alpha-thujaplicin profile

Alpha-thujaplicin, also known as hinokitiol, is a tropolone derivative found in the heartwood of several coniferous trees, including Western red cedar (Thuja plicata) and Japanese cypress (Chamaecyparis obtusa). It exhibits a wide range of biological activities, including antibacterial, antifungal, antiviral, antioxidant, and anti-inflammatory properties. Alpha-thujaplicin has been shown to inhibit the growth of various bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. It also possesses antifungal activity against Candida albicans and Aspergillus niger. Additionally, alpha-thujaplicin has demonstrated antiviral activity against influenza virus and herpes simplex virus. The compound's antioxidant properties are attributed to its ability to scavenge free radicals, while its anti-inflammatory effects are thought to be mediated through the inhibition of pro-inflammatory cytokines. Research into alpha-thujaplicin is ongoing to explore its potential as a therapeutic agent for various diseases, including infections, inflammation, and cancer. Its natural origin, wide range of bioactivities, and low toxicity make it an attractive candidate for the development of novel drugs.'

alpha-thujaplicin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	80297
CHEMBL ID	1275969
SCHEMBL ID	355645
MeSH ID	M0554911

Synonym
6tu33pgy8a ,
1946-74-3
unii-6tu33pgy8a
alpha-thujaplicin
2,4,6-cycloheptatrien-1-one, 2-hydroxy-3-(1-methylethyl)-
.alpha.-thujaplicin
2-hydroxy-3-isopropyl-cyclohepta-2,4,6-trien-1-one
2-hydroxy-3-propan-2-ylcyclohepta-2,4,6-trien-1-one
2-hydroxy-3-isopropyl-2,4,6-cycloheptatrien-1-one
CHEMBL1275969 ,
bdbm50330793
SCHEMBL355645
thujaplicin
TUFYVOCKVJOUIR-UHFFFAOYSA-N
3it ,
DTXSID70173098
AKOS025402371
AC-8489
3-isopropyltropolone
2-hydroxy-3-(propan-2-yl)cyclohepta-2,4,6-trien-1-one

Protein Targets (2)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Polyphenol oxidase 2	Agaricus bisporus	IC50 (µMol)	9.5300	0.0340	3.9871	10.0000	AID1167964; AID1611942; AID537590
Polyphenol oxidase 2	Agaricus bisporus	Ki	3.3000	0.0006	3.2883	8.8900	AID537591
Tyrosinase	Homo sapiens (human)	IC50 (µMol)	1,000.0000	0.0230	4.4593	10.0000	AID1167965
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (11)

Process	via Protein(s)	Taxonomy
melanin biosynthetic process from tyrosine	Tyrosinase	Homo sapiens (human)
eye pigment biosynthetic process	Tyrosinase	Homo sapiens (human)
visual perception	Tyrosinase	Homo sapiens (human)
cell population proliferation	Tyrosinase	Homo sapiens (human)
response to UV	Tyrosinase	Homo sapiens (human)
response to blue light	Tyrosinase	Homo sapiens (human)
response to vitamin D	Tyrosinase	Homo sapiens (human)
melanin biosynthetic process	Tyrosinase	Homo sapiens (human)
thymus development	Tyrosinase	Homo sapiens (human)
response to cAMP	Tyrosinase	Homo sapiens (human)
pigmentation	Tyrosinase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Process	via Protein(s)	Taxonomy
tyrosinase activity	Tyrosinase	Homo sapiens (human)
copper ion binding	Tyrosinase	Homo sapiens (human)
protein binding	Tyrosinase	Homo sapiens (human)
identical protein binding	Tyrosinase	Homo sapiens (human)
protein homodimerization activity	Tyrosinase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (7)

Process	via Protein(s)	Taxonomy
cytoplasm	Tyrosinase	Homo sapiens (human)
lysosome	Tyrosinase	Homo sapiens (human)
Golgi-associated vesicle	Tyrosinase	Homo sapiens (human)
melanosome membrane	Tyrosinase	Homo sapiens (human)
melanosome	Tyrosinase	Homo sapiens (human)
intracellular membrane-bounded organelle	Tyrosinase	Homo sapiens (human)
perinuclear region of cytoplasm	Tyrosinase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (49)

