| Assay ID | Title | Year | Journal | Article |
|---|
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID647261 | Drug degradation in PBS assessed as racemisation after 48 hrs by HPLC/MS analysis | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Development of small-molecule probes that selectively kill cells induced to express mutant RAS. |
| AID647251 | Cytotoxicity against human BJeH-LT cells after 48 hrs by alamar blue assay | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Development of small-molecule probes that selectively kill cells induced to express mutant RAS. |
| AID1676458 | Selectivity ratio of EC50 for Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viability in presence of ferrostatin-1 to EC50 for Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-med | 2020 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 30, Issue:23
| Structure-activity relationships of GPX4 inhibitor warheads. |
| AID1676457 | Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viability in presence of ferrostatin-1 | 2020 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 30, Issue:23
| Structure-activity relationships of GPX4 inhibitor warheads. |
| AID1784942 | Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer. |
| AID647258 | Cytotoxicity against human BJeH cells after 48 hrs by alamar blue assay | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Development of small-molecule probes that selectively kill cells induced to express mutant RAS. |
| AID647263 | Drug degradation in PBS/DMSO assessed as GSH-adduct formation after 48 hrs in the presence of GSH | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Development of small-molecule probes that selectively kill cells induced to express mutant RAS. |
| AID702156 | Cytotoxicity against human BJeH cells expressing wild type RAS after 48 hrs by alamar blue assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
| Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death. |
| AID1662438 | Cytotoxicity against RSL3 resistance human HN3 cells assessed as reduction in cell viability | 2020 | Journal of medicinal chemistry, 09-24, Volume: 63, Issue:18
| p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. |
| AID647259 | Cytotoxicity against human BJ cells expressing HRAS G12V mutant with alternative oncogenic constructs after 48 hrs by alamar blue assay | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Development of small-molecule probes that selectively kill cells induced to express mutant RAS. |
| AID647262 | Drug degradation in PBS/DMSO assessed as GSH-adduct formation after 1 hr in the presence of GSH and triethylamine | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Development of small-molecule probes that selectively kill cells induced to express mutant RAS. |
| AID647255 | Selectivity ratio of IC50 for human BJeH cells to IC50 for human BJeLR cells | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Development of small-molecule probes that selectively kill cells induced to express mutant RAS. |
| AID647260 | Aqueous solubility of the compound | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Development of small-molecule probes that selectively kill cells induced to express mutant RAS. |
| AID647252 | Cytotoxicity against human BJeLR cells expressing HRAS G12V mutant after 48 hrs by alamar blue assay | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Development of small-molecule probes that selectively kill cells induced to express mutant RAS. |
| AID1676456 | Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viability | 2020 | Bioorganic & medicinal chemistry letters, 12-01, Volume: 30, Issue:23
| Structure-activity relationships of GPX4 inhibitor warheads. |
| AID1662439 | Inhibition of Vps34 (unknown origin) | 2020 | Journal of medicinal chemistry, 09-24, Volume: 63, Issue:18
| p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. |
| AID1784943 | Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 48 hrs in presence of Fer-1 by MTT assay | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer. |
| AID1784941 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer. |
| AID1784940 | Cytotoxicity against human 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer. |
| AID647254 | Selectivity ratio of IC50 for human BJeH cells to to IC50 for human BJeLR cells | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Development of small-molecule probes that selectively kill cells induced to express mutant RAS. |
| AID647264 | Selectivity ratio of IC50 for human BJeH-LT cells to IC50 for human BJeLR cells | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Development of small-molecule probes that selectively kill cells induced to express mutant RAS. |
| AID1662440 | Inhibition of Vps34 (unknown origin) interaction with PIK3 assessed as reduction in autophagy by increasing LC3 level | 2020 | Journal of medicinal chemistry, 09-24, Volume: 63, Issue:18
| p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators. |
| AID1784945 | Inhibition of GPX4 in human 4T1 cells at 1 uM incubated for 1 hr relative to control | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer. |
| AID702157 | Cytotoxicity against human BJeLR cells expressing RAS G12V mutant after 48 hrs by alamar blue assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
| Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death. |
| AID1784944 | Selectivity index, ratio of IC50 for cytotoxicity against human HT-1080 cells in presence of Fer-1 to IC50 for cytotoxicity against human HT-1080 cells | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |