Microscopic Polyangiitis

A primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls.

Synonyms(1)

Synonym
Microscopic Polyangiitis

Research Excerpts

Overview

Excerpt	Reference
"Microscopic polyangiitis is an autoimmune small-vessel vasculitis that often manifests as focal and necrotizing glomerulonephritis and renal failure."	( Borza, DB; Chang, J; Fugger, L; Hickey, MJ; Holdsworth, SR; Kitching, AR; Ooi, JD, 2012)
"Microscopic polyangiitis is characterized by pauci-immune, necrotizing small-vessel vasculitis and an anti-neutrophil cytoplasmic antibody-associated vasculitis."	( Fukushima, M; Imai, Y; Inokuma, T; Inoue, S; Ono, Y; Tamaki, Y; Yoshimura, H, 2013)
"Microscopic polyangiitis is an ANCA-associated vasculitis and affects small sized vessels."	( Abouzid, Z; Bayahia, R; Benamar, L; Benjaafar, A; Bouattar, T; Chattahi, M; Ouzeddoun, N; Rouass, L; Sebti, K, 2022)
"Microscopic polyangiitis is a necrotising vasculitis characterised by anti-neutrophil cytoplasmic antibodies against myeloperoxidase."	( Kataoka, H; Kondo, M; Mukai, M; Nakanowatari, M; Tomita, T, 2023)
"Microscopic polyangiitis is an important and common component of cytoplasmic antibody-associated vasculitides that can lead to serious morbidity and even death."	( Akdam, H; Alp, A; Ersoy, M; Kahraman Çetin, N; Meteoğlu, İ; Yeniçerioğlu, Y, 2023)

Research

Studies (252)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	8 (3.17)	18.1394
2010's	168 (66.67)	28.8240
2020's	76 (30.16)	9.53

Drug	Relationship Strength	Studies	Trials
salicylic acid	low	1	0
gabexate	low	1	0
leflunomide	low	1	0
nafamostat	low	1	0
corticosterone	low	1	0
isoxazoles	low	1	0
citrulline	low	2	0
azetidyl-2-carboxylic acid	low	1	0
betamethasone valerate	low	1	0
hypochlorous acid	low	1	0
ursodeoxycholic acid	low	1	0
piperacillin	low	1	0
azelnidipine	low	1	0
fluorodeoxyglucose f18	low	4	0
mizoribine	low	4	0
methotrexate	medium	10	2
trimethoprim, sulfamethoxazole drug combination	low	4	0
dihydropyridines	low	1	0
resveratrol	low	1	0
tacrolimus	low	1	0
mycophenolic acid	medium	13	3
propylthiouracil	low	2	0
mocetinostat	medium	122	3
tofacitinib	low	1	0
cardiovascular agents	low	1	0
piperidines	low	1	0
interleukin-8	low	1	0
acenocoumarol	low	1	0
nephrin	low	1	0
ganciclovir	low	1	0
eye	low	1	0

