Page last updated: 2024-12-10

hispidol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

hispidol : A hydroxyaurone that is aurone substituted by hydroxy groups at positions 6 and 4' respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID5281254
CHEMBL ID426110
CHEBI ID5731
SCHEMBL ID5707753

Synonyms (41)

Synonym
6,4' -dihydroxy aurone
nsc-356828
nsc356828
(2z)-6-hydroxy-2-[(4-hydroxyphenyl)methylene]benzofuran-3-one
3(2h)-benzofuranone, 6-hydroxy-2-[(4-hydroxyphenyl)methylene]-, (2z)-
C08644
5786-54-9
hispidol
AKOS001354021
CHEMBL426110 ,
chebi:5731 ,
bdbm50180260
(z)-2-(4-hydroxybenzylidene)-6-hydroxybenzofuran-3(2h)-one
2-(4''-hydroxybenzylidene)-6-hydroxybenzofuran-3(2h)-one
(2z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-1-benzofuran-3-one
AB00767717-01
SCHEMBL5707753
(2z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-1-benzofuran-3(2h)-one
benzofuran-6-ol-3-one, 2-[4-hydroxybenzylidene]-
(2z)-6-hydroxy-2-(4-hydroxybenzylidene)-1-benzofuran-3(2h)-one #
KEZLDSPIRVZOKZ-AUWJEWJLSA-N
(z)-4',6-dihydroxyaurone
(2z)-6-hydroxy-2-[(4-hydroxyphenyl)methylidene]-2,3-dihydro-1-benzofuran-3-one
(z)-6-hydroxy-2-(4-hydroxybenzylidene)benzofuran-3(2h)-one
HY-102040
CS-7503
Q27106875
(z)-hispidol
nsc 356828
unii-cs1235i0wt
cs1235i0wt ,
4',6-dihydroxyaurone
(2z)-6-hydroxy-2-((4-hydroxyphenyl)methylene)-3(2h)-benzofuranone
3(2h)-benzofuranone, 6-hydroxy-2-((4-hydroxyphenyl)methylene)-, (2z)-
2-((4-hydroxyphenyl)methylidene)-6-oxidanyl-1-benzofuran-3-one
isoliquiritigenin metabolite m6
6,4''-dihydroxyaurone
ze-hispidol
MS-23577
nsc814362
nsc-814362
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
hydroxyauroneAny member of the class of aurones in which one or more ring hydrogens are replaced by hydroxy groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
hispidol and hispidol 4'-O-u03B2-D-glucoside biosynthesis018

Protein Targets (6)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Polyphenol oxidase 2Agaricus bisporusIC50 (µMol)38.40000.03403.987110.0000AID1611942
TyrosinaseHomo sapiens (human)IC50 (µMol)38.40000.02304.459310.0000AID258981
Amine oxidase [flavin-containing] AHomo sapiens (human)IC50 (µMol)0.26000.00002.37899.7700AID1373671
Amine oxidase [flavin-containing] AHomo sapiens (human)Ki0.10000.00192.379710.0000AID1373669
Adenosine receptor A1Rattus norvegicus (Norway rat)Ki0.35200.00011.20929.9700AID1637890
Amine oxidase [flavin-containing] BHomo sapiens (human)IC50 (µMol)2.45000.00001.89149.5700AID1373672
Amine oxidase [flavin-containing] BHomo sapiens (human)Ki0.51000.00061.777110.0000AID1373670
Adenosine receptor A2aRattus norvegicus (Norway rat)Ki100.00000.00021.494010.0000AID1637891
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (26)

Processvia Protein(s)Taxonomy
melanin biosynthetic process from tyrosineTyrosinaseHomo sapiens (human)
eye pigment biosynthetic processTyrosinaseHomo sapiens (human)
visual perceptionTyrosinaseHomo sapiens (human)
cell population proliferationTyrosinaseHomo sapiens (human)
response to UVTyrosinaseHomo sapiens (human)
response to blue lightTyrosinaseHomo sapiens (human)
response to vitamin DTyrosinaseHomo sapiens (human)
melanin biosynthetic processTyrosinaseHomo sapiens (human)
thymus developmentTyrosinaseHomo sapiens (human)
response to cAMPTyrosinaseHomo sapiens (human)
pigmentationTyrosinaseHomo sapiens (human)
biogenic amine metabolic processAmine oxidase [flavin-containing] AHomo sapiens (human)
positive regulation of signal transductionAmine oxidase [flavin-containing] AHomo sapiens (human)
dopamine catabolic processAmine oxidase [flavin-containing] AHomo sapiens (human)
response to xenobiotic stimulusAmine oxidase [flavin-containing] BHomo sapiens (human)
response to toxic substanceAmine oxidase [flavin-containing] BHomo sapiens (human)
response to aluminum ionAmine oxidase [flavin-containing] BHomo sapiens (human)
response to selenium ionAmine oxidase [flavin-containing] BHomo sapiens (human)
negative regulation of serotonin secretionAmine oxidase [flavin-containing] BHomo sapiens (human)
phenylethylamine catabolic processAmine oxidase [flavin-containing] BHomo sapiens (human)
substantia nigra developmentAmine oxidase [flavin-containing] BHomo sapiens (human)
response to lipopolysaccharideAmine oxidase [flavin-containing] BHomo sapiens (human)
dopamine catabolic processAmine oxidase [flavin-containing] BHomo sapiens (human)
response to ethanolAmine oxidase [flavin-containing] BHomo sapiens (human)
positive regulation of dopamine metabolic processAmine oxidase [flavin-containing] BHomo sapiens (human)
hydrogen peroxide biosynthetic processAmine oxidase [flavin-containing] BHomo sapiens (human)
response to corticosteroneAmine oxidase [flavin-containing] BHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (11)

Processvia Protein(s)Taxonomy
tyrosinase activityTyrosinaseHomo sapiens (human)
copper ion bindingTyrosinaseHomo sapiens (human)
protein bindingTyrosinaseHomo sapiens (human)
identical protein bindingTyrosinaseHomo sapiens (human)
protein homodimerization activityTyrosinaseHomo sapiens (human)
protein bindingAmine oxidase [flavin-containing] AHomo sapiens (human)
primary amine oxidase activityAmine oxidase [flavin-containing] AHomo sapiens (human)
aliphatic amine oxidase activityAmine oxidase [flavin-containing] AHomo sapiens (human)
monoamine oxidase activityAmine oxidase [flavin-containing] AHomo sapiens (human)
flavin adenine dinucleotide bindingAmine oxidase [flavin-containing] AHomo sapiens (human)
protein bindingAmine oxidase [flavin-containing] BHomo sapiens (human)
primary amine oxidase activityAmine oxidase [flavin-containing] BHomo sapiens (human)
electron transfer activityAmine oxidase [flavin-containing] BHomo sapiens (human)
identical protein bindingAmine oxidase [flavin-containing] BHomo sapiens (human)
aliphatic amine oxidase activityAmine oxidase [flavin-containing] BHomo sapiens (human)
monoamine oxidase activityAmine oxidase [flavin-containing] BHomo sapiens (human)
flavin adenine dinucleotide bindingAmine oxidase [flavin-containing] BHomo sapiens (human)
G protein-coupled adenosine receptor activityAdenosine receptor A2aRattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (14)

Processvia Protein(s)Taxonomy
cytoplasmTyrosinaseHomo sapiens (human)
lysosomeTyrosinaseHomo sapiens (human)
Golgi-associated vesicleTyrosinaseHomo sapiens (human)
melanosome membraneTyrosinaseHomo sapiens (human)
melanosomeTyrosinaseHomo sapiens (human)
intracellular membrane-bounded organelleTyrosinaseHomo sapiens (human)
perinuclear region of cytoplasmTyrosinaseHomo sapiens (human)
mitochondrionAmine oxidase [flavin-containing] AHomo sapiens (human)
mitochondrial outer membraneAmine oxidase [flavin-containing] AHomo sapiens (human)
cytosolAmine oxidase [flavin-containing] AHomo sapiens (human)
mitochondrionAmine oxidase [flavin-containing] AHomo sapiens (human)
mitochondrionAmine oxidase [flavin-containing] BHomo sapiens (human)
mitochondrial envelopeAmine oxidase [flavin-containing] BHomo sapiens (human)
mitochondrial outer membraneAmine oxidase [flavin-containing] BHomo sapiens (human)
dendriteAmine oxidase [flavin-containing] BHomo sapiens (human)
neuronal cell bodyAmine oxidase [flavin-containing] BHomo sapiens (human)
mitochondrionAmine oxidase [flavin-containing] BHomo sapiens (human)
Golgi membraneAdenosine receptor A2aRattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (46)

