ACY2 Deficiency

Synonym
Canavan Disease, Type I
Canavan Disease, Type II
Canavan Disease, Type III
Infantile Canavan Disease
Canavan-van Bogaert-Bertrand Disease
Type III Canavan Disease
Deficiency Disease, Aspartoacylase
Canavan Disease, Familial Form
Aminoacylase 2 Deficiency
Type I Canavan Disease
Sporadic Form of Canavan Disease
Spongy Disease of White Matter
Spongy Disease of Central Nervous System
Spongy Degeneration of White Matter In Infancy
Canavan Disease, Juvenile
Von Bogaert-Bertrand Disease
Familial Form of Canavan Disease
Spongy Degeneration of the Central Nervous System
Neonatal Canavan Disease
Spongy Degeneration of the Brain
Type II Canavan Disease
Spongy Degeneration of Infancy
Spongy Degeneration Of Central Nervous System
ACY2 Deficiency
Canavan Disease, Neonatal
ASP Deficiency
ASPA Deficiency
Leukodystrophy, Spongiform
Aspartoacylase Deficiency
Juvenile Canavan Disease
Canavan Disease, Infantile
Van Bogaert-Bertrand Syndrome
Canavan Disease, Sporadic Form

Excerpt	Reference
"Canavan disease, spongy degeneration of the brain, is an autosomal recessive disorder with increased prevalence among Ashkenazi Jews."	( Matalon, R, 1997)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	25 (19.38)	12.5806
2000's	63 (48.84)	18.1394
2010's	35 (27.13)	28.8240
2020's	6 (4.65)	9.53

Drug	Relationship Strength	Studies	Trials
alpha-hydroxyglutarate	low	1	0
acetoacetic acid	low	1	0
gamma-aminobutyric acid	low	2	0
acetic acid	low	2	0
choline	low	4	0
3-hydroxybutyric acid	low	1	0
creatine	low	4	0
cytosine	low	1	0
lactic acid	low	3	0
glutaric acid	low	3	0
glycine	low	2	0
glycerol	low	1	0
inositol	low	2	0
orotic acid	low	1	0
thymine	low	1	0
acetazolamide	low	1	0
triacetin	medium	2	2
alanine	low	2	0
aspartic acid	medium	97	1
glutamine	low	2	0
tyrosine	low	2	0
calcium acetate	low	2	0
asparagine	low	1	0
histidine	low	3	0
pyrrolidonecarboxylic acid	low	2	0
kainic acid	low	1	0
4-hydroxybutyric acid	low	1	0
isovaleric acid	low	1	0
lithium citrate	low	2	0
n-methylaspartate	low	1	0
phenyl acetate	medium	7	1
glutamic acid	medium	11	1
n-acetylaspartic acid	medium	91	1
triheptanoin	low	1	0
beta-hydroxyisovaleric acid	low	1	0
n-acetylhistidine	low	1	0
n-acetylasparagine	low	1	0
cobalt	low	1	0
valerates	low	1	0
3beta-(n-(n',n'-dimethylaminoethane)carbamoyl)cholesterol	low	1	0
lac dye	low	1	0
isospaglumic acid	low	12	0
lithium chloride	low	1	0
mevalonic acid	low	1	0
resveratrol	low	1	0
myelin basic protein	low	6	0
cysteine	low	1	0
heroin	low	7	0
phosphocreatine	low	1	0
acebutolol	low	1	0
cytochromes c1	low	1	0
eye	low	1	0

Protein Targets (592)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	2	0	2
Solute carrier family 22 member 20	0	4	0	4
Solute carrier family 22 member 6	0	4	0	4
Gamma-aminobutyric acid receptor subunit pi	3	4	0	7
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	3	4	0	7
Gamma-aminobutyric acid receptor subunit delta	3	4	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	3	4	1	8
Gamma-aminobutyric acid receptor subunit alpha-5	3	4	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	3	4	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	3	4	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	3	4	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	3	4	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	3	4	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	3	4	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	3	4	1	8
Gamma-aminobutyric acid receptor subunit beta-3	3	4	0	7
Gamma-aminobutyric acid receptor subunit beta-2	3	4	1	8
Tetraspanin	0	1	0	1
Proton-coupled amino acid transporter 1	0	5	0	5
GABA theta subunit	3	4	0	7
Gamma-aminobutyric acid receptor subunit epsilon	3	4	0	7
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	2	0	0	2
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
thioredoxin reductase	6	0	0	6
GALC protein	1	0	0	1
GLI family zinc finger 3	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
glucocorticoid receptor [Homo sapiens]	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
retinoid X nuclear receptor alpha	6	0	0	6
estrogen-related nuclear receptor alpha	9	0	0	9
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	6	0	0	6
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	11	0	0	11
Bloom syndrome protein isoform 1	6	0	0	6
thyroid hormone receptor beta isoform a	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
geminin	9	0	0	9
peripheral myelin protein 22	3	0	0	3
survival motor neuron protein isoform d	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	2
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	4	1	10
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	1	0	3
Bile salt export pump	0	2	0	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	5	1	19
Carbonic anhydrase 2	0	5	2	19
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Carbonic anhydrase 3	0	4	1	9
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	4	0	4
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Androgen receptor	0	1	0	1
Translocator protein	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	4	1	9
Carbonic anhydrase 6	0	4	1	9
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	1	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	2
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	1	0	3
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 2C19	0	3	0	3
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	4	2	11
Carbonic anhydrase	0	2	0	4
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	4	1	9
Carbonic anhydrase	0	2	0	2
D(1A) dopamine receptor	1	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	4
D(2) dopamine receptor	0	2	0	2
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	11	4	18
Squalene synthase	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Carbonic anhydrase 9	0	4	1	10
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	4
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	4	1	7
Canalicular multispecific organic anion transporter 1	0	2	0	2
Carbonic anhydrase 4	0	4	0	7
Carbonic anhydrase 15	0	3	0	6
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	3	0	6
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	4	1	10
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	4	1	10
estrogen nuclear receptor alpha	9	0	0	9
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	0	1	1
Fibrinogen C domain-containing protein 1	0	1	0	1
Monocarboxylate transporter 4	0	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	3
Glutamate receptor ionotropic, NMDA 1	0	10	4	17
Adenosine deaminase	0	0	0	1
Methylcytosine dioxygenase TET2	0	1	1	2
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	6
Amino acid transporter	0	2	0	2
Chain A, Ferritin light chain	3	0	0	3
phosphopantetheinyl transferase	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
cytochrome P450 2C19 precursor	2	0	0	2
lethal factor (plasmid)	1	0	0	1
lamin isoform A-delta10	10	0	0	10
Metabotropic glutamate receptor 6	0	1	3	5
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	9	4	16
Glutamate receptor ionotropic, NMDA 2C	0	9	4	16
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Glutamate receptor ionotropic, NMDA 2D	0	9	4	16
Glutamate receptor ionotropic, NMDA 3B	0	9	4	16
Glutamate receptor ionotropic, NMDA 3A	0	9	4	16
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
muscarinic acetylcholine receptor M1	3	0	0	3
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Solute carrier family 22 member 1	0	1	0	2
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
ATP-dependent phosphofructokinase	5	0	0	5
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
RAR-related orphan receptor gamma	5	0	0	5
IDH1	3	0	0	3
Deoxycytidine kinase	0	0	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
ATAD5 protein, partial	3	0	0	3
Hsf1 protein	0	0	1	1
thyroid stimulating hormone receptor	3	0	0	3
regulator of G-protein signaling 4	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
D(1A) dopamine receptor	2	0	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
histone acetyltransferase KAT2A isoform 1	3	0	0	3
neuropeptide S receptor isoform A	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	2	0	0	2
Histone deacetylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
glp-1 receptor, partial	2	0	0	2
GLS protein	6	0	0	6
TDP1 protein	5	0	0	5
AR protein	5	0	0	5
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	3	0	1	4
Integrin alpha-IIb	3	0	1	4
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	5	2	7
Glutamate receptor 2	1	5	2	8
Glutamate receptor 3	0	5	2	7
Glutamate receptor 4	0	5	2	7
Glutamate receptor ionotropic, kainate 1	0	5	2	7
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	3	2	5
Metabotropic glutamate receptor 5	0	1	2	4
Glutamate receptor ionotropic, kainate 2	0	5	3	8
Glutamate receptor 1	0	3	2	5
Glutamate receptor 2	0	3	2	5
Glutamate receptor 3	0	1	2	3
Glutamate receptor ionotropic, kainate 3	0	5	0	5
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	3	1	4
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	5	0	5
Glutamate carboxypeptidase 2	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	3	2	5
Glutamate receptor ionotropic, kainate 3	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	3	0	3
Glutamate receptor ionotropic, kainate 5	0	5	0	5
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
peripheral myelin protein 22 isoform 1	2	0	0	2
flap endonuclease 1	3	0	0	3
Asc-type amino acid transporter 1	0	1	0	1
Chain A, Protein (aspartate Aminotransferase)	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
acetylcholinesterase	4	0	0	4
estrogen receptor 2 (ER beta)	4	0	0	4
thyroid hormone receptor beta isoform 2	4	0	0	4
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
peroxisome proliferator-activated receptor delta	2	0	0	2
activating transcription factor 6	2	0	0	2
Cellular tumor antigen p53	5	0	0	5
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
cytochrome P450 3A4 isoform 1	3	0	0	3
Plasma kallikrein	0	0	0	2
Histidine-binding periplasmic protein	0	0	1	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
DNA polymerase iota isoform a (long)	3	0	0	3
Amyloid-beta precursor protein	0	2	1	3
Sodium/myo-inositol cotransporter 2	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
DNA polymerase kappa isoform 1	4	0	0	4
Solute carrier family 15 member 2	0	1	0	1
pregnane X nuclear receptor	4	0	0	4
Chain A, Glutamate receptor 2	0	0	1	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain C, Glutamate receptor 2	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
endonuclease IV	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
chromobox protein homolog 1	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Glutamate receptor ionotropic, kainate 4	0	1	0	1
cytochrome P450 2D6	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
cellular tumor antigen p53 isoform a	3	0	0	3
inositol monophosphatase 1	1	0	0	1
Cholecystokinin receptor type A	1	0	0	1
Gastrin/cholecystokinin type B receptor	1	0	0	1
Glycogen synthase kinase-3 beta	0	1	1	2
67.9K protein	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
progesterone receptor	2	0	0	2
peroxisome proliferator activated receptor gamma	2	0	0	2
heat shock protein beta-1	1	0	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Smad3	1	0	0	1
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Luciferase	1	0	0	1
BRCA1	1	0	0	1
ClpP	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
farnesoid X nuclear receptor	1	0	0	1
G	1	0	0	1
Parkin	1	0	0	1
P53	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
pyruvate kinase	1	0	0	1
caspase-3	1	0	0	1
M18 aspartyl aminopeptidase	0	1	0	1
cathepsin L1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
aryl hydrocarbon receptor	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
Histone H2A.x	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
glucokinase regulatory protein	1	0	0	1
huntingtin isoform 2	1	0	0	1
DNA polymerase beta	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	0	0	1	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Vif	0	1	0	1
M-phase phosphoprotein 8	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
transcription factor p65 isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
POsterior Segregation	0	0	1	1
Aryl hydrocarbon receptor	0	1	0	1
Estrogen receptor beta	0	0	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Acetylcholinesterase	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
Lysine-specific histone demethylase 1A	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Tyrosine-protein kinase ABL1	0	1	0	2
Myc proto-oncogene protein	0	1	0	2
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Transthyretin	0	0	1	1
Estrogen receptor	0	1	0	1
Cytochrome P450 1A1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	1	2
Cholinesterase	0	1	0	1
Cathepsin D	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	2
Luciferin 4-monooxygenase	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Breakpoint cluster region protein	0	1	0	2
Tyrosinase	0	2	0	2
Aromatase	0	2	0	2
Ornithine decarboxylase	0	1	0	1
Tyrosinase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	1	3
Protein kinase C alpha type	0	0	1	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
5-hydroxytryptamine receptor 1A	0	0	0	1
Estrogen receptor	0	0	1	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Endothelin receptor type B	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sucrase-isomaltase, intestinal	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	1	3
Endothelin-1 receptor	1	0	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Histamine H2 receptor	1	0	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Alpha-glucosidase MAL12	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	0	0	1
Bcl-2-like protein 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Nuclear factor erythroid 2-related factor 2	0	0	1	2
Cytochrome P450 1B1	0	2	0	2
N1L	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	2
Tubulin beta-2B chain	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	0	1	1
Inositol hexakisphosphate kinase 1	1	0	0	1
NAD-dependent protein deacetylase sirtuin-1	0	0	1	3
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Prenyltransferase homolog	0	0	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Zinc finger protein mex-5	0	0	1	1
cytochrome P450 2C9, partial	1	0	0	1
large T antigen	0	1	0	1
Thymidine phosphorylase	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
SLC16A10 protein	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(33)

Research Excerpts

Overview

Research

Studies (129)

Protein Targets (592)

ACY2 Deficiency

Synonyms(33)

Research Excerpts

Overview

Research

Studies (129)

Drugs Studied (67)

Protein Targets (592)