| Assay ID | Title | Year | Journal | Article |
|---|
| AID715990 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as change in RBC count at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID1699970 | Antiproliferative activity against human K562/A02 cells overexpressing P-gp by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24
| Discovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells. |
| AID716228 | Inhibition to 59Fe uptake from 59Fe-transferrin in human SK-N-MC cells at 25 uM after 3 hrs | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID1501300 | Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease. |
| AID716220 | Antiproliferative activity at human A549 cells after 72 hrs by MTT assay | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID1626658 | Cytotoxicity against human A2780 cells incubated for 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14
| Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention. |
| AID303516 | Effect on iron efflux in human SK-N-MC cells assessed as cellular iron release | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
| Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues. |
| AID439767 | Antitumor activity against human SK-MEL-28 cells implanted in nude mouse assessed as reduction in tumor growth at 0.4 mg/kg/day measured up to 7 weeks relative to control | 2009 | Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
| Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors. |
| AID370489 | Reduction of cellular iron uptake from 59Fe]transferrin in human SK-N-MC cells at 25 uM after 3 hrs relative to control | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| 2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity. |
| AID1550741 | Antiproliferative activity against human HCT116 cells expressing wild type p53 incubated for 72 hrs by MTS assay | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety. |
| AID439768 | Octanol-water partition coefficient, log P of the compound | 2009 | Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
| Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors. |
| AID271691 | Antiproliferative activity against human SK-N-MC cells after 96 hrs by MTT assay | 2006 | Journal of medicinal chemistry, Nov-02, Volume: 49, Issue:22
| Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity. |
| AID1626663 | Cytotoxicity against human KBC1 cells incubated for 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14
| Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention. |
| AID715975 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as change in WBC count at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID716219 | Antiproliferative activity at human MRC5 cells after 72 hrs by MTT assay | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID716003 | Toxicity in human DMS53 cells xenografted BALB/c nu/nu mouse assessed as body weight change at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID671699 | Potentiation of theophylline transdermal permeation in pig ear skin assessed as enhancement ratio at 20 mg after 24 hrs by Franz diffusion cell method | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1
| Investigation of substituted 6-aminohexanoates as skin penetration enhancers. |
| AID1319028 | Induction of ROS accumulation in human KBV1 cells over expressing P-gp at 10 uM after 30 mins by DCF-DA staining based flow cytometry | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID677923 | Antiproliferative activity against human HCT116 cells expressing p53 assessed as cell survival at 5 nM after 9 days by clonogenic assay relative to control | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
| Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy. |
| AID722572 | Induction of 59Fe efflux in human SK-N-MC cells prelabeled with 59Fe2-Tf at 25 uM after 3 hrs by gamma-scintillation counting analysis (Rvb = 5 +/- 1%) | 2013 | Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1
| Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation. |
| AID370485 | Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| 2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity. |
| AID677908 | Antiproliferative activity against human NHDF cells after 72 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
| Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy. |
| AID1550510 | Cytotoxicity against human CFPAC-1 cells incubated for 24 hrs by MTT assay | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Multi-target compounds acting in cancer progression: Focus on thiosemicarbazone, thiazole and thiazolidinone analogues. |
| AID716229 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as cardiac fibrosis at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days by hematoxylin and eosin staining method | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID1319033 | Induction of P-gp-mediated lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as increase in LAMP2 fluorescence at 10 uM after 24 hrs in presence of P-gp inhibitor elacridar by TexasRed staining based immunofluorescence | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID1626661 | Resistance factor, ratio of IC50 for triapine-resistant human SW480 cells to IC50 for human SW480 cells incubated for 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14
| Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention. |
| AID715985 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as change in hemoglobin level at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID370490 | Induction of iron removal from 59Fe]transferrin assessed as iron release after 3 hrs relative to control | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| 2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity. |
| AID715743 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as hepatocellular fibrosis at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days by hematoxylin and eosin staining method | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID1550747 | Selectivity index, ratio of IC50 for human NHDF cells to IC50 for human HCT116 cells expressing wild type p53 | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety. |
| AID271700 | Increase in Fe(2+)-mediated hydroxyl radical production measured as hydroxylation of benzoate at IBE of 3 relative to control | 2006 | Journal of medicinal chemistry, Nov-02, Volume: 49, Issue:22
| Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity. |
| AID370487 | Induction of iron mobilization in 59Fe]transferrin labeled human SK-N-MC cells assessed as iron release at 25 uM after 3 hrs by gamma scintillation counter | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| 2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity. |
| AID539493 | Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay | 2010 | Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
| Investigating the activity of 2-substituted alkyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoates as skin penetration enhancers. |
| AID1501301 | Binding affinity to 59Fe2+ in human SK-N-MC cells labeled with 59Fe2-transferrin assessed as Fe release at 25 uM after 3 hrs by gamma scintillation counting method relative to total cellular 59Fe2+ (Rvb = 6%) | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease. |
| AID716222 | Induction of 59Fe mobilization in human SK-N-MC cells at 25 uM after 3 hrs by gamma-scintillation counter | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID271694 | Increase in Fe(3+)-mediated ascorbate oxidation at IBE of 1 relative to control | 2006 | Journal of medicinal chemistry, Nov-02, Volume: 49, Issue:22
| Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity. |
| AID411003 | Partition coefficient, log P of the compound | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity. |
| AID715996 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as change in organ weight at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID1501308 | Metal chelating activity assessed as inhibition of Cu2+ mediated amyloid beta (1 to 42) (unknown origin) aggregation at 25 uM after 2 hrs by turbidity assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease. |
| AID1550745 | Antiproliferative activity against human Hs683 cells incubated for 72 hrs by MTS assay | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety. |
| AID619952 | Toxicity in human SK-N-MC cells assessed as cell viability after 3 hrs by trypan blue staining | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity. |
| AID1319044 | Induction of oxidative stress-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 10 uM after 24 hrs in presence of antioxidant N-acetyl-L-cystein | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID439770 | Effect on iron metabolism in human SK-N-MC cells assessed as cellular iron uptake from transferrin at 25 uM after 3 hrs in presence of pronase relative to control | 2009 | Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
| Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors. |
| AID715747 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as hepatocellular necrosis at 3 mg/kg, iv administered for 5 days a week measured after 21 days by hematoxylin and eosin staining method | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID722571 | Reduction of cellular 59Fe uptake from 59Fe-Transferrin in human SK-N-MC cells assessed as 59Fe level prelabeled with 59Fe2-Tf at 25 uM after 3 hrs relative to control | 2013 | Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1
| Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation. |
| AID370486 | Octanol-water partition coefficient, log P of the compound | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| 2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity. |
| AID292406 | Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay | 2007 | Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
| Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents. |
| AID271695 | Increase in Fe(3+)-mediated ascorbate oxidation at IBE of 3 relative to control | 2006 | Journal of medicinal chemistry, Nov-02, Volume: 49, Issue:22
| Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity. |
| AID1319030 | Induction of P-gp-mediated lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as cathepsin D release from lysosome to cytosol at 10 uM after 24 hrs by TexasRed staining based immunofluorescence microscopic analysis | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID735438 | Antiproliferative activity against human SK-N-MC cells measured after 72 hrs at 37 degC by MTT assay | 2013 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
| Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy. |
| AID1319023 | Substrate activity at P-gp (unknown origin) in P-gp enriched membranes assessed as increase in ATPase activity at 50 uM in presence of Mg2-ATP after 40 mins by luciferase reporter gen assay relative to control | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID1699973 | Inhibition of recombinant human HDAC6 using Boc-Lys(Ac)-AMC as substrate incubated for 60 mins by fluorimetric assay | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24
| Discovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells. |
