An inhibitor of peroxidases (EC 1.11.1.*) that inhibits the action of glutathione peroxidase (EC 1.11.1.9).
ChEBI ID: 176342
| Member | Definition | Class |
|---|---|---|
| ML-210 | An N-acylpiperazine that is piperazine substituted by 5-methyl-4-nitro-1,2-oxazole-3-carbonyl and bis(4-chlorophenyl)methyl groups at positions 1 and 4, respectively. It is a glutathione peroxidase 4 (GPX4) inhibitor which induces ferroptosis in cancer cells expressing the RAS oncogene. | ML-210 |
| ML162 | A monochlorobenzene that is benzene substituted by (chloroacetyl){2-oxo-2-[(2-phenylethyl)amino]-1-(thiophen-2-yl)ethyl}amino, chloro and methoxy groups at positions 1, 3 and 4, respectively. It is a covalent inhibitor of glutathione peroxidase 4 (GPX4) that induces ferroptosis in cells. | ML162 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 9 (56.25) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 18 (100.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 10.6101 | 2 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 5.3547 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 5.3547 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 3.3721 | 2 | 2 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 0.5012 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 5.3547 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 5.3547 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 5.3547 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 0.1259 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 11.2202 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 3.9811 | 1 | 1 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.2512 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 8.8025 | 4 | 4 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 2.0255 | 2 | 2 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 10.0000 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 3.9811 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 3.9811 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| fatty acid synthase | Homo sapiens (human) | IC50 | 10.4000 | 2 | 2 |
| melanocortin receptor 4 | Homo sapiens (human) | IC50 | 64.5850 | 1 | 1 |
| Phosphatidylinositol 3-kinase catalytic subunit type 3 | Homo sapiens (human) | IC50 | 0.0215 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| bcl-2-like protein 11 isoform 1 | Homo sapiens (human) | EC50 | 70.6000 | 1 | 1 |
| Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | EC50 | 70.6000 | 1 | 1 |
| Phospholipid hydroperoxide glutathione peroxidase | Homo sapiens (human) | EC50 | 8.8180 | 2 | 4 |
| recombinase A | Mycobacterium tuberculosis H37Rv | EC50 | 0.5976 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Bcl-2-like protein 11 | Homo sapiens (human) | AC50 | 41.9100 | 1 | 1 |
| Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | AC50 | 82.4533 | 6 | 6 |
| HRAS, partial | Homo sapiens (human) | AC50 | 23.0470 | 3 | 3 |
| PAX8 | Homo sapiens (human) | AC50 | 0.3230 | 1 | 1 |
| replicative DNA helicase | Mycobacterium tuberculosis H37Rv | AC50 | 1.2485 | 2 | 2 |