Compounds > zaluzanin C
Page last updated: 2024-11-06

zaluzanin C

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Description

Zaluzanin C is a sesquiterpene lactone isolated from the plant genus Zaluzania. It exhibits a variety of biological activities, including anti-inflammatory, cytotoxic, and antimicrobial effects. Research suggests that zaluzanin C exerts its effects by inhibiting the production of pro-inflammatory cytokines and by inducing apoptosis in cancer cells. It has also been found to be effective against certain bacterial and fungal infections. The compound's unique structure and diverse biological activities have made it a target of interest for medicinal chemistry research. Studies are ongoing to further elucidate its mechanisms of action and its potential therapeutic applications.'

zaluzanin C: from Ainsliaea yunnanensis and Zaluzania robinsonii; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

zaluzanin C : A sesquiterpene lactone that is decahydroazuleno[4,5-b]furan-2(3H)-one substituted by methylidene groups at positions 3, 6 and 9 and a hydroxy group at position 8. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID72646
CHEMBL ID462318
CHEBI ID10103

Synonyms (13)

Synonym
nsc 177851
3beta,6alpha-dihydroxy-1beta-guaia-4(15),10(14),11(13)-trien-12-oic acid, gamma-lactone
(3as,6ar,8s,9ar,9bs)-8-hydroxy-3,6,9-tris(methylene)decahydroazuleno[4,5-b]furan-2(3h)-one
16838-87-2
zaluzanin c
C09606
(3as,6ar,8s,9ar,9bs)-8-hydroxy-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one
CHEMBL462318
chebi:10103 ,
(3as,6ar,8s,9ar,9bs)-8-hydroxy-3,6,9-trimethylidenedecahydroazuleno[4,5-b]furan-2(3h)-one
3beta-hydroxy-4(15),10(14),11(13)-guaiatrien-12,6-olide
DTXSID40168557
Q27108584

Research Excerpts

Overview

Zaluzanin C (ZC) is a sesquiterpene lactones used in herbal medicines.

ExcerptReferenceRelevance
"Zaluzanin C (ZC) is a sesquiterpene lactones used in herbal medicines. "( Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
Jang, WG; Kim, KM, 2017)		3.34
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
EC 1.14.13.39 (nitric oxide synthase) inhibitorAn EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of nitric oxide synthase (EC 1.14.13.39).
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
gamma-lactoneA lactone having a five-membered lactone ring.
guaiane sesquiterpenoid
organic heterotricyclic compoundAn organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms.
sesquiterpene lactoneAny member of a diverse class of complex, multicyclic phytochemicals showing a variety of skeleton arrangements and bioactivities, and having in common a sesquiterpenoid structure including a lactone ring.
secondary alcoholA secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (63)

Assay IDTitleYearJournalArticle
AID1101217Stimulation of root length of Lactuca sativa cv. Roman (lettuce) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101213Stimulation of germination of Solanum lycopersicum cv. Tres Cantos (tomato) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101206Stimulation of root length of Allium cepa cv. Valenciana (onion) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1365845Induction of osteoblast differentiation in mouse MC3T3-E1 cells assessed as increase in Id1 mRNA expression at 5 uM after 2 days by qPCR analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1101198Inhibition of hypocotyl length of Lepidium sativum at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1365850Induction of osteoblast differentiation in mouse MC3T3-E1 cells assessed as increase in ALP activity at 5 uM after 4 days BCIP/NBT liquid substrate based assay2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1101203Inhibition of root length of Lactuca sativa cv. Roman (lettuce) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101199Inhibition of germination of Solanum lycopersicum cv. Tres Cantos (tomato) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101204Inhibition of germination of Lactuca sativa cv. Roman (lettuce) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1365835Cytotoxicity against mouse MC3T3-E1 cells assessed as reduction in cell viability at >10 uM after 24 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1365853Induction of mineralization in mouse MC3T3-E1 cells at 5 uM after 14 days in presence of ascorbic acid/beta-GP by alizarin red S staining based assay2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1101216Stimulation of germination of Lepidium sativum at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1365851Induction of mineralization in mouse MC3T3-E1 cells at 5 uM after 14 days by alizarin red S staining based assay2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1607869Inhibition of iNOS (unknown origin) at 20 uM relative to control2019European journal of medicinal chemistry, Oct-01, Volume: 179Human disorders associated with inflammation and the evolving role of natural products to overcome.
AID1607868Inhibition of N-terminal His6-tagged recombinant human COX2 expressed in baculovirus infected sf21 cells at 20 uM relative to control2019European journal of medicinal chemistry, Oct-01, Volume: 179Human disorders associated with inflammation and the evolving role of natural products to overcome.
AID1365839Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in Id1 mRNA expression at 5 uM after 2 days by qPCR analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1101209Stimulation of root length of Triticum aestivum cv. Cortex (wheat) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1183795Antifungal activity against Candida albicans ATCC 10231 by bioautography TLC plate assay based MTT method2014Journal of natural products, Jul-25, Volume: 77, Issue:7
Antifungal terpenoids from Hyalis argentea var. latisquama.
AID1365832Cytotoxicity against mouse C3H10T1/2 cells assessed as reduction in cell viability at 1 to 5 uM after 24 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1365843Induction of osteoblast differentiation in mouse MC3T3-E1 cells assessed as increase in Dlx5 mRNA expression at 5 uM after 2 days by RT-PCR analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1365849Induction of osteoblast differentiation in mouse MC3T3-E1 cells assessed as increase in Runx2 protein level at 5 uM after 2 days by Western blot analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1101191Inhibition of hypocotyl length of Allium cepa cv. Valenciana (onion) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101193Inhibition of root length of Triticum aestivum cv. Cortex (wheat) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1183810Antifungal activity against Candida albicans ATCC 10231 assessed as microbial growth inhibition after 48 hrs broth microdilution method2014Journal of natural products, Jul-25, Volume: 77, Issue:7
Antifungal terpenoids from Hyalis argentea var. latisquama.
AID1101195Inhibition of germination of Triticum aestivum cv. Cortex (wheat) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101200Inhibition of root length of Lepidium sativum at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1365834Cytotoxicity against mouse C3H10T1/2 cells assessed as reduction in cell viability at >10 uM after 24 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1101211Stimulation of hypocotyl length of Solanum lycopersicum cv. Tres Cantos (tomato) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101215Stimulation of root length of Lepidium sativum at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101218Stimulation of hypocotyl length of Lactuca sativa cv. Roman (lettuce) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID356399Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay2003Journal of natural products, Sep, Volume: 66, Issue:9
