Myc-Max complex
Definition
Target type: cellularcomponent
A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max. [GOC:cna, PMID:16620027, PMID:16620031, PMID:20170194]
The Myc-Max complex is a heterodimeric transcription factor that plays a crucial role in regulating cell growth, proliferation, and differentiation. It is composed of two proteins: c-Myc and Max. c-Myc is a proto-oncogene that is frequently overexpressed in cancer cells. Max is a ubiquitously expressed protein that can also form homodimers. The Myc-Max complex binds to specific DNA sequences called E-boxes, which are found in the regulatory regions of target genes. Binding of the Myc-Max complex to E-boxes can either activate or repress gene expression, depending on the context. The cellular component of the Myc-Max complex is the nucleus. This is where the complex binds to DNA and regulates gene expression. The Myc-Max complex is located in the nucleus, specifically associated with chromatin, which is the complex of DNA and proteins that make up chromosomes. This association with chromatin is essential for the complex to function as a transcription factor. The Myc-Max complex is also found in other nuclear structures, such as nucleoli and nuclear speckles. These structures are involved in various aspects of gene expression, including RNA processing and transcription. The exact role of the Myc-Max complex in these structures is still being investigated. The cellular component of the Myc-Max complex is therefore complex and dynamic, reflecting its diverse roles in regulating gene expression.'
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Proteins (3)
| Protein | Definition | Taxonomy |
|---|---|---|
| Myc proto-oncogene protein | A c-myc protein that is encoded in the genome of chicken. [OMA:P01109, PRO:DNx] | Gallus gallus (chicken) |
| Protein max | A protein max that is encoded in the genome of human. [PRO:CNA] | Homo sapiens (human) |
| Myc proto-oncogene protein | A c-myc protein that is encoded in the genome of human. [PRO:CNA, UniProtKB:P01106] | Homo sapiens (human) |
Compounds (10)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| aurintricarboxylic acid | aurintricarboxylic acid : A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'. Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues. | monohydroxybenzoic acid; quinomethanes; tricarboxylic acid | fluorochrome; histological dye; insulin-like growth factor receptor 1 antagonist |
| mefenamic acid | mefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis. Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase. | aminobenzoic acid; secondary amino compound | analgesic; antipyretic; antirheumatic drug; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; non-steroidal anti-inflammatory drug; xenobiotic |
| methyl red | methyl red : An azo dye consisting of benzoic acid substituted at position 2 by a 4-[(dimethylamino)phenyl]diazenyl group. methyl red: RN given refers to parent cpd; structure | ||
| 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine | 1,2,4-triazines | ||
| avasimibe | monoterpenoid | ||
| resveratrol | trans-resveratrol : A resveratrol in which the double bond has E configuration. | resveratrol | antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger |
| 10074-g5 | 10074-G5: structure in first source | ||
| tws 119 | pyrroles | ||
| sgi-1027 | SGI-1027: inhibits DNA methyltransferase 1; structure in first source | ||
| kj-pyr-9 | KJ-Pyr-9: antineoplastic; structure in first source |