Compounds > dmu-212
Page last updated: 2024-12-11

dmu-212

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Cross-References

ID SourceID
PubMed CID5388065
CHEMBL ID87982
SCHEMBL ID1394054
MeSH IDM0512234

Synonyms (31)

Synonym
CHEMBL87982 ,
10e-3,4,4',5-tetramethoxystilbene
(e)-3,4,5,4'-tetramethoxystilbene
nsc-631365
5-[2-(4-methoxyphenyl)ethenyl]-1,3-trimethoxy benzene
nsc631365
3,4,5,4'-tetramethoxy-trans-stilbene
trans-3,4,5,4'-tetramethoxystilbene
dmu-212
1,2,3-trimethoxy-5-[(e)-2-(4-methoxyphenyl)ethenyl]benzene
134029-49-5
AKOS015911629
134029-62-2
SCHEMBL1394054
AC-24228
dmu 212
(z)-3,4,5,4'-tetramethoxystilbene
1,2,3-trimethoxy-5-[(1e)-2-(4-methoxyphenyl)ethenyl]benzene
3,4,5,4/'-tetramethoxystilbene
GGFQQRXTLIJXNY-AATRIKPKSA-N
(e)-3,4,5-trimethoxy-4'-methoxystilbene
pethidinicacid
(e)-3,4,5,4''''-tetramethoxystilbene
10e-3,4,4'''',5-tetramethoxystilbene
bdbm50229491
(z)-1,2,3-trimethoxy-5-(4-methoxystyryl)benzene
MS-24329
DTXSID501300535
CS-0143458
HY-137977
EN300-21686167

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" These results serve to highlight the contrasting effects on different activities brought about by methoxylation, which is widely employed as a structural modification approach to improve potency and bioavailability of resveratrol."( Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties.
Go, ML; Zhang, W, 2011)		0.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (87)

Assay IDTitleYearJournalArticle
AID646312Cytotoxicity against human HeLa cells after 96 hrs by MTT assay2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID1294065Growth inhibition of human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID646321Downregulation of cyclin D1 expression in human HepG2 cells after 24 hrs by Western blot analysis2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID568518Selectivity ratio of IC50 for human IMR90 cells to IC50 for human HCT116 cells2011Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties.
AID1294050Growth inhibition of human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294066Growth inhibition of human Hs 578T cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294058Growth inhibition of human A498 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID646309Cell cycle arrest in human MCF7 cells assessed as accumulation at S phase at 10 uM after 24 hrs using propidium iodide staining by flow cytometry2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID1294022Growth inhibition of human HL-60(TB) cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID568514Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties.
AID568515Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties.
AID568508Cytotoxicity against mouse Hepa-1c1c7 cells after 24 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties.
AID420700Displacement of [3H]colchicine from bovine brain tubulin at 1 uM by scintillation counting2009European journal of medicinal chemistry, Jun, Volume: 44, Issue:6
A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4.
AID646313Induction of apoptosis in human MCF7 cells assessed as nuclear fragmentation at 30 uM after 24 hrs using DAPI staining by immunofluorescence method2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID1294062Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID84127Cytotoxic concentration required to inhibit 50% cell growth in HT-29 colon adenocarcinoma cell lines1991Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.
AID202827Cytotoxic concentration required to inhibit 50% cell growth in SKMEL-5 melanoma cell lines1991Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.
AID1294060Growth inhibition of human Caki1 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294053Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294023Growth inhibition of human K562 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294063Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294048Growth inhibition of human SK-MEL-2 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID646304Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID420701Displacement of [3H]colchicine from bovine brain tubulin at 5 uM by scintillation counting2009European journal of medicinal chemistry, Jun, Volume: 44, Issue:6
A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4.
AID646307Cell cycle arrest in human MCF7 cells assessed as accumulation at G1 phase at 10 uM after 24 hrs using propidium iodide staining by flow cytometry2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID646311Cell cycle arrest in human HeLa cells assessed as accumulation at G2/M phase at 10 uM after 24 hrs using propidium iodide staining by flow cytometry2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID420703Inhibition of bovine brain tubulin by spectrophotometry2009European journal of medicinal chemistry, Jun, Volume: 44, Issue:6
A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4.
AID1294056Growth inhibition of human SKOV3 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294031Growth inhibition of human NCI-H522 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID646306Cell cycle arrest in human HepG2 cells assessed as accumulation at G2/M phase at 10 uM after 24 hrs using propidium iodide staining by flow cytometry2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID106876Cytotoxic concentration required to inhibit 50% cell growth in MLM melanoma cell lines1991Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.
AID1294036Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294064Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294044Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID646303Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID294470Cytotoxicity against mouse Hepa 1c1c7 cells assessed as cell viability at 1 uM after 24 hrs by MTT assay2007European journal of medicinal chemistry, Jun, Volume: 42, Issue:6
Quinone reductase induction activity of methoxylated analogues of resveratrol.
AID646310Cell cycle arrest in human HepG2 cells assessed as accumulation at S phase at 10 uM after 24 hrs using propidium iodide staining by flow cytometry2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID420699Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay2009European journal of medicinal chemistry, Jun, Volume: 44, Issue:6
A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4.
AID1294052Growth inhibition of human IGROV1 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID568516Cytotoxicity against human IMR90 cells after 24 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties.
AID646317Antimitotic activity in human MCF7 cells assessed as decrease in localization of beta-tubulin expression around cell nucleus at 30 uM after 48 hrs by immunofluorescence staining2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID1294057Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294051Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID568507Induction of NQO1 activity in mouse Hepa1c1c7 cells assessed as concentration required to twofold increase of NQO1 activity at IC50 concentration relative to control2011Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties.
AID1294055Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID646323Upregulation of p53 protein expression in human HepG2 cells after 24 hrs by Western blot analysis2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID646316Antimitotic activity in human MCF7 cells assessed as decrease in localization of beta-tubulin expression around cell nucleus at 30 uM after 24 hrs by immunofluorescence staining2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID1294038Growth inhibition of human SW620 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294030Growth inhibition of human NCI-H23 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID646320Downregulation of cyclin D1 expression in human MCF7 cells after 24 hrs by Western blot analysis2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID42665Ability to inhibit Tubulin polymerization in Bovine brain1991Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.
AID1294061Growth inhibition of human UO31 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294021Growth inhibition of human CCRF-CEM cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID294475Induction of quinone reductase activity in mouse Hepa 1c1c7 cells at 1 uM after 24 hrs relative to control2007European journal of medicinal chemistry, Jun, Volume: 42, Issue:6
Quinone reductase induction activity of methoxylated analogues of resveratrol.
AID1294041Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID646305Cell cycle arrest in human MCF7 cells assessed as accumulation at G2/M phase at 10 uM after 24 hrs using propidium iodide staining by flow cytometry2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID568517Selectivity ratio of IC50 for human IMR90 cells to IC50 for human MCF7 cells2011Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties.
AID1294047Growth inhibition of human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294045Growth inhibition of human LOXIMVI cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294049Growth inhibition of human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294042Growth inhibition of human SNB19 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294025Growth inhibition of human RPMI8226 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID646318Downregulation of beta-tubulin expression in human MCF7 cells at >30 uM after 24 hrs by Western blot analysis2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID1294027Growth inhibition of human A549/ATCC cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294032Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294043Growth inhibition of human SNB75 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID646322Upregulation of p53 protein expression in human MCF7 cells after 24 hrs by Western blot analysis2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID1294035Growth inhibition of human HCT15 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294039Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID9208Cytotoxic concentration required to inhibit 50% cell growth in A-549 lung carcinoma cell lines1991Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.
AID1294054Growth inhibition of human OVCAR4 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID646315Antimitotic activity in human MCF7 cells assessed as effect on beta-tubulin distribution at 10 uM after 24 hrs by immunofluorescence staining2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID1294067Growth inhibition of human MDA-MB-468 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID103262Cytotoxic concentration required to inhibit 50% cell growth in MCF-7 breast carcinoma cell lines1991Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.
AID1294046Growth inhibition of human M14 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID646314Induction of apoptosis in human MCF7 cells assessed as nuclear fragmentation at 10 uM after 24 hrs using DAPI staining by immunofluorescence method2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID1294024Growth inhibition of human MOLT4 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294028Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294040Growth inhibition of human SF295 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294059Growth inhibition of human ACHN cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294026Growth inhibition of human SR cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294033Growth inhibition of human HCC2998 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294037Growth inhibition of human KM12 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID646319Downregulation of beta-tubulin expression in human HepG2 cells at >30 uM after 24 hrs by Western blot analysis2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID646308Cell cycle arrest in human HepG2 cells assessed as accumulation at G1 phase at 10 uM after 24 hrs using propidium iodide staining by flow cytometry2011European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.
AID1294029Growth inhibition of human HOP92 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
AID1294034Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 18.00

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index18.00 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.77 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (18.00)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
beta-naphthoflavone
beta-Naphthoflavone: A polyaromatic hydrocarbon inducer of P4501A1 and P4501A2 cytochromes. (Proc Soc Exp Biol Med 1994 Dec:207(3):302-308). beta-naphthoflavone : An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.		2.0310extended flavonoid;
naphtho-gamma-pyrone;
organic heterotricyclic compound		aryl hydrocarbon receptor agonist
sulforaphane
sulforaphane: from Cardaria draba L.. sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.		2.0310isothiocyanate;
sulfoxide		antineoplastic agent;
antioxidant;
EC 3.5.1.98 (histone deacetylase) inhibitor;
plant metabolite
podophyllotoxin
Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.		1.9710furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
thiocholchicine
thiocholchicine: RN refers to (S)-isomer		1.9710
erianin
Erianin: from Dendrobium chrysotoxum; structure in first source		2.4120
(4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone
(4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone: a tubulin inhibitor with antineoplastic activity; structure in first source		2.0510
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		2.4520resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		2.0610stilbene
pinosylvin
pinosylvin: phytoalexin found in pine and eucalyptus		2.4520pinosylvin
fosbretabulin
[no description available]		1.9710stilbenoid
3,3',4,5'-tetramethoxy-trans-stilbene
(E)-3,4,3',5'-tetramethoxystilbene: from the leaves of Eugenia rigida; structure in first source		1.9710
3,4',5-trimethoxystilbene
3,4',5-trimethoxystilbene: structure in first source		2.4520
1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene
[no description available]		2.7130
3,5-dihydroxy-4'-methoxystilbene
4'-methoxyresveratrol: has anti-inflammatory effects in cell culture model		2.4520
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		01.9710
Cancer of Colon
[description not available]		01.9710
Cancer of Lung
[description not available]		01.9710
Malignant Melanoma
[description not available]		01.9710
Breast Neoplasms
Tumors or cancer of the human BREAST.		01.9710
Colonic Neoplasms
Tumors or cancer of the COLON.		01.9710
Lung Neoplasms
Tumors or cancer of the LUNG.		01.9710
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		01.9710