You're asking about a compound called **1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene**, also known by its IUPAC name, **(E)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene**. This compound is a type of **stilbene**, a class of organic compounds with a specific structural feature: a central ethylene (C=C) bond connecting two aromatic rings.
Here's a breakdown:
* **Structure:** The molecule has a double bond (C=C) at its center, with a 4-methoxyphenyl ring (a benzene ring with a methoxy group attached at the 4th position) attached to one end and a 3,4,5-trimethoxyphenyl ring (a benzene ring with three methoxy groups at positions 3, 4, and 5) attached to the other end.
* **Properties:** It's likely a solid at room temperature, and its exact properties would depend on factors like its purity and crystalline form.
* **Importance in research:** Stilbenes, including this specific compound, are interesting for several research areas:
* **Pharmacology:** Some stilbenes have shown biological activity as:
* **Antioxidants:** They can help protect cells from damage caused by free radicals.
* **Anti-inflammatory agents:** They can reduce inflammation in the body.
* **Anti-cancer agents:** Some have been studied for their potential to inhibit cancer cell growth.
* **Antimicrobial agents:** They might have activity against certain bacteria and fungi.
* **Materials Science:** Stilbenes can be used in the synthesis of polymers and other materials with unique properties.
* **Organic Chemistry:** They serve as model compounds for understanding the reactivity and photochemistry of organic molecules.
**Note:** It's important to remember that the specific importance of this exact compound (1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene) might be limited. Research on stilbenes focuses on the entire class of compounds, with various substituents and modifications, to explore their diverse biological and chemical properties.
If you have a specific research area in mind, it might be helpful to provide more context to understand the relevance of this particular stilbene derivative.
1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene, also known as **resveratrol**, is a naturally occurring stilbene compound found in various plants, including grapes, peanuts, and berries.
**Importance in Research:**
Resveratrol has attracted significant research interest due to its diverse biological activities and potential health benefits. Here are some key areas where it plays a role:
* **Antioxidant Activity:** Resveratrol acts as a potent antioxidant, neutralizing free radicals that damage cells and contribute to aging and disease.
* **Cardiovascular Health:** Studies suggest resveratrol may improve heart health by reducing blood pressure, lowering cholesterol levels, and protecting blood vessels from damage.
* **Cancer Prevention:** Resveratrol has shown promise in inhibiting the growth and spread of cancer cells in laboratory studies, particularly for cancers like breast, colon, and prostate cancer.
* **Neuroprotective Effects:** Research indicates that resveratrol may protect brain cells from damage caused by oxidative stress, inflammation, and aging, potentially mitigating cognitive decline and neurodegenerative diseases like Alzheimer's and Parkinson's.
* **Anti-inflammatory Properties:** Resveratrol possesses anti-inflammatory properties that may help reduce inflammation in various tissues and organs.
* **Metabolic Regulation:** Resveratrol has been linked to improvements in insulin sensitivity and glucose metabolism, potentially aiding in the management of diabetes.
* **Lifespan Extension:** Studies in animal models have shown that resveratrol can extend lifespan and improve healthspan.
**Current Research Focus:**
Current research on resveratrol focuses on:
* Understanding its mechanisms of action at the molecular level.
* Developing safe and effective ways to deliver resveratrol to the body.
* Evaluating its long-term effects in humans.
* Exploring its potential therapeutic applications in various diseases.
**Conclusion:**
Resveratrol is a natural compound with a wide range of biological activities, making it a promising candidate for various health benefits and therapeutic applications. Ongoing research is exploring its potential to prevent and treat chronic diseases, promote healthy aging, and enhance overall well-being.
1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene: inhibits tubulin polymerization; RN & structure given in first source
ID Source | ID |
---|---|
PubMed CID | 125922 |
MeSH ID | M0191925 |
PubMed CID | 5388779 |
CHEMBL ID | 47426 |
SCHEMBL ID | 3834841 |
MeSH ID | M0191925 |
Synonym |
---|
NCI60_010242 |
NCI60_012884 |
3,4,5,4'-tetramethoxystilbene |
1,2,3-trimethoxy-5-[2-(4-methoxyphenyl)ethenyl]benzene |
1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene |
3,4,4',5-tetramethoxystilbene |
GGFQQRXTLIJXNY-UHFFFAOYSA-N |
FT-0770743 |
BCP31049 |
DTXSID201341726 |
(z) 3,4',5-tetramethoxystilbene |
nsc638499 |
nsc-638499 |
CHEMBL47426 , |
10z-3,4,4',5-tetramethoxystilbene |
1,2,3-trimethoxy-5-[(z)-2-(4-methoxyphenyl)ethenyl]benzene |
1,2,3-trimethoxy-5-[(z)-2-(4-methoxy-phenyl)-vinyl]-benzene |
5-(4-methoxystyryl)-1,2,3-trimethoxybenzene |
bdbm50006677 |
10z-3,4,4'',5-tetramethoxystilbene |
1,2,3-trimethoxy-5-[2-(4-methoxy-phenyl)-vinyl]-benzene |
3,4,4'',5-tetramethoxy-(z)-stilbene |
(z)-1,2,3-trimethoxy-5-(2-(4-methoxyphenyl)ethenyl)benzene |
1-mtpe |
benzene, 1,2,3-trimethoxy-5-(2-(4-methoxyphenyl)ethenyl)-, (z)- |
SCHEMBL3834841 |
cis-3,4,5,4'-tetramethoxystilbene |
PD181080 |
Excerpt | Reference | Relevance |
---|---|---|
" As part of a chemoprevention drug development programme, the pharmacokinetic properties of DMU 212 were compared with those of resveratrol in the plasma, liver, kidney, lung, heart, brain and small intestinal and colonic mucosa of mice." | ( Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4'-tetramethoxystilbene. Boocock, D; Farmer, PB; Gescher, AJ; Jones, DJ; Potter, GA; Ruparelia, KC; Sale, S; Steward, WP; Verschoyle, RD; Wilsher, N, 2004) | 0.32 |
" The pharmacokinetic profiles of MR-4 were subsequently assessed in rats using 2-hydroxypropyl-β-cyclodextrin as a dosing vehicle." | ( Quantification of trans-3,4,5,4'-Tetramethoxystilbene in rat plasma by HPLC: application to pharmacokinetic study. Go, ML; Ho, PC; Lin, HS; Spatafora, C; Tringali, C; Zhang, W, 2011) | 0.37 |
Excerpt | Relevance | Reference |
---|---|---|
" The pharmacokinetic profiles of MR-4 were subsequently assessed in rats using 2-hydroxypropyl-β-cyclodextrin as a dosing vehicle." | ( Quantification of trans-3,4,5,4'-Tetramethoxystilbene in rat plasma by HPLC: application to pharmacokinetic study. Go, ML; Ho, PC; Lin, HS; Spatafora, C; Tringali, C; Zhang, W, 2011) | 0.37 |
" All compounds activated AhR, but their efficacies, potencies and dose-response profiles differed substantially." | ( Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes. Bachleda, P; Dvořák, Z; Pastorková, B; Vrzalová, A, 2017) | 0.46 |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Tubulin alpha-1A chain | Sus scrofa (pig) | IC50 (µMol) | 1.3000 | 0.0067 | 2.1603 | 10.0000 | AID214546 |
Tubulin beta-4A chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 1.9680 | 10.0000 | AID273359; AID310083 |
Tubulin beta chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 2.0529 | 10.0000 | AID273359; AID310083 |
Tubulin alpha-3C chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 1.9555 | 10.0000 | AID273359; AID310083 |
Tyrosinase | Mus musculus (house mouse) | IC50 (µMol) | 500.0000 | 0.0300 | 2.2104 | 5.2300 | AID1801525 |
Tubulin alpha-1B chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 1.9555 | 10.0000 | AID273359; AID310083 |
Tubulin alpha-4A chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 1.9555 | 10.0000 | AID273359; AID310083 |
Tubulin beta-4B chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 1.9680 | 10.0000 | AID273359; AID310083 |
Tubulin beta-3 chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 1.8945 | 10.0000 | AID273359; AID310083 |
Tubulin beta-2A chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 1.9680 | 10.0000 | AID273359; AID310083 |
Tubulin beta-8 chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 1.9680 | 10.0000 | AID273359; AID310083 |
Tubulin beta-2B chain | Bos taurus (cattle) | IC50 (µMol) | 1.6500 | 0.2500 | 1.8838 | 8.7000 | AID214032; AID214160 |
Tubulin alpha-3E chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 1.9555 | 10.0000 | AID273359; AID310083 |
Tubulin alpha-1A chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 1.9555 | 10.0000 | AID273359; AID310083 |
Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 (µMol) | 1.6500 | 0.2500 | 1.8779 | 8.7000 | AID214032; AID214160 |
Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 (µMol) | 1.3000 | 0.2500 | 1.8656 | 8.7000 | AID214160 |
Tubulin alpha-1C chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 1.9555 | 10.0000 | AID273359; AID310083 |
Tubulin beta-6 chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 1.9680 | 10.0000 | AID273359; AID310083 |
Tubulin beta-2B chain | Homo sapiens (human) | IC50 (µMol) | 1.8500 | 0.0005 | 1.9680 | 10.0000 | AID273359; AID310083 |
Tubulin beta-1 chain | Homo sapiens (human) | IC50 (µMol) | 1.3000 | 0.0005 | 1.9870 | 10.0000 | AID241105; AID273359; AID310083 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID568507 | Induction of NQO1 activity in mouse Hepa1c1c7 cells assessed as concentration required to twofold increase of NQO1 activity at IC50 concentration relative to control | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
AID214184 | Percentage inhibition of colchicine binding to tubulin by compound was evaluated | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Antineoplastic agents. 379. Synthesis of phenstatin phosphate. |
AID568508 | Cytotoxicity against mouse Hepa-1c1c7 cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
AID273358 | Inhibition of [3H]colchicine binding to tubulin at 5 uM | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21 | 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
AID228455 | Inhibition of tubulin polymerization | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. |
AID106876 | Cytotoxic concentration required to inhibit 50% cell growth in MLM melanoma cell lines | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. |
AID214546 | Concentration required to inhibit polymerization of tubulin | 2001 | Bioorganic & medicinal chemistry letters, Apr-09, Volume: 11, Issue:7 | Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents. |
AID310083 | Inhibition of tubulin polymerization | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | Conformationally restricted macrocyclic analogues of combretastatins. |
AID273362 | Antiproliferative activity against human H460 cell line by methylene blue dye assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21 | 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
AID273361 | Antiproliferative activity against human KB-VIN10 cell line by methylene blue dye assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21 | 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
AID221962 | Compound was evaluated for cytotoxicity against human SKMEL-5 melanoma cell line. | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. |
AID273365 | Antiproliferative activity against human MKN45 cell line by methylene blue dye assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21 | 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
AID568517 | Selectivity ratio of IC50 for human IMR90 cells to IC50 for human MCF7 cells | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
AID103367 | Cytotoxicity against human MCF-7 breast cancer cell line. | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. |
AID273359 | Inhibition of tubulin polymerization | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21 | 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
AID143037 | Concentration required to inhibit proliferation of Human lung carcinoma NCI-H460 cell line | 2001 | Bioorganic & medicinal chemistry letters, Apr-09, Volume: 11, Issue:7 | Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents. |
AID221796 | Compound was evaluated for cytotoxicity against human A-549 non-small cell lung cancer cell line. | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. |
AID294475 | Induction of quinone reductase activity in mouse Hepa 1c1c7 cells at 1 uM after 24 hrs relative to control | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Quinone reductase induction activity of methoxylated analogues of resveratrol. |
AID568515 | Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
AID214160 | The compound was tested for the concentration to inhibit 50% of tubulin polymerization. | 1998 | Journal of medicinal chemistry, May-07, Volume: 41, Issue:10 | Antineoplastic agents. 379. Synthesis of phenstatin phosphate. |
AID241105 | Concentration required for 50% inhibition of tubulin polymerization | 2005 | Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2 | Quantitative structure-activity relationship (5D-QSAR) study of combretastatin-like analogues as inhibitors of tubulin assembly. |
AID9208 | Cytotoxic concentration required to inhibit 50% cell growth in A-549 lung carcinoma cell lines | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. |
AID568514 | Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
AID202827 | Cytotoxic concentration required to inhibit 50% cell growth in SKMEL-5 melanoma cell lines | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. |
AID78625 | Concentration required to inhibit proliferation of multidrug resistant Human colon carcinoma HCT-15 cell line | 2001 | Bioorganic & medicinal chemistry letters, Apr-09, Volume: 11, Issue:7 | Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents. |
AID273360 | Antiproliferative activity against human KB cell line by methylene blue dye assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21 | 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
AID568518 | Selectivity ratio of IC50 for human IMR90 cells to IC50 for human HCT116 cells | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
AID84127 | Cytotoxic concentration required to inhibit 50% cell growth in HT-29 colon adenocarcinoma cell lines | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. |
AID294470 | Cytotoxicity against mouse Hepa 1c1c7 cells assessed as cell viability at 1 uM after 24 hrs by MTT assay | 2007 | European journal of medicinal chemistry, Jun, Volume: 42, Issue:6 | Quinone reductase induction activity of methoxylated analogues of resveratrol. |
AID273364 | Antiproliferative activity against human TSGH stomach carcinoma cell line by methylene blue dye assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21 | 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
AID273363 | Antiproliferative activity against human HT29 cell line by methylene blue dye assay | 2006 | Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21 | 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. |
AID221950 | Cytotoxicity against human MLM melanoma cell line. | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. |
AID214171 | Effect on the binding of radiolabeled [3H]colchicine to tubulin | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. |
AID221812 | Cytotoxicity against human HT-29 colon cell line. | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. |
AID42665 | Ability to inhibit Tubulin polymerization in Bovine brain | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. |
AID214032 | In vitro inhibition of bovine electrophoretically homogeneous tubulin polymerization. | 1993 | Journal of medicinal chemistry, Sep-17, Volume: 36, Issue:19 | Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization. |
AID103262 | Cytotoxic concentration required to inhibit 50% cell growth in MCF-7 breast carcinoma cell lines | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8 | Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. |
AID568516 | Cytotoxicity against human IMR90 cells after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3 | Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties. |
AID1801525 | Tyrosinase Activity from Article 10.1016/j.bioorg.2016.01.001: \\Synthesis and tyrosinase inhibition activity of trans-stilbene derivatives.\\ | 2016 | Bioorganic chemistry, Feb, Volume: 64 | Synthesis and tyrosinase inhibition activity of trans-stilbene derivatives. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 4 (10.26) | 18.2507 |
2000's | 10 (25.64) | 29.6817 |
2010's | 21 (53.85) | 24.3611 |
2020's | 4 (10.26) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.82) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Observational | 0 (0.00%) | 0.25% |
Other | 30 (100.00%) | 84.16% |
Other | 11 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |