Page last updated: 2024-12-11
irigenin
Description
irigenin: a phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
irigenin : A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 5, 7 and 3' and methoxy groups at positions 6, 4' and 5' respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|
| Belamcanda chinensis | species | [no description available] | Iridaceae | A plant family of the Asparagales order. Comprised of perennial herbs with BULBS, corms, or RHIZOMES and grass-like leaves with bisexual flowers that have 2 whorls of petaloid tepals which are usually showy.[MeSH] |
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 5464170 |
| CHEMBL ID | 487013 |
| CHEBI ID | 81409 |
| SCHEMBL ID | 554864 |
| MeSH ID | M0497499 |
Synonyms (32)
| Synonym |
|---|
| irigenin |
| 548-76-5 |
| C17957 |
| CHEMBL487013 |
| chebi:81409 , |
| 5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxychromen-4-one |
| 5,7,3'-trimethoxy-6,4',5'-trimethoxyisoflavone |
| LMPK12050417 |
| einecs 208-958-3 |
| 5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4-benzopyrone |
| 6o4nx37350 , |
| unii-6o4nx37350 |
| S9121 |
| CCG-214382 |
| SCHEMBL554864 |
| irigenin [mi] |
| 3',5,7-trihydroxy-4',5',6-trimethoxyisoflavone |
| 5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4h-1-benzopyran-4-one |
| 5,7,3'-trihydroxy-6,4',5'-trimethoxyisoflavone |
| AC-35036 |
| DTXSID90203285 |
| SR-05000002617-1 |
| sr-05000002617 |
| AKOS030632868 |
| mfcd00597047 |
| BS-17232 |
| Q2481557 |
| 5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4h-chromen-4-one |
| CS-0022931 |
| HY-N2587 |
| FT-0775730 |
| A923655 |
Research Excerpts
Effects
Pharmacokinetics
Roles (1)
| Role | Description |
|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (2)
| Class | Description |
|---|
| hydroxyisoflavone | Member of the class of isoflavones bearing at least one hydroxy group. |
| 4'-methoxyisoflavones | Any methoxyisoflavone which has a methoxy group at the 4-position of the phenyl substituent. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Bioassays (5)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID377458 | Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3
| Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID377456 | Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3
| Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID377455 | Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3
| Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID377457 | Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3
| Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID338974 | Inhibition of cow milk xanthine oxidase at 50 ug/mL | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (14)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 5 (35.71) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 23.56
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 23.56 (24.57) | | Research Supply Index | 2.89 (2.92) | | Research Growth Index | 4.81 (4.65) | | Search Engine Demand Index | 23.28 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 17 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |