Page last updated: 2024-08-05 15:44:59

EC 1.11.1.9 (glutathione peroxidase) inhibitor

An inhibitor of peroxidases (EC 1.11.1.*) that inhibits the action of glutathione peroxidase (EC 1.11.1.9).

ChEBI ID: 176342

Members (2)

MemberDefinitionClass
ML-210An N-acylpiperazine that is piperazine substituted by 5-methyl-4-nitro-1,2-oxazole-3-carbonyl and bis(4-chlorophenyl)methyl groups at positions 1 and 4, respectively. It is a glutathione peroxidase 4 (GPX4) inhibitor which induces ferroptosis in cancer cells expressing the RAS oncogene.ML-210
ML162A monochlorobenzene that is benzene substituted by (chloroacetyl){2-oxo-2-[(2-phenylethyl)amino]-1-(thiophen-2-yl)ethyl}amino, chloro and methoxy groups at positions 1, 3 and 4, respectively. It is a covalent inhibitor of glutathione peroxidase 4 (GPX4) that induces ferroptosis in cells.ML162

Research

Studies (16)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (6.25)29.6817
2010's6 (37.50)24.3611
2020's9 (56.25)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (100.00%)84.16%

Protein Targets (44)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency10.610122
ATAD5 protein, partialHomo sapiens (human)Potency20.596211
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency39.810711
cytochrome P450 2C9, partialHomo sapiens (human)Potency5.354711
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency12.589311
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency35.481311
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency89.125111
GVesicular stomatitis virusPotency5.354711
gemininHomo sapiens (human)Potency3.372122
glp-1 receptor, partialHomo sapiens (human)Potency11.220211
Glycoprotein hormones alpha chainHomo sapiens (human)Potency0.501211
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency5.354711
IDH1Homo sapiens (human)Potency18.356411
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency5.354712
Interferon betaHomo sapiens (human)Potency5.354711
lamin isoform A-delta10Homo sapiens (human)Potency35.481311
Microtubule-associated protein tauHomo sapiens (human)Potency11.220211
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency0.125911
neuropeptide S receptor isoform AHomo sapiens (human)Potency12.589311
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency0.891311
Nrf2Homo sapiens (human)Potency3.548111
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency11.220211
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency84.921411
plasminogen precursorMus musculus (house mouse)Potency3.981111
ras-related protein Rab-9AHomo sapiens (human)Potency0.251211
Smad3Homo sapiens (human)Potency8.802544
survival motor neuron protein isoform dHomo sapiens (human)Potency35.481311
TDP1 proteinHomo sapiens (human)Potency2.025522
thioredoxin glutathione reductaseSchistosoma mansoniPotency10.000011
thioredoxin reductaseRattus norvegicus (Norway rat)Potency14.125411
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency3.981111
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency3.981111
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency89.125111

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
fatty acid synthaseHomo sapiens (human)IC5010.400022
melanocortin receptor 4Homo sapiens (human)IC5064.585011
Phosphatidylinositol 3-kinase catalytic subunit type 3Homo sapiens (human)IC500.021522

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
bcl-2-like protein 11 isoform 1Homo sapiens (human)EC5070.600011
Chain A, BCL-2-RELATED PROTEIN A1Homo sapiens (human)EC5070.600011
Phospholipid hydroperoxide glutathione peroxidaseHomo sapiens (human)EC508.818024
recombinase AMycobacterium tuberculosis H37RvEC500.597622

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Bcl-2-like protein 11Homo sapiens (human)AC5041.910011
Chain A, BCL-2-RELATED PROTEIN A1Homo sapiens (human)AC5082.453366
HRAS, partialHomo sapiens (human)AC5023.047033
PAX8Homo sapiens (human)AC500.323011
replicative DNA helicaseMycobacterium tuberculosis H37RvAC501.248522