Roles > EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor
Page last updated: 2024-08-05 15:50:31
EC 1.14.99.66 (lysine-specific histone demethylase 1A) inhibitor
An EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of lysine-specific histone demethylase 1A (EC 1.14.99.66).
ChEBI ID: 131509
Members (1)
| Member | Definition | Class |
|---|
| gsk2879552 | A member of the class of piperidines that is piperidine substituted by (4-carboxyphenyl)methyl and {[(1R,2S)-2-phenylcyclopropyl]amino}methyl groups at positions 1 and 4, respectively. It is a potent and irreversible inhibitor of lysine specific demethylase 1 (LSD1, also known as KDM1A). It was under clinical investigation for the treatment of acute myeloid leukaemia and small cell lung carcinoma. | GSK2879552 |
Research
Studies (29)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 18 (62.07) | 24.3611 |
| 2020's | 11 (37.93) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 2 (6.90%) | 5.53% |
| Reviews | 5 (17.24%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 22 (75.86%) | 84.16% |
Protein Targets (5)
Inhibition Measurements
Activation Measurements