Protein Targets (1,024)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Luciferase	3	0	0	3
RAR-related orphan receptor gamma	10	0	0	10
retinoid X nuclear receptor alpha	12	0	0	12
G	9	0	0	9
peroxisome proliferator activated receptor gamma	10	0	0	10
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
thyroid stimulating hormone receptor	6	0	0	6
chromobox protein homolog 1	6	0	0	6
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
geminin	14	0	0	14
muscleblind-like protein 1 isoform 1	5	0	0	5
Interferon beta	12	0	0	12
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Guanine nucleotide-binding protein G	2	0	0	2
Inositol hexakisphosphate kinase 1	9	0	0	9
cytochrome P450 2C9, partial	9	0	0	9
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Ferritin light chain	3	0	0	3
interleukin 8	2	0	0	2
acetylcholinesterase	5	0	0	5
thioredoxin reductase	8	0	0	8
phosphopantetheinyl transferase	5	0	0	5
SMAD family member 2	4	0	0	4
ATAD5 protein, partial	4	0	0	4
Fumarate hydratase	4	0	0	4
SMAD family member 3	4	0	0	4
TDP1 protein	14	0	0	14
GLI family zinc finger 3	11	0	0	11
Microtubule-associated protein tau	4	0	0	4
AR protein	12	0	0	12
thioredoxin glutathione reductase	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
EWS/FLI fusion protein	9	0	0	9
glucocorticoid receptor [Homo sapiens]	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
estrogen-related nuclear receptor alpha	12	0	0	12
farnesoid X nuclear receptor	7	0	0	7
pregnane X nuclear receptor	11	0	0	11
estrogen nuclear receptor alpha	15	0	0	15
polyprotein	4	0	0	4
P53	3	0	0	3
peroxisome proliferator-activated receptor delta	7	0	0	7
arylsulfatase A	5	0	0	5
IDH1	6	0	0	6
aryl hydrocarbon receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
Histone H2A.x	6	0	0	6
Bloom syndrome protein isoform 1	7	0	0	7
peripheral myelin protein 22 isoform 1	3	0	0	3
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
thyroid hormone receptor beta isoform 2	11	0	0	11
heat shock protein beta-1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
DNA polymerase iota isoform a (long)	6	0	0	6
peripheral myelin protein 22	6	0	0	6
survival motor neuron protein isoform d	9	0	0	9
cytochrome P450 3A4 isoform 1	6	0	0	6
M-phase phosphoprotein 8	3	0	0	3
muscarinic acetylcholine receptor M1	2	0	0	2
lamin isoform A-delta10	9	0	0	9
Gamma-aminobutyric acid receptor subunit pi	6	0	0	6
ATP-binding cassette sub-family C member 3	0	10	0	10
Multidrug resistance-associated protein 4	0	10	0	11
Bile salt export pump	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Bile salt export pump	0	15	0	15
Cellular tumor antigen p53	9	0	0	9
Gamma-aminobutyric acid receptor subunit beta-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit delta	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	6	0	0	6
Glutamate receptor 2	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-5	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	6	0	0	6
Nuclear receptor ROR-gamma	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-2	6	0	0	6
GABA theta subunit	6	0	0	6
Canalicular multispecific organic anion transporter 1	0	10	0	10
ATPase family AAA domain-containing protein 5	9	0	0	9
Ataxin-2	9	0	0	9
Gamma-aminobutyric acid receptor subunit epsilon	6	0	0	6
Protein-arginine deiminase type-4	0	3	0	3
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
USP1 protein, partial	4	0	0	4
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	5	0	0	5
progesterone receptor	11	0	0	11
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
cytochrome P450 2D6	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	8	0	0	8
caspase-3	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
nuclear receptor ROR-gamma isoform 1	5	0	0	5
Spike glycoprotein	4	0	0	4
Proton-coupled amino acid transporter 1	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
General amino-acid permease GAP1	0	0	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
pregnane X receptor	2	0	0	2
NFKB1 protein, partial	2	0	0	2
GALC protein	1	0	0	1
Thrombopoietin	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
nonstructural protein 1	3	0	0	3
thyroid hormone receptor beta isoform a	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
mitogen-activated protein kinase 1	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 3	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	2	2	4
Androgen receptor	0	4	0	4
C-8 sterol isomerase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
cytochrome P450 2D6 isoform 1	1	0	0	1
lethal factor (plasmid)	2	0	0	2
Membrane primary amine oxidase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Coagulation factor X	0	2	0	2
Plasminogen	0	4	0	4
Coagulation factor XII	0	2	0	2
Urokinase-type plasminogen activator	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Serine protease hepsin	0	3	0	3
Histamine H2 receptor	3	0	0	3
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Thymidine kinase	0	1	0	1
endonuclease IV	1	0	0	1
ClpP	3	0	0	3
GLS protein	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	1	0	3
glp-1 receptor, partial	3	0	0	3
matrix metalloproteinase 1, partial	0	0	1	1
PPM1D protein	5	0	0	5
Parkin	2	0	0	2
pyruvate kinase	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
histone deacetylase 9 isoform 3	2	0	0	2
huntingtin isoform 2	3	0	0	3
ras-related protein Rab-9A	2	0	0	2
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
histone acetyltransferase KAT2A isoform 1	4	0	0	4
neuropeptide S receptor isoform A	1	0	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Integrin beta-3	3	1	0	4
