| Assay ID | Title | Year | Journal | Article |
|---|
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1182495 | Induction of mitotic accumulation in human HCT116 cells Hoechst 33342 staining based by fluorescence microscopy | 2014 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 24, Issue:16
| Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives. |
| AID1262054 | Cytotoxicity against human SK-MEL-28 cells assessed as cell viability by tryphan blue staining based microscopy | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1182496 | Growth inhibition of human HCT116 cells | 2014 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 24, Issue:16
| Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives. |
| AID1182507 | Toxicity in human A2780 cells xenografted SCID mouse assessed as mortality at 100 mg/kg, po bid for 5 days | 2014 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 24, Issue:16
| Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives. |
| AID1262049 | Cell cycle arrest in human SK-MEL-5 cells assessed as accumulation of cells with 4N DNA at 5 uM after 96 hrs by propidium iodide staining-based FACS analysis | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1262053 | Cytotoxicity against human SK-MEL-5 cells assessed as cell viability by tryphan blue staining based microscopy | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1262056 | Reduction in cyclin D1 protein level in human SK-MEL-28 cells at 5 uM after 24 hrs by RT-PCR analysis relative to control | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1262050 | Cell cycle arrest in human SK-MEL-28 cells assessed as accumulation of cells with 4N DNA at 5 uM after 96 hrs by propidium iodide staining-based FACS analysis | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1406250 | Inhibition of human recombinant BChE using butyrylthiocholine as substrate preincubated for 300 secs followed by substrate addition and measured for 1 min by Ellman's assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities. |
| AID1262040 | Antiproliferative activity against human SK-MEL-5 cells assessed as reduction in cell viability at 5 to 50 uM after 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1406285 | Binding affinity to N-terminal His6-tagged human Eg5 motor domain (1 to 368 residues) expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry method | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors. |
| AID1262052 | Cytotoxicity against human PC3 cells assessed as cell viability by tryphan blue staining based microscopy | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1406286 | Inhibition of basal ATPase activity of N-terminal His6-tagged human Eg5 motor domain (1 to 368 residues) expressed in Escherichia coli BL21 (DE3) by pyruvate kinase-lactate dehydrogenase coupled assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors. |
| AID1398519 | Inhibition EG5 (unknown origin) | 2018 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 28, Issue:17
| Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5. |
| AID1262044 | Inhibition of kinesin Eg5 (unknown origin) assessed as reduction in microtubule activated ATPase activity at 0.1 to 1 ug/ml by HTS kinesin ATPase endpoint assay | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1262047 | Cell cycle arrest in human SK-MEL-28 cells assessed as accumulation at G2/M phase at 5 uM after 24 hrs by propidium iodide staining-based FACS analysis | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1182501 | Antitumor activity against human A2780 cells xenografted in SCID mouse assessed as tumor volume ratio at 100 mg/kg, po bid for 5 days relative to untreated control | 2014 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 24, Issue:16
| Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives. |
| AID1262041 | Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability at 5 to 50 uM after 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1262055 | Reduction in cyclin D1 protein level in human SK-MEL-5 cells at 5 uM after 24 hrs by RT-PCR analysis relative to control | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1182508 | Toxicity in human A2780 cells xenografted SCID mouse assessed as induction of body weight loss at 100 mg/kg, po bid for 5 days | 2014 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 24, Issue:16
| Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives. |
| AID1406287 | Inhibition of microtubule-stimulated recombinant human Eg5 ATPase activity | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors. |
| AID1262048 | Cell cycle arrest in human PC3 cells assessed as accumulation of cells with 4N DNA at 5 uM after 96 hrs by propidium iodide staining-based FACS analysis | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1262045 | Cell cycle arrest in human PC3 cells assessed as accumulation at G2/M phase at 5 uM after 24 hrs by propidium iodide staining-based FACS analysis | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1262046 | Cell cycle arrest in human SK-MEL-5 cells assessed as accumulation at G2/M phase at 5 uM after 24 hrs by propidium iodide staining-based FACS analysis | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1262039 | Antiproliferative activity against human PC3 cells assessed as reduction in cell viability at 0.5 to 100 uM after 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1406284 | Inhibition of N-terminal His6-tagged microtubule-stimulated ATPase activity of human Eg5 motor domain (1 to 368 residues) expressed in Escherichia coli BL21 (DE3) by pyruvate kinase-lactate dehydrogenase coupled assay | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors. |
| AID740539 | Inhibition of Eg5 in human HCT116 cells assessed as inhibition of microtubule-induced ATPase activity after 18 hrs | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents. |
| AID1182497 | Inhibition of Eg5 (unknown origin) | 2014 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 24, Issue:16
| Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives. |
| AID1262043 | Cytotoxicity against human PC3 cells assessed as cell viability at 5 uM after 72 hrs by tryphan blue staining based microscopy (Rvb = 95 to 98 %) | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1262051 | Reduction in cyclin D1 protein level in human PC3 cells at 5 uM after 24 hrs by RT-PCR analysis relative to control | 2015 | European journal of medicinal chemistry, Nov-13, Volume: 105 | Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma. |
| AID1398518 | Inhibition of MT-stimulated EG5 ATPase activity (unknown origin) by pyruvate kinase/lactate dehydrogenase enzyme coupled photometric assay | 2018 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 28, Issue:17
| Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5. |
| AID1398520 | Inhibition of MT-stimulated EG5 ATPase activity (unknown origin) by pyruvate kinase/lactate dehydrogenase enzyme coupled photometric assay relative to control | 2018 | Bioorganic & medicinal chemistry letters, 09-15, Volume: 28, Issue:17
| Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6
| A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |