Compounds > artonin e
Page last updated: 2024-11-11

artonin e

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

artonin E: structure given in first source; isolated from the bark of Artocarpus communis Forst. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
ArtocarpusgenusA plant genus of the family MORACEAE. Puag-haad extract, from A. lakoocha, contains STILBENES and related 4-substituted RESORCINOLS.[MeSH]MoraceaeThe mulberry plant family of the order Urticales, subclass Hamamelidae, class Magnoliopsida. They have milky latex and small, petalless male or female flowers.[MeSH]

Cross-References

ID SourceID
PubMed CID5481962
CHEMBL ID463106
SCHEMBL ID4929818
MeSH IDM0183089

Synonyms (13)

Synonym
artonin e
5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)-2-(2,4,5-trihydroxyphenyl)pyrano[2,3-h]chromen-4-one
129683-93-8
5-hydroxy-8,8-dimethyl-3-(3-methyl-but-2-enyl)-2-(2,4,5-trihydroxy-phenyl)-8h-benzo[1,2-b:4,3-b']dipyran-4-one
CHEMBL463106
LMPK12110925
5'-hydroxymorusin
4h,8h-benzo(1,2-b:3,4-b')dipyran-4-one, 5-hydroxy-8,8-dimethyl-3-(3-methyl-2-butenyl)-2-(2,4,5-trihydroxyphenyl)-
SCHEMBL4929818
DTXSID30156221
kb 3
CS-0092473
HY-125612

Research Excerpts

Overview

Artonin E is a prenylated flavonoid compound isolated from the stem bark of Artocarpus elasticus Reinw.

ExcerptReferenceRelevance
"Artonin E is a prenylated flavonoid compound isolated from the stem bark of "( Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells.
Abdul, AB; Etti, CJ; Etti, IC; Hashim, NM; Kadir, A; Lim, KL; Malami, I; Rasedee, A; Waziri, P; Yeap, SK, 2017)		3.34
"Artonin E is a prenylated flavonoid isolated from the stem bark of Artocarpus elasticus Reinw.(Moraceae). "( Artonin E Induces Apoptosis via Mitochondrial Dysregulation in SKOV-3 Ovarian Cancer Cells.
Ali, HM; Dehghan, F; Hashim, NM; Karimian, H; Mohan, S; Nordin, N; Rahman, MA; Ramli, F, 2016)		3.32
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID1190090Induction of mitochondrial membrane depolarization in human AGS cells assessed as depolarized cells after 24 hrs by JC-1 staining-based flow cytometric analysis (Rvb = 27.1%)2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance.
AID1190083Induction of apoptosis in TRAIL-resistant human AGS cells assessed as fold increase in caspase 3/7 at 3 uM after 24 hrs by Caspase-Glo 3/7 assay kit in presence of TRAIL2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance.
AID1190091Induction of apoptosis in TRAIL-resistant human AGS cells assessed as fold increase in caspase 3/7 at 5 uM after 24 hrs by Caspase-Glo 3/7 assay kit in presence of TRAIL2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance.
AID401542Cytotoxicity against human SK-MEL-2 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID1190084Induction of apoptosis in TRAIL-resistant human AGS cells assessed as population of apoptotic cells after 6 hrs by annexin-V-FLOUS/ propidium iodide staining based flow cytometry in presence of TRAIL2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance.
AID1190081Induction of apoptosis in TRAIL-resistant human AGS cells assessed as fold increase in caspase 3/7 at 5 uM after 24 hrs by Caspase-Glo 3/7 assay kit2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance.
AID401537Cytotoxicity against human A549 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID1557453Antiproliferative activity against mouse P388 cells assessed as reduction in cell viability2019Journal of natural products, 03-22, Volume: 82, Issue:3
Potential Anticancer Agents Characterized from Selected Tropical Plants.
AID401538Cytotoxicity against human MCF7 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID401543Cytotoxicity against human U87MG cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID401540Cytotoxicity against human HCT8 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID401547Cytotoxicity against human KBVIN cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID1190088Induction of apoptosis in TRAIL-resistant human AGS cells assessed as increase in death receptor 5 protein level at 3 uM after 6 hrs by Western blotting analysis2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance.
AID1190085Induction of apoptosis in TRAIL-resistant human AGS cells assessed as population of apoptotic cells after 6 hrs by annexin-V-FLOUS/ propidium iodide staining based flow cytometry in presence of pan-caspase inhibitor z-VAD-FMK2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance.
AID1190087Induction of apoptosis in TRAIL-resistant human AGS cells assessed as increase in p53 protein level at 3 uM after 6 hrs by Western blotting analysis2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance.
AID401546Cytotoxicity against human KB cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID1190086Induction of apoptosis in TRAIL-resistant human AGS cells assessed as population of apoptotic cells after 6 hrs by annexin-V-FLOUS/ propidium iodide staining based flow cytometry2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance.
AID1190078Induction of apoptosis in TRAIL-resistant human AGS cells assessed as decrease in cell viability at 3 uM after 24 hrs in presence of TRAIL (Rvb = 9%)2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance.
AID1190082Induction of apoptosis in TRAIL-resistant human AGS cells assessed as fold increase in caspase 3/7 at 3 uM after 24 hrs by Caspase-Glo 3/7 assay kit2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance.
AID1190089Induction of apoptosis in TRAIL-resistant human AGS cells assessed as ROS-mediated increase in death receptor 5 protein level at 3 uM after 6 hrs pretreated with NAC by Western blotting analysis2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Prenylated flavonoids and resveratrol derivatives isolated from Artocarpus communis with the ability to overcome TRAIL resistance.
AID401544Cytotoxicity against human PC3 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID401541Cytotoxicity against human Caki1 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID401545Cytotoxicity against human MDA-MB-231 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
AID401539Cytotoxicity against human 1A9 cells2004Journal of natural products, May, Volume: 67, Issue:5
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (6.25)18.2507
2000's4 (25.00)29.6817
2010's10 (62.50)24.3611
2020's1 (6.25)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.13 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index5.16 (4.65)
Search Engine Demand Index25.99 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (6.25%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (93.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydrazine
diamine : Any polyamine that contains two amino groups.		2.0410azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
calotropin
calotropin: structure in first source		3.3110cardenolide glycoside
streptomycin
[no description available]		7.1110antibiotic antifungal drug;
antibiotic fungicide;
streptomycins		antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor
parthenolide
[no description available]		3.3110germacranolide
justicidin a
justicidins: from Justica procumbens		3.3110lignan
sitosterol, (3beta)-isomer
Sobatum: tradename; active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity. sitosterol : A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.		3.31103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
C29-steroid;
phytosterols;
stigmastane sterol		anticholesteremic drug;
antioxidant;
mouse metabolite;
plant metabolite;
sterol methyltransferase inhibitor
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		2.0610
digitoxin
Digitoxin: A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665). digitoxin : A cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain.		3.3110cardenolide glycosideEC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		2.1110resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		2.1110stilbene
1,1-diphenyl-2-picrylhydrazyl
1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)		2.0410
luteolin
[no description available]		2.11103'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
amentoflavone
[no description available]		3.3110biflavonoid;
hydroxyflavone;
ring assembly		angiogenesis inhibitor;
antiviral agent;
cathepsin B inhibitor;
P450 inhibitor;
plant metabolite
chrysosplenetin b
chrysosplenetin B: constituent of the root of Berneuxia thibetica Decne. chrysosplenetin : A tetramethoxyflavone that is the 3,6,7,3'-tetramethyl ether derivative of quercetagetin.		3.3110dihydroxyflavone;
tetramethoxyflavone		antiviral agent;
plant metabolite
euxanthone
euxanthone : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1 and 7 and an oxo group at position 9. It has been isolated from Cratoxylum cochinchinense.		3.3110phenols;
xanthones		metabolite;
plant metabolite
mangostin
mangostin: xanthone from rind of Garcinia mangostana Linn. fruit. alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.		3.3110aromatic ether;
phenols;
xanthones		antimicrobial agent;
antineoplastic agent;
antioxidant;
plant metabolite
morusin
morusin: from Morus root bark; structure given in first source. morusin : An extended flavonoid that is flavone substituted by hydroxy groups at positions 5, 2' and 4', a prenyl group at position 3 and a 2,2-dimethyl pyran group across positions 7 and 8.		2.4220extended flavonoid;
trihydroxyflavone		antineoplastic agent;
plant metabolite
muromonab-cd3
cudraflavone B: antiproliferative from Cudrania tricuspidata. cudraflavone B : An extended flavonoid that consists of a pyranochromane skeleton that is 2H,6H-pyrano[3,2-g]chromen-6-one substituted by geminal methyl groups at position 2, a 2,4-dihydroxyphenyl group at position 8, a hydroxy group at position 5 and a prenyl group at position 7. Isolated from Morus alba and Morus species it exhibits anti-inflammatory activity.		2.1110extended flavonoid;
pyranochromane;
trihydroxyflavone		anti-inflammatory agent;
plant metabolite
furanoheliangolide
furanoheliangolide: structure in first source		3.3110
artocarpin lectin
artocarpin lectin: a mannose-specific lectin; from the seeds of Artocarpus integrifolia; a homotetramic protein distinct from jacalin, another jackfruit lectin; MW 65 kDa; devoid of covalently-attached carbohydrates; consists of 4 isolectins with pI 5 - 6.5; do not confuse with artocarpin flavone. artocarpin : A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 5, 2', and 4', a methoxy group at position 7, a prenyl group at position 3 and a (1E)-3-methylbut-1-enyl group at position 6. Isolated from Artocarpus heterophyllus and Artocarpus integrifolia, it exhibits antineoplastic activity.		2.0210monomethoxyflavone;
trihydroxyflavone		antineoplastic agent;
metabolite
gambogic acid
gambogic acid: RN given refers to (1R-(1alpha,1(Z),3abeta,5alpha,11beta,14aS*))-isomer		3.3110pyranoxanthonesmetabolite
Cycloartobiloxanthone
cycloartobiloxanthone: a flavonoid isolated from stem bark of Artocarpus gomezianus; has antineoplastic properties		2.0210pyranoxanthones
morelloflavone
morelloflavone: also inhibits cruzain; RN given for (2S-trans)-isomer; structure in first source. (+)-morelloflavone : A biflavonoid found in Rheedia edulis and Garcinia livingstonei.		3.3110biflavonoid;
hydroxyflavanone;
hydroxyflavone		plant metabolite
15-deoxygoyazensolide
15-deoxygoyazensolide: an NSAID with schistossomicidal and trypanosomicidal activities; structure in first source		3.3110
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.1310
lychnopholide
lychnopholide: isolated from Vanillosmopsis erythropappa; structure in first source		3.3110
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Colon
[description not available]		02.4110
Colonic Neoplasms
Tumors or cancer of the COLON.		02.4110
ER-Negative PR-Negative HER2-Negative Breast Cancer
[description not available]		02.1510
Triple Negative Breast Neoplasms
Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.		02.1510
Carcinoma, Non-Small Cell Lung
[description not available]		02.4820
Cancer of Lung
[description not available]		02.4820
Invasiveness, Neoplasm
[description not available]		02.0810
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.4820
Lung Neoplasms
Tumors or cancer of the LUNG.		02.4820
Cancer of Ovary
[description not available]		02.1310
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.1310
Breast Cancer
[description not available]		07.1310
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.1310