Inability to experience pleasure due to impairment or dysfunction of normal psychological and neurobiological mechanisms. It is a symptom of many PSYCHOTIC DISORDERS (e.g., DEPRESSIVE DISORDER, MAJOR; and SCHIZOPHRENIA).
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| "Anhedonia is not rare non-motor symptom in Japanese patients with Parkinson's disease." | ( Aizawa, H; Ayabe, M; Hauser, M; Kida, H; Miura, S; Nagasato, K; Nakajima, J; Noda, K; Taniwaki, T, 2012) |
| "Anhedonia is a core symptom of clinical depression." | ( Feng, P; Nocjar, C; Panksepp, J; Zhang, J, 2012) |
| "Anhedonia is a core feature of major depressive disorder (MDD), but the precise nature of anhedonic symptoms is unknown." | ( Bossaller, NA; Shelton, RC; Treadway, MT; Zald, DH, 2012) |
| "Anhedonia is a condition in which the capacity to experience pleasure is totally or partially lost." | ( Di Giannantonio, M; Martinotti, G, 2012) |
| "Anhedonia is characterized by a reduced capacity to experience pleasure in response to rewarding stimuli and has been considered a possible candidate endophenotype in depression and schizophrenia." | ( Cucurell, D; Mallorquí, A; Marco-Pallares, J; Padrão, G; Rodriguez-Fornells, A, 2013) |
| "Anhedonia is the inability to experience pleasure from normally pleasant stimuli." | ( Keller, J; Kelley, E; Levitin, DJ; Menon, V; Prater, K; Young, CB, 2013) |
| "Anhedonia is associated with reward-processing deficits of the dopamine system, which may increase the risk of depression." | ( Chan, RC; Cheung, EF; Li, Z; Liu, WH; Shang, HR; Shen, Y; Wang, LZ, 2014) |
| "Anhedonia is present in Parkinson's Disease (PD) as well as in addictive behaviors." | ( Bentivoglio, AR; Conte, G; De Risio, L; Di Nicola, M; Fasano, A; Janiri, L; Loria, G; Martinotti, G; Pettorruso, M; Ricciardi, L, 2014) |
| "Anhedonia is one of the core symptoms of depression and has been linked to blunted responses to rewarding stimuli in striatal regions." | ( Berghorst, LH; Dutra, SJ; Goer, FK; Greve, DN; Kumar, P; Nickerson, LD; Pizzagalli, DA, 2014) |
| "Anhedonia is a hallmark symptom of major depressive disorder (MDD)." | ( Chan, RC; Cheung, EF; Huang, J; Wang, YF; Xie, GR; Yang, XH; Zhu, CY, 2014) |
| "Anhedonia is a relevant symptom in depression and schizophrenia." | ( De Montis, MG; Ferrari, A; Gambarana, C; Pelliccia, T; Scheggi, S, 2015) |
| "Stress-induced anhedonia is associated with depression vulnerability (Bogdan & Pizzagalli, 2006)." | ( Morris, BH; Rottenberg, J, 2015) |
| "Anhedonia is a cardinal symptom of major depression and is often refractory to standard treatment, yet no approved medication for this specific symptom exists." | ( Lally, N; Luckenbaugh, DA; Niciu, MJ; Nugent, AC; Roiser, JP; Zarate, CA, 2015) |
| "Such stress-related anhedonia is further associated with other depressive symptoms and problematic alcohol use through substance-related coping." | ( Baranger, DA; Bogdan, R; Corral-Frías, NS; Hariri, AR; Michalski, LJ; Nikolova, YS, 2015) |
| "Anhedonia is the reduced ability to experience pleasure." | ( Chin, SC; Harbajan Singh, MK; Hashim, AH; Loh, HS; Ng, CG; Sulaiman, AH; Yee, A, 2015) |
| "Anhedonia is one of the core negative symptoms of schizophrenia that affect the ultimate outcome of this disorder." | ( Chan, RC; Cheung, EF; Huang, J; Lui, SS; Wang, J; Yang, XH, 2015) |
| "Anhedonia is a cardinal feature of major depression and is hypothesized to be driven by low motivation, in particular blunted reward sensitivity." | ( Chan, RCK; Cheung, EFC; Huang, J; Liu, WH; Neumann, DL; Roiser, JP; Shum, DHK; Wang, LZ; Zhu, YH, 2016) |
