sulfoxaflor profile

sulfoxaflor: insecticide targeting sap-feeding pests; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

sulfoxaflor : A mixture of the four diastereoisomers arising from the two tetrahedral stereocentres of [methyl(oxido){1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-lambda(6)-sulfanylidene]cyanamide (the sulfur atom and the carbon attached to position 3 of the pyridine ring). [Both E- and Z-isomers involving the S=N double bond and the cyano group exist, but they interconvert rapidly at r.t.]. A nicotinic acetylcholine receptor agonist in insects, sulfoxaflor is used as an insecticide, particularly for the control of aphids. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

[methyl(oxido){1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-lambda(6)-sulfanylidene]cyanamide : A member of the class of pyridines that is 5-ethyl-2-trifluoromethylpyridine in which the ethyl group is substituted at position 1 by an N-cyano-S-methylsulfonimidoyl group. The insecticide sulfoxalor is a mixture of the four possible stereoisomers arising from the two tetrahedral stereocentres. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	16723172
CHEMBL ID	2230078
CHEBI ID	133306
SCHEMBL ID	520711
MeSH ID	M0560136

Synonym
CHEBI:133306
[methyl(oxido){1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-lambda(6)-sulfanylidene]cyanamide
gf 2372
sulfoxaflor [iso]
n-(methyloxido(1-(6-(trifluoromethyl)-3-pyridinyl)ethyl)-lambda4-sulfanylidene)cyanamide
xde 208
gf 2032
unii-671w88oy8k
946578-00-3
sulfoxaflor
671w88oy8k ,
hsdb 8245
sulfoxaflor b
transform
sulfoxaflor a
cyanamide, n-(methyloxido(1-(6-(trifluoromethyl)-3-pyridinyl)ethyl)-.lambda.4-sulfanylidene)-
xde-208
methyl(1-(2-trifluoromethylpyridin-5-yl)ethyl)-n-cyanosulfoximine
gf-2372
gf-2032
SCHEMBL520711
CHEMBL2230078
DTXSID0074687
AKOS027322695
[methyl(oxo){1-[6-(trifluoromethyl)-3-pyridyl]ethyl}-lambda6-sulfanylidene]cyanamide
n-[methyl-oxo-[1-[6-(trifluoromethyl)-3-pyridyl]ethyl]-lambda6-sulfanylidene]cyanamide
gf 2032; gf 2372; methyl[1-(2-trifluoromethylpyridin-5-yl)ethyl]-n-cyanosulfoximine; sulfoxaflor; transform; xde 208, cyanamide, n-[methyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-?4-sulfanylidene]-
[methyl-oxo-[1-[6-(trifluoromethyl)pyridin-3-yl]ethyl]-lambda6-sulfanylidene]cyanamide
HY-118504
sulfoxaflor 100 microg/ml in acetonitrile
Q14566721
gf 2032; gf 2372; xde 208
CS-0066179
n-(methyl(oxo)(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-l6-sulfanylidene)cyanamide
cyanamide,n-[methyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-l4-sulfanylidene]-
WMB57800
cyanamide, n-[methyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-.lamda.4-sulfanylidene]-
Z3244811863
1ST20444

Excerpt	Reference	Relevance
"Sulfoxaflor is a fourth-generation neonicotinoid insecticide mainly used to control sap-feeding pests. "	( Enantioselective bioaccumulation and toxicity of rac-sulfoxaflor in zebrafish (Danio rerio). Chen, X; Deng, Y; Hu, D; Lu, P; Song, B; Wang, R; Xiao, X; Yang, Y, 2022)	2.41
"Sulfoxaflor is a sulfoximine insecticide that retains efficacy against M."	( Overexpression of UDP-glucuronosyltransferase and cytochrome P450 enzymes confers resistance to sulfoxaflor in field populations of the aphid, Myzus persicae. Bass, C; Edwards, OR; Gardner, J; Hunt, BJ; Matthews, A; Pym, A; Reidy-Crofts, J; Troczka, BJ; Umina, PA; van Rooyen, AR, 2022)	1.66
"Sulfoxaflor is a new insecticide which acts on the nicotinic acetylcholine receptor (nAChRs) in a similar way to neonicotinoids. "	( Impairments in learning and memory performances associated with nicotinic receptor expression in the honeybee Apis mellifera after exposure to a sublethal dose of sulfoxaflor. Cartereau, A; Lebreton, J; Mathé-Allainmat, M; Pineau, X; Taillebois, E; Thany, SH, 2022)	2.36
"Sulfoxaflor is a new systemic insecticide that, like neonicotinoids, acts as a modulator of nicotinic acetylcholine receptors."	( Effects of chronic exposure to the new insecticide sulfoxaflor in combination with a SDHI fungicide in a solitary bee. Azpiazu, C; Bosch, J; Martins, C; Sgolastra, F, 2022)	1.69
"Sulfoxaflor is a widely used pesticide in agriculture. "	( Proteome analysis reveals the molecular basis of honeybee brain and midgut response to sulfoxaflor. Cao, H; Jiang, X; Meng, L; Shi, T; Yu, L, 2022)	2.39
"Sulfoxaflor is a new systemic insecticide developed as a replacement for older neonicotinoids which are known to be toxic to pollinators. "	( Identification and quantitation of the novel insecticide sulfoxaflor and its metabolites in floral nectar from Salvia splendens Ker Gawl. (Lamiaceae). Chen, MH; Gu, WJ; Hu, MF; Liu, XY; Song, YQ; Zha, HG; Zhou, HX; Zhou, J, 2022)	2.41
"Sulfoxaflor is a highly powerful insecticide that has strong efficacy in controlling sap-sucking pests."	( Impact of Sulfoxaflor Exposure on Bacterial Community and Developmental Performance of the Predatory Ladybeetle Propylea japonica. Cui, J; Li, W; Li, X; Peng, Y; Wang, W; Zhang, S; Zhao, Y, 2023)	2.03
"Sulfoxaflor is a novel sulfoximine insecticide that, like neonicotinoids, acts as a competitive modulator of nicotinic acetylcholine receptors (nAChR) in insects."	( The sulfoximine insecticide sulfoxaflor exposure reduces the survival status and disrupts the intestinal metabolism of the honeybee Apis mellifera. Chen, Z; Cheng, S; Dai, P; Gao, X; Li, R; Liang, P; Xie, X; Zhen, C, 2023)	1.93
"Sulfoxaflor is a widely used sulfoximine insecticide that has been regarded as an important alternative insecticide for IPM strategies, but a comprehensive study of its potential ecological toxicity is still lacking. "	( Sulfoxaflor adversely influences the biological characteristics of Coccinella septempunctata by suppressing vitellogenin expression and predation activity. Cui, L; Ji, X; Rui, C; Wang, L; Wang, Q; Wang, W; Yuan, H; Zhai, Y; Zhu, J, 2023)	3.8
"Sulfoxaflor is an insecticide that is widely used and affects the nervous system of sucking pests. "	( Sulfoxaflor induces immunotoxicity in zebrafish (Danio rerio) by activating TLR4/NF-κB signaling pathway. Cheng, B; Guo, J; Huang, Y; Lu, H; Peng, Y; Wang, K; Zeng, S; Zhang, J, 2023)	3.8
"Sulfoxaflor is a promising neonicotinoid. "	( Characterization of Sulfoxaflor and Its Metabolites on Survival, Growth, Reproduction, Biochemical Markers, and Transcription of Genes of Ai, L; Chen, Y; Hu, D; Jiao, H; Lu, P; Yuan, T, 2023)	2.68
"Sulfoxaflor (SFX) is a fourth-generation neonicotinoid used widely in modern agriculture. "	( Unicellular cyanobacteria degrade sulfoxaflor to its amide metabolite of potentially higher aquatic toxicity. Caban, M; Haliński, ŁP; Kropidłowska, K; Siudak, P; Łukaszewicz, P, 2023)	2.63
"Sulfoxaflor is a globally important novel insecticide that can have negative impacts on the reproductive output of bumblebee ("	( Individual and combined impacts of sulfoxaflor and Brown, MJF; Folly, AJ; Leadbeater, E; Siviter, H, 2020)	2.28
"Sulfoxaflor is a newly introduced systemic insecticide that is effective against many sap-feeding insect pests such as aphids, whiteflies and true bugs."	( Inheritance mode and metabolic mechanism of the sulfoximine insecticide sulfoxaflor resistance in Oxycarenus hyalinipennis (Costa). Shad, SA; Wazir, S, 2021)	1.58
"Sulfoxaflor is a new insecticide for controlling against Aphis gossypii in the field. "	( Overexpression of ATP-binding cassette transporters associated with sulfoxaflor resistance in Aphis gossypii glover. Cui, L; Huang, W; Ji, X; Rui, C; Wang, L; Wang, Q; Yang, Q; Zhu, J, 2021)	2.3
"Sulfoxaflor is a novel sulfoximine insecticide which is widely used to control crop pests. "	( Sublethal effects of Isoclast™ Active (50% sulfoxaflor water dispersible granules) on larval and adult worker honey bees (Apis mellifera L.). Huang, S; Li, J; Qi, S; Wu, L; Xue, X; Zhao, L; Zhao, W, 2021)	2.33
"Sulfoxaflor is a new insecticide for controlling Nilaparvata lugens in the field. "	( Characterization of sulfoxaflor resistance in the brown planthopper, Nilaparvata lugens (Stål). Ali, E; Jin, R; Li, J; Liao, X; Mao, K; Wan, H; Xu, P; Zhang, X, 2019)	2.28
"Sulfoxaflor is an agonist at insect nicotinic acetylcholine receptors (nAChRs) and functions in a manner distinct from other insecticides acting at nAChRs."	( Sulfoxaflor and the sulfoximine insecticides: chemistry, mode of action and basis for efficacy on resistant insects. Babcock, JM; Geng, C; Loso, MR; Sparks, TC; Thomas, JD; Watson, GB, 2013)	2.55
"Sulfoxaflor is a novel insecticide belonging to sulfoximine chemical class that can be used to control sap-feeding insects, notably Aphis gossypii Glover. "	( Sublethal and transgenerational effects of sulfoxaflor on the biological traits of the cotton aphid, Aphis gossypii Glover (Hemiptera: Aphididae). Chen, X; Desneux, N; Gao, X; Guo, T; Li, F; Liang, P; Liu, Y; Ma, K; Song, D, 2016)	2.14

Excerpt	Reference	Relevance
"Sulfoxaflor has been considered as a new tool for Nilaparvata lugens control in the field. "	( Inheritance and fitness costs of sulfoxaflor resistance in Nilaparvata lugens (Stål). Ali, E; Jin, R; Li, J; Li, W; Li, Z; Liao, X; Mao, K; Wan, H, 2019)	2.24

Excerpt	Reference	Relevance
"Sulfoxaflor showed lower lethality than imidacloprid to midges, with LC50 values of 84.1 (81.5-87.3), 66.3 (34.8-259), and 47.5 (29.5-306) μg/L for 96-h, 10-d, and 23-d exposures, respectively."	( The neonicotinoid alternative sulfoxaflor causes chronic toxicity and impairs mitochondrial energy production in Chironomus kiinensis. Li, H; Liu, P; Wu, F; You, J, 2021)	1.63

Excerpt	Reference	Relevance
"Sulfoxaflor treatment for 14 days led to reduced aggressiveness of S."	( Toxicity and sublethal effects of sulfoxaflor on the red imported fire ant, Solenopsis invicta. Lu, Y; Pan, F; Wang, L, 2017)	1.46

Excerpt	Reference	Relevance
" This study provides important information on the enantioselective behavior and toxic effects of sulfoxaflor, which can help assess the potential ecological risk of chiral pesticides to aquatic organisms."	( Enantioselective bioaccumulation and toxicity of rac-sulfoxaflor in zebrafish (Danio rerio). Chen, X; Deng, Y; Hu, D; Lu, P; Song, B; Wang, R; Xiao, X; Yang, Y, 2022)	1.19

Excerpt	Reference	Relevance
" The proposed method was used to study the pharmacokinetic dissipation of sulfoxaflor stereoisomers in soil under greenhouse conditions."	( Stereoselective separation and pharmacokinetic dissipation of the chiral neonicotinoid sulfoxaflor in soil by ultraperformance convergence chromatography/tandem mass spectrometry. Chen, Z; Cheng, Y; Dong, F; Liu, N; Liu, X; Pan, X; Tao, Y; Xu, J; Zheng, Y, 2014)	0.86

Excerpt	Reference	Relevance
" Therefore, it is important to assess the potential effects of chronic exposure to sulfoxaflor, alone and in combination with fungicides, on pollinators."	( Effects of chronic exposure to the new insecticide sulfoxaflor in combination with a SDHI fungicide in a solitary bee. Azpiazu, C; Bosch, J; Martins, C; Sgolastra, F, 2022)	1.2

Excerpt	Relevance	Reference
" This finding triggered the inclusion of dose-response investigations of the potential key events for rodent liver carcinogenesis, concurrent with the hazard assessment studies."	( An integrated approach for prospectively investigating a mode-of-action for rodent liver effects. Billington, R; Elcombe, C; Geter, DR; Gollapudi, BB; Kan, HL; LeBaron, MJ; McEwan, J; Murray, J; Rasoulpour, RJ; Terry, C; Thomas, J; Vardy, A; Wood, AJ, 2013)	0.39
" The number of insects was counted before and 2, 3, 7 and 10 days after the application of pesticide in the test area within different dosage groups."	( [Research on control effect of sulfoxaflor and flonicamid on Lonicera japonica]. Hou, SY; Li, JX; Wang, PS; Wang, YJ; Xue, J, 2018)	0.77

Class	Description
pyridines	Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives.
sulfoximide	Compounds having the structure RS(=O)=NR.
nitrile	A compound having the structure RC#N; thus a C-substituted derivative of hydrocyanic acid, HC#N. In systematic nomenclature, the suffix nitrile denotes the triply bound #N atom, not the carbon atom attached to it.
organofluorine compound	An organofluorine compound is a compound containing at least one carbon-fluorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (32)

Assay ID	Title	Year	Journal	Article
AID1081834	Insecticidal activity against DAS insecticide-resistant Bemisia tabaci B-biotype R-PBI (sweet potato whitefly) by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081816	Displacement of [3H]imidacloprid from nicotinic acetylcholine receptor in Myzus persicae (green peach aphid) homogenates by scintillation counting	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081839	Insecticidal activity against drug resistant Myzus persicae R-4013A (green peach aphid) by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081840	Insecticidal activity against Myzus persicae S-USIL (green peach aphid) by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081818	Drug metabolism in Drosophila melanogaster D.mel-2 cells over-expressing in CYP6G1 assessed as drug recovery measured 24 hr post dose by HPLC method	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081826	Resistance index, ratio of LC50 for drug resistant rothamsted-resistant Bemisia tabaci R-4991BT1 (sweet potato whitefly) to LC50 for DAS-susceptible Bemisia tabaci S-4971BT1	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081830	Insecticidal activity against Bemisia tabaci SUD-S (sweet potato whitefly) by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081821	Insecticidal activity against Myzus persicae (green peach aphid) infested UV irradiated leaves of pepper plant exposed to compound at 124 ppm assessed as insect control efficacy post 3 days UV exposure relative to untreated control	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081822	Insecticidal activity against Myzus persicae (green peach aphid) infested UV irradiated leaves of pepper plant exposed to compound at 124 ppm assessed as insect control efficacy post 0 day UV exposure relative to untreated control	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081841	Insecticidal activity against Myzus persicae (green peach aphid) DAS lab strain by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081838	Insecticidal activity against Aphis gossypii (cotton aphid) DAS lab strain by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081825	Resistance index, ratio of LC50 for rothamsted-resistant Bemisia tabaci Q-biotype R-4971BT9 (sweet potato whitefly) to LC50 for Bemisia tabaci S-4971BT1	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1112903	Displacement of [3H]-methyl-SFX from nAChR in Myzus persicae 4106A (green peach aphid) membrane after 70 min	2013	Pest management science, May, Volume: 69, Issue:5	Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid.
AID1081836	Insecticidal activity against Bemisia tabaci DAS (sweet potato whitefly) lab strain by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1112898	Resistance index, ratio of LC50 for neonicotinoid-resistant Myzus persicae FRC-P (green peach aphid) to LC50 for Myzus persicae 4106A	2013	Pest management science, May, Volume: 69, Issue:5	Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid.
AID1112902	Displacement of [3H]IMD from nAChR in Myzus persicae 4106A (green peach aphid) membrane after 70 min	2013	Pest management science, May, Volume: 69, Issue:5	Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid.
AID1112900	Insecticidal activity against neonicotinoid-resistant Myzus persicae FRC-P (green peach aphid) fed on compound treated chinese cabbage discs after 72 hr	2013	Pest management science, May, Volume: 69, Issue:5	Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid.
AID1081828	Resistance index, ratio of LC50 for drug resistant Myzus persicae R-4013A (green peach aphid) to LC50 for Myzus persicae S-USIL	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081823	Stability assessed as half life for photolysis in UV chamber at 1000 ppm by HPLC method	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081837	Insecticidal activity against Latrodectus hesperus DAS lab strain by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081833	Insecticidal activity against DAS-susceptible Bemisia tabaci S-4971BT1 (sweet potato whitefly) by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1112899	Insecticidal activity against Myzus persicae 4106A (green peach aphid) fed on compound treated chinese cabbage discs after 72 hr	2013	Pest management science, May, Volume: 69, Issue:5	Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid.
AID1081829	Insecticidal activity against rothamsted-resistant Bemisia tabaci Q-biotype R-CHLORAKA (sweet potato whitefly) by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081824	Resistance index, ratio of LC50 for rothamsted-resistant Bemisia tabaci Q-biotype R-CHLORAKA (sweet potato whitefly) to LC50 for Bemisia tabaci SUD-S	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081832	Insecticidal activity against rothamsted-resistant Bemisia tabaci R-4991BT1 (sweet potato whitefly) by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081817	Activation of Drosophila melanogaster nicotinic acetylcholine receptor alpha2 expressed in Xenopus laevis co-expressing chicken nicotinic acetylcholine receptor beta2 subunit by electrophysiology method	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081819	Drug metabolism in Drosophila melanogaster D.mel-2 cells deficient in CYP6G1 assessed as drug recovery measured 24 hr post dose by HPLC method	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081842	Insecticidal activity against Bemisia tabaci S-4971BT1 (sweet potato whitefly) by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081831	Insecticidal activity against rothamsted-resistant Bemisia tabaci Q-biotype R-4971BT9 (sweet potato whitefly) by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081835	Insecticidal activity against drug sensitive Bemisia tabaci DAS (sweet potato whitefly) lab strain by leaf disk bioassay	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081827	Resistance index, ratio of LC50 for DAS insecticide-resistant Bemisia tabaci B-biotype R-PB (sweet potato whitefly) to LC50 for drug sensitive Bemisia tabaci DAS lab strain	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
