Compounds > nyasol
Page last updated: 2024-12-10

nyasol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

nyasol: from roots Asparagus africanus; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Asparagusgenus[no description available]AsparagaceaeA family of flowering subshrubs and shrubs in the class Magnoliopsida.[MeSH]

Cross-References

ID SourceID
PubMed CID6915833
CHEMBL ID451713
CHEBI ID67889
SCHEMBL ID799383
MeSH IDM0283902

Synonyms (19)

Synonym
MEGXP0_001405
CHEMBL451713
chebi:67889 ,
nyasol
4-[(1z,3r)-3-(4-hydroxyphenyl)penta-1,4-dienyl]phenol
(-)-nyasol
96895-25-9
lk6ch9d7ur ,
SCHEMBL799383
NCGC00385801-01
Q27136365
phenol, 4,4'-[(1z,3r)-3-ethenyl-1-propene-1,3-diyl]bis-
z-(-)hinokiresinol
phenol, 4,4-((1z,3r)-3-ethenyl-1-propene-1,3-diyl)bis-
4,4-((1z,3r)-3-ethenyl-1-propene-1,3-diyl)bis(phenol)
phenol, 4,4-(3-ethenyl-1-propene-1,3-diyl)bis-, (r-(z))-
DTXSID501337053
AKOS040762132
FS-6877

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
1,3-bis(p-hydroxyphenyl)pentane-1,4-dieneA norlignan that is pentane-1,4-diene in which a hydrogen at position 1 and a hydrogen at position 3 are replaced by p-hydroxyphenyl groups. The isomer in which the 1,2-disubstituted double bond has Z configuration is known as nyasol; the corresponding E isomer is hinokiresinol.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (21)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID334019Selectivity index, ratio of IC50 for human lymphocyte to IC50 for chloroquine-susceptible Plasmodium falciparum 3D71997Journal of natural products, Oct, Volume: 60, Issue:10
Antiprotozoal compounds from Asparagus africanus.
AID399558Cytotoxicity against human Lu1 cells2004Journal of natural products, Feb, Volume: 67, Issue:2
Bioactive constituents from Asparagus cochinchinensis.
AID334016Selectivity index, ratio of IC50 for human lymphocyte to IC50 for Leishmania major1997Journal of natural products, Oct, Volume: 60, Issue:10
Antiprotozoal compounds from Asparagus africanus.
AID334014Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 24 hrs by [3H]hypoxanthine uptake1997Journal of natural products, Oct, Volume: 60, Issue:10
Antiprotozoal compounds from Asparagus africanus.
AID399555Cytotoxicity against human KB cells2004Journal of natural products, Feb, Volume: 67, Issue:2
Bioactive constituents from Asparagus cochinchinensis.
AID399557Cytotoxicity against human LNCAP cells2004Journal of natural products, Feb, Volume: 67, Issue:2
Bioactive constituents from Asparagus cochinchinensis.
AID334015Inhibition of phytohemagglutininin A-induced human lymphocyte proliferation assessed as radiolabeled [14C]thymidine uptake1997Journal of natural products, Oct, Volume: 60, Issue:10
Antiprotozoal compounds from Asparagus africanus.
AID468347Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining2009Journal of natural products, Oct, Volume: 72, Issue:10
Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides.
AID399556Cytotoxicity against human Col2 cells2004Journal of natural products, Feb, Volume: 67, Issue:2
Bioactive constituents from Asparagus cochinchinensis.
AID399553Antiviral activity against HIV1 3B infected in human HOG.R5 cells after 4 days2004Journal of natural products, Feb, Volume: 67, Issue:2
Bioactive constituents from Asparagus cochinchinensis.
AID334012Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine uptake1997Journal of natural products, Oct, Volume: 60, Issue:10
Antiprotozoal compounds from Asparagus africanus.
AID399554Cytotoxicity against human HOG.R5 cells2004Journal of natural products, Feb, Volume: 67, Issue:2
Bioactive constituents from Asparagus cochinchinensis.
AID334009Antileishmanial activity against Leishmania major promastigotes assessed as inhibition of [3H]thymidine uptake after 18 hrs by scintillation counting1997Journal of natural products, Oct, Volume: 60, Issue:10
Antiprotozoal compounds from Asparagus africanus.
AID399559Cytotoxicity against HUVEC2004Journal of natural products, Feb, Volume: 67, Issue:2
Bioactive constituents from Asparagus cochinchinensis.
AID334020Selectivity index, ratio of IC50 for human lymphocyte to IC50 for chloroquine-resistant Plasmodium falciparum Dd21997Journal of natural products, Oct, Volume: 60, Issue:10
Antiprotozoal compounds from Asparagus africanus.
AID334013Antiplasmodial activity against Plasmodium falciparum schizonts assessed as [3H]hypoxanthine incorporation by liquid scintillation counting1997Journal of natural products, Oct, Volume: 60, Issue:10
Antiprotozoal compounds from Asparagus africanus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (11.76)18.2507
2000's8 (47.06)29.6817
2010's5 (29.41)24.3611
2020's2 (11.76)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		1.9910aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.0210indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		2.0110alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
metalaxyl
metalaxyl: RN given refers to (DL-Ala)-isomer. metalaxyl : A racemate comprising equal amounts of (R)- and (S)-metalaxyl. A systemic fungicide, it is active against phytopathogens of the order Peronosporales and is used to conrtrol Pythium in a number of vegetable crops.. methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate : An alanine derivative that is methyl alaninate in which one of the hydrogens attached to the nitrogen is substituted by a methoxyacetyl group, while the other is substituted by a 2,6-dimethylphenyl group.		2.0110alanine derivative;
aromatic amide;
carboxamide;
ether;
methyl ester
2,3-bis(4-hydroxyphenyl)-propionitrile
2,3-bis(4-hydroxyphenyl)-propionitrile: a selective estrogen receptor beta agonist or modulator. also called DPN compound. 2,3-bis(4-hydroxyphenyl)propionitrile : A nitrile that is acetonitrile in which one of the hydrogens is replaced by a 4-hydroxyphenyl group while a second hydrogen is replaced by a 4-hydroxybenzyl group. It is a specific agonist for estrogen receptor beta (ERbeta).		2.0510nitrile;
phenols		estrogen receptor agonist
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		3.91120
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		2.0510resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
isoliquiritigenin
[no description available]		2.0510chalconesantineoplastic agent;
biological pigment;
EC 1.14.18.1 (tyrosinase) inhibitor;
GABA modulator;
geroprotector;
metabolite;
NMDA receptor antagonist
coniferyl alcohol
coniferyl alcohol: structure. coniferol : A phenylpropanoid that is one of the main monolignols, produced by the reduction of the carboxy functional group in cinnamic acid and the addition of a hydroxy and a methoxy substituent to the aromatic ring.		2.0210guaiacols;
phenylpropanoid		animal metabolite;
monolignol;
mouse metabolite;
pheromone;
plant metabolite;
volatile oil component
broussonin a
broussonin A: has antiviral activity; isolated from Anemarrhena asphodeloides; structure in first source		7.7530
3-deoxysappanchalcone
3-deoxysappanchalcone: Anti-allergic from the roots and heartwood of Caesalpinia sappan; structure in first source. 2'-O-methylisoliquiritigenin : A member of the class of chalcones that is isoliquiritigenin in which one of the hydroxy groups at position 2' is replaced by a methoxy group.		2.0510chalcones;
monomethoxybenzene;
phenols		metabolite
hinokiresinol
hinokiresinol: RN given for (S-(E))-isomer; inhibits binding of leukotriene B4 to neutrophils; structurein first source		7.0210
sapogenins
Sapogenins: The aglucon moiety of a saponin molecule. It may be triterpenoid or steroid, usually spirostan, in nature.		1.9910
ConditionIndicatedRelationship StrengthStudiesTrials
Congenital Zika Syndrome
[description not available]		02.2510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.5120
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.		02.2510
Anasarca
[description not available]		02.110
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.110
Innate Inflammatory Response
[description not available]		02.4720
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.4720