corynoxeine: active principles of Uncariae Ramulus et Uncus; structure given in first source for ((7beta,16E,20alpha)-isomer) and ((16E,20alpha)-isomer); RN given refers to ((7beta,16E,20alpha)-isomer) [MeSH]
| ID Source | ID |
|---|---|
| PubMed CID | 44568160 |
| CHEMBL ID | 481358 |
| SCHEMBL ID | 23259426 |
| MeSH ID | M0154563 |
| Synonym |
|---|
| corynoxeine |
| CHEMBL481358 |
| 630-94-4 |
| 27kic0q2va , |
| unii-27kic0q2va |
| corynoxan-16-carboxylic acid, 16,17,18,19-tetradehydro-17-methoxy-2-oxo-, methyl ester, (7beta,16e,20alpha)- |
| S9306 |
| AKOS016010994 |
| CS-3803 |
| spiro(3h-indole-3,1'(5'h)-indolizine)-7'-acetic acid, 6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-.alpha.-(methoxymethylene)-2-oxo-, methyl ester, (.alpha.e,1'r,6'r,7's,8'as)- |
| .delta.18-rhynchophylline |
| corynoxan-16-carboxylic acid, 16,17,18,19-tetradehydro-17-methoxy-2-oxo-, methyl ester, (7.beta.,16e,20.alpha.)- |
| .delta.18-rhyncophylline |
| corynoxein |
| HY-N0590 |
| CCG-268431 |
| Q27254211 |
| SCHEMBL23259426 |
| methyl (e)-2-[(3r,6'r,7's,8'as)-6'-ethenyl-2-oxospiro[1h-indole-3,1'-3,5,6,7,8,8a-hexahydro-2h-indolizine]-7'-yl]-3-methoxyprop-2-enoate |
| AC-34615 |
| DTXSID001318311 |
| AS-76851 |
| delta18-rhynchophylline |
| spiro(3h-indole-3,1'(5'h)-indolizine)-7'-acetic acid, 6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-alpha-(methoxymethylene)-2-oxo-, methyl ester, (alphae,1'r,6'r,7's,8'as)- |
| delta18-rhyncophylline |
| methyl (7beta,16e,20alpha)-17-methoxy-2-oxocorynoxa-16,18-dien-16-carboxylate |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID340409 | Inhibition of LPS-stimulated NO release in rat cortical microglial cells assessed as nitrite accumulation after 48 hrs | 2008 | Journal of natural products, Jul, Volume: 71, Issue:7 ISSN: 1520-6025 | Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. |
| AID340407 | Inhibition of LPS-stimulated NO release in rat cortical microglial cells assessed as nitrite accumulation at 1 ug/ml after 48 hrs relative to LPS | 2008 | Journal of natural products, Jul, Volume: 71, Issue:7 ISSN: 1520-6025 | Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. |
| AID340410 | Inhibition of LPS-stimulated NO release in rat cortical microglial cells assessed as nitrite accumulation at 100 ug/ml after 48 hrs relative to LPS | 2008 | Journal of natural products, Jul, Volume: 71, Issue:7 ISSN: 1520-6025 | Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. |
| AID1385453 | Cytotoxicity against human HT-29 cells assessed as reduction in cell viability at 100 uM after 24 hrs by MTT assay | 2018 | Journal of natural products, 08-24, Volume: 81, Issue:8 ISSN: 1520-6025 | Alkaloids with Immunosuppressive Activity from the Bark of Pausinystalia yohimbe. |
| AID1385454 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability at 100 uM after 24 hrs by MTT assay | 2018 | Journal of natural products, 08-24, Volume: 81, Issue:8 ISSN: 1520-6025 | Alkaloids with Immunosuppressive Activity from the Bark of Pausinystalia yohimbe. |
| AID340405 | Cell viability of rat cortical microglial cells after 48 hrs by MTT assay | 2008 | Journal of natural products, Jul, Volume: 71, Issue:7 ISSN: 1520-6025 | Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. |
| AID340404 | Cell viability of LPS-stimulated rat cortical microglial cells after 48 hrs by MTT assay | 2008 | Journal of natural products, Jul, Volume: 71, Issue:7 ISSN: 1520-6025 | Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. |
| AID1385452 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 100 uM after 24 hrs by MTT assay | 2018 | Journal of natural products, 08-24, Volume: 81, Issue:8 ISSN: 1520-6025 | Alkaloids with Immunosuppressive Activity from the Bark of Pausinystalia yohimbe. |
| AID340408 | Inhibition of LPS-stimulated NO release in rat cortical microglial cells assessed as nitrite accumulation at 10 ug/ml after 48 hrs relative to LPS | 2008 | Journal of natural products, Jul, Volume: 71, Issue:7 ISSN: 1520-6025 | Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. |
| AID340406 | Inhibition of NO release in rat cortical microglial cells | 2008 | Journal of natural products, Jul, Volume: 71, Issue:7 ISSN: 1520-6025 | Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia. |
| AID1385451 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability at 100 uM after 24 hrs by MTT assay | 2018 | Journal of natural products, 08-24, Volume: 81, Issue:8 ISSN: 1520-6025 | Alkaloids with Immunosuppressive Activity from the Bark of Pausinystalia yohimbe. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 13 (72.22) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 19 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| corynanthine | yohimban alkaloid | 2018 | 2018 | 6.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | ||
| resveratrol | resveratrol | antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| hirsutine, (16e,20beta)-isomer | alkaloid | metabolite | 2018 | 2018 | 6.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |
| isorhyncophylline | indolizines | metabolite | 2008 | 2008 | 16.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 | |
| Rhynchophylline | indolizines | metabolite | 2008 | 2008 | 16.0 | high | 0 | 0 | 0 | 1 | 0 | 0 | |
| corynoxine b | indolizines | metabolite | 2018 | 2018 | 6.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |
| corynoxine | indolizines | metabolite | 2018 | 2018 | 6.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Depression | 0 | 2024 | 2024 | 0.0 | high | 0 | 0 | 0 | 0 | 0 | 1 | |
| Muscle Contraction | 0 | 1987 | 1987 | 37.0 | high | 0 | 1 | 0 | 0 | 0 | 0 |
| Article | Year |
|---|---|
| Development of a novel UHPLC-MS/MS method for the quantification of corynoxeine: Application to pharmacokinetics and tissue distribution studies in normal and chronic unpredictable mild stress-induced depression rats. Journal of pharmaceutical and biomedical analysis, , Jan-20, Volume: 238 | 2024 |