Isoliquiritigenin 4,4'-dimethyl ether profile

ID Source	ID
PubMed CID	5357488
CHEMBL ID	229907
CHEBI ID	184704
SCHEMBL ID	634186

Synonym
AKOS002385545
smr000112982
MLS000438960
1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one
AE-641/01149036
2198-19-8
nsc-78638
nsc78638
CMLD3_000158
(e)-1-(2-hydroxy-4-methoxy-phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
2'-hydroxy-4,4'-dimethoxychalcone
NCGC00090537-01
LMPK12120100
isoliquiritigenin 4,4'-dimethyl ether
CHEMBL229907 ,
1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
bdbm50213232
2''-hydroxy-4,4''-dimethoxychalcone
(e)-1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
CHEBI:184704
HMS2206A19
nsc 78638
2-propen-1-one, 1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-
2-propen-1-one,1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-
SCHEMBL634186
(2e)-1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one #
OAAPAFSEMHJNTF-BJMVGYQFSA-N
2-hydroxy-4-methoxy-alpha-(p-methoxybenzylidene)acetophenone
4,4'-methoxy-2'-hydroxychalcone
4,4'-dimethoxy-2'-hydroxychalcone, aldrichcpr
4,4'-dimethoxy-2'-hydroxychalcone
mfcd00098911

Excerpt	Reference	Relevance
"A total of 30 chalcone analogues was synthesized via a base catalyzed Claisen Schmidt condensation and screened for their in vitro antibacterial activity against Methicillin-sensitive Staphylococcus aureus (MSSA) and Methicillin-resistant Staphylococcus aureus (MRSA) alone or in combination with non beta-lactam antibiotics namely ciprofloxacin, chloramphenicol, erythromycin, vancomycin, doxycycline and gentamicin."	( Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. Do, TH; Huynh, TN; Ngo, TD; Thai, KM; Tran, CD; Tran, NC; Tran, TD, 2012)	0.38

Class	Description
chalcones	A ketone that is 1,3-diphenylpropenone (benzylideneacetophenone), ArCH=CH(=O)Ar, and its derivatives formed by substitution.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Luciferase	Photinus pyralis (common eastern firefly)	Potency	7.5686	0.0072	15.7588	89.3584	AID588342
Nrf2	Homo sapiens (human)	Potency	31.6228	0.0920	8.2222	23.1093	AID624171
ATAD5 protein, partial	Homo sapiens (human)	Potency	23.1093	0.0041	10.8903	31.5287	AID504467
TDP1 protein	Homo sapiens (human)	Potency	5.1735	0.0008	11.3822	44.6684	AID686979
Microtubule-associated protein tau	Homo sapiens (human)	Potency	3.7619	0.1800	13.5574	39.8107	AID1460
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	0.3981	0.0025	5.8400	31.6228	AID899
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	6.5131	0.0041	9.9848	25.9290	AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	39.8107	3.5481	19.5427	44.6684	AID743266
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	39.8107	0.0398	16.7842	39.8107	AID1454
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	1.4125	0.0501	27.0736	89.1251	AID588590
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	14.1254	0.1585	5.2879	12.5893	AID540303
plasminogen precursor	Mus musculus (house mouse)	Potency	14.1254	0.1585	5.2879	12.5893	AID540303
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	14.1254	0.1585	5.2879	12.5893	AID540303
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	4.6144	0.0079	8.2332	1,122.0200	AID2551
geminin	Homo sapiens (human)	Potency	24.8446	0.0046	11.3741	33.4983	AID624296; AID624297
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	0.7943	0.1259	12.2344	35.4813	AID1458
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	3.1623	0.0316	10.2792	39.8107	AID884; AID885
lamin isoform A-delta10	Homo sapiens (human)	Potency	12.5893	0.8913	12.0676	28.1838	AID1487
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	1.9953	1.9953	25.5327	50.1187	AID624287
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	6.3096	1.7783	16.2081	35.4813	AID652104
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	3.1623	1.0000	12.2248	31.6228	AID885
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Amyloid-beta precursor protein	Homo sapiens (human)	IC50 (µMol)	8.4000	0.0005	3.8895	10.0000	AID761463
Aromatase	Homo sapiens (human)	IC50 (µMol)	351.7000	0.0000	1.2904	10.0000	AID288830
Delta-type opioid receptor	Mus musculus (house mouse)	IC50 (µMol)	351.7000	0.0001	0.7298	10.0000	AID288830
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50 (µMol)	3.2000	0.0040	1.9666	10.0000	AID638477; AID638478
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
cognition	Amyloid-beta precursor protein	Homo sapiens (human)
G2/M transition of mitotic cell cycle	Amyloid-beta precursor protein	Homo sapiens (human)
microglial cell activation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of protein phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
suckling behavior	Amyloid-beta precursor protein	Homo sapiens (human)
astrocyte activation involved in immune response	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of translation	Amyloid-beta precursor protein	Homo sapiens (human)
protein phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
intracellular copper ion homeostasis	Amyloid-beta precursor protein	Homo sapiens (human)
endocytosis	Amyloid-beta precursor protein	Homo sapiens (human)
response to oxidative stress	Amyloid-beta precursor protein	Homo sapiens (human)
cell adhesion	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of epidermal growth factor-activated receptor activity	Amyloid-beta precursor protein	Homo sapiens (human)
Notch signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
axonogenesis	Amyloid-beta precursor protein	Homo sapiens (human)
learning or memory	Amyloid-beta precursor protein	Homo sapiens (human)
learning	Amyloid-beta precursor protein	Homo sapiens (human)
mating behavior	Amyloid-beta precursor protein	Homo sapiens (human)
locomotory behavior	Amyloid-beta precursor protein	Homo sapiens (human)
axo-dendritic transport	Amyloid-beta precursor protein	Homo sapiens (human)
cholesterol metabolic process	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of cell population proliferation	Amyloid-beta precursor protein	Homo sapiens (human)
adult locomotory behavior	Amyloid-beta precursor protein	Homo sapiens (human)
visual learning	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of peptidyl-threonine phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of G2/M transition of mitotic cell cycle	Amyloid-beta precursor protein	Homo sapiens (human)
microglia development	Amyloid-beta precursor protein	Homo sapiens (human)
axon midline choice point recognition	Amyloid-beta precursor protein	Homo sapiens (human)
neuron remodeling	Amyloid-beta precursor protein	Homo sapiens (human)
dendrite development	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of Wnt signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular matrix organization	Amyloid-beta precursor protein	Homo sapiens (human)
forebrain development	Amyloid-beta precursor protein	Homo sapiens (human)
neuron projection development	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of chemokine production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of interleukin-1 beta production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of interleukin-6 production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
ionotropic glutamate receptor signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of multicellular organism growth	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of neuron differentiation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of glycolytic process	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of mitotic cell cycle	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of JNK cascade	Amyloid-beta precursor protein	Homo sapiens (human)
astrocyte activation	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of long-term neuronal synaptic plasticity	Amyloid-beta precursor protein	Homo sapiens (human)
collateral sprouting in absence of injury	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of inflammatory response	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of peptidyl-tyrosine phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of synapse structure or activity	Amyloid-beta precursor protein	Homo sapiens (human)
synapse organization	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of calcium-mediated signaling	Amyloid-beta precursor protein	Homo sapiens (human)
neuromuscular process controlling balance	Amyloid-beta precursor protein	Homo sapiens (human)
synaptic assembly at neuromuscular junction	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of protein metabolic process	Amyloid-beta precursor protein	Homo sapiens (human)
neuron apoptotic process	Amyloid-beta precursor protein	Homo sapiens (human)
smooth endoplasmic reticulum calcium ion homeostasis	Amyloid-beta precursor protein	Homo sapiens (human)
neuron cellular homeostasis	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Amyloid-beta precursor protein	Homo sapiens (human)
response to interleukin-1	Amyloid-beta precursor protein	Homo sapiens (human)
modulation of excitatory postsynaptic potential	Amyloid-beta precursor protein	Homo sapiens (human)
NMDA selective glutamate receptor signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of spontaneous synaptic transmission	Amyloid-beta precursor protein	Homo sapiens (human)
cytosolic mRNA polyadenylation	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of long-term synaptic potentiation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of long-term synaptic potentiation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	Amyloid-beta precursor protein	Homo sapiens (human)
cellular response to amyloid-beta	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of presynapse assembly	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of amyloid fibril formation	Amyloid-beta precursor protein	Homo sapiens (human)
amyloid fibril formation	Amyloid-beta precursor protein	Homo sapiens (human)
neuron projection maintenance	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of T cell migration	Amyloid-beta precursor protein	Homo sapiens (human)
central nervous system development	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of chronic inflammatory response	Aromatase	Homo sapiens (human)
steroid biosynthetic process	Aromatase	Homo sapiens (human)
estrogen biosynthetic process	Aromatase	Homo sapiens (human)
androgen catabolic process	Aromatase	Homo sapiens (human)
syncytium formation	Aromatase	Homo sapiens (human)
negative regulation of macrophage chemotaxis	Aromatase	Homo sapiens (human)
sterol metabolic process	Aromatase	Homo sapiens (human)
female genitalia development	Aromatase	Homo sapiens (human)
mammary gland development	Aromatase	Homo sapiens (human)
uterus development	Aromatase	Homo sapiens (human)
prostate gland growth	Aromatase	Homo sapiens (human)
testosterone biosynthetic process	Aromatase	Homo sapiens (human)
positive regulation of estradiol secretion	Aromatase	Homo sapiens (human)
female gonad development	Aromatase	Homo sapiens (human)
response to estradiol	Aromatase	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
renal water homeostasis	Guanine nucleotide-binding protein G	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Guanine nucleotide-binding protein G	Homo sapiens (human)
regulation of insulin secretion	Guanine nucleotide-binding protein G	Homo sapiens (human)
cellular response to glucagon stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
negative regulation of protein phosphorylation	TAR DNA-binding protein 43	Homo sapiens (human)
mRNA processing	TAR DNA-binding protein 43	Homo sapiens (human)
RNA splicing	TAR DNA-binding protein 43	Homo sapiens (human)
negative regulation of gene expression	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of protein stability	TAR DNA-binding protein 43	Homo sapiens (human)
positive regulation of insulin secretion	TAR DNA-binding protein 43	Homo sapiens (human)
response to endoplasmic reticulum stress	TAR DNA-binding protein 43	Homo sapiens (human)
positive regulation of protein import into nucleus	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of circadian rhythm	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of apoptotic process	TAR DNA-binding protein 43	Homo sapiens (human)
negative regulation by host of viral transcription	TAR DNA-binding protein 43	Homo sapiens (human)
rhythmic process	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of cell cycle	TAR DNA-binding protein 43	Homo sapiens (human)
3'-UTR-mediated mRNA destabilization	TAR DNA-binding protein 43	Homo sapiens (human)
3'-UTR-mediated mRNA stabilization	TAR DNA-binding protein 43	Homo sapiens (human)
nuclear inner membrane organization	TAR DNA-binding protein 43	Homo sapiens (human)
amyloid fibril formation	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of gene expression	TAR DNA-binding protein 43	Homo sapiens (human)
lipid transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
organic anion transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
urate transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
biotin transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
sphingolipid biosynthetic process	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
riboflavin transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
urate metabolic process	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
transmembrane transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
transepithelial transport	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
renal urate salt excretion	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
export across plasma membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
transport across blood-brain barrier	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
cellular detoxification	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
xenobiotic transport across blood-brain barrier	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Amyloid-beta precursor protein	Homo sapiens (human)
DNA binding	Amyloid-beta precursor protein	Homo sapiens (human)
serine-type endopeptidase inhibitor activity	Amyloid-beta precursor protein	Homo sapiens (human)
signaling receptor binding	Amyloid-beta precursor protein	Homo sapiens (human)
protein binding	Amyloid-beta precursor protein	Homo sapiens (human)
heparin binding	Amyloid-beta precursor protein	Homo sapiens (human)
enzyme binding	Amyloid-beta precursor protein	Homo sapiens (human)
identical protein binding	Amyloid-beta precursor protein	Homo sapiens (human)
transition metal ion binding	Amyloid-beta precursor protein	Homo sapiens (human)
receptor ligand activity	Amyloid-beta precursor protein	Homo sapiens (human)
PTB domain binding	Amyloid-beta precursor protein	Homo sapiens (human)
protein serine/threonine kinase binding	Amyloid-beta precursor protein	Homo sapiens (human)
signaling receptor activator activity	Amyloid-beta precursor protein	Homo sapiens (human)
iron ion binding	Aromatase	Homo sapiens (human)
steroid hydroxylase activity	Aromatase	Homo sapiens (human)
electron transfer activity	Aromatase	Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Aromatase	Homo sapiens (human)
oxygen binding	Aromatase	Homo sapiens (human)
heme binding	Aromatase	Homo sapiens (human)
aromatase activity	Aromatase	Homo sapiens (human)
G protein activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
adenylate cyclase activator activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
double-stranded DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
RNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
mRNA 3'-UTR binding	TAR DNA-binding protein 43	Homo sapiens (human)
protein binding	TAR DNA-binding protein 43	Homo sapiens (human)
lipid binding	TAR DNA-binding protein 43	Homo sapiens (human)
identical protein binding	TAR DNA-binding protein 43	Homo sapiens (human)
pre-mRNA intronic binding	TAR DNA-binding protein 43	Homo sapiens (human)
molecular condensate scaffold activity	TAR DNA-binding protein 43	Homo sapiens (human)
protein binding	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
ATP binding	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
organic anion transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
ABC-type xenobiotic transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
urate transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
biotin transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
efflux transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
ATP hydrolysis activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
riboflavin transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
ATPase-coupled transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
identical protein binding	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
protein homodimerization activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
xenobiotic transmembrane transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
sphingolipid transporter activity	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
extracellular space	Amyloid-beta precursor protein	Homo sapiens (human)
dendrite	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular region	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular space	Amyloid-beta precursor protein	Homo sapiens (human)
nuclear envelope lumen	Amyloid-beta precursor protein	Homo sapiens (human)
cytoplasm	Amyloid-beta precursor protein	Homo sapiens (human)
mitochondrial inner membrane	Amyloid-beta precursor protein	Homo sapiens (human)
endosome	Amyloid-beta precursor protein	Homo sapiens (human)
early endosome	Amyloid-beta precursor protein	Homo sapiens (human)
endoplasmic reticulum	Amyloid-beta precursor protein	Homo sapiens (human)
endoplasmic reticulum lumen	Amyloid-beta precursor protein	Homo sapiens (human)
smooth endoplasmic reticulum	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi apparatus	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi lumen	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi-associated vesicle	Amyloid-beta precursor protein	Homo sapiens (human)
cytosol	Amyloid-beta precursor protein	Homo sapiens (human)
plasma membrane	Amyloid-beta precursor protein	Homo sapiens (human)
clathrin-coated pit	Amyloid-beta precursor protein	Homo sapiens (human)
cell-cell junction	Amyloid-beta precursor protein	Homo sapiens (human)
synaptic vesicle	Amyloid-beta precursor protein	Homo sapiens (human)
cell surface	Amyloid-beta precursor protein	Homo sapiens (human)
membrane	Amyloid-beta precursor protein	Homo sapiens (human)
COPII-coated ER to Golgi transport vesicle	Amyloid-beta precursor protein	Homo sapiens (human)
axon	Amyloid-beta precursor protein	Homo sapiens (human)
growth cone	Amyloid-beta precursor protein	Homo sapiens (human)
platelet alpha granule lumen	Amyloid-beta precursor protein	Homo sapiens (human)
neuromuscular junction	Amyloid-beta precursor protein	Homo sapiens (human)
endosome lumen	Amyloid-beta precursor protein	Homo sapiens (human)
trans-Golgi network membrane	Amyloid-beta precursor protein	Homo sapiens (human)
ciliary rootlet	Amyloid-beta precursor protein	Homo sapiens (human)
dendritic spine	Amyloid-beta precursor protein	Homo sapiens (human)
dendritic shaft	Amyloid-beta precursor protein	Homo sapiens (human)
perikaryon	Amyloid-beta precursor protein	Homo sapiens (human)
membrane raft	Amyloid-beta precursor protein	Homo sapiens (human)
apical part of cell	Amyloid-beta precursor protein	Homo sapiens (human)
synapse	Amyloid-beta precursor protein	Homo sapiens (human)
perinuclear region of cytoplasm	Amyloid-beta precursor protein	Homo sapiens (human)
presynaptic active zone	Amyloid-beta precursor protein	Homo sapiens (human)
spindle midzone	Amyloid-beta precursor protein	Homo sapiens (human)
recycling endosome	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular exosome	Amyloid-beta precursor protein	Homo sapiens (human)
receptor complex	Amyloid-beta precursor protein	Homo sapiens (human)
early endosome	Amyloid-beta precursor protein	Homo sapiens (human)
membrane raft	Amyloid-beta precursor protein	Homo sapiens (human)
cell surface	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi apparatus	Amyloid-beta precursor protein	Homo sapiens (human)
plasma membrane	Amyloid-beta precursor protein	Homo sapiens (human)
endoplasmic reticulum	Aromatase	Homo sapiens (human)
endoplasmic reticulum membrane	Aromatase	Homo sapiens (human)
membrane	Aromatase	Homo sapiens (human)
endoplasmic reticulum	Aromatase	Homo sapiens (human)
plasma membrane	Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)
plasma membrane	Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)
plasma membrane	Guanine nucleotide-binding protein G	Homo sapiens (human)
plasma membrane	Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)
intracellular non-membrane-bounded organelle	TAR DNA-binding protein 43	Homo sapiens (human)
nucleus	TAR DNA-binding protein 43	Homo sapiens (human)
nucleoplasm	TAR DNA-binding protein 43	Homo sapiens (human)
perichromatin fibrils	TAR DNA-binding protein 43	Homo sapiens (human)
mitochondrion	TAR DNA-binding protein 43	Homo sapiens (human)
cytoplasmic stress granule	TAR DNA-binding protein 43	Homo sapiens (human)
nuclear speck	TAR DNA-binding protein 43	Homo sapiens (human)
interchromatin granule	TAR DNA-binding protein 43	Homo sapiens (human)
nucleoplasm	TAR DNA-binding protein 43	Homo sapiens (human)
chromatin	TAR DNA-binding protein 43	Homo sapiens (human)
nucleoplasm	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
plasma membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
apical plasma membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
brush border membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
mitochondrial membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
membrane raft	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
external side of apical plasma membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
plasma membrane	Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (72)

Assay ID	Title	Year	Journal	Article
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1431514	Inhibition of human ERG by Tracer Red dye based fluorescence polarization assay	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1431519	Inhibition of human CYP2C19 expressed in baculovirus-infected insect cells at 10 uM using Luciferin-H EGE as substrate in presence of NADPH by P450-Glo luminescence assay relative to control	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1439706	Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability at 10 ug/ml after 24 hrs by MTT assay relative to control	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents.
AID670950	Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 at 256 ug/ml after 24 hrs by disc diffusion method	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics.
AID1431524	Inhibition of human CYP3A4 expressed in baculovirus-infected insect cells using Luciferin-PFBE as substrate in presence of NADPH by P450-Glo luminescence assay	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1197890	Inhibition of ALR2 (unknown origin)	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Chalcones and their therapeutic targets for the management of diabetes: structural and pharmacological perspectives.
AID1697935	Antiproliferative activity against human K562 cells assessed as reduction in cell viability at 25 uM after 72 hrs by MTS assay relative to control	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors.
AID375388	Cytotoxicity against human SK-MEL-1 cells by MTT assay	2009	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13	The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris.
AID670957	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 at 256 ug/ml after 24 hrs by disc diffusion method	2012	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14	Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics.
AID1439702	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS-dependent nitric oxide production after 24 hrs by Griess assay	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents.
AID638551	Inhibition of MRP1 overexpressed in human 2008 MRP1 cells assessed as calcein AM accumulation at 10 uM by fluorimetry	2012	Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1	Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein.
AID761458	Cytotoxicity against human SH-SY5Y cells after 48 hrs by MTT assay	2013	European journal of medicinal chemistry, Aug, Volume: 66	Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase.
AID1439700	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS-dependent nitric oxide production at 5 ug/ml after 24 hrs by Griess assay relative to control	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents.
AID1439703	Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability at 1.25 ug/ml after 24 hrs by MTT assay relative to control	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents.
AID622584	Inhibition of NF-kappaB activation expressed in HCT116 cells assessed as inhibition of TNF-alpha-induced transcriptional activation at 10 uM after 12 hrs by luciferase reporter gene assay relative to control	2011	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 21, Issue:20	Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities.
AID1431509	Cytotoxicity against human W138 cells assessed as cell growth by Cell titer-Glo assay	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1439705	Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability at 5 ug/ml after 24 hrs by MTT assay relative to control	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents.
AID1737236	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells at 10 uM measured after 24 hrs by Griess reagent based assay relative to control	2020	European journal of medicinal chemistry, May-01, Volume: 193	Development of a novel nitric oxide (NO) production inhibitor with potential therapeutic effect on chronic inflammation.
AID1439704	Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability at 2.5 ug/ml after 24 hrs by MTT assay relative to control	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents.
AID638477	Inhibition of BCRP in human MCF7/MX cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by Fluorometry	2012	Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1	Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein.
AID1431511	Mitochondrial toxicity in human 786-O cells by mitotracker red chloromethyl-Xrosamine staining based-uptake method	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1431516	Inhibition of human CYP1A2 expressed in baculovirus-infected insect cells using Luciferin-1A2 as substrate in presence of NADPH by P450-Glo luminescence assay	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1431506	Cytotoxicity against human A549 cells assessed as cell growth at 10 uM by Cell titer-Glo assay relative to control	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID375391	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced IL6 secretion at 1 uM after 12 hrs	2009	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13	The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris.
AID1431521	Inhibition of human CYP2D6 expressed in baculovirus-infected insect cells at 10 uM using Luciferin-ME EGE as substrate in presence of NADPH by P450-Glo luminescence assay relative to control	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1431499	Cytotoxicity against human THP1 cells by MTT assay	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1697932	Antiproliferative activity against human THP-1 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors.
AID1431512	Inhibition of N-terminal-GST-tagged recombinant full length human Aurora B expressed in baculovirus infected Sf9 cells at 10 uM using native Swine Myelin Basic Protein as substrate measured after 60 mins by ADP-Glo assay relative to control	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1431513	Inhibition of human ERG at 10 uM by Tracer Red dye based fluorescence polarization assay relative to control	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1431515	Inhibition of human CYP1A2 expressed in baculovirus-infected insect cells at 10 uM using Luciferin-1A2 as substrate in presence of NADPH by P450-Glo luminescence assay relative to control	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1431504	Anti-parasitic activity against Trypanosoma cruzi Y promastigotes infected in HG39 cells at 10 uM by qPCR analysis relative to control	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1431556	Lipophilicity, log P of the compound	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1439701	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS-dependent nitric oxide production at 10 ug/ml after 24 hrs by Griess assay relative to control	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents.
AID1697942	Inhibition of FLT3 ITD mutant in human MV4-11 cells assessed as inhibition of STAT5 phosphorylation at 25 to 50 uM incubated for 2 hrs by immunoblotting analysis	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors.
AID1431510	Mitochondrial toxicity in human 786-O cells at 10 uM by mitotracker red chloromethyl-Xrosamine staining based-uptake method relative to control	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1697934	Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability at 50 uM after 72 hrs by MTS assay relative to control	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors.
AID1431508	Cytotoxicity against human W138 cells assessed as cell growth at 10 uM by Cell titer-Glo assay relative to control	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1697931	Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors.
AID761463	Inhibition of amyloid beta (1-42) self-mediated aggregation (unknown origin) after 5 days by thioflavin T fluorescence method	2013	European journal of medicinal chemistry, Aug, Volume: 66	Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase.
AID1431507	Cytotoxicity against human A549 cells assessed as cell growth by Cell titer-Glo assay	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID761462	Inhibition of potato 5-LOX using linoleic acid as substrate assessed as hydroperoxides production after 5 mins by enzyme immuno assay	2013	European journal of medicinal chemistry, Aug, Volume: 66	Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase.
AID1697936	Antiproliferative activity against human K562 cells assessed as reduction in cell viability at 50 uM after 72 hrs by MTS assay relative to control	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors.
AID1697933	Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability at 25 uM after 72 hrs by MTS assay relative to control	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors.
AID1431520	Inhibition of human CYP2C19 expressed in baculovirus-infected insect cells using Luciferin-H EGE as substrate in presence of NADPH by P450-Glo luminescence assay	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1439699	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS-dependent nitric oxide production at 2.5 ug/ml after 24 hrs by Griess assay relative to control	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents.
AID1439698	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS-dependent nitric oxide production at 1.25 ug/ml after 24 hrs by Griess assay relative to control	2017	Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7	Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents.
AID288830	Inhibition of human aromatase	2007	Journal of medicinal chemistry, Jun-14, Volume: 50, Issue:12	Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer.
AID638550	Inhibition of MDR1 in human A2780adr cells assessed as calcein AM accumulation at 10 uM by fluorimetry	2012	Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1	Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein.
AID1197889	Inhibition of ALR1 (unknown origin)	2015	European journal of medicinal chemistry, Mar-06, Volume: 92	Chalcones and their therapeutic targets for the management of diabetes: structural and pharmacological perspectives.
AID375389	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced TNFalpha secretion at 0.01 uM after 12 hrs	2009	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13	The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris.
AID375387	Cytotoxicity against human MCF7 cells by MTT assay	2009	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13	The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris.
AID1431523	Inhibition of human CYP3A4 expressed in baculovirus-infected insect cells at 10 uM using Luciferin-PFBE as substrate in presence of NADPH by P450-Glo luminescence assay relative to control	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1431522	Inhibition of human CYP2D6 expressed in baculovirus-infected insect cells using Luciferin-ME EGE as substrate in presence of NADPH by P450-Glo luminescence assay	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID375386	Cytotoxicity against human HeLa cells by MTT assay	2009	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13	The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris.
AID1431498	Anti-parasitic activity against bloodstream form of Trypanosoma brucei brucei Lister 427 at 10 uM after 72 hrs by resazurin-based assay relative to control	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID638478	Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry	2012	Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1	Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein.
AID1431517	Inhibition of human CYP2C9 expressed in baculovirus-infected insect cells at 10 uM using Luciferin-H as substrate in presence of NADPH by P450-Glo luminescence assay relative to control	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
AID1697930	Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors.
AID1431518	Inhibition of human CYP2C9 expressed in baculovirus-infected insect cells using Luciferin-H as substrate in presence of NADPH by P450-Glo luminescence assay	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (18.75)	29.6817
2010's	10 (62.50)	24.3611
2020's	3 (18.75)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (6.25%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (93.75%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
aminoglutethimide Aminoglutethimide: An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.. aminoglutethimide : A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.	2.03	1	dicarboximide; piperidones; substituted aniline	adrenergic agent; anticonvulsant; antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor
berberine [no description available]	2.07	1	alkaloid antibiotic; berberine alkaloid; botanical anti-fungal agent; organic heteropentacyclic compound	antilipemic drug; antineoplastic agent; antioxidant; EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor; EC 1.21.3.3 (reticuline oxidase) inhibitor; EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.11.10 (IkappaB kinase) inhibitor; EC 3.1.1.4 (phospholipase A2) inhibitor; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor; EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; geroprotector; hypoglycemic agent; metabolite; potassium channel blocker
beta-naphthoflavone beta-Naphthoflavone: A polyaromatic hydrocarbon inducer of P4501A1 and P4501A2 cytochromes. (Proc Soc Exp Biol Med 1994 Dec:207(3):302-308). beta-naphthoflavone : An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.	2.06	1	extended flavonoid; naphtho-gamma-pyrone; organic heterotricyclic compound	aryl hydrocarbon receptor agonist
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.07	1	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
miltefosine miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.	2.15	1	phosphocholines; phospholipid	anti-inflammatory agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antiprotozoal drug; apoptosis inducer; immunomodulator; protein kinase inhibitor
nocodazole [no description available]	2.25	1	aromatic ketone; benzimidazoles; carbamate ester; thiophenes	antimitotic; antineoplastic agent; microtubule-destabilising agent; tubulin modulator
masoprocol nordihydroguaretic acid: antioxidant compound found in the creosote bush (Larrea tridentata)	2.08	1	catechols; lignan; tetrol	antioxidant; ferroptosis inhibitor; geroprotector; plant metabolite
pentamidine Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.	2.15	1	aromatic ether; carboxamidine; diether	anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic
chloramphenicol Amphenicol: Chloramphenicol and its derivatives.	2.07	1	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor
flavone flavone: RN given refers to unlabeled cpd; structure given in first source. flavone : The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.	2.06	1	flavones	metabolite; nematicide
alpha-naphthoflavone alpha-naphthoflavone: inhibits P4501A1 and P4501A2; stimulates some activities of P4503A4. alpha-naphthoflavone : An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).	2.06	1	extended flavonoid; naphtho-gamma-pyrone; organic heterotricyclic compound	aryl hydrocarbon receptor agonist; aryl hydrocarbon receptor antagonist; EC 1.14.14.14 (aromatase) inhibitor
erythromycin Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.	2.07	1	cyclic ketone; erythromycin
vancomycin Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.	2.07	1	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
5-hydroxyflavone [no description available]	2.06	1	flavones
beta-amyrin beta-amyrin: alpha-amyrin is also available; a 5 ring triterpene derived from oleanane that differs from alpha-amyrin in having the 29-carbon at the 20 position; RN given refers to (3 beta)-isomer. beta-amyrin : A pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants.	2.96	1	pentacyclic triterpenoid; secondary alcohol	Aspergillus metabolite; plant metabolite
3-methylflavone-8-carboxylic acid 3-methylflavone-8-carboxylic acid: metabolite of flavoxate; RN in Chemline for the Na salt: 58348-97-3. 3-methylflavone-8-carboxylic acid : A member of the class of flavones that is flavone substituted at position 3 by a methyl group and at position 8 by a carboxylic acid group.	2.06	1	flavones; oxo monocarboxylic acid	EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
5,7,4'-trimethylapigenin 5,7,4'-trimethylapigenin: a flavonoid from the East Asian medicinal plant Orthosiphon spicatus; prevents oxidative inactivation of 15-lipoxygenase; structure given in first source	2.06	1	ether; flavonoids
beta-amyrin acetate [no description available]	2.96	1	triterpenoid
5-Methoxyflavone 5-methoxyflavone: DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity; structure in first source	2.06	1	ether; flavonoids
sitosterol, (3beta)-isomer Sobatum: tradename; active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity. sitosterol : A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.	2.96	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; C29-steroid; phytosterols; stigmastane sterol	anticholesteremic drug; antioxidant; mouse metabolite; plant metabolite; sterol methyltransferase inhibitor
lupeol [no description available]	2.96	1	pentacyclic triterpenoid; secondary alcohol	anti-inflammatory drug; plant metabolite
5,7-dimethoxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one [no description available]	2.06	1	ether; flavonoids
naringenin (S)-naringenin : The (S)-enantiomer of naringenin.	2.06	1	(2S)-flavan-4-one; naringenin	expectorant; plant metabolite
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.08	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
clindamycin Clindamycin: An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.. clindamycin : A carbohydrate-containing antibiotic that is the semisynthetic derivative of lincomycin, a natural antibiotic.	2.07	1
5,7,3',4'-tetramethylluteolin 5,7,3',4'-tetramethylluteolin: a flavonoid from the East Asian medicinal plant Orthosiphon spicatus; prevents oxidative inactivation of 15-lipoxygenase; structure given in first source	2.06	1
chalcone trans-chalcone : The trans-isomer of chalcone.	2.07	1	chalcone	EC 3.2.1.1 (alpha-amylase) inhibitor
7-methoxyisoflavone 7-methoxyisoflavone : A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 7.	2.06	1	7-methoxyisoflavones
2'-hydroxychalcone 2'-hydroxychalcone : A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'.	2.8	3	chalcones; phenols	anti-inflammatory agent
2,2'-dihydroxychalcone 2,2'-dihydroxychalcone: an antineoplastic agent; structure in first source	2.07	1
isoliquiritigenin [no description available]	2.08	1	chalcones	antineoplastic agent; biological pigment; EC 1.14.18.1 (tyrosinase) inhibitor; GABA modulator; geroprotector; metabolite; NMDA receptor antagonist
xanthohumol xanthohumol: from hop plant, Humulus lupulus. xanthohumol : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4', a methoxy group at position 6' and a prenyl group at position 3'. Isolated from Humulus lupulus, it induces apoptosis in human malignant glioblastoma cells.	3.21	1	aromatic ether; chalcones; polyphenol	anti-HIV-1 agent; antineoplastic agent; antiviral agent; apoptosis inducer; EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor; metabolite
xanthoangelol xanthoangelol: from Angelica keiskei; structure given in first source; RN given refers to (E,E)-isomer	3.21	1
epalrestat epalrestat : A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.	3.21	1	monocarboxylic acid; thiazolidines	EC 1.1.1.21 (aldehyde reductase) inhibitor
tandutinib [no description available]	2.25	1	aromatic ether; N-arylpiperazine; N-carbamoylpiperazine; phenylureas; piperidines; quinazolines; tertiary amino compound	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
7-methoxy-2-(4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one [no description available]	2.03	1	ether; flavonoids
luteolin [no description available]	2.25	1	3'-hydroxyflavonoid; tetrahydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; c-Jun N-terminal kinase inhibitor; EC 2.3.1.85 (fatty acid synthase) inhibitor; immunomodulator; nephroprotective agent; plant metabolite; radical scavenger; vascular endothelial growth factor receptor antagonist
isobavachalcone isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.	2.25	1	chalcones; polyphenol	antibacterial agent; metabolite; platelet aggregation inhibitor
gossypin gossypin: do not confuse with gossypin(e) which is synonym for choline. gossypin : A glycosyloxyflavone that is gossypetin attached to a beta-D-glucopyranosyl residue at position 8 via a glycosidic linkage.	2.06	1	7-hydroxyflavonol; glycosyloxyflavone; monosaccharide derivative; pentahydroxyflavone	neuroprotective agent; plant metabolite
prunetin prunetin: reduces herpes virus-1 plaque formation. prunetin : A hydroxyisoflavone that is genistein in which the hydroxy group at position 7 is replaced by a methoxy group.	2.06	1	7-methoxyisoflavones; hydroxyisoflavone	anti-inflammatory agent; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor; metabolite
4-hydroxychalcone 4-hydroxychalcone: structure in first source. 4-hydroxychalcone : A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4.	2.07	1	chalcones; phenols	antihypertensive agent; plant metabolite
isorhamnetin 3-o-glucoside isorhamnetin 3-O-glucoside: from the flowers of Persea gratissima; structure in first source. isorhamnetin 3-O-beta-D-glucopyranoside : A glycosyloxyflavone that is isorhamnetin substituted at position 3 by a beta-D-glucosyl residue.	2.06	1	beta-D-glucoside; glycosyloxyflavone; monomethoxyflavone; monosaccharide derivative; trihydroxyflavone	metabolite
licochalcone a licochalcone A: has both anti-inflammatory and antineoplastic activities; structure given in first source; isolated from root of Glycyrrhiza inflata; RN given refers to (E)-isomer	2.15	1	chalcones
2'-hydroxy-4-methoxychalcone [no description available]	2.8	3
flavokawain a flavokawain A: from kava extract, induces apoptosis in bladder cancer cells; structure in first source	2.53	2	chalcones
flavokawain b flavokawain B: from Piper methysticum Forst (Kava Kava) roots; structure in first source. flavokawain B : A member of the class of chalcones that consists of trans-chalcone substituted by hydroxy group at positions 2' and methoxy groups at positions 4' and 6'. Isolated from Piper methysticum and Piper rusbyi, it exhibits antileishmanial, anti-inflammatory and antineoplastic activities.	2.59	2	chalcones; dimethoxybenzene; phenols	anti-inflammatory agent; antileishmanial agent; antineoplastic agent; apoptosis inducer; metabolite
2',4'-dihydroxychalcone 2',4'-dihydroxychalcone: RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 6/89; structure given in first source	2.07	1
Crotaoprostrin [no description available]	2.07	1	chalcones
4-hydroxylonchocarpin 4-hydroxylonchocarpin: structure in first source	2.25	1
2-chloro-4',6'-dimethoxy-2'-hydroxychalcone 2-chloro-4',6'-dimethoxy-2'-hydroxychalcone: induces glutathione biosynthesis; structure in first source	2.07	1
metochalcone metochalcone: structure	2.07	1
flavokawain C flavokawain C: antineoplastic from roots of Kava (Piper methysticum Forst); structure in first source	2.25	1	chalcones
4-hydroxyderricin 4-hydroxyderricin: from Angelica keiskei; RN given refers to (E)-isomer; structure in first source	3.21	1	chalcones
broussochalcone a broussochalcone A: RN given for (E)-isomer; inhibits neutrophil respiratory burst; structure in first source	3.66	2
bavachalcone bavachalcone: structure in first source	3.21	1	chalcones
nifurtimox Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.	2.15	1	nitrofuran antibiotic
gentamicin sulfate [no description available]	2.07	1
glutinol glutinol: from a medicinal lichen, Usnea longissima; structure in first source. glutinol : A pentacyclic triterpenoid that is picene which has been fully hydrogenated except for a double bond between the 4a and 5 positions and is substituted by methyl groups at the 4, 4, 6bbeta, 8abeta, 11, 11, 12balpha and 14bbeta positions, and by a hydroxy group at the 3beta position.	2.96	1	pentacyclic triterpenoid; secondary alcohol
ko 143 [no description available]	2.07	1	beta-carbolines; tert-butyl ester
4-Methoxylonchocarpin [no description available]	2.25	1	chalcones
Kanzonol B [no description available]	2.25	1	chalcones

Condition	Relationship Strength	Studies
Breast Cancer [description not available]	2.46	2
Breast Neoplasms Tumors or cancer of the human BREAST.	2.46	2
Innate Inflammatory Response [description not available]	2.52	2
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.52	2
Cancer of Colon [description not available]	2.06	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.06	1
Diabetes Mellitus A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.	3.03	1
Chronic Illness [description not available]	2.25	1
Polyarthritis [description not available]	2.25	1
Arthritis Acute or chronic inflammation of JOINTS.	2.25	1
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	2.25	1
Acute Myelogenous Leukemia [description not available]	2.25	1
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	2.25	1

Isoliquiritigenin 4,4'-dimethyl ether

Cross-References

Synonyms (32)

Research Excerpts

Compound-Compound Interactions

Drug Classes (1)

Protein Targets (40)

Potency Measurements

Inhibition Measurements

Biological Processes (128)

Molecular Functions (40)

Ceullar Components (55)

Bioassays (72)

Research

Studies (16)

Market Indicators

Research Demand Index: 11.79

Study Types

Isoliquiritigenin 4,4'-dimethyl ether

Cross-References

Synonyms (32)

Research Excerpts

Compound-Compound Interactions

Drug Classes (1)

Protein Targets (40)

Potency Measurements

Inhibition Measurements

Biological Processes (128)

Molecular Functions (40)

Ceullar Components (55)

Bioassays (72)

Research

Studies (16)

Market Indicators

Research Demand Index: 11.79

Study Types

Related Drugs (61)

Related Conditions (13)