Page last updated: 2024-09-27

Bone Malalignment

Displacement of bones out of line in relation to joints. It may be congenital or traumatic in origin.

Synonyms(3)

Synonym
Bone Misalignment
Bone Malalignment
Bone Malposition

Research

Studies (79)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's10 (12.66)12.5806
2000's30 (37.97)18.1394
2010's33 (41.77)28.8240
2020's6 (7.59)9.53
DrugIndicatedRelationship StrengthStudiesTrials
tranexamic acid0low10
durapatite0medium31
tantalum0low40
titanium0low30
calcium phosphate, dibasic, anhydrous0medium11
tricalcium phosphate0medium51
trolamine salicylate0medium144
propiconazole0low10
oxazolidin-2-one0low10
technetium tc 99m hydroxymethylene diphosphonate0low10
linezolid0low10
resveratrol0low10
gadolinium dtpa0low10
jaw0low10
vendex0medium91
technetium tc 99m medronate0medium31
chondroitin sulfates0low10

Protein Targets (323)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
ATAD5 protein, partial2002
estrogen-related nuclear receptor alpha3003
Chymotrypsinogen A0101
ATP-dependent phosphofructokinase2002
TDP1 protein3003
EWS/FLI fusion protein2002
estrogen nuclear receptor alpha3003
G2002
potassium voltage-gated channel subfamily H member 2 isoform d1001
streptokinase A precursor0011
lamin isoform A-delta103003
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Bile salt export pump0101
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Cytochrome P450 1A20203
Estrogen receptor0011
Cytochrome P450 3A40405
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Cytochrome P450 2D60102
Cytochrome P450 2C9 0203
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A0303
Prostaglandin G/H synthase 10202
Amine oxidase [flavin-containing] B0202
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial0101
Cytochrome P450 2C190203
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
50S ribosomal protein L36 20101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Estrogen receptor beta0011
Inositol hexakisphosphate kinase 12002
Canalicular multispecific organic anion transporter 10101
Renin0101
cytochrome P450 2C9, partial2002
vitamin D3 receptor isoform VDRA3003
DNA polymerase iota isoform a (long)3003
geminin2002
Vpr1001
Rap guanine nucleotide exchange factor 42002
Chain A, Beta-lactamase2002
Chain A, Ferritin light chain1001
glp-1 receptor, partial2002
pregnane X receptor1001
phosphopantetheinyl transferase2002
RAR-related orphan receptor gamma3003
SMAD family member 22002
SMAD family member 32002
GLI family zinc finger 32002
AR protein2002
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor2002
nonstructural protein 11001
glucocorticoid receptor [Homo sapiens]2002
retinoic acid nuclear receptor alpha variant 12002
retinoid X nuclear receptor alpha3003
farnesoid X nuclear receptor2002
pregnane X nuclear receptor2002
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
chromobox protein homolog 12002
thyroid hormone receptor beta isoform a2002
thyroid hormone receptor beta isoform 22002
heat shock protein HSP 90-alpha isoform 20001
nuclear factor erythroid 2-related factor 2 isoform 12002
nuclear receptor ROR-gamma isoform 12002
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Voltage-dependent calcium channel gamma-2 subunit2002
Cellular tumor antigen p532002
Glutamate receptor 22002
Histamine H2 receptor2002
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 431001
ATPase family AAA domain-containing protein 52002
Ataxin-22002
heat shock protein 90, putative0001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Luciferase1001
thioredoxin reductase1001
BRCA11001
ClpP1001
GLS protein1001
Microtubule-associated protein tau1001
caspase 7, apoptosis-related cysteine protease1001
aldehyde dehydrogenase 1 family, member A11001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
regulator of G-protein signaling 41001
cytochrome P450 family 3 subfamily A polypeptide 41001
cytochrome P450 2D61001
67.9K protein1001
Parkin1001
P531001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
arylsulfatase A1001
pyruvate kinase1001
caspase-31001
M18 aspartyl aminopeptidase0101
IDH11001
cathepsin L10101
euchromatic histone-lysine N-methyltransferase 21001
thyroid stimulating hormone receptor1001
Histone H2A.x1001
Bloom syndrome protein isoform 11001
lysosomal alpha-glucosidase preproprotein1001
hexokinase-4 isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
peripheral myelin protein 22 isoform 11001
cellular tumor antigen p53 isoform a1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
histone deacetylase 9 isoform 31001
glucokinase regulatory protein1001
huntingtin isoform 21001
DNA polymerase beta1001
atrial natriuretic peptide receptor 2 precursor1001
nuclear factor NF-kappa-B p105 subunit isoform 10011
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
FAD-linked sulfhydryl oxidase ALR0001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
DNA polymerase kappa isoform 12002
Vif0101
survival motor neuron protein isoform d1001
cytochrome P450 3A4 isoform 11001
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
transcription factor p65 isoform 10011
serine/threonine-protein kinase 33 isoform a0011
POsterior Segregation0011
Aryl hydrocarbon receptor0101
Estrogen receptor beta0011
Gamma-aminobutyric acid receptor subunit pi1001
Acetylcholinesterase0101
Polyphenol oxidase 20101
Carbonic anhydrase 120101
Lysine-specific histone demethylase 1A0101
Transient receptor potential cation channel subfamily A member 10112
Tyrosine-protein kinase ABL10102
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Myc proto-oncogene protein0102
Transthyretin0011
Estrogen receptor0101
Cytochrome P450 1A10101
Amyloid-beta precursor protein0112
Integrin beta-31001
Prostaglandin G/H synthase 10112
Tyrosine-protein kinase Lck0101
Cholinesterase0101
Cathepsin D0101
Carbonic anhydrase 30101
Aldo-keto reductase family 1 member B10202
ATP-dependent translocase ABCB10102
Integrin alpha-IIb1001
Luciferin 4-monooxygenase0101
Neuronal acetylcholine receptor subunit alpha-40101
DNA polymerase alpha catalytic subunit0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Leukotriene A-4 hydrolase0101
Breakpoint cluster region protein0102
Tyrosinase0202
Aromatase0202
Ornithine decarboxylase0101
Neuronal acetylcholine receptor subunit beta-20101
Tyrosinase0101
Gamma-aminobutyric acid receptor subunit beta-11001
Ribosyldihydronicotinamide dehydrogenase [quinone]0213
Protein kinase C alpha type0011
Tyrosine-protein phosphatase non-receptor type 10101
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
5-hydroxytryptamine receptor 1A0001
Estrogen receptor0011
Nuclear factor NF-kappa-B p105 subunit0101
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Endothelin receptor type B1001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Sucrase-isomaltase, intestinal0101
Sodium-dependent noradrenaline transporter 0213
Endothelin-1 receptor1001
Dipeptidyl peptidase 40101
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10101
Nitric oxide synthase, inducible0101
Gamma-aminobutyric acid receptor subunit alpha-61001
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
Cannabinoid receptor 10101
D(1A) dopamine receptor1001
Nuclear receptor ROR-gamma1001
Alpha-glucosidase MAL120101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Prostaglandin G/H synthase 20101
Cholinesterase0101
Inositol monophosphatase 11001
Nuclear factor NF-kappa-B p100 subunit 0101
Squalene synthase0101
Transcription factor p650101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0001
Bcl-2-like protein 10101
Serine/threonine-protein kinase PAK 10101
Nuclear factor erythroid 2-related factor 20012
Cytochrome P450 1B10202
Carbonic anhydrase 90101
N1L 0101
NAD(P)H dehydrogenase [quinone] 10002
Tubulin beta-2B chain0101
Lysosomal alpha-glucosidase0101
Transient receptor potential cation channel subfamily A member 10101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
NAD-dependent protein deacetylase sirtuin-20011
Carbonic anhydrase 130101
GABA theta subunit1001
NAD-dependent protein deacetylase sirtuin-10013
Carbonic anhydrase 150101
Gamma-aminobutyric acid receptor subunit epsilon1001
Prenyltransferase homolog0001
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Carbonic anhydrase 140101
Zinc finger protein mex-50011
Carbonic anhydrase 5B, mitochondrial0101
large T antigen0101
Chain A, PLASMINOGEN0011
Chain A, PLASMINOGEN0011
Plasminogen0213
Urokinase-type plasminogen activator0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]