| AID1319042 | Induction of oxidative stress-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 10 uM after 24 hrs by TexasRed staining based immunofluorescence | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID619948 | Induction of Fe efflux in human SK-N-MC cells assessed as release of intracellular 59Fe up to 25 uM after 3 hrs by gamma-scintillation counting | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity. |
| AID1550783 | Binding affinity to calf thymus DNA assessed as hypochromism incubated for 1.5 hrs by spectrophotometric method | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety. |
| AID1550748 | Selectivity index, ratio of IC50 for human NHDF cells to IC50 for human HCT116 cells deficient in p53 | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety. |
| AID439769 | Iron chelating activity in human SK-N-MC cells assessed as cellular iron efflux at 25 uM after 3 hrs relative to control | 2009 | Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
| Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors. |
| AID677922 | Antiproliferative activity against human HCT116 cells expressing p53 assessed as cell survival at 1 nM after 9 days by clonogenic assay relative to control | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
| Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy. |
| AID439764 | Toxicity in iv dosed CD2F1 hybrid mouse assessed as maximum tolerated dose administered BID at an interval of 6 hrs for 5 days a week over 2 weeks | 2009 | Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
| Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors. |
| AID1626659 | Cytotoxicity against human SW480 cells incubated for 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14
| Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention. |
| AID715748 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as hepatocellular necrosis at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days by hematoxylin and eosin staining method | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID460409 | Toxicity in MDCK cells by MTT method | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Conjugates of desferrioxamine B (DFOB) with derivatives of adamantane or with orally available chelators as potential agents for treating iron overload. |
| AID1550749 | Selectivity index, ratio of IC50 for human NHDF cells to IC50 for human MCF7 cells | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety. |
| AID715733 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as change in lungs histology at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days by hematoxylin and eosin staining method | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID1550751 | Selectivity index, ratio of IC50 for human NHDF cells to IC50 for human Hs683 cells | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety. |
| AID671697 | Lipophilicity, log K of the compound by RP-HPLC analysis | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1
| Investigation of substituted 6-aminohexanoates as skin penetration enhancers. |
| AID1699974 | Inhibition of recombinant human HDAC8 using Boc-Lys(Ac)-AMC as substrate incubated for 60 mins by fluorimetric assay | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24
| Discovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells. |
| AID1626660 | Cytotoxicity against triapine-resistant human SW480 cells incubated for 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14
| Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention. |
| AID722575 | Cytotoxicity against human SK-N-MC cells assessed as growth inhibition after 72 hrs by MTT assay | 2013 | Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1
| Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation. |
| AID1626664 | Resistance factor, ratio of IC50 for human KBC1 cells to IC50 for human KB-3-1 cells incubated for 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14
| Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention. |
| AID411004 | Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2
| Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity. |
| AID619945 | Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTS assay | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity. |
| AID1319019 | Antiproliferative activity against human KB3-1 cells after 24 hrs in presence of P-gp inhibitor elacridar by MTT assay | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID439762 | Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
| Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors. |
| AID1550746 | Antiproliferative activity against human NHDF cells incubated for 72 hrs by MTS assay | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety. |
| AID303517 | Inhibition of cellular iron uptake from 59Fe]transferrin in human SK-N-MC cells at 50 uM relative to control | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
| Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues. |
| AID677924 | Antiproliferative activity against human HCT116 cells expressing p53 assessed as cell survival at 0.5 nM after 9 days by clonogenic assay relative to control | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
| Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy. |
| AID716214 | Antitumor activity against human DMS53 cells xenografted BALB/c nu/nu mouse assessed as reduction of tumor volume at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days (RVb = 922 94 mm'3) | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID1626662 | Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14
| Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention. |
| AID292410 | Partition coefficient, log P of the compound | 2007 | Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
| Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents. |
