Compounds > isoelemicin
Page last updated: 2024-12-11

isoelemicin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

isoelemicin: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5318557
CHEMBL ID121548
CHEBI ID80837
SCHEMBL ID68067
SCHEMBL ID8350155
MeSH IDM0087508

Synonyms (40)

Synonym
benzene, 1,2,3-trimethoxy-5-(1-propenyl)-, (e)-
9260la114i ,
unii-9260la114i
ai3-36724
nsc16705
487-12-7
isoelemicin
nsc-16705
chebi:80837 ,
CHEMBL121548
5273-85-8
C16975
1,2,3-trimethoxy-5-[(e)-prop-1-enyl]benzene
benzene, 1,2,3-trimethoxy-5-(1-propenyl)-
nsc 16705
5-propenyl-1,2,3-trimethoxy
SCHEMBL68067
SCHEMBL8350155
RRXOQHQFJOQLQR-AATRIKPKSA-N
benzene, 1,2,3-trimethoxy-5-propenyl-, (e)-
1,2,3-trimethoxy-5-[(1e)-prop-1-en-1-yl]benzene
trans-isoelemicin
1,2,3-trimethoxy-5-((1e)-1-propenyl)benzene
isoelemicin, trans-
benzene, 1,2,3-trimethoxy-5-(1e)-1-propen-1-yl-
(e)-isoelemicin
isoelemicin, (e)-
1,2,3-trimethoxy-5-(1-propenyl)-benzene
1,2,3-trimethoxy-5-(1-propenyl)-(e)-benzene
(e)-isoelemicine
1,2,3-trimethoxy-5-(1-propenyl)benzene
1,2,3-trimethoxy-5-[(1e)-1-propenyl]benzene
trans-isoelemicine
AKOS032948345
Q27149878
FS-9419
(e)-1,2,3-trimethoxy-5-(prop-1-enyl)benzene
DTXSID801017541
1,2,3-trimethoxy-5-(1e)-1-propen-1-ylbenzene; (e)-isoelemicin; 1,2,3-trimethoxy-5-((e)-prop-1-enyl)benzene; 1,2,3-trimethoxy-5-[(1e)-1-propenyl]benzene
3-(4-imidazolyl)-2-oxopropionicacid

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
olefinic compoundAny organic molecular entity that contains at least one C=C bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (38)

Assay IDTitleYearJournalArticle
AID408535Cytotoxicity against Salmonella Typhimurium TA100 assessed as growth inhibition after 48 to 72 hrs2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID1502972Increase in HDL-C level in rat dosed for 7 days2017European journal of medicinal chemistry, Nov-10, Volume: 140Lipid lowering agents of natural origin: An account of some promising chemotypes.
AID408513Mutagenic activity in Salmonella Typhimurium TA100 assessed as number of his+ revertants at 1000 ug/plate after 48 to 72 hrs by Ames test in absence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408497Mutagenic activity in Salmonella Typhimurium TA97 assessed as number of his+ revertants at 100 ug/plate after 48 to 72 hrs by Ames test in absence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408503Mutagenic activity in Salmonella Typhimurium TA98 assessed as number of his+ revertants at 100 ug/plate after 48 to 72 hrs by Ames test in absence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID224688Effect on acute pulmonary thromboembolism in mice at 100 mg/kg expressed as no. of killed or paralyzed to no. of tested observed after 10 min2000Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20
Synthesis and hypolipidemic and antiplatelet activities of alpha-asarone isomers in humans (in vitro), mice (in vivo), and rats (in vivo).
AID408519Mutagenic activity in Salmonella Typhimurium TA102 assessed as number of his+ revertants at 1000 ug/plate after 48 to 72 hrs by Ames test in absence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408498Mutagenic activity in Salmonella Typhimurium TA97 assessed as number of his+ revertants at 100 ug/plate after 48 to 72 hrs by Ames test in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408533Cytotoxicity against Salmonella Typhimurium TA102 assessed as reduction in his+ revertants after 48 to 72 hrs in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408504Mutagenic activity in Salmonella Typhimurium TA98 assessed as number of his+ revertants at 100 ug/plate after 48 to 72 hrs by Ames test in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408505Mutagenic activity in Salmonella Typhimurium TA98 assessed as number of his+ revertants at 500 ug/plate after 48 to 72 hrs by Ames test in absence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408512Mutagenic activity in Salmonella Typhimurium TA100 assessed as number of his+ revertants at 500 ug/plate after 48 to 72 hrs by Ames test in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408507Mutagenic activity in Salmonella Typhimurium TA98 assessed as number of his+ revertants at 1000 ug/plate after 48 to 72 hrs by Ames test in absence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID224856Effect on acute pulmonary thromboembolism in mice at 100 mg/kg2000Journal of medicinal chemistry, Oct-05, Volume: 43, Issue:20
Synthesis and hypolipidemic and antiplatelet activities of alpha-asarone isomers in humans (in vitro), mice (in vivo), and rats (in vivo).
AID408518Mutagenic activity in Salmonella Typhimurium TA102 assessed as number of his+ revertants at 500 ug/plate after 48 to 72 hrs by Ames test in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408499Mutagenic activity in Salmonella Typhimurium TA97 assessed as number of his+ revertants at 500 ug/plate after 48 to 72 hrs by Ames test in absence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408509Mutagenic activity in Salmonella Typhimurium TA100 assessed as number of his+ revertants at 100 ug/plate after 48 to 72 hrs by Ames test in absence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408511Mutagenic activity in Salmonella Typhimurium TA100 assessed as number of his+ revertants at 500 ug/plate after 48 to 72 hrs by Ames test in absence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408536Cytotoxicity against Salmonella Typhimurium TA97 assessed as reduction in his+ revertants after 48 to 72 hrs in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408510Mutagenic activity in Salmonella Typhimurium TA100 assessed as number of his+ revertants at 100 ug/plate after 48 to 72 hrs by Ames test in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID1502971Reduction in LDL-C level in rat dosed for 7 days2017European journal of medicinal chemistry, Nov-10, Volume: 140Lipid lowering agents of natural origin: An account of some promising chemotypes.
AID408534Cytotoxicity against Salmonella Typhimurium TA97 assessed as growth inhibition after 48 to 72 hrs2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408521Genotoxicity against mouse L929 cells assessed as number of micronuclei at 100 ug/ml2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID1615748Inhibition of H2O2-induced ROS accumulation in human HepG2 cells assessed as ROS generation at 10 uM preincubated for 1 hr followed by H2O2-stimulation and measured after 30 mins by H2DCFDA staining based flow cytometry (Rvb = 100 +/- 11.53%)2019Journal of natural products, 09-27, Volume: 82, Issue:9
Furanocoumarins from the Roots of
AID408502Mutagenic activity in Salmonella Typhimurium TA97 assessed as number of his+ revertants at 1000 ug/plate after 48 to 72 hrs by Ames test in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408514Mutagenic activity in Salmonella Typhimurium TA100 assessed as number of his+ revertants at 1000 ug/plate after 48 to 72 hrs by Ames test in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408508Mutagenic activity in Salmonella Typhimurium TA98 assessed as number of his+ revertants at 1000 ug/plate after 48 to 72 hrs by Ames test in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408506Mutagenic activity in Salmonella Typhimurium TA98 assessed as number of his+ revertants at 500 ug/plate after 48 to 72 hrs by Ames test in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408516Mutagenic activity in Salmonella Typhimurium TA102 assessed as number of his+ revertants at 100 ug/plate after 48 to 72 hrs by Ames test in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408500Mutagenic activity in Salmonella Typhimurium TA97 assessed as number of his+ revertants at 500 ug/plate after 48 to 72 hrs by Ames test in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID1615747Hepatoprotective activity against H2O2-induced cell death in human HepG2 cells assessed as cell viability at 10 uM preincubated for 1 hr followed by H2O2-stimulation and measured after 24 hrs by EZ-Cytox cell viability assay (Rvb = 43.9 +/- 5.25%)2019Journal of natural products, 09-27, Volume: 82, Issue:9
Furanocoumarins from the Roots of
AID1615746Cytotoxicity against human HepG2 cells assessed as cell viability at 10 uM incubated for 1 hr by EZ-Cytox cell viability assay2019Journal of natural products, 09-27, Volume: 82, Issue:9
Furanocoumarins from the Roots of
AID408515Mutagenic activity in Salmonella Typhimurium TA102 assessed as number of his+ revertants at 100 ug/plate after 48 to 72 hrs by Ames test in absence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408538Cytotoxicity against Salmonella Typhimurium TA100 assessed as reduction in his+ revertants after 48 to 72 hrs in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408537Cytotoxicity against Salmonella Typhimurium TA98 assessed as reduction in his+ revertants after 48 to 72 hrs in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408520Mutagenic activity in Salmonella Typhimurium TA102 assessed as number of his+ revertants at 1000 ug/plate after 48 to 72 hrs by Ames test in presence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408517Mutagenic activity in Salmonella Typhimurium TA102 assessed as number of his+ revertants at 500 ug/plate after 48 to 72 hrs by Ames test in absence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
AID408501Mutagenic activity in Salmonella Typhimurium TA97 assessed as number of his+ revertants at 1000 ug/plate after 48 to 72 hrs by Ames test in absence of S9 fraction2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Genotoxicity of alpha-asarone analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's4 (50.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.40 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (11.11%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pyrogallol
benzenetriol : A triol in which three hydroxy groups are substituted onto a benzene ring.		2.9640benzenetriol;
phenolic donor		plant metabolite
aspirin
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.		210benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
berberine
[no description available]		3.2510alkaloid antibiotic;
berberine alkaloid;
botanical anti-fungal agent;
organic heteropentacyclic compound		antilipemic drug;
antineoplastic agent;
antioxidant;
EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor;
EC 1.21.3.3 (reticuline oxidase) inhibitor;
EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
hypoglycemic agent;
metabolite;
potassium channel blocker
5-methoxypsoralen
5-Methoxypsoralen: A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.. 5-methoxypsoralen : A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5.		2.21105-methoxyfurocoumarin;
organic heterotricyclic compound;
psoralens		hepatoprotective agent;
plant metabolite
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		210aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
ketorolac
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed). ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.. 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.		210amino acid;
aromatic ketone;
monocarboxylic acid;
pyrrolizines;
racemate		analgesic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug
methoxsalen
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.. methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.		2.2110aromatic ether;
psoralens		antineoplastic agent;
cross-linking reagent;
dermatologic drug;
photosensitizing agent;
plant metabolite
myristicin
myristicin: asaricin is an isomer; structure; a methylene dioxy version of elemicin;		2.1310organic molecular entitymetabolite
ficusin
Ficusin: A naturally occurring furocoumarin, found in PSORALEA. After photoactivation with UV radiation, it binds DNA via single and double-stranded cross-linking.. psoralen : The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.		2.2110psoralensplant metabolite
9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-7h-furo(3,2-g)(1)benzopyran-7-one
9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-7H-furo(3,2-g)(1)benzopyran-7-one: isolated from Angelica dahurica (Umbelliferae); structure in first source		2.2110psoralens
imperatorin
imperatorin: tumor necrosis factor antagonist; furanocoumarin from West African medicinal plant Clausena anisata; structure in Negwer, 5th ed, #3005. imperatorin : A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.		2.2110psoralensEC 3.1.1.7 (acetylcholinesterase) inhibitor;
metabolite
elemicin
[no description available]		6.9510olefinic compound
aviprin
aviprin: isolated from Angelica dahurica; structure in first source		2.2110furanocoumarinmetabolite
lovastatin
Lovastatin: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.. lovastatin : A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).		3.2510delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring)		anticholesteremic drug;
antineoplastic agent;
Aspergillus metabolite;
prodrug
simvastatin
Simvastatin: A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.. simvastatin : A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.		3.2510delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
statin (semi-synthetic)		EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor;
EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor;
ferroptosis inducer;
geroprotector;
prodrug
isoimperatorin
isoimperatorin: tumor necrosis factor antagonist isolated from Glehniae root. isoimperatorin : A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.		2.2110psoralensEC 3.1.1.7 (acetylcholinesterase) inhibitor;
metabolite
phellopterin
phellopterin: a naturally occurring furanocoumarin found in roots of Angelica dahurica; structure in first source		2.2110psoralens
malabaricone c
malabaricone C: from maize (Myristica fragrans); structure given in first source		2.1310butanonemetabolite
malabaricone b
malabaricone B: from maize (Myristica fragrans); structure given in first source		2.1310
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		2.1310
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		2.1310
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		3.2510resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
alpha-asarone
asarone: structure in Merck Index, 9th ed, #847. asarone : A phenylpropanoid that is benzene substituted by methoxy groups at positions 1, 2 and 4 and a propen-1-yl group at position 5. It has been isolated from Acorus.. alpha-asarone : The trans-isomer of asarone.		3.5520asaroneanticonvulsant;
GABA modulator
sesquiterpenes
[no description available]		2.1510
cnidilin
cnidilin: from roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan; structure in first source		2.2110psoralens
oxypeucadanin, (r)-(+)-isomer
[no description available]		2.2110furanocoumarinmetabolite
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		3.2510aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
rosmarinic acid
rosmarinic acid: RN given refers to parent cpd; promote OT project. (R)-rosmarinic acid : A stereoisomer of rosmarinic acid having (R)-configuration.. rosmarinic acid : The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.		2.2110rosmarinic acidgeroprotector;
plant metabolite
surinamensin
surinamensin: RN given for (S-(R*,R*-(E)))-isomer; structure in first source		2.1310phenylpropanoid
aldosterone
dehydrodiisoeugenol: an isoeugenol dimer, inhibits lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxygenase-2 expression in macrophages; structure in first source		2.1310
licarin b
licarin B: neolignan; RN given for (2S-(2alpha,3beta,5(E)))-isomer; isolated from seeds of Myristica fragrans; structure in first source		2.1310
beta-bisabolene
(S)-beta-bisabolene : A beta-bisabolene which has (1S)-configuration.. beta-bisabolene : A bisabolene that is cyclohexene substituted by a methyl group at position 1 and a 6-methylhepta-1,5-dien-2-yl group at position 4.		2.1510beta-bisabolene
ConditionIndicatedRelationship StrengthStudiesTrials
Thromboembolism
Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.		0210
Dyslipidemia
[description not available]		03.0610
Dyslipidemias
Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.		03.0610