Assay ID	Title	Year	Journal	Article
AID1103251	Acaricidal activity against Dermatophagoides farinae after 24 hr	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID537591	Competitive inhibition of mushroom tyrosinase after 15 mins by Lineweaver-Burke plot analysis	2010	Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22	Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.
AID1232069	Inhibition of Escherichia coli ribonuclease H	2014	MedChemComm, Jul-01, Volume: 5, Issue:7	The biology and synthesis of α-hydroxytropolones.
AID1103250	Acaricidal activity against Tyrophagus putrescentiae at high concentration	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103256	Acaricidal activity against Dermatophagoides farinae assessed as mortality at 0.01 g/m'2 after 24 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1167967	Ratio of kojic acid IC50 to compound IC50 for human tyrosinase	2014	Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21	Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase.
AID1103289	Antifungal activity against Thanatephorus cucumeris IFO 30455 after 15 days by agar dilution method	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103284	Antifungal activity against Colletotrichum lagenaria after 15 days by agar dilution method	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103248	Growth inhibition of Mus musculus (mouse) P388 cells at >1.25 ug/ml after 24 hr by MTT assay	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1611942	Inhibition of mushroom tyrosinase	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Inhibitors of Melanogenesis: An Updated Review.
AID1167969	Ratio of IC50 for tyrosinase in human G-361 cells to IC50 for mushroom tyrosinase	2014	Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21	Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase.
AID1103283	Antifungal activity against Colletotrichum orbiculare MAFF 306518 after 15 days by agar dilution method	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1232067	Inhibition of HIV1 reverse transcriptase RNase H	2014	MedChemComm, Jul-01, Volume: 5, Issue:7	The biology and synthesis of α-hydroxytropolones.
AID1103285	Antifungal activity against Phomopsis obscurans MAFF 744018 after 15 days by agar dilution method	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103287	Antifungal activity against Fusarium solani IFO 9955 after 15 days by agar dilution method	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID537592	Inhibition of mushroom tyrosinase at 3 uM after 15 mins by Michaelis-Menten constant analysis	2010	Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22	Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.
AID1103278	Insecticidal activity against Reticulitermes speratus assessed as mortality at 0.1 g/m'2 at 48 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103275	Insecticidal activity against Reticulitermes speratus assessed as mortality at 0.04 g/m'2 at 24 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103245	Growth inhibition of Mus musculus (mouse) P388 cells at >1.25 ug/ml after 48 hr by MTT assay	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID537593	Inhibition of mushroom tyrosinase at 6 uM after 15 mins by Michaelis-Menten constant analysis	2010	Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22	Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.
AID1103272	Insecticidal activity against Reticulitermes speratus assessed as mortality at 0.02 g/m'2 at 24 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103273	Insecticidal activity against Reticulitermes speratus assessed as mortality at 0.03 g/m'2 at 48 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103279	Insecticidal activity against Reticulitermes speratus assessed as mortality at 0.05 g/m'2 at 24 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103286	Antifungal activity against Botryotinia fuckeliana IFO 30915 after 15 days by agar dilution method	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103276	Insecticidal activity against Reticulitermes speratus assessed as mortality at 0.04 g/m'2 at 48 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103288	Antifungal activity against Pythium aphanidermatum IFO 32440 after 15 days by agar dilution method	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103246	Growth inhibition of Mus musculus (mouse) P388 cells at 0.63 ug/ml after 48 hr by MTT assay	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103269	Insecticidal activity against Reticulitermes speratus assessed as mortality at 0.01 g/m'2 at 48 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103274	Insecticidal activity against Reticulitermes speratus assessed as mortality at 0.03 g/m'2 at 24 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103281	Antibacterial activity against Legionella pneumophila SG 3 after 7 days by agar dilution method	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103252	Insecticidal activity against Reticulitermes speratus at 48 hr	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103271	Insecticidal activity against Reticulitermes speratus assessed as mortality at 0.01 g/m'2 at 24 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1167965	Competitive inhibition of tyrosinase in human G-361 cells incubated for 10 mins measured for 2 hrs by MBTH-based spectrophotometry	2014	Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21	Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase.
AID1611944	Selectivity ratio of IC50 for human tyrosinase to IC50 for mushroom tyrosinase	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Inhibitors of Melanogenesis: An Updated Review.
AID1167964	Non-competitive inhibition of mushroom tyrosinase	2014	Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21	Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase.
AID1103259	Acaricidal activity against Dermatophagoides farinae assessed as mortality at 1 g/m'2 after 24 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103277	Insecticidal activity against Reticulitermes speratus assessed as mortality at 0.05 g/m'2 at 48 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1167966	Inhibition of tyrosinase in human G-361 cells at >200 uM incubated for 10 mins measured for 2 hrs by MBTH-based spectrophotometry	2014	Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21	Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase.
AID1103282	Antibacterial activity against Legionella pneumophila SG 1 after 7 days by agar dilution method	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103249	Growth inhibition of Mus musculus (mouse) P388 cells after 24 to 48 hr by MTT assay	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103247	Growth inhibition of Mus musculus (mouse) P388 cells at 0.63 ug/ml after 24 hr by MTT assay	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1232068	Inhibition of HIV2 reverse transcriptase RNase H	2014	MedChemComm, Jul-01, Volume: 5, Issue:7	The biology and synthesis of α-hydroxytropolones.
AID537590	Inhibition of mushroom tyrosinase after 15 mins	2010	Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22	Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.
AID1103244	Toxicity against ip dosed Mus musculus Slc:ddY (mouse) after 8 days	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1232070	Inhibition of human ribonuclease H	2014	MedChemComm, Jul-01, Volume: 5, Issue:7	The biology and synthesis of α-hydroxytropolones.
AID1103257	Acaricidal activity against Dermatophagoides farinae assessed as mortality at 0.1 g/m'2 after 24 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103270	Insecticidal activity against Reticulitermes speratus assessed as mortality at 0.02 g/m'2 at 48 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103258	Acaricidal activity against Dermatophagoides farinae assessed as mortality at 0.5 g/m'2 after 24 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
AID1103280	Insecticidal activity against Reticulitermes speratus assessed as mortality at 0.1 g/m'2 at 24 hr relative to control	2004	Biological & pharmaceutical bulletin, Jun, Volume: 27, Issue:6	Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (16.67)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	4 (66.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (16.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (83.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hydroquinone [no description available]	3.27	1	benzenediol; hydroquinones	antioxidant; carcinogenic agent; cofactor; Escherichia coli metabolite; human xenobiotic metabolite; mouse metabolite; skin lightening agent
chlorpyrifos Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.	2.02	1	chloropyridine; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic
beta-thujaplicin beta-thujaplicin: structure. beta-thujaplicin : A monoterpenoid that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4. Isolated from Thuja plicata and Chamaecyparis obtusa, it exhibits antimicrobial activities.	4.08	4	cyclic ketone; enol; monoterpenoid	antibacterial agent; antifungal agent; antineoplastic agent; antiplasmodial drug; plant metabolite
kojic acid [no description available]	3.89	3	4-pyranones; enol; primary alcohol	Aspergillus metabolite; EC 1.10.3.1 (catechol oxidase) inhibitor; EC 1.10.3.2 (laccase) inhibitor; EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor; EC 1.14.18.1 (tyrosinase) inhibitor; EC 1.4.3.3 (D-amino-acid oxidase) inhibitor; NF-kappaB inhibitor; skin lightening agent
deet N,N-diethyl-m-toluamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of m-toluic acid with the nitrogen of diethylamine. First developed by the U.S. Army in 1946 for use by military personnel in insect-infested areas, it is the most widely used insect repellent worldwide.	2.02	1	benzamides; monocarboxylic acid amide	environmental contaminant; insect repellent; xenobiotic
pd 169316 2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole: p38 MAP kinase inhibitor	3.27	1	imidazoles
sb 202190 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole: structure given in first source; inhibits p38 MAP kinase	3.27	1	imidazoles; organofluorine compound; phenols; pyridines	apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	2.1	1	mitomycin	alkylating agent; antineoplastic agent