| AID1550744 | Antiproliferative activity against human U251 cells incubated for 72 hrs by MTS assay | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety. |
| AID677905 | Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
| Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy. |
| AID715738 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as change in brain histology at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days by hematoxylin and eosin staining method | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID722565 | Toxicity in intact human RBC assessed as methemoglobin formation at 25 uM after 3 hrs relative to untreated control | 2013 | Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1
| Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation. |
| AID1319032 | Induction of P-gp-mediated lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as cathepsin D release from lysosome to cytosol at 10 uM after 24 hrs in presence of P-gp inhibitor elacridar by TexasRed staining based immun | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID1501306 | Induction of autophagy in human SK-N-MC cells assessed as decrease in p62 level at 25 uM after 24 hrs by Western blot analysis | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease. |
| AID271690 | Partition coefficient, log P of the compound | 2006 | Journal of medicinal chemistry, Nov-02, Volume: 49, Issue:22
| Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity. |
| AID1319038 | Induction of copper-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 10 uM after 24 hrs by TexasRed staining based immunofluorescence microscop | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID1550742 | Antiproliferative activity against human HCT116 cells deficient in p53 incubated for 72 hrs by MTS assay | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety. |
| AID1319021 | Antiproliferative activity against human KBV1 cells over expressing P-gp after 24 hrs in presence of P-gp inhibitor elacridar by MTT assay | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID1626665 | Cytotoxicity against human WI38 cells incubated for 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14
| Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention. |
| AID1550743 | Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTS assay | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety. |
| AID715970 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as change in platelet count at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID722570 | Induction of ascorbate oxidation in citrate buffer in presence of 10 uM Fe3+ at 1 to 60 uM | 2013 | Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1
| Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation. |
| AID715753 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as vacuolation at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days by hematoxylin and eosin staining method | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID722568 | Toxicity in human RBC lysates assessed as methemoglobin formation at 25 uM after 3 hrs (Rvb = 1.2 +/- 8%) | 2013 | Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1
| Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation. |
| AID1319031 | Induction of P-gp-mediated lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as increase in LAMP2 fluorescence at 10 uM after 24 hrs by TexasRed staining based immunofluorescence microscopic analysis | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID439765 | Antitumor activity against mouse M109 cells implanted in CD2F1 hybrid mouse assessed as reduction of tumor weight at 0.4 mg/kg, iv administered 4 days after implantation BID for 5 days measured on day 12 after implantation relative to control | 2009 | Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
| Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors. |
| AID1699972 | Inhibition of recombinant human HDAC1 using Boc-Lys(Ac)-AMC as substrate incubated for 60 mins by fluorimetric assay | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24
| Discovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells. |
| AID1699971 | Resistance index, ratio of of IC50 for human K562/A02 cells to IC50 for human K562 cells | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24
| Discovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells. |
| AID619949 | Inhibition of 59Fe uptake from transferrin in human SK-N-MC cells at 25 uM after 3 hrs relative to control | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity. |
| AID460410 | Toxicity in human SK-N-MC cells by MTT method | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Conjugates of desferrioxamine B (DFOB) with derivatives of adamantane or with orally available chelators as potential agents for treating iron overload. |
| AID671698 | Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry, Jan-01, Volume: 20, Issue:1
| Investigation of substituted 6-aminohexanoates as skin penetration enhancers. |
| AID1501307 | Induction of autophagy in human SK-N-MC cells assessed as increase in LC3 accumulation at 25 uM after 24 hrs in presence of autophagy inhibitor Baf1 by Western blot analysis | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease. |
| AID1319040 | Induction of copper-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 10 uM after 24 hrs in presence of Cu chelator tetrathiomolybdate by TexasR | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID1550508 | Cytotoxicity against human PANC1 cells incubated for 24 hrs by MTT assay | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Multi-target compounds acting in cancer progression: Focus on thiosemicarbazone, thiazole and thiazolidinone analogues. |