Cytochrome P450 1A2	0	2	0	2
Aldo-keto reductase family 1 member B1	0	4	0	4
Integrin alpha-IIb	3	1	0	4
Amine oxidase [flavin-containing] A	0	2	0	2
Endothelin receptor type B	2	0	0	2
Sodium-dependent noradrenaline transporter	0	4	1	5
Endothelin-1 receptor	2	0	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
dopamine D1 receptor	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
flap endonuclease 1	2	0	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
ATP-dependent phosphofructokinase	5	0	0	5
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
acid sphingomyelinase	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
67.9K protein	3	0	0	3
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
vitamin D3 receptor isoform VDRA	3	0	0	3
transcriptional regulator ERG isoform 3	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
DNA polymerase beta	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
DNA polymerase kappa isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	2	4
Carbonic anhydrase 2	0	3	1	4
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	3
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	1	2	3
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	6	3	14
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
regulator of G-protein signaling 4	2	0	0	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Cytochrome P450 3A4	0	5	0	5
Leukotriene A-4 hydrolase	0	2	0	2
Cytochrome P450 2D6	0	2	0	2
Integrin alpha-4	0	1	0	1
Cytochrome P450 2C19	0	3	0	3
Histone deacetylase 4	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Alpha-synuclein	2	0	0	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
ubiquitin-like modifier-activating enzyme 1	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
ubiquitin-conjugating enzyme E2 variant 1 isoform a	0	1	0	1
Prothrombin	0	1	0	1
Complement C1r subcomponent	0	1	0	1
Cationic trypsin	0	1	0	1
Interstitial collagenase	0	1	0	1
Cathepsin D	0	2	0	2
Trypsin-1	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Complement C1s subcomponent	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Neutrophil collagenase	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Collagenase 3	0	1	0	1
Hepatocyte growth factor activator	0	2	1	3
Suppressor of tumorigenicity 14 protein	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase OXA-7	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	3	0	3
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Androgen receptor	0	2	0	2
Cytochrome P450 2C9	0	3	0	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	3	1	4
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	1	0	1
Estrogen receptor beta	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
NADH-cytochrome b5 reductase 3	0	1	0	1
Myeloperoxidase	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Chain A, Beta-lactamase	3	0	0	3
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
BRCA1	1	0	0	1
M18 aspartyl aminopeptidase	0	1	0	1
cathepsin L1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	0	0	1	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Vif	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
transcription factor p65 isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
POsterior Segregation	0	0	1	1
Aryl hydrocarbon receptor	0	1	0	1
Estrogen receptor beta	0	0	1	2
Acetylcholinesterase	0	1	0	1
Polyphenol oxidase 2	0	2	0	3
Carbonic anhydrase 12	0	2	0	2
Lysine-specific histone demethylase 1A	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Carbonic anhydrase 1	0	3	0	3
Myc proto-oncogene protein	0	1	0	2
Transthyretin	0	0	1	1
Cytochrome P450 1A1	0	1	0	1
Amyloid-beta precursor protein	0	1	1	2
Prostaglandin G/H synthase 1	0	1	1	2
Tyrosine-protein kinase Lck	0	2	1	3
Cholinesterase	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	2
Luciferin 4-monooxygenase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Breakpoint cluster region protein	0	1	1	3
Tyrosinase	0	2	0	2
Aromatase	0	2	0	2
Ornithine decarboxylase	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Tyrosinase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	2	4
Protein kinase C alpha type	0	1	2	3
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
5-hydroxytryptamine receptor 1A	0	1	0	2
Estrogen receptor	0	0	1	2
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Acetylcholinesterase	0	2	0	2
Carbonic anhydrase 4	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 6	0	2	0	2
Sucrase-isomaltase, intestinal	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Carbonic anhydrase 7	0	2	0	2
Cannabinoid receptor 1	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Alpha-glucosidase MAL12	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Cholinesterase	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Squalene synthase	0	1	0	1
Transcription factor p65	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	0	0	1
Bcl-2-like protein 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	1	2
Cytochrome P450 1B1	0	2	0	2
Carbonic anhydrase 9	0	2	0	2
N1L	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	2
Tubulin beta-2B chain	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	0	1	1
Carbonic anhydrase 13	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
NAD-dependent protein deacetylase sirtuin-1	0	0	1	3
Carbonic anhydrase 15	0	2	0	2
Prenyltransferase homolog	0	0	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Carbonic anhydrase 14	0	2	0	2
Zinc finger protein mex-5	0	0	1	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
large T antigen	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	2
Solute carrier family 22 member 6	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	1	1	2
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	2
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	2
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	2
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	1	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase JAK2	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
tyrosine-protein kinase Yes	1	0	0	1
Serine/threonine-protein kinase Sgk1	0	1	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Membrane-associated progesterone receptor component 1	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
Serine/threonine-protein kinase 25	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	1	1	2
Serine/threonine-protein kinase Chk1	0	1	1	2
Peripheral plasma membrane protein CASK	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Mitogen-activated protein kinase 13	0	1	1	2
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
NUAK family SNF1-like kinase 1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Tyrosine-protein kinase JAK2	0	3	2	7
Rho-associated protein kinase 2	0	1	1	2
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	1	1	2
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
Epidermal growth factor receptor	0	1	1	2
RAF proto-oncogene serine/threonine-protein kinase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	1	2
High affinity nerve growth factor receptor	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	0	1	1
Insulin receptor	0	1	1	2
Tyrosine-protein kinase Fyn	0	0	1	1
Cyclin-dependent kinase 1	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Cytochrome P450 2C8	0	1	0	1
Mast/stem cell growth factor receptor Kit	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
Cytochrome P450 2A6	0	1	0	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	0	1	1
Insulin receptor-related protein	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Platelet-derived growth factor receptor alpha	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
Vascular endothelial growth factor receptor 1	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	1	1	2
Tyrosine-protein kinase JAK1	0	3	2	7
Protein kinase C eta type	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Activin receptor type-2A	0	0	1	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	3	2	7
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	1	1	2
RAC-beta serine/threonine-protein kinase	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Tyrosine-protein kinase CSK	0	1	1	2
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	1	1
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase Tec	0	1	1	2
Tyrosine-protein kinase TXK	0	1	1	2
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	1	1	2
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	1	1
MAP kinase-activated protein kinase 2	0	1	1	2
Cyclin-dependent kinase 8	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	1	1	2
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Tyrosine-protein kinase Blk	0	1	1	2
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	1	1	2
Cytoplasmic tyrosine-protein kinase BMX	0	1	1	2
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	3	2	8
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
Death-associated protein kinase 1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 12	0	1	1	2
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-B receptor 1	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Actin-related protein 3	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Tubulin alpha-1A chain	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	1	1	2
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Protein kinase C epsilon type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
Angiopoietin-1 receptor	0	0	1	1
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	1	1	2
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	1	1	2
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Serine/threonine-protein kinase ATR	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
Serine/threonine-protein kinase D1	0	0	1	1
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	1	1	2
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	1	1	2
Serine/threonine-protein kinase STK11	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	1	1	2
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Rab-like protein 3	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Sigma intracellular receptor 2	0	1	0	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Tyrosine-protein kinase JAK3	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	1	1	2
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
Phosphatidylinositol 4-kinase beta	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Serine/threonine-protein kinase TBK1	0	1	1	2
Septin-9	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Long-chain-fatty-acid--CoA ligase 5	0	0	1	1
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Vitamin D3 receptor	0	1	1	2
Ileal sodium/bile acid cotransporter	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
Bile acid receptor	0	0	1	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
M1-family alanyl aminopeptidase	0	1	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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