Epilepsy Progressive Myoclonic 2

A form of stimulus sensitive MYOCLONIC EPILEPSY inherited as an autosomal recessive condition. The most common presenting feature is a single seizure in the second decade of life. This is followed by progressive myoclonus, myoclonic seizures, tonic-clonic seizures, focal occipital seizures, intellectual decline, and severe motor and coordination impairments. Most affected individuals do not live past the age of 25 years. Concentric amyloid (Lafora) bodies are found in neurons, liver, skin, bone, and muscle (From Menkes, Textbook of Childhood Neurology, 5th ed, pp111-110).

Synonyms(17)

Synonym
Lafora Body Disorder
Lafora Progressive Myoclonus Epilepsy
Lafora Progressive Myoclonic Epilepsy
Lafora Type Progressive Myoclonic Epilepsy
Late Onset Lafora Body Disease
Lafora-Body Disease, Late Onset
Epilepsy, Progressive Myoclonic 2A
Epilepsy, Progressive Myoclonic, Lafora
Lafora Body Disease
Progressive Myoclonic Epilepsy Type 2
Epilepsy Progressive Myoclonic 2
Progressive Myoclonic Epilepsy, Lafora
Progressive Myoclonic Epilepsy, Lafora Type
Lafora Body Disease, Late Onset
Myoclonic Epilepsy of Lafora
Progressive Myoclonus Epilepsy, Lafora Type
Lafora Disease

Research Excerpts

Overview

Excerpt	Reference
"Lafora disease is a progressive myoclonus epilepsy with an early fatal issue."	( Girard, JM; Lê, KH; Lederer, F, 2006)
"Abstract Lafora progressive myoclonus epilepsy is an autosomal recessive, fatal, generalized polyglucosan storage disorder that occurs in childhood or adolescence with stimulus sensitive epilepsy (resting and action myoclonias, grand mal, and absence), dementia, ataxia and rapid neurologic deterioration."	( Delgado-Escueta, AV, 2007)
"Lafora disease is a progressive myoclonus epilepsy with onset typically in the second decade of life and death within 10 years."	( Delgado-Escueta, AV; Depaoli-Roach, AA; Girard, JM; Minassian, BA; Roach, PJ; Skurat, AV; Tagliabracci, VS; Turnbull, J; Wang, W; Zhao, X, 2007)
"Lafora disease is a progressive myoclonus epilepsy with onset in the teenage years followed by neurodegeneration and death within 10 years."	( Depaoli-Roach, AA; Girard, JM; Meyer, C; Minassian, BA; Roach, PJ; Segvich, D; Tagliabracci, VS; Turnbull, J; Zhao, X, 2008)
"Lafora progressive myoclonus epilepsy is a fatal neurodegenerative disorder caused by defects in the function of at least two proteins: laforin, a dual-specificity protein phosphatase, and malin, an E3-ubiquitin ligase."	( Hardie, DG; Knecht, E; Moreno, D; Sanz, P; Towler, MC, 2010)
"Lafora disease is caused by deficiency of either the laforin glycogen phosphatase or the malin E3 ubiquitin ligase."	( Ackerley, CA; Draginov, AG; Girard, JM; Kameka, AP; Minassian, BA; Pencea, N; Ruggieri, A; Turnbull, J; Wang, P; Wang, TJ; Zhao, X, 2010)
"Lafora disease is a fatal autosomal recessive form of progressive myoclonus epilepsy."	( Baulac, S; Couarch, P; Depienne, C; Dulac, O; Fedirko, E; Gataullina, S; Gourfinkel-An, I; Leguern, E; Lesca, G; Sanz, P; Steschenko, D; Trouillard, O; Vernia, S, 2011)
"Lafora disease is one of the rare, most fatal progressive myoclonic epilepsies reported."	( Ehtesham, Z; Hashmi, M; Mustafa, MS; Saleem, F; Sheerani, M; Siddiqui, K, 2010)
"Lafora disease is a rare yet invariably fatal form of progressive neurodegenerative epilepsy resulting from mutations in the phosphatase laforin."	( Delgado-Escueta, AV; Gentry, MS; Johnson, MB; Sherwood, AR, 2013)
"Lafora disease is a fatal neurodegenerative condition characterized by the accumulation of abnormal glycogen inclusions known as Lafora bodies."	( Delgado-García, JM; Duran, J; García-Rocha, M; Gruart, A; Guinovart, JJ, 2014)
"Lafora disease is likely caused by over-accumulation of abnormal glycogen in insoluble deposits termed Lafora bodies in neurons."	( Roach, PJ, 2015)
"Lafora disease is caused by loss-of-function mutations in either the EPM2A or EPM2B genes."	( Sánchez, MP; Sánchez-Elexpuru, G; Serratosa, JM, 2017)
"Lafora disease is a severe, autosomal recessive, progressive myoclonus epilepsy."	( Ahonen, SJ; Minassian, BA; Mitra, S; Nitschke, F; Nitschke, S, 2018)
"Lafora disease is a fatal neurodegenerative epilepsy caused by aggregates of long-chained, and as a result insoluble, glycogen, termed Lafora bodies (LBs)."	( Israelian, L; Lee, JPY; Minassian, BA; Nitschke, F; Nitschke, S; Perri, AM; Verhalen, B; Wang, P; Zhao, X, 2021)
"Lafora disease is an autosomal recessive lysosomal storage disorder leading to an accumulation of toxic glycogen bodies into the cells of the central nervous system and other tissues."	( Bart, K; Deutschland, M; Gruber, AD; Kershaw, O, 2020)
"Lafora disease is a severe late childhood onset progressive myoclonus epilepsy."	( Dear, M; Guisso, DR; Gumusgoz, E; Kasiri, S; Minassian, BA; Mitra, S; Nitschke, F; Nitschke, S; Verhalen, B; Wu, J, 2021)
"Lafora disease is a rare genetic disorder involving glycogen metabolism disorder."	( Bejiqi, R; Gerguri, A; Maloku, A; Maxharaj, J; Mustafa, A; Ratkoceri, R; Shahini, L; Zeka, N; Zogaj, L, 2022)
"Lafora disease is a fatal form of progressive myoclonic epilepsy caused by mutations in the EPM2A or NHLRC1/EPM2B genes that usually appears during adolescence."	( Burgos, DF; Giráldez, BG; González-Fernández, J; Iglesias-Cabeza, N; Machío-Castello, M; Sánchez, MP; Sánchez-Martín, G; Serratosa, JM, 2023)
"Lafora disease is a rare disorder caused by loss of function mutations in either the EPM2A or NHLRC1 gene."	( Duran, J, 2023)

Context

Excerpt	Reference
"Patients with Lafora disease have a mutation in EPM2A or EPM2B, resulting in dysregulation of glycogen metabolism throughout the body and aberrant glycogen molecules that aggregate into Lafora bodies."	( Bruntz, RC; Burke, SN; Clarke, HA; Coburn, PT; Donohue, KJ; Fitzsimmons, B; Gentry, MS; Griffith, LE; Klier, J; Kordasiewisz, HB; Markussen, KH; Maurer, AP; Minassian, BA; Sanders, W; Sun, RC; Young, LEA, 2023)

Treatment

Excerpt	Reference
"Several therapeutic options for Lafora disease patients are currently being explored, and these therapies would benefit from a biochemical means of assessing functional laforin activity following treatment."	( Delgado-Escueta, AV; Gentry, MS; Johnson, MB; Sherwood, AR, 2013)

Research

Studies (114)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	2 (1.75)	12.5806
2000's	22 (19.30)	18.1394
2010's	60 (52.63)	28.8240
2020's	30 (26.32)	9.53

Drug	Relationship Strength	Studies	Trials
choline	low	2	0
4-nitrophenylphosphate	low	3	0
creatine	low	1	0
phosphorylethanolamine	low	1	0
selenic acid	low	1	0
carbamazepine	low	1	0
valproic acid	low	2	0
erythrosine	low	1	0
memantine	low	1	0
metformin	low	6	0
phenobarbital	low	1	0
4-phenylbutyric acid	low	2	0
piracetam	low	2	0
propranolol	low	1	0
zonisamide	low	2	0
pentylenetetrazole	low	3	0
serine	low	1	0
aspartic acid	low	2	0
glutamine	low	1	0
lysine	low	1	0
adenosine monophosphate	low	1	0
trehalose	low	3	0
uridine diphosphate glucose	low	1	0
catechin	low	1	0
isoxazoles	low	1	0
kainic acid	low	1	0
malachite green	low	1	0
acetylcysteine	low	2	0
c.i. 42510	low	1	0
gold	low	1	0
4-methoxyamphetamine	low	1	0
glutamic acid	low	2	0
epigallocatechin gallate	low	1	0
n-acetylaspartic acid	low	1	0
fluorodeoxyglucose f18	low	2	0
fibrinogen	low	1	0
foxes	low	1	0
leupeptins	low	2	0
glycogen	medium	72	0
glucosamine	low	1	0
maltohexaose	low	1	0
resveratrol	low	1	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	low	2	0
levetiracetam	low	3	0
sirolimus	low	1	0
geldanamycin	low	1	0
lactacystin	low	1	0
perampanel	medium	2	1
3-o-methylfluorescein phosphate	low	1	0
quetiapine fumarate	low	1	0
minocycline	low	1	0
nitrophenols	low	3	0
exudates	low	1	0
eye	low	1	0
leptin	low	1	0

