Page last updated: 2024-09-27

Mucopolysaccharidosis III

Mucopolysaccharidosis characterized by heparitin sulfate in the urine, progressive mental retardation, mild dwarfism, and other skeletal disorders. There are four clinically indistinguishable but biochemically distinct forms, each due to a deficiency of a different enzyme.

Synonyms(1)

Synonym
Mucopolysaccharidosis III

Research Excerpts

Overview

ExcerptReference
"Mucopolysaccharidosis IIIB is a lysosomal disease characterized by a severe neurological deterioration, the pathophysiological mechanisms of which are poorly understood."( Ausseil, J; Belin, MF; Cheillan, D; Heard, JM; Honnorat, J; Maire, I; Malleval, C; Touret, M; Vitry, S, 2008)
"Sanfilippo disease (Mucopolysaccharidosis III) is a neurodegenerative lysosomal disorder characterized by accumulation of the glycosaminoglycan heparan sulfate (HS)."( de Ruijter, J; Ijlst, L; Kulik, W; van Lenthe, H; van Vlies, N; Wagemans, T; Wijburg, FA, 2013)
"Mucopolysaccharidosis IIIA is a heritable neurodegenerative disorder resulting from the dysfunction of the lysosomal hydrolase sulphamidase."( Byers, S; Derrick-Roberts, A; Fletcher, J; Kaidonis, X; Ranieri, E; Sharp, P, 2016)
"Mucopolysaccharidosis IIIB is a paediatric lysosomal storage disease caused by deficiency of the enzyme α-N-acetylglucosaminidase (NAGLU), involved in the degradation of the glycosaminoglycan heparan sulphate."( Bigger, BW; D'Souza, Z; Dickson, PI; Ellison, SM; Fil, D; Gleitz, HFE; Holley, RJ; Kan, SH; Langford-Smith, AWW; Liao, A; McDermott, J; O'Leary, C; Parker, H; Rowlston, S; Senthivel, N; Wilkinson, FL, 2018)
"Mucopolysaccharidosis IIIB is caused by a marked decrease in N-acetyl-α-d-glucosaminidase (NAGLU) enzyme activity, which leads to the accumulation of heparan sulfate in key organs, progressive brain atrophy, and neurocognitive decline."( Bubb, G; Cinar, A; Dai, Y; Escolar, ML; Parker, GJM; Patki, KC; Pineda, M; Rojas-Caro, S; Vijay, S; Whitley, CB; Yao, B; Zhang, X, 2019)

Research

Studies (237)

TimeframeStudies, This Condition (%)All Conditions %
pre-199061 (25.74)23.3326
1990's20 (8.44)12.5806
2000's44 (18.57)18.1394
2010's80 (33.76)28.8240
2020's32 (13.50)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carnitine0low10
methane0low10
glycine0low10
melatonin0low30
aspirin0low10
fentanyl0low10
fluoxetine0low10
gentamicin0low10
lamotrigine0low10
propofol0low20
risperidone0medium21
sevoflurane0low10
succinylcholine0low10
suramin0low10
prednisolone0low20
estrone0low10
serine0low10
aspartic acid0low10
glutamine0low10
mannitol0low10
asparagine0low10
histidine0low10
arginine0low20
rhodamine b0low10
trehalose0low10
thiazoles0low10
evans blue0low10
isovaleric acid0low10
uridine diphosphate n-acetylglucosamine0low10
galactitol0low10
erythromycin0low10
fucose0low10
mannose0low10
mercury0low10
technetium0low10
gadolinium0low10
acetylglucosamine0low100
galactosamine0low40
galactose0low10
1-deoxynojirimycin0medium31
s-adenosylmethionine0low10
acetylgalactosamine0low20
miglustat0medium31
acridine orange0low10
thiazolyl blue0low10
6-sulfatoxymelatonin0low10
coenzyme a0low10
paxilline0low10
4-methylumbelliferyl 2-acetamido-2-deoxy-beta-d-glucopyranoside0low30
antibiotic g 4180low10
proline0low10
n-acetylglucosaminitol0low10
n-acetylgalactosaminitol0low10
mannose-6-phosphate0low30
glucosamine0low180
elastin0low10
naringenin0low10
n-acetylglucosamine-6-sulfate0low40
betadex0low10
acetyl coenzyme a0low20
resveratrol0low10
keratan sulfate0low50
glycosides0low10
arginine vasopressin0low10
nadp0low10
dermatan sulfate0low80
sch 233900low10
apigenin0low10
hymecromone0low40
kaempferol0low10
genistein0medium114
daidzein0low10
coenzyme q100low10
irosustat0low10
dexmedetomidine0low10
sulfur0low20
cysteine0low10
triolein0low10
estradiol-3-o-sulfamate0low10
n-acetylglucosaminono-1,5-lactone o-(phenylcarbamoyl)oxime0low10
g(m2) ganglioside0low70
g(m1) ganglioside0low30
alpha-synuclein0low30
acid phosphatase0low30
oligonucleotides0low10
ubiquinone0low10
calpain0low10
glycolipids0low50
vasoactive intestinal peptide0low10
chondroitin0low20
heparitin sulfate0medium1258
warfarin0low10
transforming growth factor beta0low10
g(m3) ganglioside0low90
hyaluronoglucosaminidase0low10
muramidase0low10
amyloid beta-peptides0low10
chondroitin sulfates0low100
olanzapine0low10
sildenafil citrate0low10
alcian blue0low10
eye0low30

Protein Targets (1,020)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE120012
glucocerebrosidase7007
Alpha-mannosidase0202
alpha-galactosidase3003
Trehalase 0202
lysosomal alpha-glucosidase preproprotein4004
Trehalase0101
Maltase-glucoamylase, intestinal0404
Trehalase 0202
Lysosomal acid glucosylceramidase0404
Alpha-galactosidase A0101
Alpha-glucosidase MAL620101
Lactase-phlorizin hydrolase0202
Lysosomal alpha-glucosidase0404
Beta-glucosidase A0101
Sucrase-isomaltase, intestinal0202
Alpha-1B adrenergic receptor0606
Sucrase-isomaltase, intestinal0303
Alpha-1D adrenergic receptor0606
Beta-glucosidase0101
Protein-lysine 6-oxidase0404
Alpha-mannosidase 20202
Glycogen debranching enzyme0202
Glycogen debranching enzyme0101
Alpha-glucosidase MAL320202
Alpha-1A adrenergic receptor0707
Oligo-1,6-glucosidase IMA10101
Alpha-glucosidase MAL120303
Oxysterols receptor LXR-beta0202
Spike glycoprotein6118
Alpha-amylase 0101
Trehalose synthase/amylase TreS0101
Lactase-phlorizin hydrolase 0202
Oxysterols receptor LXR-alpha0202
Neutral alpha-glucosidase AB0202
Ceramide glucosyltransferase0202
Lysosomal acid glucosylceramidase0101
Probable maltase-glucoamylase 20101
Beta-glucosidase 0101
Lysosomal alpha-glucosidase0303
Cytosolic beta-glucosidase0101
Non-lysosomal glucosylceramidase0202
Putative alpha-glucosidase0202
N-alpha-acetyltransferase 500022
Fibrinogen C domain-containing protein 10101
Putative glycosyltransferase WbgO0001
Cytochrome P450 3A4010011
Cannabinoid receptor 10101
Killer cell lectin-like receptor subfamily B member 1A0101
Early activation antigen CD690101
Telomerase reverse transcriptase0101
Amyloid-beta precursor protein0516
Reverse transcriptase/RNaseH 0303
30S ribosomal protein S60213
30S ribosomal protein S70213
50S ribosomal protein L150213
50S ribosomal protein L100213
50S ribosomal protein L110213
50S ribosomal protein L7/L120213
50S ribosomal protein L190213
50S ribosomal protein L10213
50S ribosomal protein L200213
50S ribosomal protein L270213
50S ribosomal protein L280213
50S ribosomal protein L290213
50S ribosomal protein L310213
50S ribosomal protein L31 type B0213
50S ribosomal protein L320213
50S ribosomal protein L330213
50S ribosomal protein L340213
50S ribosomal protein L350213
50S ribosomal protein L360213
30S ribosomal protein S100213
30S ribosomal protein S110213
30S ribosomal protein S120213
30S ribosomal protein S130213
30S ribosomal protein S160213
30S ribosomal protein S180213
30S ribosomal protein S190213
30S ribosomal protein S200213
30S ribosomal protein S20213
30S ribosomal protein S30213
30S ribosomal protein S40213
30S ribosomal protein S50213
30S ribosomal protein S80213
30S ribosomal protein S90213
50S ribosomal protein L130213
50S ribosomal protein L140213
50S ribosomal protein L160213
50S ribosomal protein L230213
30S ribosomal protein S150213
50S ribosomal protein L170213
50S ribosomal protein L210213
50S ribosomal protein L300213
50S ribosomal protein L60213
30S ribosomal protein S140213
30S ribosomal protein S170213
30S ribosomal protein S10213
50S ribosomal protein L180213
50S ribosomal protein L20213
50S ribosomal protein L30213
50S ribosomal protein L240213
50S ribosomal protein L40213
50S ribosomal protein L220213
50S ribosomal protein L50213
30S ribosomal protein S210213
50S ribosomal protein L250213
50S ribosomal protein L36 20213
Chain A, TYROSYL-DNA PHOSPHODIESTERASE9009
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, HADH2 protein120012
Chain B, HADH2 protein120012
Chain A, 2-oxoglutarate Oxygenase100010
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain A, Cruzipain2002
Chain A, Transthyretin0033
Chain A, Transthyretin0033
Chain A, Transthyretin0033
Chain A, Transthyretin0033
Chain B, Transthyretin0033
Chain A, Transthyretin0033
Chain B, Transthyretin0033
Chain A, Casein kinase II subunit alpha0101
Chain A, Casein kinase II subunit alpha0101
Chain A, Casein Kinase Ii Subunit Alpha0101
Luciferase100010
interleukin 83003
endonuclease IV3003
BRCA13003
RGS121001
15-lipoxygenase, partial5005
phosphopantetheinyl transferase7007
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma120012
ATAD5 protein, partial7007
USP1 protein, partial7007
NFKB1 protein, partial4004
GLS protein110011
PPM1D protein4004
TDP1 protein170017
GLI family zinc finger 3190019
Microtubule-associated protein tau8008
Thrombopoietin3003
AR protein200020
Smad33003
apical membrane antigen 1, AMA12002
aldehyde dehydrogenase 1 family, member A1110011
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
thyroid stimulating hormone receptor9009
estrogen receptor 2 (ER beta)110011
nuclear receptor subfamily 1, group I, member 3140014
progesterone receptor140014
regulator of G-protein signaling 47007
cytochrome P450 family 3 subfamily A polypeptide 4130013
EWS/FLI fusion protein120012
glucocorticoid receptor [Homo sapiens]130013
retinoic acid nuclear receptor alpha variant 1160016
retinoid X nuclear receptor alpha120012
estrogen-related nuclear receptor alpha200020
farnesoid X nuclear receptor8008
pregnane X nuclear receptor150015
estrogen nuclear receptor alpha210021
G100010
cytochrome P450 2D69009
Neuraminidase 0707
67.9K protein5005
Parkin4004
peroxisome proliferator-activated receptor delta100010
peroxisome proliferator activated receptor gamma9009
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
arylsulfatase A6006
pyruvate kinase4004
IDH14004
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)4004
aryl hydrocarbon receptor8008
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a110011
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x8008
Replicase polyprotein 1ab0213
cytochrome P450 2D6 isoform 18008
NPC intracellular cholesterol transporter 1 precursor5005
peripheral myelin protein 22 isoform 19009
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a6006
cytochrome P450 2C19 precursor9009
cytochrome P450 2C9 precursor7007
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 19009
thyroid hormone receptor beta isoform a5005
nuclear factor erythroid 2-related factor 2 isoform 23003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor7007
thyroid hormone receptor beta isoform 2130013
histone deacetylase 9 isoform 35005
heat shock protein beta-14004
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
glycogen synthase kinase-3 beta isoform 10033
mitogen-activated protein kinase 14004
flap endonuclease 17007
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 1120012
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)7007
nuclear receptor ROR-gamma isoform 13003
geminin130013
DNA polymerase kappa isoform 16006
survival motor neuron protein isoform d5005
cytochrome P450 3A4 isoform 1110011
M-phase phosphoprotein 84004
lamin isoform A-delta10150015
pyruvate kinase PKM isoform b3003
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit pi112114
Gamma-aminobutyric acid receptor subunit delta0202
Polyphenol oxidase 20303
Aldo-keto reductase family 1 member B100303
Voltage-dependent calcium channel gamma-2 subunit9009
G2/mitotic-specific cyclin-B20202
Poly [ADP-ribose] polymerase tankyrase-10101
Lysozyme C-10101
Cationic trypsin0202
Carbonic anhydrase 1010016
Carbonic anhydrase 2011118
Interferon beta140014
HLA class I histocompatibility antigen, B alpha chain 100010
Transthyretin0224
Estrogen receptor011214
Glucocorticoid receptor02112
Cellular tumor antigen p53120012
Cytochrome P450 1A10707
Integrin beta-35106
Myeloperoxidase0404
Cytochrome P450 1A20505
Cyclin-dependent kinase 10303
Beta-glucuronidase0101
Aldo-keto reductase family 1 member B10909
Seed linoleate 13S-lipoxygenase-10204
ATP-dependent translocase ABCB105311
Neutrophil elastase0202
Integrin alpha-IIb5106
Ornithine decarboxylase3003
Poly [ADP-ribose] polymerase 10101
Replicase polyprotein 1a0213
Replicase polyprotein 1ab0213
Replicase polyprotein 1ab0314
Replicase polyprotein 1ab0213
Androgen receptor0509
Sialidase0303
Serine/threonine-protein kinase pim-10203
Aromatase0909
Angiotensin-converting enzyme0606
Cystic fibrosis transmembrane conductance regulator0123
17-beta-hydroxysteroid dehydrogenase type 10607
Pyruvate kinase PKM0112
G2/mitotic-specific cyclin-B10303
Gamma-aminobutyric acid receptor subunit alpha-10314
Urease subunit alpha0202
Aldo-keto reductase family 1 member B10606
G2/mitotic-specific cyclin-B0202
Gamma-aminobutyric acid receptor subunit beta-1112114
Mucin-10101
Glycogen synthase kinase-3 beta0202
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit delta112114
Gamma-aminobutyric acid receptor subunit gamma-20314
Gamma-aminobutyric acid receptor subunit gamma-2112114
Glutamate receptor 29009
Casein kinase II subunit alpha'0202
Gamma-aminobutyric acid receptor subunit alpha-5112114
Gamma-aminobutyric acid receptor subunit alpha-3112114
Amine oxidase [flavin-containing] A0606
Acetylcholinesterase0606
Carbonic anhydrase 40608
Gamma-aminobutyric acid receptor subunit gamma-1112114
Gamma-aminobutyric acid receptor subunit alpha-2112114
Amine oxidase [flavin-containing] B0707
Dipeptidyl peptidase 40505
Proteasome subunit beta type-50505
Gamma-aminobutyric acid receptor subunit alpha-4112114
Gamma-aminobutyric acid receptor subunit beta-30314
Gamma-aminobutyric acid receptor subunit gamma-3112114
Gamma-aminobutyric acid receptor subunit alpha-6112114
Substance-P receptor0606
Gamma-aminobutyric acid receptor subunit alpha-50213
Multidrug resistance-associated protein 1 0303
Gamma-aminobutyric acid receptor subunit alpha-30213
Prostaglandin G/H synthase 20606
Mu-type opioid receptor0226
Receptor-type tyrosine-protein kinase FLT30303
Testosterone 17-beta-dehydrogenase 30303
17-beta-hydroxysteroid dehydrogenase type 20404
Acetylcholinesterase0202
Peroxisome proliferator-activated receptor gamma0011
Delta-type opioid receptor0215
Kappa-type opioid receptor0215
Homeobox protein Nkx-2.5 0101
Tyrosine-protein kinase SYK0213
Histamine H2 receptor8009
Gamma-aminobutyric acid receptor subunit alpha-20213
Gamma-aminobutyric acid receptor subunit beta-20213
Xanthine dehydrogenase/oxidase0606
Gamma-aminobutyric acid receptor subunit alpha-40213
Glycogen synthase kinase-3 alpha0202
Glycogen synthase kinase-3 beta0202
Estrogen receptor0022
Nuclear receptor ROR-gamma6006
Death-associated protein kinase 10303
Mitogen-activated protein kinase 100303
Beta-secretase 10203
Gamma-aminobutyric acid receptor subunit alpha-1113115
Gamma-aminobutyric acid receptor subunit beta-3112114
Gamma-aminobutyric acid receptor subunit beta-2112114
Casein kinase II subunit beta0202
Casein kinase II subunit alpha0303
Urease subunit beta0202
Gamma-aminobutyric acid receptor subunit epsilon0202
Disintegrin and metalloproteinase domain-containing protein 172002
Lactoperoxidase0101
Xanthine dehydrogenase/oxidase0202
MO15-related protein kinase Pfmrk 0303
Inositol monophosphatase 17007
Cyclin-dependent kinase 60202
Cyclin-dependent-like kinase 5 0202
Cyclin homolog0202
Transcription factor GATA-4 0101
Cyclin-dependent kinase 5 activator 10202
Gamma-aminobutyric acid receptor subunit alpha-60213
Mitogen-activated protein kinase 140303
Cytochrome P450 1B1011011
Carbonic anhydrase 30101
Substance-K receptor0505
Integrase 0404
Gamma-aminobutyric acid receptor subunit gamma-10202
Casein kinase II subunit alpha 30202
Inositol polyphosphate multikinase0303
G2/mitotic-specific cyclin-B30202
GABA theta subunit112114
Inositol hexakisphosphate kinase 1100010
Estrogen receptor beta09212
Enoyl-acyl-carrier protein reductase 0202
Aurora kinase B0202
NACHT, LRR and PYD domains-containing protein 3 0101
ATPase family AAA domain-containing protein 56006
Ataxin-28008
Gamma-aminobutyric acid receptor subunit gamma-30202
Myocilin0011
Cyclin-dependent kinase 10202
Gamma-aminobutyric acid receptor subunit epsilon112114
Prenyltransferase homolog0005
Poly [ADP-ribose] polymerase tankyrase-20101
MAP kinase-interacting serine/threonine-protein kinase 20101
Carboxylic ester hydrolase 0202
NADPH oxidase 40202
Dipeptidyl peptidase 30303
Estrogen receptor beta0022
Inositol hexakisphosphate kinase 20303
Short transient receptor potential channel 50202
Gamma-aminobutyric acid receptor subunit theta0202
Broad substrate specificity ATP-binding cassette transporter ABCG20404
Sialidase-20303
cytochrome P450 2C9, partial100010
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
ATP-dependent phosphofructokinase7007
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
thioredoxin reductase130013
euchromatic histone-lysine N-methyltransferase 2190019
chromobox protein homolog 17007
muscarinic acetylcholine receptor M17007
lethal factor (plasmid)9009
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0102
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
vitamin D3 receptor isoform VDRA3003
peripheral myelin protein 227007
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010010
Bile salt export pump014014
Translocator protein0011
Vasopressin V2 receptor0214
Oxytocin receptor0112
Vasopressin V1a receptor0022
Vasopressin V1a receptor0112
Vasopressin V1b receptor0112
Vasopressin V2 receptor0011
Vasopressin V1b receptor0113
Translocator protein0102
Oxytocin receptor0101
Vasopressin V2 receptor 0112
Canalicular multispecific organic anion transporter 1010010
Neutral amino acid transporter A0404
Neutral amino acid transporter B(0)0404
Carbonic anhydrase-like protein, putative0004
