2-toluenesulfonamide, also known as o-toluenesulfonamide, is a white crystalline solid. It is a sulfonamide derivative of toluene, and it is a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. 2-toluenesulfonamide is synthesized by reacting o-toluenesulfonyl chloride with ammonia. It is used as a reagent in the preparation of other organic compounds, such as dyes, herbicides, and pesticides. The compound is also studied for its potential biological activity. For example, it has been shown to exhibit antibacterial activity against certain bacteria. Its importance lies in its versatility as a synthetic intermediate and its potential for biological applications.'
2-toluenesulfonamide: saccharin impurity; starting material for preparation of saccharin; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 6924 |
| CHEMBL ID | 176892 |
| SCHEMBL ID | 7369 |
| MeSH ID | M0060966 |
| Synonym |
|---|
| spr_3 |
| 2-methylbenzene-1-sulfonamide |
| bdbm35999 |
| wln: zswr b1 |
| o-toluenesulfonamide |
| toluene-2-sulfonamide |
| nsc-2185 |
| nsc2185 |
| ortho-toluenesulfonamide |
| benzenesulfonamide, 2-methyl- |
| o-methylbenzenesulfonamide |
| 2-methylbenzenesulfonamide |
| 88-19-7 |
| 1333-07-9 |
| brn 1102362 |
| ccris 8900 |
| einecs 201-808-8 |
| ai3-23216 |
| ortho-toluenesulphonamide |
| 2-tolylsulfonamide |
| hsdb 5256 |
| ortho-toluol-sulfonamid [german] |
| nsc 2185 |
| 2-toluenesulfonamide |
| toluene-2-sulphonamide |
| santicizer 9 |
| ketjenflex 9s |
| 2(or 4)-methylbenzenesulfonamide |
| 2(or 4)-toluenesulfonamide |
| einecs 232-394-7 |
| ketjenflex 9 |
| o-(or p)-toluenesulphonamide |
| benzenesulfonamide, 2(or 4)-methyl- |
| inchi=1/c7h9no2s/c1-6-4-2-3-5-7(6)11(8,9)10/h2-5h,1h3,(h2,8,9,10 |
| o-toluenesulfonamide, 99% |
| FT-0651648 |
| FT-0659866 |
| CHEMBL176892 |
| T0280 |
| AKOS000119649 |
| A806591 |
| STK325715 |
| AE-562/40299836 |
| toluenesulfonamide |
| tox21_301641 |
| dtxsid7021362 , |
| dtxcid301362 |
| cas-88-19-7 |
| NCGC00255267-01 |
| 8013-74-9 |
| 4-11-00-00229 (beilstein handbook reference) |
| ortho-toluol-sulfonamid |
| ec 201-808-8 |
| r81z6v889p , |
| unii-r81z6v889p |
| o-toluenesulfonamide [usp-rs] |
| toluenesulfonamide, o- |
| o-toluenesulfonamide [hsdb] |
| 2-toluenesulphonamide |
| methyl-benzenesulphonamide |
| 2-methylbenzene-sulfonamide |
| 2-methylbenzene sulphonamide |
| toluene sulfonamide |
| 2-methyl-benzenesulphonamide |
| o-tolylsulfonamide |
| SCHEMBL7369 |
| 2-methylbenzene-1-sulphonamide |
| STR03407 |
| TS-02327 |
| ots amide |
| uniplex 171 (salt/mix) |
| W-109319 |
| IEJ , |
| mfcd00007934 |
| o-toluenesulfonamide, united states pharmacopeia (usp) reference standard |
| o-toluenesulfonamide, pharmaceutical secondary standard; certified reference material |
| Z57902803 |
| o-toluene sulfonamide |
| E70309 |
| ortho tolune sulphonamide,(s) |
| EN300-18329 |
| AMY37132 |
| Q27287945 |
| SY048993 |
| CS-W010774 |
| PD055397 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 68.5896 | 0.0023 | 19.5956 | 74.0614 | AID651631 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 6 (40.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.17) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (6.67%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (93.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||