532 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 30.7002 | 0.0030 | 41.6115 | 22,387.1992 | AID1159552; AID1159555 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 68.7291 | 0.0015 | 30.6073 | 15,848.9004 | AID1224848; AID1224849 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 55.0822 | 0.0578 | 21.1097 | 61.2679 | AID1159526 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.3548 | 0.0100 | 39.5371 | 1,122.0200 | AID588547 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID384212 | Mutagenic activity in Salmonella Typhimurium TA100 assessed as logarithm of his+ revertant number increasing activity by amens test | 2008 | Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10 | Halogenated derivatives QSAR model using spectral moments to predict haloacetic acids (HAA) mutagenicity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (2.17) | 18.7374 |
| 1990's | 15 (32.61) | 18.2507 |
| 2000's | 18 (39.13) | 29.6817 |
| 2010's | 8 (17.39) | 24.3611 |
| 2020's | 4 (8.70) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (62.52) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 6 (11.54%) | 6.00% |
| Case Studies | 1 (1.92%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 45 (86.54%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||