Protein Targets (1,121)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	1	1	2
5-hydroxytryptamine receptor 2A	0	1	1	2
5-hydroxytryptamine receptor 1A	0	5	2	9
5-hydroxytryptamine receptor 1B	0	5	1	6
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	1	1	2
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	4	1	5
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Protein-tyrosine-phosphatase	0	0	0	1
Carbonic anhydrase 1	0	6	0	11
Carbonic anhydrase 2	0	6	1	12
Carbonic anhydrase 3	0	3	0	4
Proto-oncogene tyrosine-protein kinase Src	0	2	1	3
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Carbonic anhydrase 7	0	3	0	5
Tyrosine-protein phosphatase non-receptor type 5	0	0	0	1
Carbonic anhydrase 13	0	1	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
mitogen-activated protein kinase 1	2	0	0	2
survival motor neuron protein isoform d	5	0	0	5
Histone deacetylase 3	0	5	0	5
Histone deacetylase 4	0	5	0	5
Histone deacetylase 1	0	5	0	5
Histone deacetylase 7	0	5	0	5
Histone deacetylase 2	0	5	0	5
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	4	0	4
Histone deacetylase 8	0	5	0	5
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
Histone deacetylase 6	0	5	0	5
Histone deacetylase 9	0	5	0	5
Histone deacetylase 5	0	5	0	5
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
acetylcholinesterase	7	0	0	7
dopamine D1 receptor	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	2	0	0	2
phosphopantetheinyl transferase	8	0	0	8
RAR-related orphan receptor gamma	7	0	0	7
USP1 protein, partial	4	0	0	4
NFKB1 protein, partial	1	0	0	1
Microtubule-associated protein tau	6	0	0	6
Thrombopoietin	1	0	0	1
AR protein	12	0	0	12
regulator of G-protein signaling 4	6	0	0	6
glucocorticoid receptor [Homo sapiens]	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
retinoid X nuclear receptor alpha	6	0	0	6
farnesoid X nuclear receptor	6	0	0	6
estrogen nuclear receptor alpha	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
arylsulfatase A	8	0	0	8
euchromatic histone-lysine N-methyltransferase 2	19	0	0	19
Bloom syndrome protein isoform 1	9	0	0	9
D(1A) dopamine receptor	3	0	0	3
thyroid hormone receptor beta isoform a	6	0	0	6
thyroid hormone receptor beta isoform 2	8	0	0	8
heat shock protein beta-1	3	0	0	3
flap endonuclease 1	4	0	0	4
geminin	13	0	0	13
peripheral myelin protein 22	3	0	0	3
muscarinic acetylcholine receptor M1	3	0	0	3
Solute carrier family 22 member 6	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Ataxin-2	6	0	0	6
ATP-dependent phosphofructokinase	10	0	0	10
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
estrogen-related nuclear receptor alpha	10	0	0	10
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
2-dehydropantoate 2-reductase	0	1	1	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Cytochrome P450 2C9	0	6	0	6
Amine oxidase [flavin-containing] B	0	2	0	2
5'-nucleotidase	0	0	0	1
Choline O-acetyltransferase	0	1	0	1
Adenylate kinase 2, mitochondrial	0	1	0	2
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
Adenosine receptor A1	0	2	1	3
Adenylate kinase isoenzyme 1	0	1	0	2
P2Y purinoceptor 2	0	0	2	2
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	3	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	2
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	3	3
Adenosine deaminase-like protein	0	0	0	1
Protease	0	1	1	2
P2Y purinoceptor 11	0	0	1	1
Histamine H3 receptor	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	2	2
5'-AMP-activated protein kinase subunit beta-1	0	0	2	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Ferritin light chain	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
cytochrome P450 2C19 precursor	1	0	0	1
lethal factor (plasmid)	3	0	0	3
lamin isoform A-delta10	7	0	0	7
Metabotropic glutamate receptor 6	0	1	3	5
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	7	2	9
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	7	2	9
Glutamate receptor ionotropic, NMDA 2B	0	7	2	9
Glutamate receptor ionotropic, NMDA 2C	0	7	2	9
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	7	2	9
Glutamate receptor ionotropic, NMDA 3B	0	7	2	9
Carbonic anhydrase 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	7	2	9
Proteasome subunit beta type-11	0	2	0	2
Fumarate hydratase	3	0	0	3
PPM1D protein	2	0	0	2
EWS/FLI fusion protein	4	0	0	4
polyprotein	3	0	0	3
vitamin D3 receptor isoform VDRA	3	0	0	3
Calpain-9	0	1	0	1
Proteasome subunit alpha type-7	0	2	0	2
Interferon beta	6	0	0	6
Cathepsin B	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	3	1	4
Aromatase	0	3	0	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Calpain-2 catalytic subunit	0	1	0	1
Proteasome subunit beta type-1	0	3	0	3
Proteasome subunit alpha type-1	0	2	0	2
Proteasome subunit alpha type-2	0	2	0	2
Proteasome subunit alpha type-3	0	2	0	2
Proteasome subunit alpha type-4	0	2	0	2
NF-kappa-B inhibitor alpha	0	0	1	1
Proteasome subunit beta type-8	0	2	0	2
Proteasome subunit beta type-9	0	2	0	2
Proteasome subunit alpha type-5	0	2	0	2
Proteasome subunit beta type-4	0	2	0	2
Proteasome subunit beta type-6	0	2	0	2
Proteasome subunit beta type-5	0	4	0	4
Proteasome subunit beta type-10	0	2	0	2
Cathepsin K	0	1	0	1
Proteasome subunit beta type-3	0	2	0	2
Proteasome subunit beta type-2	0	3	0	3
Proteasome subunit alpha type-6	0	2	0	2
Proteasome subunit alpha-type 8	0	2	0	2
Proteasome subunit beta type-7	0	2	0	2
Gamma-secretase subunit PEN-2	0	1	0	1
TDP1 protein	12	0	0	12
GLI family zinc finger 3	7	0	0	7
progesterone receptor	4	0	0	4
peroxisome proliferator activated receptor gamma	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Cellular tumor antigen p53	10	0	0	10
Glutamate receptor 2	5	4	2	11
ATPase family AAA domain-containing protein 5	4	0	0	4
Chain A, Beta-lactamase	5	0	0	5
thyroid stimulating hormone receptor	2	0	0	2
pregnane X nuclear receptor	4	0	0	4
IDH1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
Vpr	1	0	0	1
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	7
Bile salt export pump	0	3	0	3
Bile salt export pump	0	14	0	14
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	4
Cytochrome P450 2B6	0	1	1	2
Sodium channel protein type 4 subunit alpha	0	1	0	2
Cytochrome P450 2J2	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Sodium channel protein type 9 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	7	0	7
P2X purinoceptor 4	0	1	0	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
thioredoxin reductase	9	0	0	9
GLS protein	9	0	0	9
peripheral myelin protein 22 isoform 1	3	0	0	3
DNA polymerase beta	3	0	0	3
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	3	0	0	3
DNA polymerase kappa isoform 1	7	0	0	7
neuropeptide S receptor isoform A	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Arginase	0	2	0	2
Pancreatic triacylglycerol lipase	0	1	0	1
Prothrombin	0	1	2	3
Prostaglandin G/H synthase 1	0	1	2	3
Aldo-keto reductase family 1 member B1	0	6	0	6
Carbonic anhydrase 4	0	4	0	5
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 6	0	4	0	5
Sucrase-isomaltase, intestinal	0	2	0	2
Adenosine receptor A1	1	1	0	2
Adenosine receptor A2a	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Mu-type opioid receptor	0	3	1	5
Delta-type opioid receptor	0	3	1	5
Kappa-type opioid receptor	0	3	1	5
Xanthine dehydrogenase/oxidase	0	1	0	1
Melatonin receptor type 1A	0	0	1	1
Melatonin receptor type 1B	0	0	1	1
Death-associated protein kinase 1	0	1	0	1
Beta-secretase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Carbonic anhydrase 3	0	2	0	2
Dihydroorotate dehydrogenase	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	3
Solute carrier family 22 member 1	0	4	0	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	3	0	3
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	1	0	3
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	2
apical membrane antigen 1, AMA1	2	0	0	2
67.9K protein	5	0	0	5
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Lysine-specific demethylase 4A	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	0	1	1
Chain A, POLYMERASE PA	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Chain A, Polymerase Pa	0	1	0	1
Genome polyprotein	0	2	1	3
Luciferase	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
thioredoxin glutathione reductase	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
thyroid stimulating hormone receptor	5	0	0	5
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
