| Assay ID | Title | Year | Journal | Article |
|---|
| AID479979 | Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometry | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
| Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. |
| AID621613 | Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2): crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones. |
| AID621612 | Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometry | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2): crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones. |
| AID621614 | Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2): crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones. |
| AID139781 | Antineoplastic activity was evaluated in vivo against murine leukemia P388 (i.p./i.p.; days 1-5) and optimum dose was reported | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| Chromophore-modified antineoplastic imidazoacridinones. Synthesis and activity against murine leukemias. |
| AID100464 | In vitro inhibitory activity against murine L1210 leukemia | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| Chromophore-modified antineoplastic imidazoacridinones. Synthesis and activity against murine leukemias. |
| AID136250 | In vivo % T/C activity was measured against P388 leukemia; 290 | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| Chromophore-modified antineoplastic imidazoacridinones. Synthesis and activity against murine leukemias. |
| AID134763 | Toxicity in CDF1 male mice following a single intraperitoneal administration | 1992 | Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
| Chromophore-modified antineoplastic imidazoacridinones. Synthesis and activity against murine leukemias. |
| AID479981 | Binding affinity to calf thymus DNA assessed as change in melting temperature at 10 uM relative to control | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
| Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. |
| AID1096392 | Binding affinity to Bos taurus (calf) thymus DNA assessed as change in melting temperature at drug to DNA base pair ratio 0.25 M | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, Nov, Volume: 20, Issue:8
| Physicochemical interaction of antitumor acridinone derivatives with DNA in view of QSAR studies. |
| AID1096393 | Antitumor activity against Mus musculus (mouse) P388 cells xenografted in Mus musculus (mouse) assessed as increase in survival time relative to control | 2011 | Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, Nov, Volume: 20, Issue:8
| Physicochemical interaction of antitumor acridinone derivatives with DNA in view of QSAR studies. |
| AID479980 | Toxicity in human HCT116 cells after 96 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
| Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |