Compounds > rhapontigenin
Page last updated: 2024-12-11

rhapontigenin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

rhapontigenin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5320954
CHEMBL ID113029
CHEBI ID174376
SCHEMBL ID1486816
MeSH IDM0393846

Synonyms (45)

Synonym
AC-7022
5-[(e)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]benzene-1,3-diol
CHEBI:174376
rhapontigenin
500-65-2
CHEMBL113029
protigenin
A827955
5-[2-(3-hydroxy-4-methoxy-phenyl)vinyl]benzene-1,3-diol
3,3',5-trihydroxy-4'-methoxy-trans-stilbene
trans-1-(3,5-dihydroxyphenyl)-2-(3-hydroxy-4-methoxyphenyl)ethylene
R0089
S9163
AKOS015915122
(e)-5-(3-hydroxy-4-methoxystyryl)benzene-1,3-diol
SCHEMBL1486816
5-[(1e)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol
PHMHDRYYFAYWEG-NSCUHMNNSA-N
HMS3648K18
5-[(1e)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]benzene-1,3-diol
AS-68092
pontigenin
HY-N2229
CS-0019552
mfcd00017718
rhapontin genin
unii-22bg4nnh6w
22bg4nnh6w ,
SR-01000946385-1
sr-01000946385
(e)-5-[2-(3-hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol
BCP15039
Q7320232
AMY40675
CCG-267039
DTXSID501023634
?rhapontigenin
5-((e)-2-(3-hydroxy-4-methoxyphenyl)ethenyl)benzene-1,3-diol
5-((1e)-2-(3-hydroxy-4-methoxyphenyl)ethenyl)-1,3-benzenediol
1,3-benzenediol, 5-((1e)-2-(3-hydroxy-4-methoxyphenyl)ethenyl)-
3,3,5-stilbenetriol, 4-methoxy-, (e)-
1,3-benzenediol, 5-(2-(3-hydroxy-4-methoxyphenyl)ethenyl)-, (e)-
prontigenin
rhapontin aglycone
rhapontigenin is known as a natural analog of resveratrol.

Research Excerpts

Overview

Rhapontigenin (RPG) is a stilben derivative and is known to bear several effects such as antiallergic, anticoagulative, hypoglycemic, antiangiogenic, and purgative. It is an active anti-cancer compound.

ExcerptReferenceRelevance
"Rhapontigenin (RPG) is a stilben derivative and is known to bear several effects such as antiallergic, anticoagulative, hypoglycemic, antiangiogenic, and purgative. "( Cardioprotective Effect of Rhapontigenin in Isoproterenol-Induced Myocardial Infarction in a Rat Model.
Fan, Y, 2019)		2.25
"Rhapontigenin is an active anti-cancer compound."( Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies.
Davies, NM; Halls, SC; Helms, GL; Roupe, KA; Yáñez, JA, 2005)		1.3

Effects

ExcerptReferenceRelevance
"Rhapontigenin (1) has various biological activities including anticancer activities."( Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
Kang, CG; Kim, JS; Kim, SH; Lee, EO, 2014)		2.57

Pharmacokinetics

ExcerptReferenceRelevance
" The developed HPLC assay is sensitive, reproducible and accurate and can be applied to pharmacokinetic and metabolism studies."( Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies.
Davies, NM; Halls, SC; Helms, GL; Roupe, KA; Yáñez, JA, 2005)		0.58

Bioavailability

ExcerptReferenceRelevance
" The estimates of oral bioavailability characterize these stilbenes as poorly bioavailable compounds."( Pharmacokinetics of selected stilbenes: rhapontigenin, piceatannol and pinosylvin in rats.
Davies, NM; Roupe, KA; Teng, XW; Yáñez, JA, 2006)		0.6
" However, there is no information describing the pharmacokinetics, bioavailability and metabolism of rhaponticin after intravenous administration."( Pharmacokinetics, bioavailability and metabolism of rhaponticin in rat plasma by UHPLC-Q-TOF/MS and UHPLC-DAD-MSn.
Bai, X; Cheng, XL; Lin, RC; Su, Q; Tan, XJ; Zhao, YY, 2012)		0.38
"UHPLC-Q-TOF/MS and UHPLC-multistage tandem MS methods were developed for the pharmacokinetics, bioavailability and metabolism of rhaponticin in rats."( Pharmacokinetics, bioavailability and metabolism of rhaponticin in rat plasma by UHPLC-Q-TOF/MS and UHPLC-DAD-MSn.
Bai, X; Cheng, XL; Lin, RC; Su, Q; Tan, XJ; Zhao, YY, 2012)		0.38
"The present pharmacokinetics, bioavailability and metabolism studies of rhaponticin will provide helpful information for development of suitable dosage forms and clinical references on rational administration."( Pharmacokinetics, bioavailability and metabolism of rhaponticin in rat plasma by UHPLC-Q-TOF/MS and UHPLC-DAD-MSn.
Bai, X; Cheng, XL; Lin, RC; Su, Q; Tan, XJ; Zhao, YY, 2012)		0.38

Dosage Studied

ExcerptRelevanceReference
"The present pharmacokinetics, bioavailability and metabolism studies of rhaponticin will provide helpful information for development of suitable dosage forms and clinical references on rational administration."( Pharmacokinetics, bioavailability and metabolism of rhaponticin in rat plasma by UHPLC-Q-TOF/MS and UHPLC-DAD-MSn.
Bai, X; Cheng, XL; Lin, RC; Su, Q; Tan, XJ; Zhao, YY, 2012)		0.38
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
stilbenoidAny olefinic compound characterised by a 1,2-diphenylethylene backbone.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (53)

Assay IDTitleYearJournalArticle
AID1157245Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells assessed as suppression of serum-induced cell migration at 10 uM after 24 hrs by wound-healing assay relative to control2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157268Effect on total PI3K protein level in human MDA-MB-231 cells at 10 to 50 uM after 24 hrs by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID82976In vitro concentration required to induce apoptosis in HL60 cells2003Journal of medicinal chemistry, Jul-31, Volume: 46, Issue:16
Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents.
AID1354540Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay2018Journal of natural products, 05-25, Volume: 81, Issue:5
Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner.
AID1667363Inhibition of alpha-glucosidase (unknown origin) using p-NPG as substrate by Dixon plot analysis2020Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
Tetra-aryl cyclobutane and stilbenes from the rhizomes of Rheum undulatum and their α-glucosidase inhibitory activity: Biological evaluation, kinetic analysis, and molecular docking simulation.
AID1374190Estrogenic activity at ERalpha/ERbeta (unknown origin) expressed in human HepG2 cells co-expressing ERE-dependent promoter assessed as increase in ER-mediated transcriptional activation at 10 uM incubated for 24 hrs by luciferase reporter gene assay relat2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Estrogenic activity of constituents from the rhizomes of Rheum undulatum Linné.
AID1372028Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced peroxyl scavenging activity by measuring Kaox/Kst ratio using CYPMPO spin trap by ESR spectroscopic method2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical.
AID1157259Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells assessed as inhibition of PAK1 phosphorylation at 10 to 50 uM after 24 hrs by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1372020Antioxidant activity assessed as Trolox equivalents of photolysis-induced methyl radical scavenging activity using DMPO spin trap by ESR spectroscopic method2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical.
AID1157266Inhibition of PI3K phosphorylation in human MDA-MB-231 cells at 10 to 50 uM after 24 hrs by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1372027Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced alkoxyl scavenging activity by measuring Kaox/Kst ratio using DMPO spin trap by ESR spectroscopic method2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical.
AID1372026Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced methyl radical scavenging activity by measuring Kaox/Kst ratio using DMPO spin trap by ESR spectroscopic method2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical.
AID1667362Mixed inhibition of alpha-glucosidase (unknown origin) using p-NPG as substrate by Lineweaver-Burk plot analysis2020Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
Tetra-aryl cyclobutane and stilbenes from the rhizomes of Rheum undulatum and their α-glucosidase inhibitory activity: Biological evaluation, kinetic analysis, and molecular docking simulation.
AID1372030Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced singlet oxygen scavenging activity by measuring Kaox/Kst ratio using 4-HO-TEMP spin trap by ESR spectroscopic method2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical.
AID82982In vitro inhibitory concentration against proliferation of HL60 cells2003Journal of medicinal chemistry, Jul-31, Volume: 46, Issue:16
Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents.
AID1157247Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells assessed as suppression of serum-induced cell migration at 50 uM after 24 hrs by wound-healing assay relative to control2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1372019Antioxidant activity assessed as Trolox equivalents of photolysis-induced hydroxyl radical scavenging activity using DMPO spin trap by ESR spectroscopic method2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical.
AID1354538Inhibition of PI3K/Akt in mouse J774 cells assessed as reduction in LPS-induced Akt phosphorylation at Ser473 after 4 hrs by Western blot analysis2018Journal of natural products, 05-25, Volume: 81, Issue:5
Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner.
AID1354542Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA2018Journal of natural products, 05-25, Volume: 81, Issue:5
Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner.
AID1372024Antioxidant activity assessed as Trolox equivalents of photolysis-induced singlet oxygen scavenging activity using 4-HO-TEMP spin trap by ESR spectroscopic method2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical.
AID1157269Effect on total AKT protein level in human MDA-MB-231 cells at 10 to 50 uM after 24 hrs by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1372022Antioxidant activity assessed as Trolox equivalents of photolysis-induced peroxyl scavenging activity using CYPMPO spin trap by ESR spectroscopic method2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical.
AID1157262Effect on total PAK1 protein level in human MDA-MB-231 cells at 10 to 50 uM after 24 hrs by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID132501Inhibitory activity against nitric oxide production in LPS-activated mouse peritoneal macrophages2000Bioorganic & medicinal chemistry letters, Feb-21, Volume: 10, Issue:4
Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages.
AID1157250Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells assessed as suppression of serum-induced cell invasion into matrigel at 50 uM preincubated for 30 mins with cells followed by loading into upper well of matrigel coated filter measured2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157244Cytotoxicity against human MDA-MB-231 cells assessed as cell viability up to 50 uM after 24 hrs by MTT assay2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157255Inhibition of PI3K in human MDA-MB-231 cells assessed as downregulation of activated Rac1-GTP protein expression at 50 uM after 30 mins by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID37425Inhibitory activity against yeast alpha-glucosidase; active2004Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14
