Page last updated: 2024-09-27

Epilepsy Progressive Myoclonic 2

A form of stimulus sensitive MYOCLONIC EPILEPSY inherited as an autosomal recessive condition. The most common presenting feature is a single seizure in the second decade of life. This is followed by progressive myoclonus, myoclonic seizures, tonic-clonic seizures, focal occipital seizures, intellectual decline, and severe motor and coordination impairments. Most affected individuals do not live past the age of 25 years. Concentric amyloid (Lafora) bodies are found in neurons, liver, skin, bone, and muscle (From Menkes, Textbook of Childhood Neurology, 5th ed, pp111-110).

Synonyms(17)

Synonym
Lafora Body Disorder
Lafora Progressive Myoclonus Epilepsy
Lafora Progressive Myoclonic Epilepsy
Lafora Type Progressive Myoclonic Epilepsy
Late Onset Lafora Body Disease
Lafora-Body Disease, Late Onset
Epilepsy, Progressive Myoclonic 2A
Epilepsy, Progressive Myoclonic, Lafora
Lafora Body Disease
Progressive Myoclonic Epilepsy Type 2
Epilepsy Progressive Myoclonic 2
Progressive Myoclonic Epilepsy, Lafora
Progressive Myoclonic Epilepsy, Lafora Type
Lafora Body Disease, Late Onset
Myoclonic Epilepsy of Lafora
Progressive Myoclonus Epilepsy, Lafora Type
Lafora Disease

Research Excerpts

Overview

ExcerptReference
"Lafora disease is a progressive myoclonus epilepsy with an early fatal issue."( Girard, JM; Lê, KH; Lederer, F, 2006)
"Abstract Lafora progressive myoclonus epilepsy is an autosomal recessive, fatal, generalized polyglucosan storage disorder that occurs in childhood or adolescence with stimulus sensitive epilepsy (resting and action myoclonias, grand mal, and absence), dementia, ataxia and rapid neurologic deterioration."( Delgado-Escueta, AV, 2007)
"Lafora disease is a progressive myoclonus epilepsy with onset typically in the second decade of life and death within 10 years."( Delgado-Escueta, AV; Depaoli-Roach, AA; Girard, JM; Minassian, BA; Roach, PJ; Skurat, AV; Tagliabracci, VS; Turnbull, J; Wang, W; Zhao, X, 2007)
"Lafora disease is a progressive myoclonus epilepsy with onset in the teenage years followed by neurodegeneration and death within 10 years."( Depaoli-Roach, AA; Girard, JM; Meyer, C; Minassian, BA; Roach, PJ; Segvich, D; Tagliabracci, VS; Turnbull, J; Zhao, X, 2008)
"Lafora progressive myoclonus epilepsy is a fatal neurodegenerative disorder caused by defects in the function of at least two proteins: laforin, a dual-specificity protein phosphatase, and malin, an E3-ubiquitin ligase."( Hardie, DG; Knecht, E; Moreno, D; Sanz, P; Towler, MC, 2010)
"Lafora disease is caused by deficiency of either the laforin glycogen phosphatase or the malin E3 ubiquitin ligase."( Ackerley, CA; Draginov, AG; Girard, JM; Kameka, AP; Minassian, BA; Pencea, N; Ruggieri, A; Turnbull, J; Wang, P; Wang, TJ; Zhao, X, 2010)
"Lafora disease is a fatal autosomal recessive form of progressive myoclonus epilepsy."( Baulac, S; Couarch, P; Depienne, C; Dulac, O; Fedirko, E; Gataullina, S; Gourfinkel-An, I; Leguern, E; Lesca, G; Sanz, P; Steschenko, D; Trouillard, O; Vernia, S, 2011)
"Lafora disease is one of the rare, most fatal progressive myoclonic epilepsies reported."( Ehtesham, Z; Hashmi, M; Mustafa, MS; Saleem, F; Sheerani, M; Siddiqui, K, 2010)
"Lafora disease is a rare yet invariably fatal form of progressive neurodegenerative epilepsy resulting from mutations in the phosphatase laforin."( Delgado-Escueta, AV; Gentry, MS; Johnson, MB; Sherwood, AR, 2013)
"Lafora disease is a fatal neurodegenerative condition characterized by the accumulation of abnormal glycogen inclusions known as Lafora bodies."( Delgado-García, JM; Duran, J; García-Rocha, M; Gruart, A; Guinovart, JJ, 2014)
"Lafora disease is likely caused by over-accumulation of abnormal glycogen in insoluble deposits termed Lafora bodies in neurons."( Roach, PJ, 2015)
"Lafora disease is caused by loss-of-function mutations in either the EPM2A or EPM2B genes."( Sánchez, MP; Sánchez-Elexpuru, G; Serratosa, JM, 2017)
"Lafora disease is a severe, autosomal recessive, progressive myoclonus epilepsy."( Ahonen, SJ; Minassian, BA; Mitra, S; Nitschke, F; Nitschke, S, 2018)
"Lafora disease is a fatal neurodegenerative epilepsy caused by aggregates of long-chained, and as a result insoluble, glycogen, termed Lafora bodies (LBs)."( Israelian, L; Lee, JPY; Minassian, BA; Nitschke, F; Nitschke, S; Perri, AM; Verhalen, B; Wang, P; Zhao, X, 2021)
"Lafora disease is an autosomal recessive lysosomal storage disorder leading to an accumulation of toxic glycogen bodies into the cells of the central nervous system and other tissues."( Bart, K; Deutschland, M; Gruber, AD; Kershaw, O, 2020)
"Lafora disease is a severe late childhood onset progressive myoclonus epilepsy."( Dear, M; Guisso, DR; Gumusgoz, E; Kasiri, S; Minassian, BA; Mitra, S; Nitschke, F; Nitschke, S; Verhalen, B; Wu, J, 2021)
"Lafora disease is a rare genetic disorder involving glycogen metabolism disorder."( Bejiqi, R; Gerguri, A; Maloku, A; Maxharaj, J; Mustafa, A; Ratkoceri, R; Shahini, L; Zeka, N; Zogaj, L, 2022)
"Lafora disease is a fatal form of progressive myoclonic epilepsy caused by mutations in the EPM2A or NHLRC1/EPM2B genes that usually appears during adolescence."( Burgos, DF; Giráldez, BG; González-Fernández, J; Iglesias-Cabeza, N; Machío-Castello, M; Sánchez, MP; Sánchez-Martín, G; Serratosa, JM, 2023)
"Lafora disease is a rare disorder caused by loss of function mutations in either the EPM2A or NHLRC1 gene."( Duran, J, 2023)

Context

ExcerptReference
"Patients with Lafora disease have a mutation in EPM2A or EPM2B, resulting in dysregulation of glycogen metabolism throughout the body and aberrant glycogen molecules that aggregate into Lafora bodies."( Bruntz, RC; Burke, SN; Clarke, HA; Coburn, PT; Donohue, KJ; Fitzsimmons, B; Gentry, MS; Griffith, LE; Klier, J; Kordasiewisz, HB; Markussen, KH; Maurer, AP; Minassian, BA; Sanders, W; Sun, RC; Young, LEA, 2023)

Treatment

ExcerptReference
"Several therapeutic options for Lafora disease patients are currently being explored, and these therapies would benefit from a biochemical means of assessing functional laforin activity following treatment."( Delgado-Escueta, AV; Gentry, MS; Johnson, MB; Sherwood, AR, 2013)

Research

Studies (114)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's2 (1.75)12.5806
2000's22 (19.30)18.1394
2010's60 (52.63)28.8240
2020's30 (26.32)9.53
DrugIndicatedRelationship StrengthStudiesTrials
choline0low20
4-nitrophenylphosphate0low30
creatine0low10
phosphorylethanolamine0low10
selenic acid0low10
carbamazepine0low10
valproic acid0low20
erythrosine0low10
memantine0low10
metformin0low60
phenobarbital0low10
4-phenylbutyric acid0low20
piracetam0low20
propranolol0low10
zonisamide0low20
pentylenetetrazole0low30
serine0low10
aspartic acid0low20
glutamine0low10
lysine0low10
adenosine monophosphate0low10
trehalose0low30
uridine diphosphate glucose0low10
catechin0low10
isoxazoles0low10
kainic acid0low10
malachite green0low10
acetylcysteine0low20
c.i. 425100low10
gold0low10
4-methoxyamphetamine0low10
glutamic acid0low20
epigallocatechin gallate0low10
n-acetylaspartic acid0low10
fluorodeoxyglucose f180low20
fibrinogen0low10
foxes0low10
leupeptins0low20
glycogen0medium720
glucosamine0low10
maltohexaose0low10
resveratrol0low10
benzyloxycarbonylleucyl-leucyl-leucine aldehyde0low20
levetiracetam0low30
sirolimus0low10
geldanamycin0low10
lactacystin0low10
perampanel0medium21
3-o-methylfluorescein phosphate0low10
quetiapine fumarate0low10
minocycline0low10
nitrophenols0low30
exudates0low10
eye0low10
leptin0low10

Protein Targets (1,121)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0112
5-hydroxytryptamine receptor 2A0112
5-hydroxytryptamine receptor 1A0529
5-hydroxytryptamine receptor 1B0516
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 2B0112
5-hydroxytryptamine receptor 60011
Sodium-dependent serotonin transporter0415
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
5-hydroxytryptamine receptor 4 0011
5-hydroxytryptamine receptor 3B0011
Protein-tyrosine-phosphatase 0001
Carbonic anhydrase 106011
Carbonic anhydrase 206112
Carbonic anhydrase 30304
Proto-oncogene tyrosine-protein kinase Src0213
Receptor-type tyrosine-protein phosphatase beta0001
Serum paraoxonase/arylesterase 10101
Carbonic anhydrase 70305
Tyrosine-protein phosphatase non-receptor type 50001
Carbonic anhydrase 130103
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE9009
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
mitogen-activated protein kinase 12002
survival motor neuron protein isoform d5005
Histone deacetylase 30505
Histone deacetylase 40505
Histone deacetylase 10505
Histone deacetylase 70505
Histone deacetylase 20505
Polyamine deacetylase HDAC100404
Histone deacetylase 11 0404
Histone deacetylase 80505
NAD-dependent protein deacylase sirtuin-5, mitochondrial0202
Histone deacetylase 60505
Histone deacetylase 90505
Histone deacetylase 50505
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, 2-oxoglutarate Oxygenase5005
Chain A, ATP-DEPENDENT DNA HELICASE Q14004
acetylcholinesterase7007
dopamine D1 receptor1001
15-lipoxygenase, partial2002
pregnane X receptor2002
phosphopantetheinyl transferase8008
RAR-related orphan receptor gamma7007
USP1 protein, partial4004
NFKB1 protein, partial1001
Microtubule-associated protein tau6006
Thrombopoietin1001
AR protein120012
regulator of G-protein signaling 46006
glucocorticoid receptor [Homo sapiens]7007
retinoic acid nuclear receptor alpha variant 18008
retinoid X nuclear receptor alpha6006
farnesoid X nuclear receptor6006
estrogen nuclear receptor alpha120012
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
arylsulfatase A8008
euchromatic histone-lysine N-methyltransferase 2190019
Bloom syndrome protein isoform 19009
D(1A) dopamine receptor3003
thyroid hormone receptor beta isoform a6006
thyroid hormone receptor beta isoform 28008
heat shock protein beta-13003
flap endonuclease 14004
geminin130013
peripheral myelin protein 223003
muscarinic acetylcholine receptor M13003
Solute carrier family 22 member 60101
Guanine nucleotide-binding protein G3003
Ataxin-26006
ATP-dependent phosphofructokinase100010
Chain A, Glycogen Phosphorylase B0011
Chain B, Glycogen Phosphorylase B0011
Chain A, ADP-dependent glucokinase0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, phosphodiesterase-nucleotide pyrophosphatase0101
Chain A, GLYCOGEN PHOSPHORYLASE B0011
Chain B, GLYCOGEN PHOSPHORYLASE B0011
Chain A, GLYCOGEN PHOSPHORYLASE B0011
estrogen-related nuclear receptor alpha100010
v-jun sarcoma virus 17 oncogene homolog (avian)5005
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
Mitogen-activated protein kinase kinase kinase 70011
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
5'-AMP-activated protein kinase subunit beta-20011
Transient receptor potential cation channel subfamily M member 20101
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
L-lactate dehydrogenase A chain0112
Adenylate kinase isoenzyme 10001
Fructose-1,6-bisphosphatase 10101
Alkaline phosphatase, tissue-nonspecific isozyme0001
Fructose-1,6-bisphosphatase 10101
2-dehydropantoate 2-reductase0112
Inosine-5'-monophosphate dehydrogenase0101
Cytochrome P450 2C9 0606
Amine oxidase [flavin-containing] B0202
5'-nucleotidase0001
Choline O-acetyltransferase0101
Adenylate kinase 2, mitochondrial0102
GTP:AMP phosphotransferase AK3, mitochondrial0001
Adenosine receptor A10213
Adenylate kinase isoenzyme 1 0102
P2Y purinoceptor 20022
P2Y purinoceptor 10011
P2Y purinoceptor 10011
5'-AMP-activated protein kinase subunit gamma-10033
5'-AMP-activated protein kinase catalytic subunit alpha-20011
Adenylate kinase 2, mitochondrial0012
Glycine--tRNA ligase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10033
Adenosine deaminase-like protein0001
Protease 0112
P2Y purinoceptor 110011
Histamine H3 receptor0101
5'-AMP-activated protein kinase subunit gamma-30011
5'-AMP-activated protein kinase subunit gamma-20022
5'-AMP-activated protein kinase subunit beta-10022
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Ferritin light chain4004
aldehyde dehydrogenase 1 family, member A16006
cytochrome P450 2C19 precursor1001
lethal factor (plasmid)3003
lamin isoform A-delta107007
Metabotropic glutamate receptor 60135
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0001
Glutamate receptor ionotropic, NMDA 1 0729
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Glutamate receptor ionotropic, NMDA 2A 0729
Glutamate receptor ionotropic, NMDA 2B0729
Glutamate receptor ionotropic, NMDA 2C0729
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0003
Glutamate receptor ionotropic, NMDA 2D0729
Glutamate receptor ionotropic, NMDA 3B0729
Carbonic anhydrase 40001
Glutamate receptor ionotropic, NMDA 3A0729
Proteasome subunit beta type-110202
Fumarate hydratase3003
PPM1D protein2002
EWS/FLI fusion protein4004
polyprotein3003
vitamin D3 receptor isoform VDRA3003
Calpain-90101
Proteasome subunit alpha type-70202
Interferon beta6006
Cathepsin B0101
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0314
Aromatase0303
Indoleamine 2,3-dioxygenase 10101
Calpain-2 catalytic subunit0101
Proteasome subunit beta type-10303
Proteasome subunit alpha type-10202
Proteasome subunit alpha type-20202
Proteasome subunit alpha type-30202
Proteasome subunit alpha type-40202
NF-kappa-B inhibitor alpha0011
Proteasome subunit beta type-80202
Proteasome subunit beta type-90202
Proteasome subunit alpha type-50202
Proteasome subunit beta type-40202
Proteasome subunit beta type-60202
Proteasome subunit beta type-50404
Proteasome subunit beta type-100202
Cathepsin K0101
Proteasome subunit beta type-30202
Proteasome subunit beta type-20303
Proteasome subunit alpha type-60202
Proteasome subunit alpha-type 80202
Proteasome subunit beta type-70202
Gamma-secretase subunit PEN-20101
TDP1 protein120012
GLI family zinc finger 37007
progesterone receptor4004
peroxisome proliferator activated receptor gamma6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 15005
Voltage-dependent calcium channel gamma-2 subunit5005
Cellular tumor antigen p53100010
Glutamate receptor 254211
ATPase family AAA domain-containing protein 54004
Chain A, Beta-lactamase5005
thyroid stimulating hormone receptor2002
pregnane X nuclear receptor4004
IDH15005
nuclear factor erythroid 2-related factor 2 isoform 23003
Vpr1001
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40707
Bile salt export pump0303
Bile salt export pump014014
Albumin0011
Major prion protein0011
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
UDP-glucuronosyltransferase 2B70204
Cytochrome P450 2B60112
Sodium channel protein type 4 subunit alpha0102
Cytochrome P450 2J20303
Potassium voltage-gated channel subfamily H member 20505
Sodium channel protein type 9 subunit alpha0202
Frizzled-80011
Canalicular multispecific organic anion transporter 10707
P2X purinoceptor 40101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
thioredoxin reductase9009
GLS protein9009
peripheral myelin protein 22 isoform 13003
DNA polymerase beta3003
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)3003
DNA polymerase kappa isoform 17007
neuropeptide S receptor isoform A1001
Prostaglandin G/H synthase 1 0101
Arginase 0202
Pancreatic triacylglycerol lipase0101
Prothrombin0123
Prostaglandin G/H synthase 10123
Aldo-keto reductase family 1 member B10606
Carbonic anhydrase 40405
Prostaglandin G/H synthase 10303
Carbonic anhydrase 60405
Sucrase-isomaltase, intestinal0202
Adenosine receptor A11102
Adenosine receptor A2a0101
Prostaglandin G/H synthase 20202
Mu-type opioid receptor0315
Delta-type opioid receptor0315
Kappa-type opioid receptor0315
Xanthine dehydrogenase/oxidase0101
Melatonin receptor type 1A0011
Melatonin receptor type 1B0011
Death-associated protein kinase 10101
Beta-secretase 10202
Prostaglandin G/H synthase 20202
Carbonic anhydrase 30202
Dihydroorotate dehydrogenase 0101
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20103
Solute carrier family 22 member 1 0405
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit alpha-40202
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20202
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-50101
Acetylcholinesterase0303
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0001
Neuronal acetylcholine receptor subunit alpha-60202
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70101
Solute carrier family 22 member 10103
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Solute carrier family 22 member 20102
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10202
apical membrane antigen 1, AMA12002
67.9K protein5005
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Lysine-specific demethylase 4A0101
Hypoxia-inducible factor 1-alpha0011
Methylcytosine dioxygenase TET20101
Deoxyhypusine hydroxylase0101
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10011
Chain A, POLYMERASE PA0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Genome polyprotein 0213
Luciferase5005
hypoxia-inducible factor 1 alpha subunit3003
thioredoxin glutathione reductase2002
nuclear receptor subfamily 1, group I, member 35005
bromodomain adjacent to zinc finger domain 2B3003
thyroid stimulating hormone receptor5005
activating transcription factor 63003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
Histone H2A.x5005
Replicase polyprotein 1ab0112
lysosomal alpha-glucosidase preproprotein2002
galactokinase1001
pyruvate kinase PKM isoform a1001
nuclear factor NF-kappa-B p105 subunit isoform 11012
POsterior Segregation0022
Prostaglandin E synthase0101
Telomerase reverse transcriptase0101
Polycomb protein EED0011
NAD kinase0213
Dihydrofolate reductase0102
Urokinase-type plasminogen activator0101
Tissue-type plasminogen activator0101
Transthyretin0022
Polymerase acidic protein0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Amyloid-beta precursor protein0213
Plasminogen activator inhibitor 10101
Heme oxygenase 1 0101
Urokinase-type plasminogen activator0101
ATP-dependent translocase ABCB108110
Heat shock protein HSP 90-beta0101
Neutrophil elastase0101
72 kDa type IV collagenase0101
Hepatocyte growth factor receptor0213
Matrilysin0202
60 kDa chaperonin0101
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Alpha-amylase 1A 0101
Apoptosis regulator Bcl-20202
Microtubule-associated protein tau0101
60 kDa heat shock protein, mitochondrial0101
Glucose-6-phosphate 1-dehydrogenase0101
Fatty acid synthase0101
CPG DNA methylase0101
Lethal factor0101
Phosphoglycerate mutase 10101
Cannabinoid receptor 10101
Heme oxygenase 20101
Sodium-dependent noradrenaline transporter 0426
DNA (cytosine-5)-methyltransferase 10101
Dipeptidyl peptidase 40303
Cannabinoid receptor 2 0101
Signal transducer and activator of transcription 1-alpha/beta0011
DNA repair protein RAD52 homolog0101
Fatty acid synthase0101
Matrix metalloproteinase-140101
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT60101
Squalene monooxygenase 0101
6-phosphogluconate dehydrogenase, decarboxylating0101
BH3-interacting domain death agonist0101
10 kDa heat shock protein, mitochondrial0101
Disintegrin and metalloproteinase domain-containing protein 170101
Lactoperoxidase0001
Bcl-2-like protein 10202
Induced myeloid leukemia cell differentiation protein Mcl-10101
Histone acetyltransferase p3000101
Alpha-(1,3)-fucosyltransferase 70101
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 10101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0112
Mitogen-activated protein kinase 140112
Bcl-2-related protein A10101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
Sigma non-opioid intracellular receptor 10202
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Reverse transcriptase/RNaseH 0101
10 kDa chaperonin 0101
3-oxoacyl-[acyl-carrier-protein] reductase 0101
MAP kinase-activated protein kinase 50112
CREB-binding protein0101
Histone acetyltransferase KAT2B0101
Bcl-2-like protein 20101
Bcl2-associated agonist of cell death 0101
Histone acetyltransferase KAT50101
Enoyl-acyl-carrier protein reductase 0202
3-oxoacyl-acyl-carrier protein reductase 0101
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)0101
Bcl-2-like protein 100101
Zinc finger protein mex-50022
chaperonin-containing TCP-1 beta subunit homolog2002
SMAD family member 24004
ATAD5 protein, partial4004
SMAD family member 34004
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 43003
G3003
cytochrome P450 2D62002
aryl hydrocarbon receptor2002
thyrotropin-releasing hormone receptor3003
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
eyes absent homolog 2 isoform a1001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
histone acetyltransferase KAT2A isoform 15005
relaxin receptor 1 isoform 11001
HLA class I histocompatibility antigen, B alpha chain 3003
Flavin reductase (NADPH)0011
Inositol hexakisphosphate kinase 13003
cytochrome P450 2C9, partial3003
large T antigen0202
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
glp-1 receptor, partial2002
beta-2 adrenergic receptor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Metabotropic glutamate receptor 80202
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3B0202
Glutathione reductase, mitochondrial0404
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Integrin beta-32013
Integrin alpha-IIb2013
ATP-citrate synthase 0101
Glutamate receptor 10426
Glutamate receptor 30426
Glutamate receptor 40426
Glutamate receptor ionotropic, kainate 10426
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10325
Metabotropic glutamate receptor 50124
Glutamate receptor ionotropic, kainate 20437
Glutamate receptor 10426
Glutamate receptor 20325
Glutamate receptor 30123
Glutamate receptor ionotropic, kainate 30404
Metabotropic glutamate receptor 80011
Glutamate receptor 40314
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, kainate 40404
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10303
Glutamate receptor ionotropic, NMDA 2A0303
Glutamate receptor ionotropic, kainate 20325
Glutamate receptor ionotropic, kainate 30303
Glutamate receptor ionotropic, NMDA 2B0303
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, kainate 50303
Glutamate receptor ionotropic, kainate 50404
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0202
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Glutamine Binding Protein0011
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Neutral amino acid transporter A0202
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0202
Amino acid transporter0202
Chain A, Glutamate receptor 20011
Chain A, Glutamate receptor 20011
Chain C, Glutamate receptor 20011
endonuclease IV1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
chromobox protein homolog 15005
importin subunit beta-1 isoform 11001
snurportin-11001
nuclear receptor ROR-gamma isoform 15005
Glutamate receptor ionotropic, kainate 40101
Splicing factor 3B subunit 30101
Synaptic vesicle glycoprotein 2A0202
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
potassium voltage-gated channel subfamily H member 2 isoform d2002
Cationic amino acid transporter 30101
caspase 7, apoptosis-related cysteine protease3003
estrogen receptor 2 (ER beta)3003
caspase-33003
Caspase-72002
caspase-32002
histone deacetylase 9 isoform 32002
huntingtin isoform 22002
serine/threonine-protein kinase mTOR isoform 13003
Acetylcholinesterase0303
5-hydroxytryptamine receptor 70202
Cholinesterase0303
Multidrug and toxin extrusion protein 10101
Gamma-aminobutyric acid receptor subunit pi2215
ATP-dependent translocase ABCB10101
Cytochrome P450 3A40606
Gamma-aminobutyric acid receptor subunit beta-12215
Translocator protein0202
Gamma-aminobutyric acid receptor subunit delta2215
Gamma-aminobutyric acid receptor subunit gamma-22215
UDP-glucuronosyltransferase 1-60102
Gamma-aminobutyric acid receptor subunit alpha-52215
Gamma-aminobutyric acid receptor subunit alpha-32215
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40102
Gamma-aminobutyric acid receptor subunit gamma-12215
Gamma-aminobutyric acid receptor subunit alpha-22215
Gamma-aminobutyric acid receptor subunit alpha-42215
Gamma-aminobutyric acid receptor subunit gamma-32215
Gamma-aminobutyric acid receptor subunit alpha-62215
UDP-glucuronosyltransferase 2B10 0101
Gamma-aminobutyric acid receptor subunit alpha-12215
Gamma-aminobutyric acid receptor subunit beta-32215
Gamma-aminobutyric acid receptor subunit beta-22215
GABA theta subunit2215
Gamma-aminobutyric acid receptor subunit epsilon2215
Albumin0022
Stromelysin-10101
Multidrug transporter MdfA0101
Matrix metalloproteinase-90101
Protein mono-ADP-ribosyltransferase PARP150101
Protein-arginine deiminase type-40202
transcriptional regulator ERG isoform 32002
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Rap guanine nucleotide exchange factor 42002
Alpha-synuclein3003
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Hsf1 protein0012
M-phase phosphoprotein 83003
Spike glycoprotein1012
Beta-1 adrenergic receptor 0113
Voltage-dependent L-type calcium channel subunit alpha-1C0101
5-hydroxytryptamine receptor 40404
Cytochrome P450 1A20202
Beta-2 adrenergic receptor0213
Muscarinic acetylcholine receptor M20314
Beta-1 adrenergic receptor0415
5-hydroxytryptamine receptor 1A0101
Alpha-2A adrenergic receptor0326
Adenosine receptor A30314
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80101
Cytochrome P450 2D60101
Muscarinic acetylcholine receptor M10314
Beta-3 adrenergic receptor0415
D(2) dopamine receptor0314
Alpha-1B adrenergic receptor0314
Alpha-2B adrenergic receptor0214
Beta-1 adrenergic receptor0214
Alpha-2C adrenergic receptor0124
D(3) dopamine receptor0101
Alpha-2B adrenergic receptor0011
Muscarinic acetylcholine receptor M30314
D(1A) dopamine receptor0314
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Alpha-1D adrenergic receptor0112
Alpha-1D adrenergic receptor0214
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 2A0415
5-hydroxytryptamine receptor 2C0415
Adenosine receptor A2a0314
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
Cytochrome P450 2C190303
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Vasopressin V1a receptor0112
5-hydroxytryptamine receptor 2B0415
Alpha-1A adrenergic receptor0314
5-hydroxytryptamine receptor 60415
Beta-2 adrenergic receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0113
Sigma non-opioid intracellular receptor 10404
Nuclear receptor subfamily 2 group E member 10022
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
BRCA11001
ClpP1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
Parkin1001
P531001
peroxisome proliferator-activated receptor delta2002
pyruvate kinase1001
M18 aspartyl aminopeptidase0101
cathepsin L10101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
hexokinase-4 isoform 11001
NPC intracellular cholesterol transporter 1 precursor2002
cellular tumor antigen p53 isoform a2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
glucokinase regulatory protein1001
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A2002
FAD-linked sulfhydryl oxidase ALR0001
Vif0101
cytochrome P450 3A4 isoform 12002
muscleblind-like protein 1 isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
transcription factor p65 isoform 10011
serine/threonine-protein kinase 33 isoform a0011
Aryl hydrocarbon receptor0101
Estrogen receptor beta0011
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Polyphenol oxidase 20101
Carbonic anhydrase 120304
Lysine-specific histone demethylase 1A0101
Transient receptor potential cation channel subfamily A member 10112
Tyrosine-protein kinase ABL10113
Myc proto-oncogene protein0102
Estrogen receptor0315
Cytochrome P450 1A10101
Tyrosine-protein kinase Lck0213
Cholinesterase0101
Cathepsin D0101
Luciferin 4-monooxygenase0101
DNA polymerase alpha catalytic subunit0101
Polyunsaturated fatty acid 5-lipoxygenase0303
Leukotriene A-4 hydrolase0101
Breakpoint cluster region protein0113
Tyrosinase0202
Ornithine decarboxylase0101
Tyrosinase0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0224
Protein kinase C alpha type0123
Tyrosine-protein phosphatase non-receptor type 10101
Estrogen receptor0011
Nuclear factor NF-kappa-B p105 subunit0101
Amine oxidase [flavin-containing] A0101
Endothelin receptor type B1001
Endothelin-1 receptor1001
Amine oxidase [flavin-containing] B0202
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10101
Nitric oxide synthase, inducible0101
Carbonic anhydrase 5A, mitochondrial0315
Cannabinoid receptor 10101
Histamine H2 receptor2002
D(1A) dopamine receptor2002
Nuclear receptor ROR-gamma2002
Alpha-glucosidase MAL120101
Inositol monophosphatase 11001
Nuclear factor NF-kappa-B p100 subunit 0101
Squalene synthase0101
Transcription factor p650101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0001
Serine/threonine-protein kinase PAK 10101
Nuclear factor erythroid 2-related factor 20012
Cytochrome P450 1B10202
Carbonic anhydrase 90304
N1L 0101
NAD(P)H dehydrogenase [quinone] 10002
Tubulin beta-2B chain0101
Lysosomal alpha-glucosidase0101
Transient receptor potential cation channel subfamily A member 10101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
NAD-dependent protein deacetylase sirtuin-20011
Carbonic anhydrase 130303
NAD-dependent protein deacetylase sirtuin-10013
Carbonic anhydrase 150202
Prenyltransferase homolog0001
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Carbonic anhydrase 140304
Carbonic anhydrase 5B, mitochondrial0304
Pyruvate kinase PKM0011
Smad31001
Bone morphogenetic protein receptor type-1B0011
Cell division cycle 7-related protein kinase0011
Serine/threonine-protein kinase PLK40011
ATP-dependent RNA helicase DDX3X0011
Pyridoxal kinase0011
Citron Rho-interacting kinase0011
Serine/threonine-protein kinase Chk10011
Aurora kinase A0011
Cyclin-G-associated kinase0011
Ephrin type-B receptor 60011
Peroxisomal acyl-coenzyme A oxidase 30011
Receptor-interacting serine/threonine-protein kinase 20011
Mitotic checkpoint serine/threonine-protein kinase BUB10011
Dynamin-like 120 kDa protein, mitochondrial0011
Tyrosine-protein kinase JAK20011
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20011
Serine/threonine-protein kinase ULK10011
Serine/threonine-protein kinase/endoribonuclease IRE10011
Nuclear receptor subfamily 1 group I member 20011
Ribosomal protein S6 kinase alpha-50011
U5 small nuclear ribonucleoprotein 200 kDa helicase0011
Ribosomal protein S6 kinase alpha-40011
Serine/threonine-protein kinase 160011
Cyclin-dependent kinase-like 50011
Serine/threonine-protein kinase 100011
Serine/threonine-protein kinase D30112
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60011
Mitogen-activated protein kinase kinase kinase kinase 40011
Serine/threonine-protein kinase LATS10011
Serine/threonine-protein kinase PAK 40011
Epidermal growth factor receptor0112
High affinity nerve growth factor receptor0011
ADP/ATP translocase 20011
Protein kinase C beta type0112
Insulin receptor0011
Tyrosine-protein kinase Fyn0112
Cyclin-dependent kinase 10011
Eukaryotic translation initiation factor 4E0011
Glycogen phosphorylase, liver form0011
Tyrosine-protein kinase Fes/Fps0011
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0011
Tyrosine-protein kinase Lyn0011
Proto-oncogene tyrosine-protein kinase receptor Ret0011
Insulin-like growth factor 1 receptor0011
Signal recognition particle receptor subunit alpha0011
Cytochrome c1, heme protein, mitochondrial0011
Tyrosine-protein kinase HCK0011
Platelet-derived growth factor receptor beta0011
Tyrosine-protein kinase Fgr0011
Serine/threonine-protein kinase A-Raf0011
Glycogen phosphorylase, brain form0011
Serine/threonine-protein kinase pim-10011
Fibroblast growth factor receptor 10011
DNA topoisomerase 2-alpha0011
Cyclin-dependent kinase 40011
ADP/ATP translocase 30011
Inosine-5'-monophosphate dehydrogenase 20011
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Serine/threonine-protein kinase B-raf0011
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0011
Tyrosine-protein kinase Fer0011
cAMP-dependent protein kinase catalytic subunit alpha0011
General transcription and DNA repair factor IIH helicase subunit XPD0011
Casein kinase II subunit alpha'0011
Ras-related protein Rab-6A0011
Ephrin type-A receptor 10011
Multifunctional protein ADE20011
cAMP-dependent protein kinase catalytic subunit beta0011
Ferrochelatase, mitochondrial0011
Ribosomal protein S6 kinase beta-10011
Tyrosine-protein kinase JAK10011
Cyclin-dependent kinase 20011
Beta-adrenergic receptor kinase 10011
Probable ATP-dependent RNA helicase DDX60011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Mitogen-activated protein kinase 3 0011
MAP/microtubule affinity-regulating kinase 30011
Deoxycytidine kinase0011
Mitogen-activated protein kinase 10011
Ephrin type-A receptor 20011
Ephrin type-B receptor 20011
Non-receptor tyrosine-protein kinase TYK20011
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0011
Heme oxygenase 20011
S-adenosylmethionine synthase isoform type-20011
DnaJ homolog subfamily A member 10011
RAC-alpha serine/threonine-protein kinase0011
RAC-beta serine/threonine-protein kinase0011
Dual specificity protein kinase TTK0011
DNA replication licensing factor MCM40011
Myosin-100011
Dual specificity mitogen-activated protein kinase kinase 20011
Receptor-type tyrosine-protein kinase FLT30011
Bone morphogenetic protein receptor type-1A0011
Activin receptor type-1B0011
TGF-beta receptor type-10011
Serine/threonine-protein kinase receptor R30011
TGF-beta receptor type-20011
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0011
Glycine--tRNA ligase0011
Protein kinase C iota type0112
Exosome RNA helicase MTR40011
Serine/threonine-protein kinase mTOR0112
Tyrosine-protein kinase Tec0011
Tyrosine-protein kinase ABL20011
Tyrosine-protein kinase FRK0011
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase SYK0011
26S proteasome regulatory subunit 6B0011
Mitogen-activated protein kinase 80011
Mitogen-activated protein kinase 90011
Dual specificity mitogen-activated protein kinase kinase 30011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform alpha0011
Casein kinase I isoform delta0011
MAP kinase-activated protein kinase 20011
Elongation factor Tu, mitochondrial0011
Choline-phosphate cytidylyltransferase A0011
Cysteine--tRNA ligase, cytoplasmic0011
Casein kinase I isoform epsilon0011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0011
Dual specificity protein kinase CLK10011
Dual specificity protein kinase CLK20011
Dual specificity protein kinase CLK30011
Glycogen synthase kinase-3 alpha0011
Glycogen synthase kinase-3 beta0011
Cyclin-dependent kinase 70011
Cyclin-dependent kinase 90011
Ras-related protein Rab-27A0011
Interleukin-1 receptor-associated kinase 10011
Ribosomal protein S6 kinase alpha-30011
Serine/threonine-protein kinase Nek20011
Serine/threonine-protein kinase Nek30011
Dual specificity mitogen-activated protein kinase kinase 60011
Serine/threonine-protein kinase PLK10011
LIM domain kinase 10011
LIM domain kinase 20011
Mitogen-activated protein kinase 100011
Tyrosine--tRNA ligase, cytoplasmic0011
Ephrin type-B receptor 30011
Ephrin type-A receptor 50011
Ephrin type-B receptor 40011
Ephrin type-A receptor 40011
Adenosine kinase0011
Ras-related protein Rab-100011
Actin-related protein 30011
Actin-related protein 20011
GTP-binding nuclear protein Ran0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Casein kinase I isoform gamma-20011
Cyclin-dependent kinase 60011
Cyclin-dependent-like kinase 5 0011
Cyclin-dependent kinase 160011
Cyclin-dependent kinase 170011
ATP-dependent 6-phosphofructokinase, platelet type0011
Dual specificity mitogen-activated protein kinase kinase 10011
DNA topoisomerase 2-beta0011
Protein kinase C theta type0112
Activin receptor type-10011
Macrophage-stimulating protein receptor0011
Focal adhesion kinase 10011
Protein kinase C zeta type0112
Protein kinase C delta type0112
Tyrosine-protein kinase BTK0011
Cyclin-dependent kinase 180011
Activated CDC42 kinase 10011
Epithelial discoidin domain-containing receptor 10011
Mitogen-activated protein kinase kinase kinase kinase 20011
Tyrosine-protein kinase Mer0011
Serine/threonine-protein kinase 40011
Dual specificity mitogen-activated protein kinase kinase 50011
Mitogen-activated protein kinase 70011
Serine/threonine-protein kinase PAK 20011
Serine/threonine-protein kinase 30011
Mitogen-activated protein kinase kinase kinase 10011
Integrin-linked protein kinase0011
Peptidyl-prolyl cis-trans isomerase FKBP50101
Rho-associated protein kinase 10011
Non-receptor tyrosine-protein kinase TNK10011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0011
Calcium/calmodulin-dependent protein kinase type II subunit delta0011
Activin receptor type-2B0011
Bone morphogenetic protein receptor type-20011
Protein-tyrosine kinase 60011
cGMP-dependent protein kinase 1 0011
Cyclin-dependent kinase 130011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0011
Protein-tyrosine kinase 2-beta0011
Maternal embryonic leucine zipper kinase0011
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40011
Peroxisomal acyl-coenzyme A oxidase 10011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10011
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0011
Mitogen-activated protein kinase 110011
Serine/threonine-protein kinase STK110011
Serine/threonine-protein kinase N10011
Serine/threonine-protein kinase N20011
Calcium/calmodulin-dependent protein kinase type IV0011