Assay IDTitleYearJournalArticle
AID607831Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production treated 1 hr before LPS challenge measured after 24 hrs by EIA2011Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.
AID611430Inhibition of HCV genotype 1b J4 N-terminal His-tagged NS5Bdelta21 polymerase expressed in Escherichia coli C41(DE3) assessed as amount of double-stranded RNA synthesis2011Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
AID1373677Reversible inhibition of human recombinant MAOA assessed as residual enzyme activity at 0.5 uM pre-incubated with enzyme for 30 mins followed by dialysis with pH 7.2 sodium phosphate buffer for 6 hrs followed by 0.06 mM kynuramine substrate addition2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Selective inhibition of monoamine oxidase A by hispidol.
AID1499302Inhibition of TNF-alpha-induced NFkappa-B transcriptional activity in human HT-29 cells at 10 uM preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by dual luciferase reporter gene assay2017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
AID1499304Inhibition of TNF-alpha-induced ROS production in human HT-29 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 30 mins by DCF-DA dye-based fluorescence microscopy2017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
AID1373676Inhibition of human recombinant MAOA assessed as residual enzyme activity at 0.5 uM pre-incubated for 30 mins followed by 0.06 mM kynuramine substrate addition2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Selective inhibition of monoamine oxidase A by hispidol.
AID1499311Antiinflammatory activity in po dosed TNBS-induced Sprague-Dawley rat colitis model assessed as recovery of colon tissue edematous inflammation administered once a day for 5 days measured on day 62017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
AID1499309Inhibition of TNF-alpha-induced AP-1 transcriptional activity in human HT-29 cells at 10 uM preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by dual luciferase reporter gene assay2017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
AID1373675Time dependent inhibition of human recombinant MAOA using kynuramine as substrate preincubated for up to 30 mins followed by substrate addition2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Selective inhibition of monoamine oxidase A by hispidol.
AID258981Inhibitory activity against tyrosinase in human melanocytes2006Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes.
AID1637891Antagonist activity at rat adenosine A2A receptor
AID1601690Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 18 to 24 hrs in aerobic condition by two-fold serial dilutions method2019European journal of medicinal chemistry, Mar-01, Volume: 165Aurone derivatives as promising antibacterial agents against resistant Gram-positive pathogens.
AID1373672Inhibition of human recombinant MAOB using benzylamine as substrate preincubated for 30 mins followed by substrate addition2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Selective inhibition of monoamine oxidase A by hispidol.
AID607830Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reaction2011Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.
AID497154Antiplasmodial activity against Plasmodium falciparum FcB1/columbia infected in human erythrocytes2010Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15
1-Azaaurones derived from the naturally occurring aurones as potential antimalarial drugs.
AID490155Cytotoxicity against mouse Hepa-1c1c7 cells assessed as cell survival at 5 uM after 48 hrs by MTT assay2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.
AID1373683Reversible inhibition of human recombinant MAOB assessed as residual enzyme activity at 5 uM pre-incubated with enzyme for 30 mins followed by dialysis with pH 7.2 sodium phosphate buffer for 6 hrs followed by 0.06 mM benzylamine substrate addition2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Selective inhibition of monoamine oxidase A by hispidol.
AID1373671Inhibition of human recombinant MAOA using kynuramine as substrate preincubated for 30 mins followed by substrate addition2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Selective inhibition of monoamine oxidase A by hispidol.
AID1499295Inhibition of TNF-alpha-induced adhesion of BCECF-labeled human U937 cells to human HT-29 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by fluorescence microscopic method2017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
AID1601691Antimicrobial activity against Pseudomonas aeruginosa after 18 to 24 hrs in aerobic condition by two-fold serial dilutions method2019European journal of medicinal chemistry, Mar-01, Volume: 165Aurone derivatives as promising antibacterial agents against resistant Gram-positive pathogens.
AID1499296Potency index, ratio of 5-ASA IC50 to test compound IC50 for inhibition of TNF-alpha-induced adhesion of BCECF-labeled human U937 cells to human HT-29 cells2017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
AID1499308Inhibition of LPS-induced TNF-alpha expression in human HT-29 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by Western blot method2017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
AID607832Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Aug-01, Volume: 21, Issue:15
Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.
AID1498691Selectivity index, ratio of IC50 for recombinant human MAO-B to IC50 for recombinant human MAO-A2018Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid.
AID1499301Inhibition of TNF-alpha-induced MCP-1 expression in human HT-29 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by Western blot analysis2017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
AID1499314Antiinflammatory activity in po dosed TNBS-induced Sprague-Dawley rat colitis model assessed as decrease in MPO levels in colon tissue administered once per day for 5 days measured on day 62017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
AID1611942Inhibition of mushroom tyrosinase2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Inhibitors of Melanogenesis: An Updated Review.
AID1499306Inhibition of LPS-induced TNF-alpha expression in human HT-29 cells at 10 uM preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by Western blot method2017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
AID1611945Inhibition of human tyrosinase at 0.1 mM relative to control2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Inhibitors of Melanogenesis: An Updated Review.
AID1637890Antagonist activity at rat adenosine A1 receptor
AID490156Induction of human NQO1 activity in mouse Hepa-1c1c7 cells at 25 uM after 48 hrs relative to control2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.
AID1499297Potency index, ratio of test compound activity to 5-ASA activity for inhibition of TNF-alpha-induced adhesion of BCECF-labeled human U937 cells to human HT-29 cells at 10 uM2017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
AID1373669Competitive inhibition of human recombinant MAOA using 0.006 to 0.15 mM kynuramine as substrate preincubated for 30 mins followed by substrate addition by Lineweaver-Burk plot2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Selective inhibition of monoamine oxidase A by hispidol.
AID490157Induction of human NQO1 activity in mouse Hepa-1c1c7 cells at 5 uM after 48 hrs relative to control2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.
AID611431Inhibition of HCV genotype 1b J4 N-terminal His-tagged NS5Bdelta21 polymerase expressed in Escherichia coli C41(DE3) assessed as amount of double-stranded RNA synthesis at 20 uM2011Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
AID611434Cytotoxicity against human HuH7 cells up to 512 uM after 72 hrs by MTT assay2011Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
AID1499293Inhibition of TNF-alpha-induced adhesion of BCECF-labeled human U937 cells to human HT-29 cells at 10 uM preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by fluorescence microscopic method relative to control2017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
AID1373670Competitive inhibition of human recombinant MAOB using 0.06 to 1.5 mM benzylamine as substrate preincubated for 30 mins followed by substrate addition by Lineweaver-Burk plot2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Selective inhibition of monoamine oxidase A by hispidol.
AID611435Cytotoxicity against human HEK293 cells up to 512 uM after 72 hrs by MTT assay2011Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
AID1461511Inhibition of baker's yeast alpha-glucosidase incubated for 30 mins using p-nitrophenyl-alpha-D-glucopyranoside substrate by spectrophotometry2017Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
Synthesis of 6-hydroxyaurone analogues and evaluation of their α-glucosidase inhibitory and glucose consumption-promoting activity: Development of highly active 5,6-disubstituted derivatives.
AID1499298Inhibition of TNF-alpha-induced ICAM-1 expression in human HT-29 cells preincubated for 1 hr followed by TNF-alpha challenge measured after 3 hrs by Western blot analysis2017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
AID258980Inhibition of tyrosinase in human melanocytes at 0.1 mM2006Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes.
AID490154Cytotoxicity against mouse Hepa-1c1c7 cells assessed as cell survival at 25 uM after 48 hrs by MTT assay2010European journal of medicinal chemistry, Jul, Volume: 45, Issue:7
Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.
AID1373673Selectivity index, ratio of IC50 for human recombinant MAOB to IC50 for human recombinant MAOA2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Selective inhibition of monoamine oxidase A by hispidol.
AID1373682Inhibition of human recombinant MAOB assessed as residual enzyme activity at 5 uM pre-incubated for 30 mins followed by 0.06 mM benzylamine substrate addition2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Selective inhibition of monoamine oxidase A by hispidol.
AID1499310Antiinflammatory activity in po dosed TNBS-induced Sprague-Dawley rat colitis model assessed as recovery in body weight decrease administered once a day for 5 days measured on day 62017European journal of medicinal chemistry, Sep-08, Volume: 137Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (6.67)29.6817
2010's11 (73.33)24.3611
2020's3 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.81

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.81 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.81)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (6.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (93.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]