Amino acid transporter0404
Chain A, Ferritin light chain6006
Bloom syndrome protein isoform 1100010
Metabotropic glutamate receptor 60011
Excitatory amino acid transporter 40101
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0002
Glutamate receptor ionotropic, NMDA 1 0416
Excitatory amino acid transporter 10101
Excitatory amino acid transporter 20101
Excitatory amino acid transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0315
Glutamate receptor ionotropic, NMDA 2B0315
Glutamate receptor ionotropic, NMDA 2C0315
Metabotropic glutamate receptor 10011
Metabotropic glutamate receptor 20011
Glutamate receptor ionotropic, NMDA 2D0315
Glutamate receptor ionotropic, NMDA 3B0315
Carbonic anhydrase 40002
Glutamate receptor ionotropic, NMDA 3A0315
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0011
ras protein, partial0011
hypothetical protein, conserved1001
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Prostaglandin-H2 D-isomerase0101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0202
Fatty acid-binding protein, liver0202
Prostaglandin G/H synthase 10213
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10707
Adenosine receptor A10203
Adenosine receptor A2a0203
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20202
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10617
Sigma non-opioid intracellular receptor 10314
Chain A, D-MALTODEXTRIN BINDING PROTEIN0011
Chain A, Limit Dextrinase0011
Chain A, Solute-binding protein0011
Chain A, Solute-binding protein0011
Chain B, SusD0011
Chain A, SusD0011
Chain A, SusD0011
Chain A, Alpha-hemolysin0011
Chain B, Alpha-hemolysin0011
Chain C, Alpha-hemolysin0011
Chain D, Alpha-hemolysin0011
Chain E, Alpha-hemolysin0011
Chain F, Alpha-hemolysin0011
Chain G, Alpha-hemolysin0011
activating transcription factor 68008
potassium voltage-gated channel subfamily H member 2 isoform d9009
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20112
Potassium channel subfamily K member 90101
Solute carrier family 22 member 50001
Solute carrier family 22 member 50001
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50001
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
Spike glycoprotein0112
glucose-6-phosphate 1-dehydrogenase isoform b0101
Transmembrane protease serine 20112
Dihydrofolate reductase 0101
DNA ligase0101
Riboflavin-binding protein0011
Major prion protein0011
Histidine-rich protein PFHRP-II0102
Procathepsin L0112
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M50606
Alpha-2A adrenergic receptor0718
Spike glycoprotein0101
Muscarinic acetylcholine receptor M10516
Ribosyldihydronicotinamide dehydrogenase [quinone]0516
Alpha-2B adrenergic receptor0707
Alpha-2C adrenergic receptor0617
DNA ligase 10101
Muscarinic acetylcholine receptor M30707
Serine/threonine-protein kinase mTOR0101
Nuclear receptor subfamily 4 group A member 20011
Calcium-dependent protein kinase 10011
DNA ligase A0101
Potassium voltage-gated channel subfamily H member 2011011
Sigma intracellular receptor 20101
Phosphoethanolamine N-methyltransferase0101
Angiotensin-converting enzyme 2 0112
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
acetylcholinesterase4004
GALC protein5005
Choline O-acetyltransferase0101
Histone acetyltransferase p3000101
Histone acetyltransferase KAT2B0101
Histone acetyltransferase KAT50101
caspase 7, apoptosis-related cysteine protease5005
caspase-35005
thyroid stimulating hormone receptor4004
ras-related protein Rab-9A5005
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
rac GTPase-activating protein 1 isoform a0202
Polyunsaturated fatty acid lipoxygenase ALOX15B2103
Carbonic anhydrase 120608
Aldehyde dehydrogenase, mitochondrial0101
Tyrosinase0404
Polyunsaturated fatty acid lipoxygenase ALOX150101
Polyunsaturated fatty acid lipoxygenase ALOX120101
UDP-glucuronosyltransferase 1A1 0202
UDP-glucuronosyltransferase 1A40002
Carbonic anhydrase 70507
Transporter0404
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)0202
Alpha-1B adrenergic receptor 0011
Alpha-1A adrenergic receptor0011
Alpha-2B adrenergic receptor0404
Alpha-2C adrenergic receptor0404
Alpha-2A adrenergic receptor0404
Alpha-1D adrenergic receptor0505
Chain A, Beta-lactamase5005
Motilin receptor0011
acid sphingomyelinase2002
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK11001
streptokinase A precursor0011
Motilin receptor0112
Rap guanine nucleotide exchange factor 33003
Albumin0033
ATP-dependent translocase ABCB10202
60 kDa chaperonin0202
60 kDa heat shock protein, mitochondrial0202
Cytochrome P450 2C9 0707
Chitinase B0101
ATP-dependent translocase ABCB10224
Low molecular weight phosphotyrosine protein phosphatase0101
Cytochrome P450 2J20303
10 kDa heat shock protein, mitochondrial0202
Thiosulfate sulfurtransferase0202
Lanosterol 14-alpha demethylase0101
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Multidrug and toxin extrusion protein 10202
Steryl-sulfatase0303
nonstructural protein 11001
hexokinase-4 isoform 13003
glucokinase regulatory protein3003
Sex hormone-binding globulin0033
Corticosteroid-binding globulin0202
Polyunsaturated fatty acid lipoxygenase ALOX150505
Androgen receptor0404
Sodium-dependent serotonin transporter0729
Mu-type opioid receptor0325
Alpha-synuclein0101
5-hydroxytryptamine receptor 2B0808
Solute carrier organic anion transporter family member 1A10101
Mu-type opioid receptor0213
TAR DNA-binding protein 433003
Ghrelin O-acyltransferase0101
Luciferin 4-monooxygenase0202
Tyrosine-protein phosphatase non-receptor type 10404
Nuclear factor NF-kappa-B p105 subunit0203
Tyrosine-protein phosphatase 10101
Ectonucleotide pyrophosphatase/phosphodiesterase family member 20202
Vesicular glutamate transporter 30101
Solute carrier family 22 member 1 0101
Nuclear receptor subfamily 1 group I member 20022
D(2) dopamine receptor0707
D(4) dopamine receptor0404
Delta-type opioid receptor0202
Delta-type opioid receptor0202
Kappa-type opioid receptor0101
Histamine H1 receptor0516
D(3) dopamine receptor0505
Kappa-type opioid receptor0202
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10404
Caspase-71001
D(1A) dopamine receptor5005
caspase-31001
huntingtin isoform 23003
atrial natriuretic peptide receptor 2 precursor2002
serine/threonine-protein kinase mTOR isoform 12002
Sodium-dependent noradrenaline transporter0101
5-hydroxytryptamine receptor 4010010
Albumin0033
Sodium channel protein type 1 subunit alpha0202
5-hydroxytryptamine receptor 2C0707
Cytochrome P450 2C80101
Cytochrome P450 2D60404
Dipeptidyl peptidase 40202
5-hydroxytryptamine receptor 2A0707
Acetylcholinesterase0202
Sodium-dependent noradrenaline transporter 07310
Sodium-dependent dopamine transporter0303
Potassium voltage-gated channel subfamily C member 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
5-hydroxytryptamine receptor 2A0808
5-hydroxytryptamine receptor 2C010010
5-hydroxytryptamine receptor 2B0707
Sodium-dependent serotonin transporter0303
Cytochrome P450 2C190202
D(1A) dopamine receptor2103
5-hydroxytryptamine receptor 60505
D(2) dopamine receptor0708
Gastrin/cholecystokinin type B receptor 0101
Sodium-dependent dopamine transporter 0415
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0102
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Sigma intracellular receptor 20101
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
Nuclear receptor subfamily 3 group C member 3 0505
Beta-2 adrenergic receptor0101
Transporter0303
Histamine H3 receptor0303
Fucose-binding lectin PA-IIL0202
CD209 antigen0303
Chain A, Estrogen receptor 1 (alpha)0101
Chain A, Transthyretin0011
Chain A, Transthyretin0011
glp-1 receptor, partial3003
SMAD family member 24004
SMAD family member 34004
P532002
DNA polymerase beta2002
tyrosine-protein kinase Yes1001
Steroid hormone receptor ERR20101
Tyrosine-protein kinase ABL10203
Pancreatic triacylglycerol lipase0303
Triosephosphate isomerase0101
Tyrosine-protein kinase Fyn0101
Solute carrier family 2, facilitated glucose transporter member 10202
Steroid hormone receptor ERR10202
Cyclin-dependent kinase 40101
Ornithine decarboxylase0202
Proto-oncogene tyrosine-protein kinase Src0101
Solute carrier family 2, facilitated glucose transporter member 40101
Protein kinase C alpha type0213
cAMP-dependent protein kinase catalytic subunit alpha0101
Amine oxidase [flavin-containing] A 0202
Amine oxidase [flavin-containing] A 0101
G1/S-specific cyclin-D10101
Thromboxane-A synthase 0101
Cruzipain0101
DNA (cytosine-5)-methyltransferase 10101
Adenosine receptor A2a0202
Adenosine receptor A10202
RAC-alpha serine/threonine-protein kinase0101
Cystic fibrosis transmembrane conductance regulator0011
Signal transducer and activator of transcription 30101
Tyrosine-protein kinase CSK0101
Tyrosine-protein kinase ABL20101
Dual specificity mitogen-activated protein kinase kinase 40101
Quinone oxidoreductase0001
Cytoplasmic tyrosine-protein kinase BMX0101
Amine oxidase [flavin-containing] B0101
Aldehyde oxidase0101
Tissue alpha-L-fucosidase0101
Solute carrier organic anion transporter family member 1B30202
DNA (cytosine-5)-methyltransferase 3-like0101
DNA (cytosine-5)-methyltransferase 3A0101
Solute carrier organic anion transporter family member 1B10202
Chain A, Glutamine Binding Protein0011
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
Asc-type amino acid transporter 10101
Glycine receptor subunit alpha-10022
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10202
Proton-coupled amino acid transporter 10303
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
Chain A, HISTIDINE-BINDING PROTEIN0011
histone acetyltransferase KAT2A isoform 12002
Plasma kallikrein0001
Carbonic anhydrase 30204
Histidine-binding periplasmic protein0011
Carbonic anhydrase 60204
Carbonic anhydrase 5A, mitochondrial0204
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90305
Carbonic anhydrase 0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Carbonic anhydrase 130102
Carbonic anhydrase 150102
Carbonic anhydrase 130103
Carbonic anhydrase 140204
Carbonic anhydrase 5B, mitochondrial0204
importin subunit beta-1 isoform 11001
snurportin-11001
caspase-1 isoform alpha precursor1001
Acetylcholinesterase0404
Genome polyprotein0101
Caspase-71001
Small conductance calcium-activated potassium channel protein 30101
Cholinesterase0404
Sorbitol dehydrogenase0101
Induced myeloid leukemia cell differentiation protein Mcl-10202
Oleandomycin glycosyltransferase0001
Chain A, Carbonic anhydrase II0011
Chain A, JmjC domain-containing histone demethylation protein 3A3003
dual specificity tyrosine-phosphorylation-regulated kinase 1A0001
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 10101
Arginase 0101
Protein E60101
Neuraminidase0101
Interstitial collagenase0101
Tyrosine-protein kinase Yes0101
Beta-glucuronidase0101
Polyunsaturated fatty acid 5-lipoxygenase0202
Tyrosinase0202
Aryl hydrocarbon receptor0101
Prolyl endopeptidase0101
E3 ubiquitin-protein ligase XIAP0101
Lactoylglutathione lyase0202
Dihydroorotate dehydrogenase 0101
Histone-lysine N-methyltransferase SETD70101
3-oxoacyl-acyl-carrier protein reductase 0101
CDGSH iron-sulfur domain-containing protein 10202
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Dihydrofolate reductase0202
Potassium voltage-gated channel subfamily E member 10101
Sodium channel protein type 4 subunit alpha0102
Potassium voltage-gated channel subfamily KQT member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 9 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
lethal(3)malignant brain tumor-like protein 1 isoform I1001
transcriptional regulator ERG isoform 32002
Alpha-mannosidase 2C10101
ClpP2002
Cytochrome P450 1A2 0101
Cholinesterase0202
Cytochrome P450 2C11 0101
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0101
Nociceptin receptor0101
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear factor erythroid 2-related factor 20013
Palmitoleoyl-protein carboxylesterase NOTUM0101
Carboxylic ester hydrolase 0202
Sucrase-isomaltase 0101
Ceramide glucosyltransferase0101
Beta-galactosidase0101
Lysosomal alpha-glucosidase0101
Non-lysosomal glucosylceramidase0101
Chain A, HYALURONIDASE0101
Chain A, Beta-hexosaminidase0101
Chain A, Alpha-n-acetylglucosaminidase0011
Chain A, Alpha-n-acetylglucosaminidase0011
Chain A, O-glcnacase Bt_43950101
Chain A, N-acetylglucosaminidase0101
Chain A, N-acetylglucosaminidase0101
Protein O-GlcNAcase0101
Protein O-GlcNAcase0101
Beta-hexosaminidase0001
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase0001
Chain A, Hth-type Transcriptional Regulator Ttgr0011
Chain A, Hth-type Transcriptional Regulator Ttgr0011
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Calmodulin-10101
Carbonyl reductase [NADPH] 10202
5-hydroxytryptamine receptor 3E0101
FAD-linked sulfhydryl oxidase ALR0002
5-hydroxytryptamine receptor 3B0101
5-hydroxytryptamine receptor 1A0235
Glucose-6-phosphate 1-dehydrogenase0101
D0406
D(3) dopamine receptor0404
5-hydroxytryptamine receptor 1A0304
D(1A) dopamine receptor0606
D(4) dopamine receptor0101
Histamine H1 receptor0213
5-hydroxytryptamine receptor 70202
Alpha-1A adrenergic receptor0303
Alpha-1B adrenergic receptor0202
5-hydroxytryptamine receptor 3A0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
bromodomain adjacent to zinc finger domain 2B1001
TPA: protein transporter TIM100101
tumor susceptibility gene 101 protein1001
POsterior Segregation0022
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30101
Zinc finger protein mex-50022
BZLF20101
luciferase0001
nuclear receptor subfamily 1, group I, member 22002
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Nociceptin receptor0011
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A80001
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
M18 aspartyl aminopeptidase0101
cathepsin L10101
nuclear factor NF-kappa-B p105 subunit isoform 10011
Vif0101
muscleblind-like protein 1 isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
transcription factor p65 isoform 10011
serine/threonine-protein kinase 33 isoform a0011
Aryl hydrocarbon receptor0101
Estrogen receptor beta0011
Lysine-specific histone demethylase 1A0101
Transient receptor potential cation channel subfamily A member 10112
Myc proto-oncogene protein0102
Tyrosine-protein kinase Lck0101
Cathepsin D0101
Neuronal acetylcholine receptor subunit alpha-40101
DNA polymerase alpha catalytic subunit0101
Leukotriene A-4 hydrolase0101
Breakpoint cluster region protein0102
Neuronal acetylcholine receptor subunit beta-20101
Estrogen receptor0011
Endothelin receptor type B1001
Endothelin-1 receptor1001
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10101
Cannabinoid receptor 10101
Nuclear factor NF-kappa-B p100 subunit 0101
Squalene synthase0101
Transcription factor p650101
Bcl-2-like protein 10101
Serine/threonine-protein kinase PAK 10101
N1L 0101
NAD(P)H dehydrogenase [quinone] 10002
Tubulin beta-2B chain0101
Transient receptor potential cation channel subfamily A member 10101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
NAD-dependent protein deacetylase sirtuin-20112
Rap guanine nucleotide exchange factor 41001
NAD-dependent protein deacetylase sirtuin-10114
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
large T antigen0101
thyrotropin-releasing hormone receptor1001
Solute carrier family 22 member 20101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Beta-1 adrenergic receptor0101
Histamine H2 receptor0202
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
5-hydroxytryptamine receptor 1A0101
Multidrug and toxin extrusion protein 20101
Met repressor 0022
Protein arginine N-methyltransferase 50011
Histone H3K27 methylase0001
Phenylethanolamine N-methyltransferase0012
S-adenosylmethionine decarboxylase proenzyme0102
Protein-L-isoaspartate(D-aspartate) O-methyltransferase0101
Catechol O-methyltransferase0001
Protein arginine N-methyltransferase 10202
Methylosome protein 500011
dopamine D1 receptor1001
beta-2 adrenergic receptor1001
Adenylate cyclase type 60101
Adenylate cyclase type 3 0101
Adenylate cyclase type 90101
Adenylate cyclase type 50101
D(1B) dopamine receptor0202
D(1) dopamine receptor0101
Adenylate cyclase type 80101
Adenylate cyclase type 70101
Neuronal acetylcholine receptor subunit alpha-70101
Adenylate cyclase type 20101
Adenylate cyclase type 10101
D0101
Adenylate cyclase type 40101
D0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
ATP-dependent 6-phosphofructokinase0101
Ectonucleoside triphosphate diphosphohydrolase 20101
Serine/threonine-protein kinase D30101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Cathepsin B0101
Protein kinase C eta type0101
P2Y purinoceptor 20112
Protein kinase C iota type0101
P2X purinoceptor 10011
P2Y purinoceptor 10011
P2X purinoceptor 20112
P2X purinoceptor 40011
P2X purinoceptor 50011
P2X purinoceptor 60011
P2Y purinoceptor 40011
NAD-dependent protein deacetylase HST20101
P2X purinoceptor 30011
DNA-dependent protein kinase catalytic subunit0101
Ectonucleoside triphosphate diphosphohydrolase 10101
DNA primase0101
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
P2Y purinoceptor 60101
Serine/threonine-protein kinase D10101
Dual specificity protein phosphatase 50101
Ectonucleoside triphosphate diphosphohydrolase 80101
RmtA0101
Ectonucleoside triphosphate diphosphohydrolase 3 0101
P2Y purinoceptor 110112
P2X purinoceptor 70011
P2Y purinoceptor 120011
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with trehalose0101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with cellobiose0101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with maltose0101
Trehalose-phosphatase0101
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]