Compounds > 4,4'-azobis(phenol)
Page last updated: 2024-12-07

4,4'-azobis(phenol)

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4,4'-azobis(phenol): isolated from fungus Agaricus xanthodermus; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID101245
CHEMBL ID116175
SCHEMBL ID901189
MeSH IDM0131146

Synonyms (48)

Synonym
4,4-dihydroxyazobenzene
nsc-402595
2050-16-0
nsc402595
CHEMBL116175
AKOS003619052
4-[(4-hydroxyphenyl)hydrazinylidene]cyclohexa-2,5-dien-1-one
4,4'-azobis(phenol)
nsc 402595
phenol, 4,4'-azobis-
ai3-08894
4,4'-dihydroxyazobenzene
4-[(4-hydroxyphenyl)diazenyl]phenol
phenol,4,4'-(1,2-diazenediyl)bis-
4-(4-hydroxyphenylazo)phenol
trans-4,4'-azodiphenol
unii-f4ylc7i7dn
phenol, 4,4'-(1,2-diazenediyl)bis-
p-azophenol
phenol, 4,4'-azodi
4,4'-azodiphenol
51437-66-2
phenol, 4,4'-(1e)-1,2-diazenediylbis-
f4ylc7i7dn ,
p,p'-dihydroxyazobenzene
SCHEMBL901189
WKODVHZBYIBMOC-UHFFFAOYSA-N
WKODVHZBYIBMOC-BUHFOSPRSA-N
di-(4-hydroxy-phenyl)-diazene
D3431
AKOS028112956
mfcd00045778
SY056471
4,4 inverted exclamation mark -dihydroxyazobenzene
(e)-4,4-(diazene-1,2-diyl)diphenol pound ws201781 pound(c)
E72619
AS-18987
10.14272/WKODVHZBYIBMOC-BUHFOSPRSA-N
doi:10.14272/wkodvhzbyibmoc-buhfosprsa-n.1
(e)-4,4'-(diazene-1,2-diyl)diphenol
N10032
Q27277636
A910719
YSWG059
4,4-(diazene-1,2-diyl)diphenol
CAA05016
4,4'-(e)-diazene-1,2-diyldiphenol
CS-W018449
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1127148Binding affinity to ERalpha (unknown origin) relative to estradiol2014Journal of medicinal chemistry, Apr-24, Volume: 57, Issue:8
Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor.
AID481675Induction of human ApoA-1 gene expression in human Caco-2 cells co-transfected with luc-beta-galactosidase after 48 hrs assessed as luciferase activity by luminometer relative to resveratrol2010European journal of medicinal chemistry, May, Volume: 45, Issue:5
Stilbene analogs as inducers of apolipoprotein-I transcription.
AID481674Induction of human ApoA-1 gene expression in human Caco-2 cells co-transfected with luc-beta-galactosidase after 48 hrs assessed as luciferase activity by luminometer relative to control2010European journal of medicinal chemistry, May, Volume: 45, Issue:5
Stilbene analogs as inducers of apolipoprotein-I transcription.
AID216186The compound was tested for antiviral activity against Herpes simplex virus type-1 in the vero cells using plaque inhibition assay; no IC50 reached without damage to the cell monolayer.1999Journal of medicinal chemistry, Aug-26, Volume: 42, Issue:17
Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adipic acid
adipic acid : An alpha,omega-dicarboxylic acid that is the 1,4-dicarboxy derivative of butane.		210alpha,omega-dicarboxylic acid;
dicarboxylic fatty acid		food acidity regulator;
human xenobiotic metabolite
succinic acid
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851). succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.		210alpha,omega-dicarboxylic acid;
C4-dicarboxylic acid		anti-ulcer drug;
fundamental metabolite;
micronutrient;
nutraceutical;
radiation protective agent
thymidine
[no description available]		210pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
cordycepin
[no description available]		2103'-deoxyribonucleoside;
adenosines		antimetabolite;
nucleoside antibiotic
formaldoxime
formaldoxime: structure in first source. nitrone : A nitrogen ylide obtained by oxygenation of any imine.		210
tropine
[no description available]		210
5-nitrobarbituric acid
[no description available]		210
deoxyuridine
[no description available]		210pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
nebularine
nebularine: structure. nebularine : A purine ribonucleoside that is 9H-purine attached to a beta-D-ribofuranosyl residue at position 9 via a glycosidic (N-glycosyl) linkage.		210purine ribonucleoside;
purines D-ribonucleoside		fungal metabolite
5-nitrouracil
5-nitrouracil: prevents thymidine degradation. 5-nitrouracil : A C-nitro compound consisting of uracil having a nitro group at the 5-position.		210C-nitro compound
5-methylcytidine
[no description available]		210methylcytidine
cyclic adp-ribose
Cyclic ADP-Ribose: A pyridine nucleotide that mobilizes CALCIUM. It is synthesized from nicotinamide adenine dinucleotide (NAD) by ADP RIBOSE CYCLASE.		2.0310cyclic purine nucleotide;
nucleotide-sugar		metabolite;
ryanodine receptor agonist
angiotensin ii
Giapreza: injectable form of angiotensin II used to increase blood pressure in adult patients with septic or other distributive shock. Ile(5)-angiotensin II : An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).		2.0510amino acid zwitterion;
angiotensin II		human metabolite
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		2.0510resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
zeranol
Zeranol: A non-steroidal estrogen analog.		2.110macrolide
genistein
[no description available]		2.1107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
7-hydroxycoumarin
7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.		210hydroxycoumarinfluorescent probe;
food component;
plant metabolite
daidzein
[no description available]		2.1107-hydroxyisoflavonesantineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
phytoestrogen;
plant metabolite
4,4'-dihydroxystilbene
[no description available]		2.0510stilbene-4,4'-diol
nitrofurantoin
Nitrofurantoin: A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.. nitrofurantoin : An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.		210imidazolidine-2,4-dione;
nitrofuran antibiotic;
organonitrogen heterocyclic antibiotic;
organooxygen heterocyclic antibiotic		antibacterial drug;
antiinfective agent;
hepatotoxic agent
inosine
[no description available]		210inosines;
purines D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Alloxan Diabetes
[description not available]		02.0510
Diabetic Glomerulosclerosis
[description not available]		02.0510
Albuminuria
The presence of albumin in the urine, an indicator of KIDNEY DISEASES.		02.0510
Diabetic Nephropathies
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.		02.0510