Yeast and mammalian alpha-glucosidase inhibitory constituents from Himalayan rhubarb Rheum emodi Wall.ex Meisson.
AID1157248Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells assessed as suppression of serum-induced cell invasion into matrigel at 10 uM preincubated for 30 mins with cells followed by loading into upper well of matrigel coated filter measured2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157256Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells assessed as downregulation of WAVE-2 protein expression at 10 to 50 uM after 24 hrs by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157251Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells at 10 uM after 30 mins by ELISA relative to untreated control2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157264Effect on total cofilin protein level in human MDA-MB-231 cells at 10 to 50 uM after 24 hrs by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157263Effect on total LIMK1/2 protein level in human MDA-MB-231 cells at 10 to 50 uM after 24 hrs by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157257Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells assessed as downregulation of Arp-2 protein expression at 10 to 50 uM after 24 hrs by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157261Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells assessed as inhibition of cofilin phosphorylation at 10 to 50 uM after 24 hrs by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1374189Estrogenic activity at ERalpha/ERbeta (unknown origin) expressed in human HepG2 cells co-expressing ERE-dependent promoter assessed as increase in ER-mediated transcriptional activation at 1 uM incubated for 24 hrs by luciferase reporter gene assay relati2018Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4
Estrogenic activity of constituents from the rhizomes of Rheum undulatum Linné.
AID1372025Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced hydroxyl radical scavenging activity by measuring Kaox/Kst ratio using DMPO spin trap by ESR spectroscopic method2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical.
AID1157246Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells assessed as suppression of serum-induced cell migration at 25 uM after 24 hrs by wound-healing assay relative to control2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157258Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells assessed as downregulation of Arp-3 protein expression at 10 to 50 uM after 24 hrs by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157252Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells at 25 uM after 30 mins by ELISA relative to untreated control2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1372021Antioxidant activity assessed as Trolox equivalents of photolysis-induced alkoxyl scavenging activity using DMPO spin trap by ESR spectroscopic method2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical.
AID1157254Effect on total Rac1 protein expression in human MDA-MB-231 cells after 30 mins by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1372023Antioxidant activity assessed as Trolox equivalents of photolysis-induced superoxide anion scavenging activity using CYPMPO spin trap by ESR spectroscopic method2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical.
AID1354541Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA2018Journal of natural products, 05-25, Volume: 81, Issue:5
Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner.
AID1372032Antioxidant activity assessed as rate constant for photolysis-induced methyl radical scavenging activity using DMPO spin trap by ESR spectroscopic method2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical.
AID1372029Antioxidant activity assessed as relative scavenging rate constant for photolysis-induced super-oxide anion scavenging activity by measuring Kaox/Kst ratio using CYPMPO spin trap by ESR spectroscopic method2017Bioorganic & medicinal chemistry letters, 12-01, Volume: 27, Issue:23
Resveratrol analogues like piceatannol are potent antioxidants as quantitatively demonstrated through the high scavenging ability against reactive oxygen species and methyl radical.
AID1157249Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells assessed as suppression of serum-induced cell invasion into matrigel at 25 uM preincubated for 30 mins with cells followed by loading into upper well of matrigel coated filter measured2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1667360Inhibition of alpha-glucosidase (unknown origin) using p-NPG as substrate by spectrophotometric analysis2020Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
Tetra-aryl cyclobutane and stilbenes from the rhizomes of Rheum undulatum and their α-glucosidase inhibitory activity: Biological evaluation, kinetic analysis, and molecular docking simulation.
AID1157265Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells assessed as inhibition of lamellipodia formation at 50 uM after 24 hrs by rhodamine phalloidin/DAPI staining-based confocal microscopic analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157253Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells at 50 uM after 30 mins by ELISA relative to untreated control2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157243Cytotoxicity against human MDA-MB-231 cells assessed as cell viability at 100 to 200 uM after 24 hrs by MTT assay2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157260Inhibition of PI3K-dependent Rac1 activation in human MDA-MB-231 cells assessed as inhibition of LIMK1/2 phosphorylation at 10 to 50 uM after 24 hrs by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
AID1157267Inhibition of PI3K in human MDA-MB-231 cells assessed as inhibition of AKT phosphorylation at 10 to 50 uM after 24 hrs by Western blot analysis2014Journal of natural products, May-23, Volume: 77, Issue:5
Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (35)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (25.71)29.6817
2010's19 (54.29)24.3611
2020's7 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.61

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.61 (24.57)
Research Supply Index3.58 (2.92)
Research Growth Index5.52 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.61)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (5.71%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other33 (94.29%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		2.0810amino-acid anion
gallic acid
gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.		210trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		2.1310alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
emodin
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.		7.830trihydroxyanthraquinoneantineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.0110nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
gliclazide
Gliclazide: An oral sulfonylurea hypoglycemic agent which stimulates insulin secretion.		2.0810N-sulfonylureahypoglycemic agent;
insulin secretagogue;
radical scavenger
bis(2-guanidinoethyl)disulfide
bis(2-guanidinoethyl)disulfide: bifunctional cation; RN given refers to parent cpd; structure		210
isoproterenol
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.. isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.		7.2110catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source		2.1710chromones;
morpholines;
organochlorine compound		autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector
cytarabine
[no description available]		2.0110beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
1,2-dihydrostilbene
1,2-dihydrostilbene: intermdiate in biosynthesis of dihydrophenanthrenes from phenylalanine. 1,2-dihydrostilbene : A diphenylethane that is the 1,2-dihydro derivative of stilbene.		210diphenylethane
2-methylpentane
Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.		2.1310alkane
n-hexane
hexane : An unbranched alkane containing six carbon atoms.		2.1310alkane;
volatile organic compound		neurotoxin;
non-polar solvent
ethyl acetate
ethyl acetate : The acetate ester formed between acetic acid and ethanol.		2.1310acetate ester;
ethyl ester;
volatile organic compound		EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor;
metabolite;
polar aprotic solvent;
Saccharomyces cerevisiae metabolite
aloe emodin
aloe emodin: structure distinct from emodin; this does not mean emodin from aloe. Aloe emodin : A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.		2.4520aromatic primary alcohol;
dihydroxyanthraquinone		antineoplastic agent;
plant metabolite
chrysophanic acid
chrysophanic acid: RN given refers to parent cpd; structure in Merck, 9th ed, #2260. chrysophanol : A trihydroxyanthraquinone that is chrysazin with a methyl substituent at C-3. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity.		2.4120dihydroxyanthraquinoneanti-inflammatory agent;
antiviral agent;
plant metabolite
physcione
physcione: structure. physcion : A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources.		2.0210dihydroxyanthraquinoneanti-inflammatory agent;
antibacterial agent;
antifungal agent;
antineoplastic agent;
apoptosis inducer;
hepatoprotective agent;
metabolite
daunorubicin
Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.		2.0110aminoglycoside antibiotic;
anthracycline;
p-quinones;
tetracenequinones		antineoplastic agent;
bacterial metabolite
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		2.1310benzenes;
phenyl acetates
etoposide
[no description available]		2.0110beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
[no description available]		2.1510chromanol;
monocarboxylic acid;
phenols		antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor
acarbose
[no description available]		2.2510tetrasaccharide derivativeEC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
geroprotector;
hypoglycemic agent
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.1710D-glucopyranoseepitope;
mouse metabolite
repaglinide
[no description available]		2.0810piperidines
fulvestrant
Fulvestrant: An estradiol derivative and estrogen receptor antagonist that is used for the treatment of estrogen receptor-positive, locally advanced or metastatic breast cancer.. fulvestrant : A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.		2.171017beta-hydroxy steroid;
3-hydroxy steroid;
organofluorine compound;
sulfoxide		antineoplastic agent;
estrogen antagonist;
estrogen receptor antagonist
omega-n-methylarginine
omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent.		210amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid
3,3',4,5'-tetrahydroxybibenzyl
3,3',4,5'-tetrahydroxybibenzyl: from Cassia garrettiana; structure given in first source		210
dihydroresveratrol
dihydroresveratrol: structure in first source. dihydroresveratrol : A stilbenol that is 1,1'-ethane-1,2-diyldibenzene with hydroxy groups at positions 1, 3 and 4'.		210stilbenolplant metabolite;
xenobiotic metabolite
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		2.1710
wortmannin
[no description available]		2.110acetate ester;
cyclic ketone;
delta-lactone;
organic heteropentacyclic compound		anticoronaviral agent;
antineoplastic agent;
autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector;
Penicillium metabolite;
radiosensitizing agent
chrysophanol 8-o-glucoside
chrysophanol 8-O-glucoside: has anti-hepatitis B virus activity; also has antiplatelet and anticoagulant activities; isolated from Rheum palmatum. chrysophanol 8-O-beta-D-glucoside : A beta-D-glucoside in which the aglycone species is chrysophanol, the glycosidic linkage being to the hydroxy group at C-8.		2.4620beta-D-glucoside;
monohydroxyanthraquinone
ergosterol
[no description available]		2.08103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols		fungal metabolite;
Saccharomyces cerevisiae metabolite
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		9.7990resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
rhapontin
rhapontin: constituent of rhubarb rhizome		5.13130rhaponticinangiogenesis inhibitor;
anti-allergic agent;
anti-inflammatory agent;
antilipemic drug;
antineoplastic agent;
apoptosis inducer;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
hypoglycemic agent;
neuroprotective agent;
plant metabolite
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		11.33270stilbene
3,3',4,5'-tetrahydroxystilbene
3,3',4,5'-tetrahydroxystilbene: demethyl derivative of isorhapontigenin; structure in first source; a Syk kinase inhibitor; found in heartwood of FABACEAE; inhibitor of photosynthesis in spinach chloroplasts; may be inhibitor of plant growth; RN given refers to (E)-isomer. piceatannol : A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.		4.6880catechols;
polyphenol;
resorcinols;
stilbenol		antineoplastic agent;
apoptosis inducer;
geroprotector;
hypoglycemic agent;
plant metabolite;
protein kinase inhibitor;
tyrosine kinase inhibitor
cis-resveratrol
cis-resveratrol : The cis-stereoisomer of resveratrol.		2.0110resveratrol
nadp
[no description available]		210
oxalylglycine
oxalylglycine: structure given in first source. N-oxalylglycine : An amino dicarboxylic acid that is iminodiacetic acid with an oxo substituent. It is used as an inhibitor of alpha-ketoglutarate dependent (EC 1.14.11.*) enzymes.		2.0610amino dicarboxylic acid;
N-acylglycine		EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor
pinosylvin
pinosylvin: phytoalexin found in pine and eucalyptus		8.8530pinosylvin
entacapone
entacapone: structure given in first source. entacapone : A monocarboxylic acid amide that is N,N-diethylprop-2-enamide in which the hydrogen at position 2 is substituted by a cyano group and the hydrogen at the 3E position is substituted by a 3,4-dihydroxy-5-nitrophenyl group.		2.25102-nitrophenols;
catechols;
monocarboxylic acid amide;
nitrile		antidyskinesia agent;
antiparkinson drug;
central nervous system drug;
EC 2.1.1.6 (catechol O-methyltransferase) inhibitor
astringin
astringin: structure in first source. trans-astringin : A stilbenoid that is piceatannol substituted at position 3 by a beta-D-glucosyl residue.		2.5820beta-D-glucoside;
monosaccharide derivative;
polyphenol;
stilbenoid		antineoplastic agent;
antioxidant;
metabolite
isorhapontin
isorhapontin: from spruce (Picea); structure in first source		210glycoside;
stilbenoid
trans-2,3',4,5'-tetrahydroxystilbene
trans-2,3',4,5'-tetrahydroxystilbene: hydroxystilbene oxyresveratrol		2.1510stilbenoid
polydatin
trans-piceid : A stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue.		2.2510beta-D-glucoside;
monosaccharide derivative;
polyphenol;
stilbenoid		anti-arrhythmia drug;
antioxidant;
geroprotector;
hepatoprotective agent;
metabolite;
nephroprotective agent;
potassium channel modulator
Pinosylvin methyl ether
[no description available]		2.1710stilbenoid
pterostilbene
[no description available]		4.2750diether;
methoxybenzenes;
stilbenol		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
hypoglycemic agent;
neuroprotective agent;
neurotransmitter;
plant metabolite;
radical scavenger
epsilon-viniferin
epsilon-viniferin: stilbene dimer; isolated from the Oriental medicinal plant Vitis coignetiae; structure given in first source. (-)-trans-epsilon-viniferin : A stilbenoid that is the (-)-trans-stereoisomer of epsilon-viniferin, obtained by cyclodimerisation of trans-resveratrol.		2.17101-benzofurans;
