Page last updated: 2024-10-24

Myc-Max complex

Definition

Target type: cellularcomponent

A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max. [GOC:cna, PMID:16620027, PMID:16620031, PMID:20170194]

The Myc-Max complex is a heterodimeric transcription factor that plays a crucial role in regulating cell growth, proliferation, and differentiation. It is composed of two proteins: c-Myc and Max. c-Myc is a proto-oncogene that is frequently overexpressed in cancer cells. Max is a ubiquitously expressed protein that can also form homodimers. The Myc-Max complex binds to specific DNA sequences called E-boxes, which are found in the regulatory regions of target genes. Binding of the Myc-Max complex to E-boxes can either activate or repress gene expression, depending on the context. The cellular component of the Myc-Max complex is the nucleus. This is where the complex binds to DNA and regulates gene expression. The Myc-Max complex is located in the nucleus, specifically associated with chromatin, which is the complex of DNA and proteins that make up chromosomes. This association with chromatin is essential for the complex to function as a transcription factor. The Myc-Max complex is also found in other nuclear structures, such as nucleoli and nuclear speckles. These structures are involved in various aspects of gene expression, including RNA processing and transcription. The exact role of the Myc-Max complex in these structures is still being investigated. The cellular component of the Myc-Max complex is therefore complex and dynamic, reflecting its diverse roles in regulating gene expression.'
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Proteins (3)

ProteinDefinitionTaxonomy
Myc proto-oncogene proteinA c-myc protein that is encoded in the genome of chicken. [OMA:P01109, PRO:DNx]Gallus gallus (chicken)
Protein maxA protein max that is encoded in the genome of human. [PRO:CNA]Homo sapiens (human)
Myc proto-oncogene proteinA c-myc protein that is encoded in the genome of human. [PRO:CNA, UniProtKB:P01106]Homo sapiens (human)

Compounds (10)

CompoundDefinitionClassesRoles
aurintricarboxylic acidaurintricarboxylic acid : A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.

Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.
monohydroxybenzoic acid;
quinomethanes;
tricarboxylic acid
fluorochrome;
histological dye;
insulin-like growth factor receptor 1 antagonist
mefenamic acidmefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.

Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
aminobenzoic acid;
secondary amino compound
analgesic;
antipyretic;
antirheumatic drug;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-steroidal anti-inflammatory drug;
xenobiotic
methyl redmethyl red : An azo dye consisting of benzoic acid substituted at position 2 by a 4-[(dimethylamino)phenyl]diazenyl group.

methyl red: RN given refers to parent cpd; structure
3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine1,2,4-triazines
avasimibemonoterpenoid
resveratroltrans-resveratrol : A resveratrol in which the double bond has E configuration.resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
10074-g510074-G5: structure in first source
tws 119pyrroles
sgi-1027SGI-1027: inhibits DNA methyltransferase 1; structure in first source
kj-pyr-9KJ-Pyr-9: antineoplastic; structure in first source