positive regulation of metanephric cap mesenchymal cell proliferation
Definition
Target type: biologicalprocess
Any process that increases the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip. [GOC:dph, GOC:tb, GOC:yaf]
Positive regulation of metanephric cap mesenchymal cell proliferation is a complex process that is essential for the development of the kidneys. The metanephric cap mesenchyme (MCM) is a specialized tissue that forms the nephrons, the functional units of the kidneys. The MCM cells are initially undifferentiated and undergo a series of proliferation, differentiation, and morphogenetic events to form the mature nephrons.
Several signaling pathways and transcription factors are involved in regulating MCM cell proliferation. One of the key pathways is the Wnt signaling pathway. Wnt ligands, secreted proteins, activate the Wnt signaling pathway and promote MCM cell proliferation. The Wnt signaling pathway involves a cascade of events that ultimately leads to the activation of the transcription factor beta-catenin. Beta-catenin then translocates to the nucleus and activates the expression of target genes, including genes involved in cell cycle progression and proliferation.
Another important signaling pathway is the fibroblast growth factor (FGF) pathway. FGFs, a family of secreted proteins, activate the FGF signaling pathway and also promote MCM cell proliferation. The FGF signaling pathway involves the activation of receptor tyrosine kinases (RTKs), which in turn activate downstream signaling cascades that lead to the activation of transcription factors. These transcription factors then regulate the expression of genes involved in cell proliferation.
In addition to these signaling pathways, several transcription factors are also known to regulate MCM cell proliferation. One such transcription factor is Six2. Six2 is a homeobox transcription factor that is specifically expressed in the MCM. Six2 is essential for MCM cell proliferation and prevents premature differentiation. Another transcription factor, Pax2, is also important for MCM cell proliferation and differentiation. Pax2 is a paired box transcription factor that is expressed in the MCM and other tissues.
The regulation of MCM cell proliferation is tightly controlled and involves the integration of multiple signaling pathways and transcription factors. Dysregulation of these pathways can lead to kidney developmental defects. For example, mutations in the Wnt signaling pathway can cause kidney agenesis, a condition in which one or both kidneys are absent. Similarly, mutations in the FGF signaling pathway can lead to kidney hypoplasia, a condition in which the kidneys are smaller than normal.
In summary, positive regulation of metanephric cap mesenchymal cell proliferation is a complex process that is essential for kidney development. The process involves the activation of several signaling pathways, including the Wnt and FGF pathways, and the regulation of several transcription factors, including Six2 and Pax2. Dysregulation of these pathways can lead to kidney developmental defects.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Myc proto-oncogene protein | A c-myc protein that is encoded in the genome of human. [PRO:CNA, UniProtKB:P01106] | Homo sapiens (human) |
Compounds (9)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| aurintricarboxylic acid | aurintricarboxylic acid : A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'. Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues. | monohydroxybenzoic acid; quinomethanes; tricarboxylic acid | fluorochrome; histological dye; insulin-like growth factor receptor 1 antagonist |
| mefenamic acid | mefenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis. Mefenamic Acid: A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase. | aminobenzoic acid; secondary amino compound | analgesic; antipyretic; antirheumatic drug; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; non-steroidal anti-inflammatory drug; xenobiotic |
| methyl red | methyl red : An azo dye consisting of benzoic acid substituted at position 2 by a 4-[(dimethylamino)phenyl]diazenyl group. methyl red: RN given refers to parent cpd; structure | ||
| 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine | 1,2,4-triazines | ||
| avasimibe | monoterpenoid | ||
| resveratrol | trans-resveratrol : A resveratrol in which the double bond has E configuration. | resveratrol | antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger |
| 10074-g5 | 10074-G5: structure in first source | ||
| sgi-1027 | SGI-1027: inhibits DNA methyltransferase 1; structure in first source | ||
| kj-pyr-9 | KJ-Pyr-9: antineoplastic; structure in first source |