Compounds > chrysophaentin a
Page last updated: 2024-11-13

chrysophaentin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

chrysophaentin A: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID46872004
CHEMBL ID2418095
SCHEMBL ID14225547
MeSH IDM0592559

Synonyms (5)

Synonym
chembl2418095 ,
bdbm50439495
SCHEMBL14225547
chrysophaentin a
DTXSID601019058
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cell division protein FtsZEscherichia coli K-12INH9.88005.81008.125010.0000AID1628114
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
protein polymerizationCell division protein FtsZEscherichia coli K-12
cell divisionCell division protein FtsZEscherichia coli K-12
division septum assemblyCell division protein FtsZEscherichia coli K-12
FtsZ-dependent cytokinesisCell division protein FtsZEscherichia coli K-12
protein polymerizationCell division protein FtsZEscherichia coli K-12
cell divisionCell division protein FtsZEscherichia coli K-12
cell septum assemblyCell division protein FtsZEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
GTPase activityCell division protein FtsZEscherichia coli K-12
protein bindingCell division protein FtsZEscherichia coli K-12
GTP bindingCell division protein FtsZEscherichia coli K-12
identical protein bindingCell division protein FtsZEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
cytoplasmCell division protein FtsZEscherichia coli K-12
cell division siteCell division protein FtsZEscherichia coli K-12
plasma membraneCell division protein FtsZEscherichia coli K-12
divisome complexCell division protein FtsZEscherichia coli K-12
cytoplasmCell division protein FtsZEscherichia coli K-12
cell division siteCell division protein FtsZEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID767368Antibacterial activity against Escherichia coli BL21 (DE3) envA1 assessed as growth inhibition after 18 hrs by microbroth dilution method2013Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria.
AID1326317Antimicrobial activity against vancomycin-resistant Enterococcus faecalis after 18 hrs by broth microdilution method2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.
AID767358Inhibition of recombinant Staphylococcus aureus FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as production of inorganic phosphate up to 600 uM after 20 mins by malachite green-phosphomolybdate colorimetric assay in presence of tr2013Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria.
AID1201462Inhibition of Escherichia coli FtsZ GTPase activity2015European journal of medicinal chemistry, May-05, Volume: 95Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ.
AID1201475Antimicrobial activity against multidrug-resistant Staphylococcus aureus2015European journal of medicinal chemistry, May-05, Volume: 95Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ.
AID767373Inhibition of recombinant Escherichia coli FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as production of inorganic phosphate after 10 mins by malachite green-phosphomolybdate colorimetric assay2013Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria.
AID767374Inhibition of recombinant Staphylococcus aureus FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as production of inorganic phosphate after 20 mins by malachite green-phosphomolybdate colorimetric assay2013Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria.
AID767369Inhibition of C-terminal YFP-fused Escherichia coli FtsZ cloned in Escherichia coli envA1 assessed as protein dispersion in from of patches throughout cytoplasm at 125 uM after 30 to 60 mins by fluorescence microscopic analysis2013Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria.
AID1326306Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by broth microdilution method2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.
AID1326307Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC BAA-41 after 18 hrs by broth microdilution method2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.
AID767367Inhibition of C-terminal YFP-fused Escherichia coli FtsZ transformed in Escherichia coli envA1 assessed as Z ring formation at 125 uM after 30 to 60 mins by fluorescence microscopic analysis2013Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria.
AID1326318Antimicrobial activity against vancomycin-sensitive Enterococcus faecalis after 18 hrs by broth microdilution method2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.
AID1326319Antibacterial activity against Klebsiella pneumoniae ATCC BAA-1144 after 18 hrs by broth microdilution method2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.
AID1628114Inhibition of Escherichia coli FtsZ assessed as reduction in GTPase activity by malachite green assay2016Journal of medicinal chemistry, Aug-11, Volume: 59, Issue:15
Targeting the Bacterial Division Protein FtsZ.
AID1201476Antimicrobial activity against cancomycin-resistant Enterococcus2015European journal of medicinal chemistry, May-05, Volume: 95Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ.
AID767357Inhibition of recombinant Escherichia coli FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as production of inorganic phosphate up to 600 uM after 10 mins by malachite green-phosphomolybdate colorimetric assay in presence of triton 2013Bioorganic & medicinal chemistry, Sep-15, Volume: 21, Issue:18
Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria.