Mitogen-activated protein kinase kinase kinase 110011
Discoidin domain-containing receptor 20011
AP2-associated protein kinase 10011
Myosin light chain kinase 30011
Uncharacterized aarF domain-containing protein kinase 50011
Programmed cell death protein 40011
Putative heat shock protein HSP 90-beta 20011
Serine/threonine-protein kinase MRCK alpha0011
Serine/threonine-protein kinase MRCK gamma0011
Acyl-CoA dehydrogenase family member 100011
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30011
Uncharacterized protein FLJ452520011
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20011
Serine/threonine-protein kinase MARK20011
ATP-dependent RNA helicase DHX300011
Serine/threonine-protein kinase TAO10011
STE20-related kinase adapter protein alpha0011
Myosin-140011
AarF domain-containing protein kinase 10011
Mitogen-activated protein kinase kinase kinase kinase 30011
Regulatory-associated protein of mTOR0101
Misshapen-like kinase 10011
Atypical kinase COQ8A, mitochondrial0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase 150011
Serine/threonine-protein kinase Nek90011
ATP-dependent RNA helicase DDX10011
Mitogen-activated protein kinase kinase kinase kinase 10011
Aurora kinase B0011
MAP/microtubule affinity-regulating kinase 40011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase Nek10011
PAS domain-containing serine/threonine-protein kinase0011
Calcium/calmodulin-dependent protein kinase kinase 20011
EKC/KEOPS complex subunit TP53RK0011
Dual specificity testis-specific protein kinase 20011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0011
Mitogen-activated protein kinase kinase kinase 50011
Mitogen-activated protein kinase kinase kinase 30011
Eukaryotic translation initiation factor 2-alpha kinase 10011
Target of rapamycin complex subunit LST80101
Nucleolar GTP-binding protein 10011
Serine/threonine-protein kinase D20011
RNA cytidine acetyltransferase0011
Serine/threonine-protein kinase SIK20011
STE20-like serine/threonine-protein kinase 0011
Serine/threonine-protein kinase TAO30011
dCTP pyrophosphatase 10011
Dual specificity protein kinase CLK40011
Casein kinase I isoform gamma-10011
Serine/threonine-protein kinase mTOR 0101
Phenylalanine--tRNA ligase beta subunit0011
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0011
Obg-like ATPase 10011
Midasin0011
Interleukin-1 receptor-associated kinase 40011
Mitogen-activated protein kinase kinase kinase 200011
Cyclin-dependent kinase 120011
Serine/threonine-protein kinase 260011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0011
Serine/threonine-protein kinase NLK0011
Serine/threonine-protein kinase TBK10011
Septin-90011
Ribosomal protein S6 kinase alpha-60011
TRAF2 and NCK-interacting protein kinase0011
Serine/threonine-protein kinase TAO20011
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Serine/threonine-protein kinase ICK0011
RAC-gamma serine/threonine-protein kinase0011
Serine/threonine-protein kinase SIK30011
Mitogen-activated protein kinase kinase kinase 20011
Thyroid hormone receptor-associated protein 30011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Mitogen-activated protein kinase kinase kinase kinase 50011
Receptor-interacting serine/threonine-protein kinase 30011
Serine/threonine-protein kinase MRCK beta0011
Interleukin-1 receptor-associated kinase 30011
Serine/threonine-protein kinase 240011
Solute carrier organic anion transporter family member 1B10101
Casein kinase I isoform gamma-30011
Mitogen-activated protein kinase kinase kinase 40011
Chain A, CES1 protein0101
DNA polymerase III, partial1001
glucocerebrosidase1001
Spike glycoprotein0011
cytochrome P450 2D6 isoform 11001
interferon gamma precursor0001
ubiquitin-conjugating enzyme E2 N0101
streptokinase A precursor0011
Transmembrane protease serine 20011
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Estrogen receptor0012
Progesterone receptor0101
Procathepsin L0011
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Androgen receptor0202
Substance-K receptor0202
D(4) dopamine receptor0202
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Histamine H2 receptor0202
Substance-P receptor0202
B2 bradykinin receptor0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
D(3) dopamine receptor0202
Melanocortin receptor 30202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Sodium-dependent dopamine transporter 0202
Protein kinase C epsilon type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Estrogen receptor beta0213
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with trehalose0101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with cellobiose0101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with maltose0101
Trehalose-phosphatase0101
P2Y purinoceptor 60011
P2Y purinoceptor 140011
Cocaine esterase0101
UDP-glucuronosyltransferase 1A90001
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Prolyl endopeptidase0101
Carbonic anhydrase 20101
Arachidonate 5-lipoxygenase-activating protein0101
Sodium-dependent dopamine transporter0101
Delta-type opioid receptor0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Carbonic anhydrase0101
D(2) dopamine receptor0101
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Carbonic anhydrase 0101
Amine oxidase [flavin-containing]0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]