Histone H2A.x	5	0	0	5
Replicase polyprotein 1ab	0	1	1	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
galactokinase	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	1	2
POsterior Segregation	0	0	2	2
Prostaglandin E synthase	0	1	0	1
Telomerase reverse transcriptase	0	1	0	1
Polycomb protein EED	0	0	1	1
NAD kinase	0	2	1	3
Dihydrofolate reductase	0	1	0	2
Urokinase-type plasminogen activator	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Transthyretin	0	0	2	2
Polymerase acidic protein	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Amyloid-beta precursor protein	0	2	1	3
Plasminogen activator inhibitor 1	0	1	0	1
Heme oxygenase 1	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
ATP-dependent translocase ABCB1	0	8	1	10
Heat shock protein HSP 90-beta	0	1	0	1
Neutrophil elastase	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Hepatocyte growth factor receptor	0	2	1	3
Matrilysin	0	2	0	2
60 kDa chaperonin	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Alpha-amylase 1A	0	1	0	1
Apoptosis regulator Bcl-2	0	2	0	2
Microtubule-associated protein tau	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Fatty acid synthase	0	1	0	1
CPG DNA methylase	0	1	0	1
Lethal factor	0	1	0	1
Phosphoglycerate mutase 1	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Sodium-dependent noradrenaline transporter	0	4	2	6
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Dipeptidyl peptidase 4	0	3	0	3
Cannabinoid receptor 2	0	1	0	1
Signal transducer and activator of transcription 1-alpha/beta	0	0	1	1
DNA repair protein RAD52 homolog	0	1	0	1
Fatty acid synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	1	0	1
Squalene monooxygenase	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
BH3-interacting domain death agonist	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	0	1	0	1
Lactoperoxidase	0	0	0	1
Bcl-2-like protein 1	0	2	0	2
Induced myeloid leukemia cell differentiation protein Mcl-1	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Alpha-(1,3)-fucosyltransferase 7	0	1	0	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	1	2
Mitogen-activated protein kinase 14	0	1	1	2
Bcl-2-related protein A1	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
10 kDa chaperonin	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] reductase	0	1	0	1
MAP kinase-activated protein kinase 5	0	1	1	2
CREB-binding protein	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Bcl-2-like protein 2	0	1	0	1
Bcl2-associated agonist of cell death	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
3-oxoacyl-acyl-carrier protein reductase	0	1	0	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Bcl-2-like protein 10	0	1	0	1
Zinc finger protein mex-5	0	0	2	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
SMAD family member 2	4	0	0	4
ATAD5 protein, partial	4	0	0	4
SMAD family member 3	4	0	0	4
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
G	3	0	0	3
cytochrome P450 2D6	2	0	0	2
aryl hydrocarbon receptor	2	0	0	2
thyrotropin-releasing hormone receptor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
histone acetyltransferase KAT2A isoform 1	5	0	0	5
relaxin receptor 1 isoform 1	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Flavin reductase (NADPH)	0	0	1	1
Inositol hexakisphosphate kinase 1	3	0	0	3
cytochrome P450 2C9, partial	3	0	0	3
large T antigen	0	2	0	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
glp-1 receptor, partial	2	0	0	2
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Integrin beta-3	2	0	1	3
Integrin alpha-IIb	2	0	1	3
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	4	2	6
Glutamate receptor 3	0	4	2	6
Glutamate receptor 4	0	4	2	6
Glutamate receptor ionotropic, kainate 1	0	4	2	6
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	3	2	5
Metabotropic glutamate receptor 5	0	1	2	4
Glutamate receptor ionotropic, kainate 2	0	4	3	7
Glutamate receptor 1	0	4	2	6
Glutamate receptor 2	0	3	2	5
Glutamate receptor 3	0	1	2	3
Glutamate receptor ionotropic, kainate 3	0	4	0	4
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	3	1	4
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	4	0	4
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, kainate 2	0	3	2	5