| "Anhedonia is an important but understudied element of a neuroadaptive model underlying vulnerability to relapse in opioid dependence." | ( Ayaz, H; Bunce, SC; Deneke, E; Harris, JD; Huhn, AS; Meyer, RE; Stankoski, DM, 2016) |
| "Anhedonia is a significant clinical problem in post-traumatic stress disorder (PTSD)." | ( Frijling, JL; Koch, SB; Nawijn, L; Olff, M; van Zuiden, M; Veltman, DJ, 2016) |
| "Anxiety, fear, and anhedonia are mediated by interactions between different deep structures of the temporal lobe (e." | ( Contreras, CM; Guillén-Ruiz, G; Gutiérrez-García, AG; Moreno-Cortés, ML; Romo-González, T, 2016) |
| "Anhedonia is a transdiagnostic symptom underpinned by neurobiochemical disturbances in the reward circuit, yet an objective measure to assess anhedonia severity still eludes the field." | ( Gabbay, V; Goldstein, RZ; Malaker, P; Parvaz, MA, 2016) |
| "Anhedonia is a core feature of the negative symptoms of schizophrenia and is less responsive to antipsychotic medication." | ( Chan, RC; Cheung, EF; Li, HH; Li, X; Lui, SS; Shi, HS; Xiao, YH; Yang, ZY; Zou, LQ, 2016) |
| "Anhedonia is a predictor of poor long-term outcomes, including suicide, and poor treatment response." | ( Craske, MG; Dour, HJ; Meuret, AE; Ritz, T; Treanor, M, 2016) |
| "In contrast, anhedonia is characterized by chronically low motivation and reduced capacity to experience pleasure, and is common to depressive disorders." | ( Beauchaine, TP; Zisner, A, 2016) |
| "Anhedonia is a major public health concern and has proven particularly difficult to counteract." | ( Bos, EH; Heininga, VE; Masselink, M; Oldehinkel, AJ; Van Roekel, E; Vrijen, C, 2017) |
| "Anhedonia is central to multiple psychiatric disorders and causes substantial disability." | ( Bassett, DS; Calkins, ME; Ciric, R; Daldal, A; Davatzikos, C; Elliott, MA; Kable, JW; Katchmar, N; Moore, TM; Ruparel, K; Satterthwaite, TD; Sharma, A; Shinohara, RT; Vandekar, SN; Wolf, DH, 2017) |
| "Anhedonia is a core symptom of social defeat stress (SDS)-induced depression associated with the reward system." | ( Seki, K; Yashiro, S, 2017) |
| "Anhedonia is a core symptom of major depressive disorder (MDD)." | ( Akiyama, Y; Awai, K; Fujii, Y; Ichikawa, N; Kaichi, Y; Minagawa, H; Mori, A; Okada, G; Okamoto, Y; Takaishi, Y; Takamura, M; Toki, S; Yamamoto, T; Yamawaki, S, 2017) |
| "Anhedonia is associated with the dysfunction of VTA-NAc and VTA-OT dopaminergic pathways, the passive coping behavior is related to the dysregulation of VTA-PFC and VTA-AMy pathways, and individual exploratory interest is associated with abnormal activity of VTA-PFC and VTA-ST pathways." | ( Bai, M; Wang, Y; Xue, L; Zhang, L; Zhang, X; Zhang, Y; Zhong, M; Zhu, X, 2017) |
| "Anhedonia is considered a relevant feature in depression and psychosis, characterized by poor treatment outcome, and associated with deficits in mesolimbic dopaminergic responsiveness." | ( De Montis, MG; Gambarana, C; Pelliccia, T; Scheggi, S, 2018) |
| "Anhedonia is modeled in non food-deprived 9-week old male Sprague-Dawley rats by exposing them to a chronic unavoidable stress protocol, consisting in repeated exposure to tail-shock or restrain, which disrupts the motivation to acquire a reward-directed behavior and the competence to escape aversive stimuli." | ( De Montis, MG; Gambarana, C; Pelliccia, T; Scheggi, S, 2018) |
| "Anhedonia is defined as a diminished ability to obtain pleasure from otherwise positive stimuli." | ( Barak, S; Burstein, O; Chen, G; Doron, R; Franko, M; Gale, E; Handelsman, A; Hirshler, Y; Motsan, S; Shamir, A; Simhon, O; Toledano, R, 2017) |
| "Anhedonia is a condition that leads to the loss of feelings pleasure in response to natural reinforcers like food, sex, exercise, and social activities." | ( Badgaiyan, RD; Baron, D; Blum, K; Elman, I; Febo, M; Gold, MS; Modestino, EJ, 2018) |
| "Anhedonia is a core symptom of clinical depression, and is measured in rodents by assessing how they consume a sucrose solution: depressed mice consume less sucrose and the size of their licking bouts when drinking (their 'lick cluster sizes') also tend to be smaller." | ( Clarkson, JM; Dwyer, DM; Flecknell, PA; Leach, MC; Rowe, C, 2018) |
| "Apathy and anhedonia are common syndromes of motivation that are associated with a wide range of brain disorders and have no established therapies." | ( Husain, M; Roiser, JP, 2018) |
| "Anhedonia is the inability to experience pleasure from rewarding or enjoyable activities and is a core symptom of depression in humans." | ( Chen, H; Liu, MY; Luo, CX; Xu, C; Yin, CY; Zhou, QG; Zhu, DY; Zhu, LJ; Zhu, XH, 2018) |
| "Anhedonia is a hallmark symptom in major depression that reflects deficits in hedonic capacity and it is also linked to motivation for reward." | ( Duan, Y; Li, M; Li, Y; Liang, J; Meng, X; Qi, K; Shen, F; Sui, N, 2018) |
| "Anhedonia is associated with multiple forms of psychopathology, yet relatively, little is known about how anhedonia develops." | ( Dirks, MA; Ethridge, P; Sandre, A; Weinberg, A, 2018) |
| "Anhedonia is a symptom of multiple psychiatric conditions in young adults that is associated with poorer mental health and psychosocial function and abnormal ventral striatum reward processing." | ( Aslam, HA; Bebko, G; Bertocci, MA; Chase, HW; Eckstrand, KL; Forbes, EE; Graur, S; Greenberg, T; Lockovich, J; Phillips, ML; Stiffler, R, 2019) |
| "Anhedonia is a core feature of depressive disorders." | ( Alén, F; Díaz-Cabiale, Z; Flores-Burgess, A; Fuxe, K; Gago, B; García-Durán, L; Millón, C; Narváez, JA; Orio, L; Santín, L, 2019) |
| "Anhedonia is a negative symptom, and presumably a trait marker in schizophrenia." | ( Jakšić, N; Jezernik, D; Kosanović Rajačić, B; Kudlek Mikulić, S; Madžarac, Z; Mihaljević-Peleš, A; Pivac, N; Šagud, M; Šimunić, L; Šimunović Filipčić, I; Stefanović, I; Tudor, L; Vuksan-Ćusa, B, 2019) |
| "Anhedonia is an elusive symptom in depression symptomatology." | ( Coccurello, R, 2019) |
| "Anhedonia is a transdiagnostic psychopathological dimension, consisting in the impaired ability to experience pleasure." | ( di Giannantonio, M; Di Giuda, D; Lorusso, M; Martinotti, G; Pettorruso, M; Spano, MC; Zoratto, F, 2019) |
| "Anhedonia is an underexplored condition in neuromodulation trials." | ( di Giannantonio, M; Di Giuda, D; Lorusso, M; Martinotti, G; Pettorruso, M; Spano, MC; Zoratto, F, 2019) |
| "Anticipatory anhedonia is one of the key deficits found in patients with schizophrenia (SCZ)." | ( Chan, RCK; Cheung, EFC; Ettinger, U; Lv, QY; Neumann, D; Shao, YX; Wang, LL; Yan, C; Yi, ZH, 2020) |
| "Anhedonia is an element of depression, but these symptoms can emerge independently in PD." | ( Bono, K; Iguchi, Y; Komatsu, T; Maku, T; Mitsumura, H; Motegi, H; Murakami, H; Nakada, R; Omoto, S; Sakai, K; Sato, T; Shiraishi, T; Takahashi, M; Takatsu, H; Umehara, T, 2020) |
| "Anhedonia is thought to reflect deficits in reward processing that are associated with abnormal activity in mesocorticolimbic brain regions." | ( Arnott, SR; Ceniti, AK; Davis, AD; Downar, J; Dunlop, K; Foster, JA; Frey, BN; Harris, JK; Hassel, S; Kennedy, SH; Lam, RW; MacQueen, GM; Mansouri, F; Milev, R; Parikh, SV; Rizvi, SJ; Rotzinger, S; Schulze, L; Soares, CN; Strother, SC; Turecki, G; Uher, R; Zamyadi, M, 2020) |
| "Anhedonia is a key symptom of major depressive disorder (MDD) and comprises behavioural deficits in three reward processing subtypes: reward liking, reward wanting, and reward learning." | ( Borsini, A; Kempton, MJ; Pariante, CM; Wallis, ASJ; Zunszain, P, 2020) |
| "Anhedonia is a trans-diagnostic, multidimensional phenotype that mediates patient outcomes and suicidality." | ( Cha, DS; Gill, H; Ho, R; Kratiuk, K; Lee, Y; Lin, K; Lipsitz, O; Majeed, A; Mansur, RB; McIntyre, RS; Nasri, F; Phan, L; Rodrigues, NB; Rosenblat, JD; Subramaniapillai, M, 2020) |
| "Anhedonia is a symptom associated with poorer outcomes in depression treatment, including resistance to treatment, higher functional impact and suicidality." | ( Barbosa, MG; Del-Porto, JA; Delfino, RS; Fava, VAR; Lacerda, ALT; Lucchese, AC; Magalhães, E; Nakahira, C; Sant, LCD; Sarin, LM; Steglich, MS; Surjan, J; Tuena, MA, 2021) |
| "Anhedonia is a core characteristic of depression, the amelioration of which accounts for depressive symptom improvement." | ( Bai, T; He, K; Lv, H; Nie, J; Tian, Y; Wang, K; Xie, W; Xie, X; Zhang, T; Zhu, C, 2021) |
| "Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often inadequately treated by traditional antidepressants." | ( Leri, F; Rizvi, SJ; Wang, S, 2021) |
| "Anhedonia is indeed a pathogenetically important clinical phenotype and a promising endophenotype for depressive symptoms with a very high contribution of biological and genetic factors." | ( Kibitov, AO; Mazo, GE, 2021) |
| "Anhedonia is the loss of pleasure or motivation to engage in previously enjoyable activities, and is a transdiagnostic symptom associated with significant clinical impairment." | ( Davis, SW; Pisoni, A; Smoski, M, 2021) |
| "Anhedonia is a prominent characteristic of depression and related pathology that is associated with a prolonged course of mood disturbance and treatment resistance." | ( Geller, WN; Liu, K; Warren, SL, 2021) |
| "Anhedonia is a multidimensional construct." | ( Case, JAC; Forbes, EE; Jacobucci, R; Mattoni, M; Olino, TM; Sullivan-Toole, H, 2022) |
| "Anhedonia is a core feature of psychopathological conditions that have recent exposure to stress and trauma as central to their etiology." | ( Cunningham, S; Harkness, KL; Lamontagne, SJ, 2022) |
| "Anhedonia is frequently observed among individuals with eating disorders (ED), though its relevance to ED pathology and clinical outcomes remain poorly understood." | ( Brown, CS; Kaye, WH; Murray, SM; Wierenga, CE, 2022) |
| "Anhedonia is a common, persistent, and disabling phenomenon in patients with major depressive disorder (MDD) and bipolar depression (BD)." | ( Gu, LM; Lan, XF; Ning, YP; Sun, CH; Wang, CY; Zhang, B; Zheng, W; Zhou, YL, 2022) |
| "Anhedonia is a transdiagnostic construct conceptualized as physical or social, however, the extent to which these subtypes differ across psychotic and mood pathology remains poorly understood." | ( Fulford, D; Gandhi, A; Mote, J, 2022) |