AID1628119Antimicrobial activity against methicillin resistant Staphylococcus aureus2016Journal of medicinal chemistry, Aug-11, Volume: 59, Issue:15
Targeting the Bacterial Division Protein FtsZ.
AID1326320Antibacterial activity against methicillin-sensitive Staphylococcus aureus after 18 hrs by broth microdilution method2016Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.
AID1201466Antimicrobial activity against methicillin-resistant Staphylococcus aureus2015European journal of medicinal chemistry, May-05, Volume: 95Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ.
AID1628116Antimicrobial activity against Staphylococcus aureus2016Journal of medicinal chemistry, Aug-11, Volume: 59, Issue:15
Targeting the Bacterial Division Protein FtsZ.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (60.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other2 (40.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
coumarin
2H-chromen-2-one: coumarin derivative		3.2310coumarinsfluorescent dye;
human metabolite;
plant metabolite
berberine
[no description available]		3.620alkaloid antibiotic;
berberine alkaloid;
botanical anti-fungal agent;
organic heteropentacyclic compound		antilipemic drug;
antineoplastic agent;
antioxidant;
EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor;
EC 1.21.3.3 (reticuline oxidase) inhibitor;
EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
hypoglycemic agent;
metabolite;
potassium channel blocker
dapi
DAPI: RN given refers to parent cpd.		3.2110indolesfluorochrome
plumbagin
plumbagin: a superoxide anion generator. plumbagin : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively.		3.2310hydroxy-1,4-naphthoquinone;
phenols		anticoagulant;
antineoplastic agent;
immunological adjuvant;
metabolite
Berberine chloride (TN)
[no description available]		4.1420organic molecular entity
amikacin
Amikacin: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.. amikacin : An amino cyclitol glycoside that is kanamycin A acylated at the N-1 position by a 4-amino-2-hydroxybutyryl group.		3.2110alpha-D-glucoside;
amino cyclitol glycoside;
aminoglycoside;
carboxamide		antibacterial drug;
antimicrobial agent;
nephrotoxin
trichlorophene
trichlorophene: contains 20 carbon atoms; do not confuse with trichlorophene as name for trichloro derivs of 2,2'-methylenebisphenol (contain 13 carbon atoms)		2.0810
totarol
totarol: structure given in first source; isolated from the bark of Podocarpus nagi		3.2110diterpenoidmetabolite
dichamanetin
dichamanetin: structure in first source		3.2110diarylheptanoidmetabolite
e-z cinnamic acid
cinnamic acid : A monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. It is found in Cinnamomum cassia.. trans-cinnamic acid : The E (trans) isomer of cinnamic acid		3.2310cinnamic acidplant metabolite
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		3.2310resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
ferulic acid
ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.		3.2310ferulic acidsanti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite
cinnamaldehyde
3-phenylprop-2-enal : A member of the class of cinnamaldehydes that is prop-2-enal in which a hydrogen at position 3 has been replaced by a phenyl group. The configuration of the double bond is not specified; the name "cinnamaldehyde" is widely used to refer to the E (trans) isomer.. (E)-cinnamaldehyde : The E (trans) stereoisomer of cinnamaldehyde, the parent of the class of cinnamaldehydes.		4.76303-phenylprop-2-enal;
cinnamaldehydes		antifungal agent;
EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor;
flavouring agent;
hypoglycemic agent;
plant metabolite;
sensitiser;
vasodilator agent
trans-4-coumaric acid
hydroxycinnamic acid : Any member of the class of cinnamic acids carrying one or more hydroxy substituents.. trans-4-coumaric acid : The trans-isomer of 4-coumaric acid.. 4-coumaric acid : A coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring.		3.23104-coumaric acidfood component;
mouse metabolite;
plant metabolite
caffeic acid
trans-caffeic acid : The trans-isomer of caffeic acid.		3.2310caffeic acidgeroprotector;
mouse metabolite
3-(3,4-dimethoxyphenyl)propenoic acid
3-(3,4-dimethoxyphenyl)propenoic acid: structure given in first source; RN given refers to parent cpd. 3,4-dimethoxycinnamic acid : A methoxycinnamic acid that is trans-cinnamic acid substituted by methoxy groups at positions 3' and 4' respectively.		3.2310methoxycinnamic acid
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		3.2310aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
chlorogenic acid
caffeoylquinic acid: Antiviral Agent; structure in first source. chlorogenate : A monocarboxylic acid anion that is the conjugate base of chlorogenic acid; major species at pH 7.3.		3.2310cinnamate ester;
tannin		food component;
plant metabolite
scopoletin
[no description available]		3.2310hydroxycoumarinplant growth regulator;
plant metabolite
daphnetin
[no description available]		3.2310hydroxycoumarin
7-hydroxycoumarin
7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.		3.2310hydroxycoumarinfluorescent probe;
food component;
plant metabolite
pc190723
PC190723: Antibacterial; an inhibitor of FtsZ with potent and selective anti-staphylococcal activity including methicillin- and multi-drug-resistant Staphylococcus aureus; structure in first source		4.7630
ConditionIndicatedRelationship StrengthStudiesTrials
Bacterial Disease
[description not available]		03.0310
Bacterial Infections
Infections by bacteria, general or unspecified.		03.0310