vaticanol c

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

vaticanol C: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	49866362
CHEMBL ID	1224887
MeSH ID	M0430791

Synonyms (3)

Synonym
CHEMBL1224887 ,
vaticanol c
bdbm50362646

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	IC50 (µMol)	21.2000	0.0004	1.8773	10.0000	AID641150
Sucrase-isomaltase, intestinal	Rattus norvegicus (Norway rat)	IC50 (µMol)	94.2000	0.0400	1.8483	10.0000	AID641148
Lysosomal alpha-glucosidase	Rattus norvegicus (Norway rat)	IC50 (µMol)	140.0000	0.0800	2.5061	9.8500	AID641146
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID641148	Inhibition of alpha-glucosidase activity of sucrase in rat small intestinal brush border membrane fraction using maltose as substrate after 30 mins	2012	Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2	Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii.
AID504234	Cytotoxicity against human foreskin fibroblast at 1 uM	2010	Journal of natural products, Sep-24, Volume: 73, Issue:9	Resveratrol oligomers from Vatica albiramis.
AID641150	Inhibition of rat lens aldose reductase using DL-glyceraldehyde as substrate after 30 mins by fluorescence microplate reader analysis	2012	Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2	Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii.
AID641146	Inhibition of alpha-glucosidase activity of maltase in rat small intestinal brush border membrane fraction using maltose as substrate after 30 mins	2012	Bioorganic & medicinal chemistry, Jan-15, Volume: 20, Issue:2	Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii.
AID504233	Antiinflammatory activity in human foreskin fibroblast assessed as inhibition of IL-1-beta-induced MMP1 production at 1 uM treated for 24 hrs before IL1-beta challenge measured after 24 hrs by Western blot analysis	2010	Journal of natural products, Sep-24, Volume: 73, Issue:9	Resveratrol oligomers from Vatica albiramis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (57.14)	29.6817
2010's	2 (28.57)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.15 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	4.34 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.15)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
phlorhizin [no description available]	2.07	1	aryl beta-D-glucoside; dihydrochalcones; monosaccharide derivative	antioxidant; plant metabolite
acarbose [no description available]	2.07	1	amino cyclitol; glycoside
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	3.15	5	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
stilbenes Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.	3.29	6	stilbene
epalrestat epalrestat : A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.	2.07	1	monocarboxylic acid; thiazolidines	EC 1.1.1.21 (aldehyde reductase) inhibitor
polydatin trans-piceid : A stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue.	2.07	1	beta-D-glucoside; monosaccharide derivative; polyphenol; stilbenoid	anti-arrhythmia drug; antioxidant; geroprotector; hepatoprotective agent; metabolite; nephroprotective agent; potassium channel modulator
epsilon-viniferin epsilon-viniferin: stilbene dimer; isolated from the Oriental medicinal plant Vitis coignetiae; structure given in first source. (-)-trans-epsilon-viniferin : A stilbenoid that is the (-)-trans-stereoisomer of epsilon-viniferin, obtained by cyclodimerisation of trans-resveratrol.	2.05	1	1-benzofurans; polyphenol; stilbenoid	metabolite
vaticanol b Vaticanol B: structure in first source	2.47	2
sphingosine kinase [no description available]	2.25	1
malibatol a malibatol A: an oligostilbene from leaves of Hopea malibato; structure in first source	2.07	1
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone: an interleukin-1beta converting enzyme (ICE)-like protease inhibitor	2.25	1
hopeaphenol hopeaphenol: resveratrol tetramer in wines from North Africa	2.05	1

Condition	Relationship Strength	Studies
Cancer of Colon [description not available]	2.42	2
Colonic Neoplasms Tumors or cancer of the COLON.	2.42	2
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.03	1
Cancer of Lung [description not available]	2.03	1
Lymph Node Metastasis [description not available]	2.03	1
Experimental Mammary Neoplasms [description not available]	2.03	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.03	1

chemdatabank.com