Glutamate receptor ionotropic, kainate 3	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, kainate 5	0	3	0	3
Glutamate receptor ionotropic, kainate 5	0	4	0	4
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
Chain A, Glutamate receptor 2	0	0	1	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain C, Glutamate receptor 2	0	0	1	1
endonuclease IV	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
chromobox protein homolog 1	5	0	0	5
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	5	0	0	5
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Synaptic vesicle glycoprotein 2A	0	2	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
Cationic amino acid transporter 3	0	1	0	1
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	3	0	0	3
caspase-3	3	0	0	3
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
histone deacetylase 9 isoform 3	2	0	0	2
huntingtin isoform 2	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
Acetylcholinesterase	0	3	0	3
5-hydroxytryptamine receptor 7	0	2	0	2
Cholinesterase	0	3	0	3
Multidrug and toxin extrusion protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	2	2	1	5
ATP-dependent translocase ABCB1	0	1	0	1
Cytochrome P450 3A4	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	2	2	1	5
Translocator protein	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	2	2	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	2	2	1	5
UDP-glucuronosyltransferase 1-6	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	2	1	5
Gamma-aminobutyric acid receptor subunit alpha-3	2	2	1	5
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	2	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	2	2	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	2	2	1	5
Gamma-aminobutyric acid receptor subunit gamma-3	2	2	1	5
Gamma-aminobutyric acid receptor subunit alpha-6	2	2	1	5
UDP-glucuronosyltransferase 2B10	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	2	1	5
Gamma-aminobutyric acid receptor subunit beta-3	2	2	1	5
Gamma-aminobutyric acid receptor subunit beta-2	2	2	1	5
GABA theta subunit	2	2	1	5
Gamma-aminobutyric acid receptor subunit epsilon	2	2	1	5
Albumin	0	0	2	2
Stromelysin-1	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	2	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Alpha-synuclein	3	0	0	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Hsf1 protein	0	0	1	2
M-phase phosphoprotein 8	3	0	0	3
Spike glycoprotein	1	0	1	2
Beta-1 adrenergic receptor	0	1	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Cytochrome P450 1A2	0	2	0	2
Beta-2 adrenergic receptor	0	2	1	3
Muscarinic acetylcholine receptor M2	0	3	1	4
Beta-1 adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2A adrenergic receptor	0	3	2	6
Adenosine receptor A3	0	3	1	4
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	1	4
Beta-3 adrenergic receptor	0	4	1	5
D(2) dopamine receptor	0	3	1	4
Alpha-1B adrenergic receptor	0	3	1	4
Alpha-2B adrenergic receptor	0	2	1	4
Beta-1 adrenergic receptor	0	2	1	4
Alpha-2C adrenergic receptor	0	1	2	4
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Muscarinic acetylcholine receptor M3	0	3	1	4
D(1A) dopamine receptor	0	3	1	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
Alpha-1D adrenergic receptor	0	1	1	2
Alpha-1D adrenergic receptor	0	2	1	4
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 2C	0	4	1	5
Adenosine receptor A2a	0	3	1	4
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Cytochrome P450 2C19	0	3	0	3
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 2B	0	4	1	5
Alpha-1A adrenergic receptor	0	3	1	4
5-hydroxytryptamine receptor 6	0	4	1	5
Beta-2 adrenergic receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Sigma non-opioid intracellular receptor 1	0	4	0	4
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
BRCA1	1	0	0	1
ClpP	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
Parkin	1	0	0	1
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
pyruvate kinase	1	0	0	1
M18 aspartyl aminopeptidase	0	1	0	1
cathepsin L1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
cellular tumor antigen p53 isoform a	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Vif	0	1	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
muscleblind-like protein 1 isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
transcription factor p65 isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
Aryl hydrocarbon receptor	0	1	0	1
Estrogen receptor beta	0	0	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Polyphenol oxidase 2	0	1	0	1
Carbonic anhydrase 12	0	3	0	4
Lysine-specific histone demethylase 1A	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Tyrosine-protein kinase ABL1	0	1	1	3
Myc proto-oncogene protein	0	1	0	2
Estrogen receptor	0	3	1	5
Cytochrome P450 1A1	0	1	0	1
Tyrosine-protein kinase Lck	0	2	1	3
Cholinesterase	0	1	0	1
Cathepsin D	0	1	0	1
Luciferin 4-monooxygenase	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
Leukotriene A-4 hydrolase	0	1	0	1
Breakpoint cluster region protein	0	1	1	3
Tyrosinase	0	2	0	2
Ornithine decarboxylase	0	1	0	1
Tyrosinase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	2	4
Protein kinase C alpha type	0	1	2	3
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Estrogen receptor	0	0	1	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	3	1	5
Cannabinoid receptor 1	0	1	0	1
Histamine H2 receptor	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
Nuclear receptor ROR-gamma	2	0	0	2
Alpha-glucosidase MAL12	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Squalene synthase	0	1	0	1
Transcription factor p65	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	0	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Nuclear factor erythroid 2-related factor 2	0	0	1	2
Cytochrome P450 1B1	0	2	0	2
Carbonic anhydrase 9	0	3	0	4
N1L	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	2
Tubulin beta-2B chain	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	0	1	1
Carbonic anhydrase 13	0	3	0	3
NAD-dependent protein deacetylase sirtuin-1	0	0	1	3
Carbonic anhydrase 15	0	2	0	2
Prenyltransferase homolog	0	0	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Carbonic anhydrase 14	0	3	0	4
Carbonic anhydrase 5B, mitochondrial	0	3	0	4
Pyruvate kinase PKM	0	0	1	1
Smad3	1	0	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	1	1	2
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Epidermal growth factor receptor	0	1	1	2
High affinity nerve growth factor receptor	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	1	1	2
Insulin receptor	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	1	2
Cyclin-dependent kinase 1	0	0	1	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Cyclin-dependent kinase 2	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	1	1	2
Exosome RNA helicase MTR4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	1	2
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenosine kinase	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	1	1	2
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	1	1	2
Protein kinase C delta type	0	1	1	2
Tyrosine-protein kinase BTK	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Serine/threonine-protein kinase ICK	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
glucocerebrosidase	1	0	0	1
Spike glycoprotein	0	0	1	1
cytochrome P450 2D6 isoform 1	1	0	0	1
interferon gamma precursor	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	2
Progesterone receptor	0	1	0	1
Procathepsin L	0	0	1	1
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Androgen receptor	0	2	0	2
Substance-K receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	0	1
Histamine H2 receptor	0	2	0	2
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Protein kinase C epsilon type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Estrogen receptor beta	0	2	1	3
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with trehalose	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with cellobiose	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with maltose	0	1	0	1
Trehalose-phosphatase	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
P2Y purinoceptor 14	0	0	1	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Amine oxidase [flavin-containing]	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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