protocatechualdehyde protocatechualdehyde: found in wheat grains, wheat seedlings, & other plants; RN given refers to parent cpd; see also rancinamycins; structure	2.1	1	dihydroxybenzaldehyde
tropolone Tropolone: A seven-membered aromatic ring compound. It is structurally related to a number of naturally occurring antifungal compounds (ANTIFUNGAL AGENTS).. tropolone : A cyclic ketone that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2. It is a toxin produced by the agricultural pathogen Burkholderia plantarii.	3.09	5	alpha-hydroxy ketone; cyclic ketone; enol	bacterial metabolite; fungicide; toxin
gamma-thujaplicin 2-hydroxy-5-isopropyl- 2,4,6-cycloheptatrienone: a metal chelating agent	4.11	4	cyclic ketone
vinblastine [no description available]	2.02	1
7-hydroxytropolone 7-hydroxytropolone: structure	2.1	1
1-hydroxy-2(1h)-pyridinone 1-hydroxy-2(1H)-pyridinone: structure in first source	3.27	1
beta-thujaplicinol beta-thujaplicinol: inhibits ribonuclease H activity of HIV-1 reverse transcriptase; structure in first source	2.1	1
3,7-dihydroxytropolone 3,7-dihydroxytropolone: from Streptomyces tropolofaciens; active against B16 melanoma; structure given in first source. 3,7-dihydroxytropolone : A cyclic ketone that is tropolone in which the hydrogens at positions 3 and 7 are substituted by hydroxy groups. It is isolated from the soil bacterium Streptomyces tropolofaciens strain K611-97.	2.1	1	alpha-hydroxy ketone; cyclic ketone; enol; triol	antineoplastic agent; bacterial metabolite
salicylideneaniline salicylideneaniline: structure in first source	3.27	1
sb 203580 [no description available]	3.27	1	imidazoles; monofluorobenzenes; pyridines; sulfoxide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent
moracin m moracin M: has been isolated from Morus alba L.; structure in first source	3.27	1	benzofurans
4-n-butylresorcinol 4-n-butylresorcinol: structure in first source	3.27	1	resorcinols
arbutin hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.	3.27	1	beta-D-glucoside; monosaccharide derivative	Escherichia coli metabolite; plant metabolite
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	3.27	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
trans-4-coumaric acid hydroxycinnamic acid : Any member of the class of cinnamic acids carrying one or more hydroxy substituents.. trans-4-coumaric acid : The trans-isomer of 4-coumaric acid.. 4-coumaric acid : A coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring.	3.27	1	4-coumaric acid	food component; mouse metabolite; plant metabolite
2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-1-benzopyran-4-one [no description available]	2.1	1	flavones
hispidol hispidol : A hydroxyaurone that is aurone substituted by hydroxy groups at positions 6 and 4' respectively.	3.27	1	hydroxyaurone	plant metabolite
trans-2,3',4,5'-tetrahydroxystilbene trans-2,3',4,5'-tetrahydroxystilbene: hydroxystilbene oxyresveratrol	3.27	1	stilbenoid
methyl-p-coumarate methyl-p-coumarate: structure in first source. 4-coumaric acid methyl ester : A cinnamate ester that is the methyl ester of 4-coumaric acid.	3.27	1	4-coumaric acid methyl ester
trilinolein trilinolein: RN given refers to (Z,Z)-isomer. 1,2,3-trilinoleoylglycerol : A triglyceride formed by acylation of the three hydroxy groups of glycerol with linoleic acid.	2.1	1	1,2-diacyl-3-linoleoylglycerol; 1,3-diacyl-2-linoleoylglycerol; linoleoyl containing 1,2,3-triacyl-sn-glycerol; TG(18:2/18:2/18:2); triglyceride	mouse metabolite
mulberroside a mulberroside A: structure in first source	3.27	1	glycoside; stilbenoid
artesunate artesunic acid: RN given for (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,(2aR*))-isomer; succinic ester of artemether	2.1	1	artemisinin derivative; cyclic acetal; dicarboxylic acid monoester; hemisuccinate; semisynthetic derivative; sesquiterpenoid	antimalarial; antineoplastic agent; ferroptosis inducer
morachalcone a morachalcone A: tyrosinase inhibitor from the wood of Artocarpus heterophyllus; structure in first source	3.27	1	chalcones
ginsenoside rb1 [no description available]	3.27	1	ginsenoside; glycoside; tetracyclic triterpenoid	anti-inflammatory drug; anti-obesity agent; apoptosis inhibitor; neuroprotective agent; plant metabolite; radical scavenger
2,4,2',4'-Tetrahydroxychalcone [no description available]	3.27	1	chalcones
subamolide a subamolide A: cytotoxic constituent of the stems of Cinnamomum subavenium; structure in first source	3.27	1

Condition	Indicated	Relationship Strength	Studies	Trials
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	0	2.02	1	0

alpha-thujaplicin

Description

Cross-References

Synonyms (20)

Protein Targets (2)

Inhibition Measurements

Other Measurements

Biological Processes (11)

Molecular Functions (5)

Ceullar Components (7)

Bioassays (49)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.52

Study Types

alpha-thujaplicin

Description

Cross-References

Synonyms (20)

Protein Targets (2)

Inhibition Measurements

Other Measurements

Biological Processes (11)

Molecular Functions (5)

Ceullar Components (7)

Bioassays (49)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.52

Study Types

Related Drugs (34)

Related Conditions (1)