polyphenol;
stilbenoid		metabolite
caffeic acid phenethyl ester
phenethyl caffeate : An alkyl caffeate ester in which 2-phenylethyl is the alkyl component.		210alkyl caffeate esteranti-inflammatory agent;
antibacterial agent;
antineoplastic agent;
antioxidant;
antiviral agent;
immunomodulator;
metabolite;
neuroprotective agent
desoxyrhaponticin
[no description available]		2.4520glycoside;
stilbenoid
isorhapontigenin
isorhapontigenin: isolated from the seeds of Aiphanes aculeata Willd. (Arecaceae); structure in first source		2.4620stilbenoid
noreugenin
noreugenin : A member of the class of chromones in which the 1,4-benzopyrone skeleton is substituted with a methyl group at position 2 and with hydroxy groups at positions 5 and 7. A natural product, it is found in Pisonia aculeata.		2.0210chromones;
resorcinols		plant metabolite
4,3',5'-tri-o-methylpiceatannol
[no description available]		2.4120
3,3',4,5'-tetramethoxy-trans-stilbene
(E)-3,4,3',5'-tetramethoxystilbene: from the leaves of Eugenia rigida; structure in first source		2.4520
3,4',5-trimethoxystilbene
3,4',5-trimethoxystilbene: structure in first source		210
3,5-dihydroxy-4'-methoxystilbene
4'-methoxyresveratrol: has anti-inflammatory effects in cell culture model		2.7330
3'-hydroxypterostilbene
3'-hydroxypterostilbene: an apoptosis-inducing agent; structure in first source		2.0110
delta-viniferin
delta-viniferin: resveratrol dehydrodimer, an isomer of epsilon-viniferin; isolated from grapevine leaves; structure in first source. (2S,3S)-trans-delta-viniferin : A stilbenoid that is the (2S,3S)-trans-stereoisomer of delta-viniferin, obtained by cyclodimerisation of trans-resveratrol.		2.17101-benzofurans;
polyphenol;
stilbenoid
cis-3,4',5-trimethoxy-3'-aminostilbene
cis-3,4',5-trimethoxy-3'-aminostilbene: structure in first source		2.0110
piperidines
Piperidines: A family of hexahydropyridines.		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Hyperglycemia, Postprandial
Abnormally high BLOOD GLUCOSE level after a meal.		02.0210
Diabetes Mellitus
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.		02.0210
Hyperglycemia
Abnormally high BLOOD GLUCOSE level.		02.0210
Breast Cancer
[description not available]		07.5320
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.5320
Innate Inflammatory Response
[description not available]		02.1710
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.1710
African Swine Fever
A sometimes fatal ASFIVIRUS infection of pigs, characterized by fever, cough, diarrhea, hemorrhagic lymph nodes, and edema of the gallbladder. It is transmitted between domestic swine by direct contact, ingestion of infected meat, or fomites, or mechanically by biting flies or soft ticks (genus Ornithodoros).		07.610
Swine Diseases
Diseases of domestic swine and of the wild boar of the genus Sus.		02.610
Cancer of Colon
[description not available]		02.610
Colonic Neoplasms
Tumors or cancer of the COLON.		02.610
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2110
Cardiovascular Stroke
[description not available]		02.2110
Myocardial Infarction
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).		07.2110
Liver Steatosis
[description not available]		02.110
Hyperlipemia
[description not available]		02.110
Fatty Liver
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.		02.110
Hyperlipidemias
Conditions with excess LIPIDS in the blood.		02.110
Carcinoma, Non-Small Cell Lung
[description not available]		02.1310
Cancer of Lung
[description not available]		02.1310
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.1310
Lung Neoplasms
Tumors or cancer of the LUNG.		02.1310
Carcinoma, Anaplastic
[description not available]		02.0610
Benign Neoplasms
[description not available]		02.0610
Angiogenesis, Pathologic
[description not available]		02.0610
Cancer of Prostate
[description not available]		02.0610
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.0610
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0610
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.0610
Candida Infection
[description not available]		02.0810
Candidiasis
Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)		02.0810
Amyloid Deposits
[description not available]		02.0310
Acute Confusional Senile Dementia
[description not available]		02.0310
Nerve Degeneration
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.		02.0310
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		02.0310