AID1081820	Insecticidal activity against Myzus persicae (green peach aphid) infested UV irradiated leaves of pepper plant exposed to compound at 124 ppm assessed as insect control efficacy post 7 days UV exposure relative to untreated control	2011	Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7	Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	48 (37.21)	24.3611
2020's	81 (62.79)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	6 (4.65%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	123 (95.35%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	2.13	1	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
niacinamide nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.	2.52	2	pyridine alkaloid; pyridinecarboxamide; vitamin B3	anti-inflammatory agent; antioxidant; cofactor; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; Escherichia coli metabolite; geroprotector; human urinary metabolite; metabolite; mouse metabolite; neuroprotective agent; Saccharomyces cerevisiae metabolite; Sir2 inhibitor
nitrous oxide Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.. dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.	2.31	1	gas molecular entity; nitrogen oxide	analgesic; bacterial metabolite; food packaging gas; food propellant; general anaesthetic; greenhouse gas; inhalation anaesthetic; NMDA receptor antagonist; raising agent; refrigerant; vasodilator agent
chlorpyrifos Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.	2.15	1	chloropyridine; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic
dimethoate Dimethoate: An organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide.. dimethoate : A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.	2.6	1	monocarboxylic acid amide; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic
fipronil fipronil: has low mammalian toxicity; structure given in first source. fipronil : A racemate comprising equimolar amounts of (R)- and (S)-fipronil.. 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile : A member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfinyl, and amino groups, respectively.	2.08	1	(trifluoromethyl)benzenes; dichlorobenzene; nitrile; primary amino compound; pyrazoles; sulfoxide
mecamylamine Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.	2.21	1	primary aliphatic amine
piperonyl butoxide [no description available]	2.25	1	benzodioxoles	pesticide synergist
tubocurarine Tubocurarine: A neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae.. tubocurarine : A benzylisoquinoline alkaloid muscle relaxant which constitutes the active component of curare.. isoquinoline alkaloid : Any alkaloid that has a structure based on an isoquinoline nucleus. They are derived from the amino acids like tyrosine and phenylalanine.	2.21	1	bisbenzylisoquinoline alkaloid	drug allergen; muscle relaxant; nicotinic antagonist
uridine diphosphate Uridine Diphosphate: A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.	2.76	2	pyrimidine ribonucleoside 5'-diphosphate; uridine 5'-phosphate	Escherichia coli metabolite; mouse metabolite
dinoseb dinoseb: RN given refers to parent cpd; structure. dinoseb : A racemate composed of equimolar amounts of (R)- and (S)-dinoseb.. 2-(butan-2-yl)-4,6-dinitrophenol : A dinitrophenol that is 2,4-dinitrophenol substituted by a butan-2-yl group at position 2.	2.08	1	dinitrophenol
4-butyrolactone 4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.	3.86	9	butan-4-olide	metabolite; neurotoxin
thiazoles [no description available]	3.27	5	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.17	1	dialdehyde	biomarker
chlorphenamidine Chlorphenamidine: An acaricide used against many organophosphate and carbamate resistant pests. It acts as an uncoupling agent and monoamine oxidase inhibitor.	2.25	1
ozone Ozone: The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).. ozone : An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.	2.31	1	elemental molecule; gas molecular entity; reactive oxygen species; triatomic oxygen	antiseptic drug; disinfectant; electrophilic reagent; greenhouse gas; mutagen; oxidising agent; tracer
pirimiphos methyl pirimiphos methyl: structure. pirimiphos-methyl : An organic thiophosphate that is O,O-dimethyl O-pyrimidin-4-yl phosphorothioate substituted by a methyl group at position 6 and a diethylamino group at position 2.	2.08	1	aminopyrimidine; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; environmental contaminant; insecticide
amitraz amitraz: ixodicide (tick control); structure. amitraz : A tertiary amino compound that is 1,3,5-triazapenta-1,4-diene substituted by a methyl group at position 3 and 2,4-dimethylphenyl groups at positions 1 and 5.	2.25	1	formamidines; tertiary amino compound	acaricide; environmental contaminant; insecticide; xenobiotic
decamethrin decamethrin: pyrethroid insecticide; RN given refers to cpd without isomeric designation; structure	2.9	2	aromatic ether; cyclopropanecarboxylate ester; nitrile; organobromine compound	agrochemical; antifeedant; calcium channel agonist; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; pyrethroid ester insecticide
tebuconazole Lynx: A genus in the family FELIDAE comprising felines with long legs, ear tufts, and a short tail.. 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol : A tertiary alcohol that is pentan-3-ol substituted by a 4-chlorophenyl, methyl, methyl, and a 1H-1,2,4-triazol-1-ylmethyl at positions 1, 4, 4 and 3 respectively.. tebuconazole : A racemate composed of equimolar amounts of (R)- and (S)-tebuconazole. A fungicide effective against various smut and bunt diseases in cereals and other field crops.	7.6	1	monochlorobenzenes; tertiary alcohol; triazoles
nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	2.08	1	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic
chlorfenapyr chlorfenapyr: an experimental pour-on formulation, a new generation pyrethroid available to producers. chlorfenapyr : A member of the class of pyrroles that is 4-bromo-1H-pyrrole-3-carbonitrile which is substituted at positions 1, 2 and 5 by ethoxymethyl, p-chlorophenyl and trifluoromethyl groups, respectively. A proinsecticide used for termite control and crop protection against several insects and mite pests.	2.31	1	hemiaminal ether; monochlorobenzenes; nitrile; organochlorine acaricide; organochlorine insecticide; organofluorine acaricide; organofluorine insecticide; pyrroles	proacaricide; proinsecticide
thiamethoxam Thiamethoxam: A nitro-oxazine and thiazole derivative that is used as a broad spectrum neonicotinoid insecticide.. thiamethoxam : An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively.	8.93	10	1,3-thiazoles; 2-nitroguanidine derivative; organochlorine compound; oxadiazane	antifeedant; carcinogenic agent; environmental contaminant; neonicotinoid insectide; xenobiotic
thiacloprid thiacloprid: structure in first source. (Z)-thiacloprid : The (Z)-stereoisomer of thiacloprid.. thiacloprid : A nitrile that is cyanamide in which the hydrogens are replaced by a 1,3-thiazolidin-2-ylidene group which in turn is substituted by a (6-chloropyridin-3-yl)methyl group at the ring nitrogen.	3.11	4	monochloropyridine; nitrile; thiazolidines	environmental contaminant; neonicotinoid insectide; xenobiotic
hydroxyl radical Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.	2.82	2	oxygen hydride; oxygen radical; reactive oxygen species
scorpions [no description available]	2.08	1	dinotefuran; oxolanes	neonicotinoid insectide
prizes acetamiprid: structure in first source. (E)-acetamiprid : The (E)-stereoisomer of acetamiprid.. acetamiprid : A carboxamidine that is acetamidine in which the amino hydrogens are substituted by a (6-chloropyridin-3-yl)methyl and a methyl group while the hydrogen attached to the imino nitrogen is replaced by a cyano group.	3.42	6	carboxamidine; monochloropyridine; nitrile	environmental contaminant; neonicotinoid insectide; xenobiotic
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.72	2	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
azoxystrobin azoxystrobin: a methoxyacrylate analog; a strobilurin fungicide; structure given in first source. azoxystrobin : An aryloxypyrimidine having a 4,6-diphenoxypyrimidine skeleton in which one of the phenyl rings is cyano-substituted at C-2 and the other carries a 2-methoxy-1-(methoxycarbonyl)vinyl substituent, also at C-2. An inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1, it is used widely as a fungicide in agriculture.	3.11	3	aryloxypyrimidine; enoate ester; enol ether; methoxyacrylate strobilurin antifungal agent; methyl ester; nitrile	antifungal agrochemical; environmental contaminant; mitochondrial cytochrome-bc1 complex inhibitor; quinone outside inhibitor; xenobiotic
nitenpyram nitenpyram: a nitromethylene neonicotinoid insecticide; structure in first source. (E)-nitenpyram : A nitenpyram in which the double bond has E configuration.. nitenpyram : A C-nitro compound consisting of 2-nitroethene-1,1-diamine where one of the nitrogens bears ethyl and (6-chloro-3-pyridinyl)methyl while the other nitrogen carries a methyl group.	8.28	5	chloropyridyl insecticide; nitenpyram
cyhalothrin cyhalothrin: acaricidal & insecticidal synthetic pyrethroid; structure given in first source. cyhalothrin : A carboxylic ester obtained by formal condensation between 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol.	2.61	2	aromatic ether; cyclopropanecarboxylate ester; nitrile; organochlorine compound; organofluorine compound	agrochemical; pyrethroid ester acaricide; pyrethroid ester insecticide
sulfur Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	8.77	108	chalcogen; nonmetal atom	macronutrient
thiamethoxam [no description available]	2.08	1
bifenthrin bifenthrin: a type I pyrethroid. bifenthrin : A carboxylic ester obtained by formal condensation of cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylic acid and [(2-methyl-1,1'-biphenyl)-3-yl]methanol.. kappa-bifenthrin : A carboxylic ester obtained by formal condensation of the carboxy group of (1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-enyl]-2,2-dimethylcyclopropanecarboxylic acid with the hydroxy group of [(2-methyl-1,1'-biphenyl)-3-yl]methanol.	2.21	1	carboxylic ester; cyclopropanecarboxylate ester; cyclopropanes; organochlorine compound; organofluorine compound	pyrethroid ester acaricide; pyrethroid ester insecticide
aldicarb Aldicarb: Carbamate derivative used as an insecticide, acaricide, and nematocide.. aldicarb : The oxime carbamate resulting from the addition of 2-methyl-2-(methylsulfanyl)propanaldoxime to methyl isocyanate. A member of the class of oxime carbamate insecticides, aldicarb is a mixture of E and Z isomers; it is not known which isomer is more active.	2.08	1
flonicamid flonicamid: an insecticide; structure in first source. flonicamid : A pyridinecarboxamide that is nicotinamide substituted by a trifluoromethyl group at position 4 and a cyanomethyl group at the carbamoyl nitrogen atom.	7.52	2	nitrile; organofluorine compound; pyridinecarboxamide	environmental contaminant; insecticide; xenobiotic
mk 936 [no description available]	2.08	1
medigoxin spirotetramat: for the control of a broad spectrum of sucking insects; structure in first source. spirotetramat : An azaspiro compound that is methoxycyclohexane which is fused at position 4 to the 5-position of a 1,5-dihydro-2H-pyrrol-2-one that is substituted at positions 3 and 4 by 2,5-dimethylphenyl and (ethoxycarbonyl)oxy groups, respectively (the cis isomer). It is a proinsecticide (via hydrolysis of the ethyl carbonate group to give the corresponding 4-hydroxypyrrol-2-one, "spirotetramat-enol") and is used for the control of a wide range of sucking insects on fruit and potato crops.	2.15	1
chlorantranilipole chlorantranilipole: anthranilic diamide insecticide.that disrupts mating in codling moth (Lepidoptera: Tortricidae). chlorantraniliprole : A carboxamide resulting from the formal condensation of the carboxylic acid group of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid with the primary amino group of 2-amino-5-chloro-N,3-dimethylbenzamide. The first of the anthranilic diamide insecticides, it is a ryanodine receptor activator and is used to protect a wide variety of crops, including corn, cotton, grapes, rice and potatoes.	2.08	1	monochlorobenzenes; organobromine compound; pyrazole insecticide; pyrazoles; pyridines; secondary carboxamide	ryanodine receptor agonist
cyantraniliprole cyantraniliprole: an insecticide; structure in first source. cyantraniliprole : A carboxamide that is chlorantraniliprole in which the chlorine atom attached to the phenyl ring has been replaced by a cyano group. A ryanodine receptor agonist, it is used as insecticide for the control of whitefly, thrips, aphids, fruitflies, and fruit worms in crops such as onions, potatoes and tomatoes. It is highly toxic to honeybees.	2.63	2	nitrile; organobromine compound; organochlorine compound; pyrazole insecticide; pyridines; secondary carboxamide	ryanodine receptor agonist
dextrothyroxine [no description available]	2.17	1
fluxapyroxad fluxapyroxad: carboxamide; succinate dehydrogenase inhibitor. fluxapyroxad : An aromatic amide obtained by formal condensation of the carboxy group of 3-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid with the amino group of 3',4',5'-trifluorobiphenyl-2-amine. Used to control a number of cereal fungal pathogens including those belonging to the Ascomycetes, Basidiomycetes and Zygomycetes families.	7.31	1	anilide fungicide; aromatic amide; biphenyls; pyrazoles; trifluorobenzene	antifungal agrochemical; EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor
flupyradifurone flupyradifurone: has insecticidal activity; structure in first source. flupyradifurone : A tertiary amino compound that is ammonia in which the nitrogens have been replaced by (6-chloropyridin-3-yl)methyl, 2,2-difluoroethyl, and 5-oxo-2,5-dihydrofuran-3-yl groups, respectively. A nicotinic acetylcholine receptor (AChR) agonist, it is used as an insecticide to control sucking pests in a variety of crops.	3.97	10	butenolide; enamine; monochloropyridine; organofluorine insecticide; tertiary amino compound	insecticide; nicotinic acetylcholine receptor agonist
phosphinothricin phosphinothricin: RN given refers to parent cpd with unspecified isomeric designation; structure. phosphinothricin(1-) : Conjugate base of phosphinothricin arising from deprotonation of the phosphinate function.	2.6	1	organic anion
kaolinite Kaolin: The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: high ridge), the original site. (From Grant & Hackh's Chemical Dictionary, 5th ed). kaolin : An aluminosilicate soft white mineral named after the hill in China (Kao-ling) from which it was mined for centuries. In its natural state kaolin is a white, soft powder consisting principally of the mineral kaolinite, and varying amounts of other minerals such as muscovite, quartz, feldspar, and anatase. It is used in the manufacture of china and porcelain and also widely used in the production of paper, rubber, paint, drying agents, and many other products.	2.41	1	aluminosilicate mineral; mixture	antidiarrhoeal drug; excipient
pyrethrins [no description available]	3.16	4
imidacloprid (E)-imidacloprid : The E-isomer of imidacloprid.	2.48	2	imidacloprid; imidazolidines; monochloropyridine	environmental contaminant; genotoxin; neonicotinoid insectide; nicotinic acetylcholine receptor agonist; xenobiotic
clothianidin (E)-clothianidin : A clothiadin that has E configuration at the C=N bond of the nitroguanidine moiety.	2.08	1	1,3-thiazoles; 2-nitroguanidine derivative; clothianidin; organochlorine compound	environmental contaminant; neonicotinoid insectide; nicotinic acetylcholine receptor agonist; xenobiotic
imidacloprid imidacloprid: systemic & contact insecticide exhibiting low mammalian toxicity; structure given in first source; it is one of the neonicotinoid insecticides, which acts as an antagonist by binding to postsynaptic nicotinic receptors in the insect central nervous system. imidacloprid : An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1.	4.58	21	imidacloprid; imidazolidines; monochloropyridine	environmental contaminant; genotoxin; neonicotinoid insectide; nicotinic acetylcholine receptor agonist; xenobiotic
clothianidin clothianidin: structure in first source. clothianidin : An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3.	2.94	3	1,3-thiazoles; 2-nitroguanidine derivative; clothianidin; organochlorine compound	environmental contaminant; neonicotinoid insectide; nicotinic acetylcholine receptor agonist; xenobiotic
pyrimidinones Pyrimidinones: Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.	2.41	1

Condition	Relationship Strength	Studies
Fetal Growth Restriction [description not available]	2.6	1
Fetal Growth Retardation Failure of a FETUS to attain expected GROWTH.	2.6	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.84	3
Malnourishment [description not available]	2.31	1
Malnutrition An imbalanced nutritional status resulting from insufficient intake of nutrients to meet normal physiological requirement.	2.31	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	4.49	3
Cancer of Liver [description not available]	3.01	1
Liver Neoplasms Tumors or cancer of the LIVER.	3.01	1
Interstitial Cell Tumor [description not available]	3.01	1
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	3.4	2
Aggression Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.	2.15	1
Delayed Effects, Prenatal Exposure [description not available]	2.07	1

sulfoxaflor

Description

Cross-References

Synonyms (39)

Research Excerpts

Overview

Effects

Actions

Treatment

Toxicity

Pharmacokinetics

Compound-Compound Interactions

Dosage Studied

Drug Classes (4)

Bioassays (32)

Research

Studies (129)

Market Indicators

Research Demand Index: 38.82

Study Types

sulfoxaflor

Description

Cross-References

Synonyms (39)

Research Excerpts

Overview

Effects

Actions

Treatment

Toxicity

Pharmacokinetics

Compound-Compound Interactions

Dosage Studied

Drug Classes (4)

Bioassays (32)

Research

Studies (129)

Market Indicators

Research Demand Index: 38.82

Study Types

Related Drugs (51)

Related Conditions (12)