Cytotoxic sesquiterpene lactones from the root of Saussurea lappa.
AID1365844Induction of osteoblast differentiation in mouse MC3T3-E1 cells assessed as increase in Runx2 mRNA expression at 5 uM after 2 days by RT-PCR analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID356397Cytotoxicity against human HeLa cells after 48 hrs by MTT assay2003Journal of natural products, Sep, Volume: 66, Issue:9
Cytotoxic sesquiterpene lactones from the root of Saussurea lappa.
AID1101214Stimulation of hypocotyl length of Lepidium sativum at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1365855Increase in Runx2 (unknown origin) promoter activity expressed in mouse C3H10T1/2 cells at 5 uM after 48 hrs by luciferase reporter gene assay2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1101205Stimulation of hypocotyl length of Allium cepa cv. Valenciana (onion) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101202Inhibition of hypocotyl length of Lactuca sativa cv. Roman (lettuce) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1365847Induction of osteoblast differentiation in mouse MC3T3-E1 cells assessed as increase in Runx2 mRNA expression at 5 uM after 2 days by qPCR analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1365848Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in Runx2 protein level at 5 uM after 2 days by Western blot analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1183809Antifungal activity against Cryptococcus neoformans ATCC 32264 assessed as microbial growth inhibition after 48 hrs broth microdilution method2014Journal of natural products, Jul-25, Volume: 77, Issue:7
Antifungal terpenoids from Hyalis argentea var. latisquama.
AID1101219Stimulation of germination of Lactuca sativa cv. Roman (lettuce) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101208Stimulation of germination of Allium cepa cv. Valenciana (onion) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101197Inhibition of root length of Solanum lycopersicum cv. Tres Cantos (tomato) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID356398Cytotoxicity against human OVCAR-3 cells after 48 hrs by MTT assay2003Journal of natural products, Sep, Volume: 66, Issue:9
Cytotoxic sesquiterpene lactones from the root of Saussurea lappa.
AID1365854Increase in Runx2 (unknown origin) promoter activity expressed in mouse MC3T3-E1 cells at 5 uM after 48 hrs by luciferase reporter gene assay2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1101201Inhibition of germination of Lepidium sativum at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1365836Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in Id1 mRNA expression at 5 uM after 2 days by RT-PCR analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1365856Induction of osteoblast differentiation in Runx2 knockdown mouse MC3T3-E1 cells assessed as increase in ALP activity at 5 uM after 4 days BCIP/NBT liquid substrate based assay2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1101192Inhibition of germination of Allium cepa cv. Valenciana (onion) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1365841Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in Runx2 mRNA expression at 5 uM after 2 days by qPCR analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1101210Stimulation of germination of Triticum aestivum cv. Cortex (wheat) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101207Stimulation of hypocotyl length of Triticum aestivum cv. Cortex (wheat) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1365838Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in Runx2 mRNA expression at 5 uM after 2 days by RT-PCR analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1365842Induction of osteoblast differentiation in mouse MC3T3-E1 cells assessed as increase in Id1 mRNA expression at 5 uM after 2 days by RT-PCR analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1365846Induction of osteoblast differentiation in mouse MC3T3-E1 cells assessed as increase in Dlx5 mRNA expression at 5 uM after 2 days by qPCR analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1365833Cytotoxicity against mouse MC3T3-E1 cells assessed as reduction in cell viability at 1 to 5 uM after 24 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1365837Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in Dlx5 mRNA expression at 5 uM after 2 days by RT-PCR analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1365852Induction of osteoblast differentiation in mouse MC3T3-E1 cells assessed as increase in ALP activity at 5 uM after 4 days in presence of ascorbic acid/beta-GP BCIP/NBT liquid substrate based assay2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1365840Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in Dlx5 mRNA expression at 5 uM after 2 days by qPCR analysis2017Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
AID1101190Inhibition of root length of Allium cepa cv. Valenciana (onion) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101196Inhibition of hypocotyl length of Solanum lycopersicum cv. Tres Cantos (tomato) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101194Inhibition of hypocotyl length of Triticum aestivum cv. Cortex (wheat) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
AID1101212Stimulation of root length of Solanum lycopersicum cv. Tres Cantos (tomato) at 0.1 mM or 1 mM after 5 days relative to untreated control2000Journal of agricultural and food chemistry, Nov, Volume: 48, Issue:11
Sesquiterpene lactones with potential use as natural herbicide models. 2. guaianolides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (10.00)18.7374
1990's0 (0.00)18.2507
2000's4 (40.00)29.6817
2010's4 (40.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.43 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
nitrites
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)		2.0210monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
[no description available]		3.3110catechin
aspirin
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.		3.3110benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
celecoxib
[no description available]		3.3110organofluorine compound;
pyrazoles;
sulfonamide;
toluenes		cyclooxygenase 2 inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		2.0110C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
thiazoles
[no description available]		2.02101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
oleanolic acid
[no description available]		2.0310hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.0110glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
thiazolyl blue
thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.		2.0210organic bromide saltcolorimetric reagent;
dye
betulinic acid
[no description available]		3.5820hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
dehydrocostus lactone
dehydrocostus lactone : An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.		2.4120gamma-lactone;
guaiane sesquiterpenoid;
organic heterotricyclic compound;
sesquiterpene lactone		antimycobacterial drug;
antineoplastic agent;
apoptosis inducer;
cyclooxygenase 2 inhibitor;
metabolite;
trypanocidal drug
triasulfuron
triasulfuron : An N-sulfonylurea that is N-[o-(2-chloroethoxy)phenyl]sulfonylurea in which one of the hydrogens attached to the non-sulfonylated nitrogen has been replaced by a 4-methoxy-6-methyl-1,3,5-triazin-2-yl group. A herbicide used to control broad-leaved weeds in cereals, its use within the EU has been banned after September 2017 on the grounds of potential groundwater contamination and risks to aquatic life.		2101,3,5-triazines;
aromatic ether;
N-sulfonylurea;
organochlorine compound		agrochemical;
herbicide
syringaresinol
[no description available]		3.3110aromatic ether;
furofuran;
lignan;
polyether;
polyphenol		plant metabolite
betulonic acid
betulonic acid: isolated from Rush javanica; strucure in first source		2.0310triterpenoidanticoronaviral agent
santamarine
santamarine: sesquiterpene derivative of costunolide. santamarin : A sesquiterpene lactone of the eudesmanolide group.		2.0110sesquiterpene lactone
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		2.0310
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		3.3110resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
reynosin
reynosin: sesquiterpene derivative of costunolide. reynosin : A sesquiterpene lactone of the eudesmanolide group, found particularly in Magnolia grandiflora and Laurus nobilis.		2.0110organic heterotricyclic compound;
sesquiterpene lactone		metabolite
isoliquiritigenin
[no description available]		3.3110chalconesantineoplastic agent;
biological pigment;
EC 1.14.18.1 (tyrosinase) inhibitor;
GABA modulator;
geroprotector;
metabolite;
NMDA receptor antagonist
sesquiterpenes
[no description available]		2.6930
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		3.3110aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.0210prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
quercetin 3-o-methyl ether
quercetin 3-O-methyl ether: from Rhamnus species; structure in first source. 3',4',5,7-tetrahydroxy-3-methoxyflavone : A tetrahydroxyflavone having the 4-hydroxy groups located at the 3'- 4'- 5- and 7-positions as well as a methoxy group at the 2-position.		3.3110monomethoxyflavone;
tetrahydroxyflavone		antimicrobial agent;
metabolite
isobavachalcone
isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.		3.3110chalcones;
polyphenol		antibacterial agent;
metabolite;
platelet aggregation inhibitor
costunolide
[no description available]		2.0110germacranolide;
heterobicyclic compound		anthelminthic drug;
antiinfective agent;
antineoplastic agent;
antiparasitic agent;
antiviral drug;
metabolite
norathyriol
norathyriol: from Gentinanaceae; has vasorelaxing action on rat thoracic aorta; structure given in first source. norathyriol : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C.		3.3110polyphenol;
xanthones		antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
plant metabolite
myricitrin
myricitrin: isolated from root bark of Myrica cerifera L.; structure. myricitrin : A glycosyloxyflavone that consists of myricetin attached to a alpha-L-rhamnopyranosyl residue at position 3 via a glycosidic linkage. Isolated from Myrica cerifera, it exhibits anti-allergic activity.		3.3110alpha-L-rhamnoside;
glycosyloxyflavone;
monosaccharide derivative;
pentahydroxyflavone		anti-allergic agent;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
plant metabolite
acteoside
acteoside: a protein kinase C inhibitor with hepatoprotective, anti-asthmatic, and analgesic activities; a phenylethanoid glycoside related to isoacteoside; from leaves of Lippia multiflora (Verbenaceae). acteoside : A glycoside that is the alpha-L-rhamnosyl-(1->3)-beta-D-glucoside of hydroxytyrosol in which the hydroxy group at position 4 of the glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid.		3.3110catechols;
cinnamate ester;
disaccharide derivative;
glycoside;
polyphenol		anti-inflammatory agent;
antibacterial agent;
antileishmanial agent;
neuroprotective agent;
plant metabolite
muromonab-cd3
cudraflavone B: antiproliferative from Cudrania tricuspidata. cudraflavone B : An extended flavonoid that consists of a pyranochromane skeleton that is 2H,6H-pyrano[3,2-g]chromen-6-one substituted by geminal methyl groups at position 2, a 2,4-dihydroxyphenyl group at position 8, a hydroxy group at position 5 and a prenyl group at position 7. Isolated from Morus alba and Morus species it exhibits anti-inflammatory activity.		3.3110extended flavonoid;
pyranochromane;
trihydroxyflavone		anti-inflammatory agent;
plant metabolite
ergosterol-5,8-peroxide
ergosterol-5,8-peroxide: also inhibits sulfatase; isolated from fungus Cercospora kikuchii; structure given in first source. ergosterol peroxide : An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3beta,5alpha,8alpha,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities.		3.31103beta-sterol;
ergostanoid;
organic peroxide;
phytosterols		antimycobacterial drug;
antineoplastic agent;
metabolite;
trypanocidal drug
guttiferone e
guttiferone E: isolated from the fruits of Garcinia pyrifera collected in Malaysia; structure in first source		3.3110
lichexanthone
lichexanthone: a dihydropyranexanthone derived from the natural xanthone; structure in first source. lichexanthone : A member of the class of xanthones that is 9H-xanthen-9-one substituted by a hydroxy group at position 1, a methyl group at position 8 and methoxy groups at positions 3 and 6. It has been isolated from the bark of Cupania cinerea.		3.3110aromatic ether;
phenols;
xanthones		plant metabolite
1,3,5,6-tetrahydroxyxanthone
1,3,5,6-tetrahydroxyxanthone: from roots of Cudrania cochinchinensis		3.3110
Norartocarpetin
[no description available]		3.3110flavones
24-ethyl-4-cholesten-3-one
stigmast-4-en-3-one: from the bark of Anacardium occidentale (cashew); structure in first source		3.3110C29-steroid;
steroid		metabolite
lyoniside
daucosterol : A steroid saponin that is sitosterol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It has bee isolated from Panax japonicus var. major and Breynia fruticosa.		3.3110beta-D-glucoside;
monosaccharide derivative;
steroid saponin		plant metabolite
13-oxo-9,11-octadecadienoic acid
13-oxo-9Z,11E-ODE : An oxooctadecadienoic acid that consists of 9Z,11E-octadecadienoic acid bearing an additional 13-keto substituent. In addtion it has been found as a natural product found in Carthamus oxyacantha.		3.311013-oxo-9,11-octadecadienoic acidmetabolite;
mouse metabolite
cajanine
cajanine: isolated from Cajanus cajan L.; structure in first source		3.3110stilbenoid
gentamicin sulfate
[no description available]		2.0110
2,4,2',4'-Tetrahydroxychalcone
[no description available]		3.3110chalcones
chikusetsu saponin iva
chikusetsu saponin IVa: from the tubers of Hemsleya pengxianensis (Cucurbitaceae)		3.3110triterpenoid saponinmetabolite
Norartocarpanone
[no description available]		3.3110flavanones
(E)-1,7-Bis(4-hydroxyphenyl)hept-4-en-3-one
[no description available]		3.3110diarylheptanoid
ConditionIndicatedRelationship StrengthStudiesTrials
Hepatocellular Carcinoma
[description not available]		02.0110
Cancer of Ovary
[description not available]		02.0110
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.0110
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.0110
Rheumatoid Arthritis
[description not available]		03.1210
Innate Inflammatory Response
[description not available]		03.6420
Benign Neoplasms
[description not available]		03.1210
Dermatoses
[description not available]		03.1210
Arthritis, Rheumatoid
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.		03.1210
Cardiovascular Diseases
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.		03.1210
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		08.6420
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.1210
Skin Diseases
Diseases involving the DERMIS or EPIDERMIS.		03.1210