| AID607831 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production treated 1 hr before LPS challenge measured after 24 hrs by EIA | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
| Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells. |
| AID611430 | Inhibition of HCV genotype 1b J4 N-terminal His-tagged NS5Bdelta21 polymerase expressed in Escherichia coli C41(DE3) assessed as amount of double-stranded RNA synthesis | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
| Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase. |
| AID1373677 | Reversible inhibition of human recombinant MAOA assessed as residual enzyme activity at 0.5 uM pre-incubated with enzyme for 30 mins followed by dialysis with pH 7.2 sodium phosphate buffer for 6 hrs followed by 0.06 mM kynuramine substrate addition | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
| Selective inhibition of monoamine oxidase A by hispidol. |
| AID1499302 | Inhibition of TNF-alpha-induced NFkappa-B transcriptional activity in human HT-29 cells at 10 uM preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by dual luciferase reporter gene assay | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| AID1499304 | Inhibition of TNF-alpha-induced ROS production in human HT-29 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 30 mins by DCF-DA dye-based fluorescence microscopy | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| AID1373676 | Inhibition of human recombinant MAOA assessed as residual enzyme activity at 0.5 uM pre-incubated for 30 mins followed by 0.06 mM kynuramine substrate addition | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
| Selective inhibition of monoamine oxidase A by hispidol. |
| AID1499311 | Antiinflammatory activity in po dosed TNBS-induced Sprague-Dawley rat colitis model assessed as recovery of colon tissue edematous inflammation administered once a day for 5 days measured on day 6 | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| AID1499309 | Inhibition of TNF-alpha-induced AP-1 transcriptional activity in human HT-29 cells at 10 uM preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by dual luciferase reporter gene assay | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| AID1373675 | Time dependent inhibition of human recombinant MAOA using kynuramine as substrate preincubated for up to 30 mins followed by substrate addition | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
| Selective inhibition of monoamine oxidase A by hispidol. |
| AID258981 | Inhibitory activity against tyrosinase in human melanocytes | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes. |
| AID1637891 | Antagonist activity at rat adenosine A2A receptor | | | |
| AID1601690 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 18 to 24 hrs in aerobic condition by two-fold serial dilutions method | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Aurone derivatives as promising antibacterial agents against resistant Gram-positive pathogens. |
| AID1373672 | Inhibition of human recombinant MAOB using benzylamine as substrate preincubated for 30 mins followed by substrate addition | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
| Selective inhibition of monoamine oxidase A by hispidol. |
| AID607830 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reaction | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
| Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells. |
| AID497154 | Antiplasmodial activity against Plasmodium falciparum FcB1/columbia infected in human erythrocytes | 2010 | Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15
| 1-Azaaurones derived from the naturally occurring aurones as potential antimalarial drugs. |
| AID490155 | Cytotoxicity against mouse Hepa-1c1c7 cells assessed as cell survival at 5 uM after 48 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
| Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR. |
| AID1373683 | Reversible inhibition of human recombinant MAOB assessed as residual enzyme activity at 5 uM pre-incubated with enzyme for 30 mins followed by dialysis with pH 7.2 sodium phosphate buffer for 6 hrs followed by 0.06 mM benzylamine substrate addition | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
| Selective inhibition of monoamine oxidase A by hispidol. |
| AID1373671 | Inhibition of human recombinant MAOA using kynuramine as substrate preincubated for 30 mins followed by substrate addition | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
| Selective inhibition of monoamine oxidase A by hispidol. |
| AID1499295 | Inhibition of TNF-alpha-induced adhesion of BCECF-labeled human U937 cells to human HT-29 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by fluorescence microscopic method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| AID1601691 | Antimicrobial activity against Pseudomonas aeruginosa after 18 to 24 hrs in aerobic condition by two-fold serial dilutions method | 2019 | European journal of medicinal chemistry, Mar-01, Volume: 165 | Aurone derivatives as promising antibacterial agents against resistant Gram-positive pathogens. |
| AID1499296 | Potency index, ratio of 5-ASA IC50 to test compound IC50 for inhibition of TNF-alpha-induced adhesion of BCECF-labeled human U937 cells to human HT-29 cells | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| AID1499308 | Inhibition of LPS-induced TNF-alpha expression in human HT-29 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by Western blot method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| AID607832 | Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
| Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells. |
| AID1498691 | Selectivity index, ratio of IC50 for recombinant human MAO-B to IC50 for recombinant human MAO-A | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid. |
| AID1499301 | Inhibition of TNF-alpha-induced MCP-1 expression in human HT-29 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by Western blot analysis | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| AID1499314 | Antiinflammatory activity in po dosed TNBS-induced Sprague-Dawley rat colitis model assessed as decrease in MPO levels in colon tissue administered once per day for 5 days measured on day 6 | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| AID1611942 | Inhibition of mushroom tyrosinase | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Inhibitors of Melanogenesis: An Updated Review. |
| AID1499306 | Inhibition of LPS-induced TNF-alpha expression in human HT-29 cells at 10 uM preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by Western blot method | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| AID1611945 | Inhibition of human tyrosinase at 0.1 mM relative to control | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Inhibitors of Melanogenesis: An Updated Review. |
| AID1637890 | Antagonist activity at rat adenosine A1 receptor | | | |
| AID490156 | Induction of human NQO1 activity in mouse Hepa-1c1c7 cells at 25 uM after 48 hrs relative to control | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
| Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR. |
| AID1499297 | Potency index, ratio of test compound activity to 5-ASA activity for inhibition of TNF-alpha-induced adhesion of BCECF-labeled human U937 cells to human HT-29 cells at 10 uM | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| AID1373669 | Competitive inhibition of human recombinant MAOA using 0.006 to 0.15 mM kynuramine as substrate preincubated for 30 mins followed by substrate addition by Lineweaver-Burk plot | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
| Selective inhibition of monoamine oxidase A by hispidol. |
| AID490157 | Induction of human NQO1 activity in mouse Hepa-1c1c7 cells at 5 uM after 48 hrs relative to control | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
| Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR. |
| AID611431 | Inhibition of HCV genotype 1b J4 N-terminal His-tagged NS5Bdelta21 polymerase expressed in Escherichia coli C41(DE3) assessed as amount of double-stranded RNA synthesis at 20 uM | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
| Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase. |
| AID611434 | Cytotoxicity against human HuH7 cells up to 512 uM after 72 hrs by MTT assay | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
| Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase. |
| AID1499293 | Inhibition of TNF-alpha-induced adhesion of BCECF-labeled human U937 cells to human HT-29 cells at 10 uM preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by fluorescence microscopic method relative to control | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| AID1373670 | Competitive inhibition of human recombinant MAOB using 0.06 to 1.5 mM benzylamine as substrate preincubated for 30 mins followed by substrate addition by Lineweaver-Burk plot | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
| Selective inhibition of monoamine oxidase A by hispidol. |
| AID611435 | Cytotoxicity against human HEK293 cells up to 512 uM after 72 hrs by MTT assay | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
| Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase. |
| AID1461511 | Inhibition of baker's yeast alpha-glucosidase incubated for 30 mins using p-nitrophenyl-alpha-D-glucopyranoside substrate by spectrophotometry | 2017 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
| Synthesis of 6-hydroxyaurone analogues and evaluation of their α-glucosidase inhibitory and glucose consumption-promoting activity: Development of highly active 5,6-disubstituted derivatives. |
| AID1499298 | Inhibition of TNF-alpha-induced ICAM-1 expression in human HT-29 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by Western blot analysis | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| AID258980 | Inhibition of tyrosinase in human melanocytes at 0.1 mM | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes. |
| AID490154 | Cytotoxicity against mouse Hepa-1c1c7 cells assessed as cell survival at 25 uM after 48 hrs by MTT assay | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
| Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR. |
| AID1373673 | Selectivity index, ratio of IC50 for human recombinant MAOB to IC50 for human recombinant MAOA | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
| Selective inhibition of monoamine oxidase A by hispidol. |
| AID1373682 | Inhibition of human recombinant MAOB assessed as residual enzyme activity at 5 uM pre-incubated for 30 mins followed by 0.06 mM benzylamine substrate addition | 2018 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
| Selective inhibition of monoamine oxidase A by hispidol. |
| AID1499310 | Antiinflammatory activity in po dosed TNBS-induced Sprague-Dawley rat colitis model assessed as recovery in body weight decrease administered once a day for 5 days measured on day 6 | 2017 | European journal of medicinal chemistry, Sep-08, Volume: 137 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |