cis-3,4',5-trimethoxy-3'-aminostilbene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

cis-3,4',5-trimethoxy-3'-aminostilbene: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	10446642
CHEMBL ID	119934
SCHEMBL ID	1284983
MeSH ID	M0521661

Synonyms (8)

Synonym
CHEMBL119934
586410-12-0
cis-3,4',5-trimethoxy-3'-aminostilbene
SCHEMBL1284983
5-[(z)-2-(3,5-dimethoxyphenyl)ethenyl]-2-methoxyaniline
cis-3,5,4'-trimethoxy-3'-amino stilbene
(z)-5-(3,5-dimethoxystyryl)-2-methoxyaniline
cis-3,4?,5-trimethoxy-3?-aminostilbene

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay ID	Title	Year	Journal	Article
AID83141	In vitro inhibitory concentration against proliferation of HL60R cells along with 5 (uM) verapamil	2003	Journal of medicinal chemistry, Jul-31, Volume: 46, Issue:16	Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents.
AID82982	In vitro inhibitory concentration against proliferation of HL60 cells	2003	Journal of medicinal chemistry, Jul-31, Volume: 46, Issue:16	Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents.
AID1164173	Induction of apoptosis in human K562 cells using annexin-V/PI staining by flow cytometry	2014	ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9	Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.
AID1164172	Antiproliferative activity against human K562 cells assessed as growth inhibition after 48 hrs by trypan blue dye exclusion method	2014	ACS medicinal chemistry letters, Sep-11, Volume: 5, Issue:9	Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.
AID83137	In vitro concentration required to induce apoptosis in HL60R cells	2003	Journal of medicinal chemistry, Jul-31, Volume: 46, Issue:16	Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents.
AID348172	Solubility in water	2009	Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2	Design, synthesis and biological evaluation of novel stilbene-based antitumor agents.
AID82976	In vitro concentration required to induce apoptosis in HL60 cells	2003	Journal of medicinal chemistry, Jul-31, Volume: 46, Issue:16	Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents.
AID83140	In vitro inhibitory concentration against proliferation of HL60R cells	2003	Journal of medicinal chemistry, Jul-31, Volume: 46, Issue:16	Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (60.00)	29.6817
2010's	4 (40.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.02

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.02 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	4.42 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.02)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.01	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
vorinostat Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.. vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).	2.1	1	dicarboxylic acid diamide; hydroxamic acid	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor
vincristine [no description available]	2.05	1	acetate ester; formamides; methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; tertiary alcohol; tertiary amino compound; vinca alkaloid	antineoplastic agent; drug; microtubule-destabilising agent; plant metabolite; tubulin modulator
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	2.45	2	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
cytarabine [no description available]	2.01	1	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent
daunorubicin Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.	2.01	1	aminoglycoside antibiotic; anthracycline; p-quinones; tetracenequinones	antineoplastic agent; bacterial metabolite
etoposide [no description available]	2.01	1	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.01	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
stilbenes Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.	3.45	7	stilbene
cis-resveratrol cis-resveratrol : The cis-stereoisomer of resveratrol.	2.01	1	resveratrol
pterostilbene [no description available]	2.01	1	diether; methoxybenzenes; stilbenol	anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; hypoglycemic agent; neuroprotective agent; neurotransmitter; plant metabolite; radical scavenger
rhapontigenin rhapontigenin: structure in first source	2.01	1	stilbenoid
fosbretabulin [no description available]	2.05	1	stilbenoid
fosbretabulin fosbretabulin: a microtubule destabilizing agent isolated from Combretum caffrum; structure in first source	2.04	1
hemiasterlin hemiasterlin: structure in first source	2.5	2
4,3',5'-tri-o-methylpiceatannol [no description available]	2.01	1
3'-hydroxypterostilbene 3'-hydroxypterostilbene: an apoptosis-inducing agent; structure in first source	2.01	1

Condition	Relationship Strength	Studies
Malignant Melanoma [description not available]	2.08	1
Colorectal Cancer [description not available]	2.08	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2.08	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.08	1
Benign Neoplasms [description not available]	2.05	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.05	1

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