| "Anhedonia is conceptually strongly linked to reward processing, which involves a variety of cognitive and neural operations." | ( Kieslich, K; Roiser, JP; Valton, V, 2022) |
| "Anhedonia is a common, persistent, and disabling condition." | ( Ceban, F; Ho, R; Jasrai, AK; Kim, H; Lui, LMW; McIntyre, RS; Nasri, F; Nogo, D; Rosenblat, JD; Vinberg, M, 2022) |
| "Anhedonia is the core symptom of depression, which largely reflects the therapeutic effect of depression." | ( Chen, QJ; Huang, W; Li, M; Wang, LC; Yao, C; Zhang, Z, 2022) |
| "Anhedonia is a hallmark feature of depression and is highly prevalent among individuals with mood disorders." | ( Pizzagalli, DA; Whitton, AE, 2022) |
| "Anhedonia is the decreased ability to experience pleasure from rewarding or enjoyable activities, a core symptom of depression." | ( Almeida, A; Fonseca-Rodrigues, D; Gonçalves, J; Laranjeira, I; Pinto-Ribeiro, F, 2022) |
| "Anhedonia is a prevalent symptom across many psychiatric disorders." | ( Leri, F; Rizvi, SJ; Wang, S, 2022) |
| "Anhedonia is present in diverse psychiatric disorders and has been linked to reduced neural responses to reward." | ( Banica, I; Racine, SE; Schell, SE; Weinberg, A, 2022) |
| "Anhedonia is a core symptom of depression that predicts worse treatment outcomes." | ( Balkind, EG; Forbes, EE; Israel, ES; Lovell-Smith, N; Lukas, SE; Murray, L; Pastro, B; Pizzagalli, DA; Webb, CA, 2023) |
| "Anhedonia is a core symptom of major depressive disorder (MDD) resulting from maladaptive reward processing." | ( Barbour, T; Camprodon, JA; Cano, M; Ellard, K; Lee, E; Soriano-Mas, C; Worthley, A, 2022) |
| "Anhedonia is a cardinal characteristic of depression which predicts worse treatment outcome and is among the most common residual symptoms following treatment." | ( Forbes, EE; Murray, L; Pizzagalli, DA; Tierney, AO; Webb, CA, 2023) |
| "Social anhedonia is a psychological state with difficulty in experiencing pleasure from social interactions and is observed in various diseases, such as depressive disorders." | ( Chiba, S; Himi, T; Kawaminami, M; Murata, T; Numakawa, T, 2023) |
| "Social anhedonia is a psychological state with difficulty in experiencing pleasure from social interactions and is observed in various diseases, such as depressive disorders." | ( Chiba, S; Himi, T; Kawaminami, M; Murata, T; Numakawa, T, 2023) |
| "Social anhedonia is a psychological state with difficulty in experiencing pleasure from social interactions and is observed in various diseases, such as depressive disorders." | ( Chiba, S; Himi, T; Kawaminami, M; Murata, T; Numakawa, T, 2023) |
| "Anhedonia is hypothesized to be associated with blunted mesocorticolimbic dopamine (DA) functioning in samples with major depressive disorder." | ( Campbell, D; Cernasov, PM; Cummings, K; Dichter, GS; Dillon, DG; Hooker, JM; Izquierdo-Garcia, D; Kan, D; Kelley, L; Kinard, JL; Lalush, DS; Phillips, RD; Pizzagalli, DA; Smoski, MJ; Tseng, CE; Walsh, EC; Zürcher, NR, 2023) |
| "Anhedonia is a significant predictor of disease progression and treatment outcomes in Major Depressive Disorder (MDD), linked to reward network dysfunctions." | ( Cao, J; Chen, Q; Fang, J; Gao, S; Guo, C; Lei, Z; Luo, Y; Lv, X; Ma, Y; Sun, J, 2024) |
| "Anhedonia is a common residual symptom associated with treatment resistance as well as low function and quality of life." | ( Asp, M; Björkstrand, J; Deierborg, T; Eklund, M; Jensen, J; Lindahl, J; Lindqvist, D; Månsson, K; Ståhl, D; Svensson, M; Tjernberg, J; Tornberg, Å; van Westen, D; Ventorp, F, 2023) |