Page last updated: 2024-11-12
hs 1793
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
4-(6-hydroxy-2-naphthyl)-1,3-benzenediol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 16215105 |
| CHEMBL ID | 248499 |
| MeSH ID | M0536128 |
Synonyms (21)
| Synonym |
|---|
| hs-1793 |
| hs 1793 |
| 4-(6-hydroxy-2-naphthyl)-1,3-benzenediol |
| bdbm50197244 |
| 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-diol , |
| CHEMBL248499 , |
| 927885-00-5 |
| unii-5ywk2uv4r5 |
| 5ywk2uv4r5 , |
| brd-6688;brd 6688 |
| BCP17387 |
| AS-16807 |
| AKOS037643535 |
| EX-A4732 |
| 4-(6-oxidanylnaphthalen-2-yl)benzene-1,3-diol |
| 1,3-benzenediol, 4-(6-hydroxy-2-naphthalenyl)- |
| 4-(6-hydroxy-2-naphthalenyl)1,3-benzenediol |
| CMB88500 |
| CS-0103797 |
| HY-129156 |
| AC-36623 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (1)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 (µMol) | 0.0340 | 0.0340 | 3.9871 | 10.0000 | AID305160 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Bioassays (7)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID757918 | Reduction of ouabain-induced mitochondrial calcium flux in Sprague-Dawley rat cardiomyocytes at 10 uM after 15 mins by Rhod 2AM staining relative to control | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage. |
| AID305160 | Inhibition of mushroom tyrosinase | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2 | Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase. |
| AID757921 | Cardioprotective activity in Sprague-Dawley rat cardiomyocytes assessed as prevention of hypoxia/reoxygenation-induced collapse of state 3 respiration in presence of 100 uM ADP | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage. |
| AID757922 | Cardioprotective activity in Sprague-Dawley rat heart assessed as reduction of hypoxia/reoxygenation-induced infarct size at 10 uM treated 30 mins before reoxygenation by triphenyltetrazolium chloride staining (Rvb = 42.10 +/- 7.36%) | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage. |
| AID757920 | Cardioprotective activity in Sprague-Dawley rat cardiomyocytes assessed as reduction of hypoxia/reoxygenation-induced mitochondrial superoxide level at 10 uM after 15 mins by MitoSOX red staining relative to control | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage. |
| AID757919 | Cardioprotective activity in Sprague-Dawley rat cardiomyocytes assessed as reduction of hypoxia/reoxygenation-induced mitochondrial calcium flux at 10 uM after 15 mins by Rhod 2AM staining relative to control | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage. |
| AID757917 | Inhibition of calcium-induced cardiac mitochondria swelling in Sprague-Dawley rat at 1 uM after 10 mins | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (19)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 14 (73.68) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 11.89
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.89) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 19 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||