Page last updated: 2024-11-11

1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone: from stems of Kielmeyera coriacea; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Kielmeyeragenus[no description available]Calophyllaceae[no description available]

Cross-References

ID SourceID
PubMed CID5495920
CHEMBL ID506229
SCHEMBL ID5188386
MeSH IDM0573968

Synonyms (14)

Synonym
20245-39-0
1,3,7-trihydroxy-2-prenyl-xanthone
9h-xanthen-9-one, 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)-
1,3,7-trihydroxy-2-(3-methylbut-2-enyl)xanthen-9-one
1,3,7-trihydroxy-2-prenylxanthone
CHEMBL506229 ,
SCHEMBL5188386
AKOS022184783
1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone
FS-9531
B0005-190230
A879762
bdbm50509700
9h-xanthen-9-one, 1,3,7-trihydroxy-2-(3-methyl-2-buten-1-yl)-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)IC50 (µMol)1.70000.05201.20935.6000AID1542231
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (6)

Processvia Protein(s)Taxonomy
purine nucleoside catabolic process7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
DNA repair7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
response to oxidative stress7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
male gonad development7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
DNA protection7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
response to cadmium ion7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (13)

Processvia Protein(s)Taxonomy
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
protein binding7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
dATP diphosphatase activity7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
snoRNA binding7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
metal ion binding7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
ATP diphosphatase activity7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
2-hydroxy-ATP hydrolase activity7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
2-hydroxy-dATP hydrolase activity7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
N6-methyl-(d)ATP hydrolase activity7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
O6-methyl-dGTP hydrolase activity7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
acrosomal vesicle7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
extracellular space7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
nucleus7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
cytoplasm7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
mitochondrion7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
mitochondrial matrix7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
cytosol7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
nuclear membrane7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
cytoplasm7,8-dihydro-8-oxoguanine triphosphataseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID356328Antifungal activity against Aspergillus fumigatus IFM 41236 after 48 to 96 hrs by broth microdilution method2003Journal of natural products, Aug, Volume: 66, Issue:8
Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species.
AID1180663Cytotoxicity against human MDA-MB-231 cells by MTT assay2014Journal of natural products, Jul-25, Volume: 77, Issue:7
Cytotoxic and anti-inflammatory prenylated benzoylphloroglucinols and xanthones from the twigs of Garcinia esculenta.
AID1180662Cytotoxicity against human MCF7 cells by MTT assay2014Journal of natural products, Jul-25, Volume: 77, Issue:7
Cytotoxic and anti-inflammatory prenylated benzoylphloroglucinols and xanthones from the twigs of Garcinia esculenta.
AID356330Antifungal activity against Candida albicans ATCC 90028 after 48 hrs by disk diffusion assay2003Journal of natural products, Aug, Volume: 66, Issue:8
Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species.
AID1180661Cytotoxicity against human HepG2 cells by MTT assay2014Journal of natural products, Jul-25, Volume: 77, Issue:7
Cytotoxic and anti-inflammatory prenylated benzoylphloroglucinols and xanthones from the twigs of Garcinia esculenta.
AID1180665Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma plus LPS-induced NO production2014Journal of natural products, Jul-25, Volume: 77, Issue:7
Cytotoxic and anti-inflammatory prenylated benzoylphloroglucinols and xanthones from the twigs of Garcinia esculenta.
AID1328100Neuroprotective activity in human SK-N-SH cells assessed as inhibition of glutamate-induced injury by measuring increase in cell viability at 10 uM preincubated for 4 hrs followed by glutamate addition measured after 4 hrs by MTT assay2016Journal of natural products, 08-26, Volume: 79, Issue:8
Regiospecific Prenylation of Hydroxyxanthones by a Plant Flavonoid Prenyltransferase.
AID356323Antifungal activity against Candida parapsilosis ATCC 22019 after 48 to 96 hrs by broth microdilution method2003Journal of natural products, Aug, Volume: 66, Issue:8
Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species.
AID358549Cytotoxicity against HGF cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis.
AID1180664Cytotoxicity against human HL7702 cells by MTT assay2014Journal of natural products, Jul-25, Volume: 77, Issue:7
Cytotoxic and anti-inflammatory prenylated benzoylphloroglucinols and xanthones from the twigs of Garcinia esculenta.
AID356322Antifungal activity against Candida albicans ATCC 90028 after 48 to 96 hrs by broth microdilution method2003Journal of natural products, Aug, Volume: 66, Issue:8
Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species.
AID514379Induction of apoptosis in human HeLaC3 cells assessed as reduction of yellow fluorescent protein/cyan fluorescent protein emission ratio below 3 at 50 uM after 72 hrs by FRET assay2010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Identification and evaluation of apoptotic compounds from Garcinia paucinervis.
AID514381Induction of apoptosis in human HeLaC3 cells assessed as reduction of yellow fluorescent protein/cyan fluorescent protein emission ratio below 3 at 10 uM after 72 hrs by FRET assay2010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Identification and evaluation of apoptotic compounds from Garcinia paucinervis.
AID356327Antifungal activity against Aspergillus fumigatus IFM 41374 after 48 to 96 hrs by broth microdilution method2003Journal of natural products, Aug, Volume: 66, Issue:8
Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species.
AID358548Cytotoxicity against human HSC2 cells2001Journal of natural products, Jan, Volume: 64, Issue:1
Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis.
AID514386Induction of apoptosis in human HeLaC3 cells at < 100 uM after 72 hrs2010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Identification and evaluation of apoptotic compounds from Garcinia paucinervis.
AID356329Antifungal activity against Aspergillus nidulans IFM 5396 after 48 to 96 hrs by broth microdilution method2003Journal of natural products, Aug, Volume: 66, Issue:8
Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species.
AID514378Induction of apoptosis in human HeLaC3 cells assessed as reduction of yellow fluorescent protein/cyan fluorescent protein emission ratio below 3 at 100 uM after 72 hrs by FRET assay2010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Identification and evaluation of apoptotic compounds from Garcinia paucinervis.
AID356324Antifungal activity against Candida glabrata ATCC 90030 after 48 to 96 hrs by broth microdilution method2003Journal of natural products, Aug, Volume: 66, Issue:8
Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species.
AID356325Antifungal activity against Candida krusei ATCC 6258 after 48 to 96 hrs by broth microdilution method2003Journal of natural products, Aug, Volume: 66, Issue:8
Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species.
AID1542231Inhibition of recombinant C-terminal 6xHis-tagged MTH1 (3 to 156 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP as substrate measured after 30 mins by malachite green dye based inorganic phosphatase coupled absorbance 2019European journal of medicinal chemistry, Apr-01, Volume: 167Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening.
AID1328101Neuroprotective activity in human SK-N-SH cells assessed as inhibition of glutamate-induced injury by measuring cell survival at 10 uM preincubated for 4 hrs followed by glutamate addition measured after 4 hrs by MTT assay relative to control2016Journal of natural products, 08-26, Volume: 79, Issue:8
Regiospecific Prenylation of Hydroxyxanthones by a Plant Flavonoid Prenyltransferase.
AID514380Induction of apoptosis in human HeLaC3 cells assessed as reduction of yellow fluorescent protein/cyan fluorescent protein emission ratio below 3 at 25 uM after 72 hrs by FRET assay2010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Identification and evaluation of apoptotic compounds from Garcinia paucinervis.
AID356326Antifungal activity against Cryptococcus neoformans ATCC 90112 after 48 to 96 hrs by broth microdilution method2003Journal of natural products, Aug, Volume: 66, Issue:8
Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's6 (75.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.47 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]