| AID1626669 | Cytotoxicity against human A2780 cells pre-incubated with CuCl2 for 60 mins followed by compound addition for for 72 hrs by MTT assay | 2016 | Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14
| Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention. |
| AID619944 | Anticancer activity against mouse M109 cells xenografted in iv dosed CD2F1 mouse assessed as reduction in tumor growth after 5 days | 2011 | Journal of medicinal chemistry, Oct-13, Volume: 54, Issue:19
| Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity. |
| AID715960 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as change in hematopoetic cells in splenic red pulp at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days by hematoxylin and eosin staining method | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID715965 | Cardiotoxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID716225 | Antiproliferative activity at human SK-N-MC cells after 72 hrs by MTT assay | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID735441 | Inhibition of cellular iron uptake in human SK-N-MC cells assessed as iron uptake at 25 uM for 3 hrs at 37 degC relative to control | 2013 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
| Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy. |
| AID722566 | Toxicity in intact human RBC assessed as methemoglobin formation using Fe(compound)2 complex at 25 uM after 3 hrs relative to untreated control | 2013 | Journal of medicinal chemistry, Jan-10, Volume: 56, Issue:1
| Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation. |
| AID1319027 | Induction of lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp at 10 uM after 30 mins by acridine orange staining based fluorescence microscopic analysis | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID312544 | Antiproliferative activity against human SK-MN-C cells by MTT assay | 2008 | Journal of medicinal chemistry, Jan-24, Volume: 51, Issue:2
| Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series. |
| AID1319018 | Antiproliferative activity against human KB3-1 cells after 24 hrs by MTT assay | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID677907 | Antiproliferative activity against human HCT116 cells expressing p53 after 72 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
| Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy. |
| AID715980 | Toxicity in BALB/c nu/nu mouse xenografted with human DMS53 cells assessed as change in reticulocyte count at 0.75 mg/kg, iv administered for 5 days a week measured after 21 days | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID1501299 | Metal chelating activity assessed as inhibition of Cu2+ mediated human amyloid beta (1 to 40) aggregation at 25 uM after 2 hrs by turbidity assay | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease. |
| AID677906 | Antiproliferative activity against p53-deficient human HCT116 cells after 72 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
| Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy. |
| AID1699969 | Antiproliferative activity against human K562 cells by MTT assay | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24
| Discovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells. |
| AID271693 | Increase in Fe(3+)-mediated ascorbate oxidation at IBE of 0.1 relative to control | 2006 | Journal of medicinal chemistry, Nov-02, Volume: 49, Issue:22
| Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity. |
| AID460413 | Inhibition of [59Fe] uptake from [59Fe]transferrin in human SK-N-MC cells assessed as at 50 uM after 3 hrs relative to untreated control | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Conjugates of desferrioxamine B (DFOB) with derivatives of adamantane or with orally available chelators as potential agents for treating iron overload. |
| AID1501302 | Inhibition of 59Fe2+ uptake from transferrin in human SK-N-MC cells labeled with 59Fe2-Tf assessed as 59Fe uptake level at 25 uM after 3 hrs by gamma scintillation counting method relative to untreated control | 2017 | European journal of medicinal chemistry, Oct-20, Volume: 139 | A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease. |
| AID1550507 | Cytotoxicity against human MIAPaCa2 cells incubated for 24 hrs by MTT assay | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Multi-target compounds acting in cancer progression: Focus on thiosemicarbazone, thiazole and thiazolidinone analogues. |
| AID1319026 | Induction of lysosomal membrane permeabilization in human KB3-1 cells at 10 uM after 30 mins by acridine orange staining based fluorescence microscopic analysis | 2016 | Journal of medicinal chemistry, Sep-22, Volume: 59, Issue:18
| Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. |
| AID716221 | Antiproliferative activity at human DMS53 cells after 72 hrs by MTT assay | 2012 | Journal of medicinal chemistry, Aug-23, Volume: 55, Issue:16
| Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo. |
| AID1550750 | Selectivity index, ratio of IC50 for human NHDF cells to IC50 for human U251 cells | 2019 | European journal of medicinal chemistry, Jun-01, Volume: 171 | Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety. |
| AID1550509 | Cytotoxicity against human Capan2 cells incubated for 24 hrs by MTT assay | 2019 | European journal of medicinal chemistry, May-15, Volume: 170 | Multi-target compounds acting in cancer progression: Focus on thiosemicarbazone, thiazole and thiazolidinone analogues. |
| AID303514 | Antiproliferative activity against human SK-N-MC cells by MTT assay | 2007 | Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
| Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |