broussonin a profile

broussonin A: has antiviral activity; isolated from Anemarrhena asphodeloides; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Anemarrhena	genus	A plant genus of the family Asparagaceae. Members contain anemarans (POLYSACCHARIDES), hinokiresinol, mangiferin (a xanthone), and timosaponin (a steroidal saponin).[MeSH]	Asparagaceae	A family of flowering subshrubs and shrubs in the class Magnoliopsida.[MeSH]

ID Source	ID
PubMed CID	5315502
CHEMBL ID	465879
SCHEMBL ID	774802
MeSH ID	M0515657

Synonym
broussonin a
bdbm50251012
CHEMBL465879 ,
2-[3-(4-hydroxyphenyl)propyl]-5-methoxyphenol ,
MSNVBURPCQDLEP-UHFFFAOYSA-N
SCHEMBL774802
73731-87-0
FS-9268
DTXSID901317996
CS-0023594
HY-N2960
broussonina
AKOS040761430
44SF3SS9W7
phenol, 2-[3-(4-hydroxyphenyl)propyl]-5-methoxy-

Excerpt	Reference	Relevance
"Treatment with broussonin A or B suppressed VEGF-A-stimulated endothelial cell proliferation by regulating the expression of cell cycle-related proteins and the phosphorylation status of retinoblastoma protein."	( Broussonin A- and B-mediated inhibition of angiogenesis by blockade of VEGFR-2 signalling pathways and integrin β1 expression. Ahn, EK; Bae, GU; Cho, YR; Han, S; Jeong, W; Kim, JH; Kim, S; Kim, SJ; Oh, JS; Seo, DW, 2022)	2.5

Protein Targets (4)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Pancreatic triacylglycerol lipase	Sus scrofa (pig)	IC50 (µMol)	98.7000	0.0040	1.1024	6.5000	AID657041
Estrogen receptor	Homo sapiens (human)	IC50 (µMol)	8.1000	0.0000	0.7237	32.7000	AID484869
Aromatase	Homo sapiens (human)	IC50 (µMol)	30.0000	0.0000	1.2904	10.0000	AID357965
Estrogen receptor beta	Homo sapiens (human)	IC50 (µMol)	1.8000	0.0001	0.5294	32.7000	AID484870
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Estrogen receptor	Homo sapiens (human)	EC50 (µMol)	1.5900	0.0000	0.5305	4.4000	AID484868
Estrogen receptor beta	Homo sapiens (human)	EC50 (µMol)	0.5300	0.0000	0.4795	4.8900	AID484865
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (57)

Process	via Protein(s)	Taxonomy
positive regulation of transcription by RNA polymerase II	Estrogen receptor	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Estrogen receptor	Homo sapiens (human)
antral ovarian follicle growth	Estrogen receptor	Homo sapiens (human)
epithelial cell development	Estrogen receptor	Homo sapiens (human)
chromatin remodeling	Estrogen receptor	Homo sapiens (human)
regulation of DNA-templated transcription	Estrogen receptor	Homo sapiens (human)
signal transduction	Estrogen receptor	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Estrogen receptor	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Estrogen receptor	Homo sapiens (human)
androgen metabolic process	Estrogen receptor	Homo sapiens (human)
male gonad development	Estrogen receptor	Homo sapiens (human)
negative regulation of gene expression	Estrogen receptor	Homo sapiens (human)
positive regulation of phospholipase C activity	Estrogen receptor	Homo sapiens (human)
intracellular steroid hormone receptor signaling pathway	Estrogen receptor	Homo sapiens (human)
intracellular estrogen receptor signaling pathway	Estrogen receptor	Homo sapiens (human)
response to estradiol	Estrogen receptor	Homo sapiens (human)
regulation of toll-like receptor signaling pathway	Estrogen receptor	Homo sapiens (human)
negative regulation of smooth muscle cell apoptotic process	Estrogen receptor	Homo sapiens (human)
negative regulation of canonical NF-kappaB signal transduction	Estrogen receptor	Homo sapiens (human)
negative regulation of DNA-binding transcription factor activity	Estrogen receptor	Homo sapiens (human)
response to estrogen	Estrogen receptor	Homo sapiens (human)
positive regulation of DNA-templated transcription	Estrogen receptor	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Estrogen receptor	Homo sapiens (human)
fibroblast proliferation	Estrogen receptor	Homo sapiens (human)
positive regulation of fibroblast proliferation	Estrogen receptor	Homo sapiens (human)
stem cell differentiation	Estrogen receptor	Homo sapiens (human)
regulation of inflammatory response	Estrogen receptor	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	Estrogen receptor	Homo sapiens (human)
RNA polymerase II preinitiation complex assembly	Estrogen receptor	Homo sapiens (human)
uterus development	Estrogen receptor	Homo sapiens (human)
vagina development	Estrogen receptor	Homo sapiens (human)
prostate epithelial cord elongation	Estrogen receptor	Homo sapiens (human)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	Estrogen receptor	Homo sapiens (human)
regulation of branching involved in prostate gland morphogenesis	Estrogen receptor	Homo sapiens (human)
mammary gland branching involved in pregnancy	Estrogen receptor	Homo sapiens (human)
mammary gland alveolus development	Estrogen receptor	Homo sapiens (human)
epithelial cell proliferation involved in mammary gland duct elongation	Estrogen receptor	Homo sapiens (human)
protein localization to chromatin	Estrogen receptor	Homo sapiens (human)
cellular response to estradiol stimulus	Estrogen receptor	Homo sapiens (human)
negative regulation of miRNA transcription	Estrogen receptor	Homo sapiens (human)
regulation of epithelial cell apoptotic process	Estrogen receptor	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Estrogen receptor	Homo sapiens (human)
cellular response to estrogen stimulus	Estrogen receptor	Homo sapiens (human)
negative regulation of chronic inflammatory response	Aromatase	Homo sapiens (human)
steroid biosynthetic process	Aromatase	Homo sapiens (human)
estrogen biosynthetic process	Aromatase	Homo sapiens (human)
androgen catabolic process	Aromatase	Homo sapiens (human)
syncytium formation	Aromatase	Homo sapiens (human)
negative regulation of macrophage chemotaxis	Aromatase	Homo sapiens (human)
sterol metabolic process	Aromatase	Homo sapiens (human)
female genitalia development	Aromatase	Homo sapiens (human)
mammary gland development	Aromatase	Homo sapiens (human)
uterus development	Aromatase	Homo sapiens (human)
prostate gland growth	Aromatase	Homo sapiens (human)
testosterone biosynthetic process	Aromatase	Homo sapiens (human)
positive regulation of estradiol secretion	Aromatase	Homo sapiens (human)
female gonad development	Aromatase	Homo sapiens (human)
response to estradiol	Aromatase	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Estrogen receptor beta	Homo sapiens (human)
regulation of DNA-templated transcription	Estrogen receptor beta	Homo sapiens (human)
signal transduction	Estrogen receptor beta	Homo sapiens (human)
cell-cell signaling	Estrogen receptor beta	Homo sapiens (human)
negative regulation of cell growth	Estrogen receptor beta	Homo sapiens (human)
intracellular estrogen receptor signaling pathway	Estrogen receptor beta	Homo sapiens (human)
positive regulation of DNA-templated transcription	Estrogen receptor beta	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	Estrogen receptor beta	Homo sapiens (human)
cellular response to estradiol stimulus	Estrogen receptor beta	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Estrogen receptor beta	Homo sapiens (human)
cellular response to estrogen stimulus	Estrogen receptor beta	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (36)

Process	via Protein(s)	Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Estrogen receptor	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Estrogen receptor	Homo sapiens (human)
TFIIB-class transcription factor binding	Estrogen receptor	Homo sapiens (human)
transcription coregulator binding	Estrogen receptor	Homo sapiens (human)
transcription corepressor binding	Estrogen receptor	Homo sapiens (human)
transcription coactivator binding	Estrogen receptor	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Estrogen receptor	Homo sapiens (human)
chromatin binding	Estrogen receptor	Homo sapiens (human)
DNA-binding transcription factor activity	Estrogen receptor	Homo sapiens (human)
nuclear receptor activity	Estrogen receptor	Homo sapiens (human)
steroid binding	Estrogen receptor	Homo sapiens (human)
protein binding	Estrogen receptor	Homo sapiens (human)
calmodulin binding	Estrogen receptor	Homo sapiens (human)
beta-catenin binding	Estrogen receptor	Homo sapiens (human)
zinc ion binding	Estrogen receptor	Homo sapiens (human)
TBP-class protein binding	Estrogen receptor	Homo sapiens (human)
enzyme binding	Estrogen receptor	Homo sapiens (human)
protein kinase binding	Estrogen receptor	Homo sapiens (human)
nitric-oxide synthase regulator activity	Estrogen receptor	Homo sapiens (human)
nuclear estrogen receptor activity	Estrogen receptor	Homo sapiens (human)
nuclear estrogen receptor binding	Estrogen receptor	Homo sapiens (human)
estrogen response element binding	Estrogen receptor	Homo sapiens (human)
identical protein binding	Estrogen receptor	Homo sapiens (human)
ATPase binding	Estrogen receptor	Homo sapiens (human)
14-3-3 protein binding	Estrogen receptor	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Estrogen receptor	Homo sapiens (human)
iron ion binding	Aromatase	Homo sapiens (human)
steroid hydroxylase activity	Aromatase	Homo sapiens (human)
electron transfer activity	Aromatase	Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Aromatase	Homo sapiens (human)
oxygen binding	Aromatase	Homo sapiens (human)
heme binding	Aromatase	Homo sapiens (human)
aromatase activity	Aromatase	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Estrogen receptor beta	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Estrogen receptor beta	Homo sapiens (human)
DNA binding	Estrogen receptor beta	Homo sapiens (human)
nuclear steroid receptor activity	Estrogen receptor beta	Homo sapiens (human)
nuclear receptor activity	Estrogen receptor beta	Homo sapiens (human)
steroid binding	Estrogen receptor beta	Homo sapiens (human)
protein binding	Estrogen receptor beta	Homo sapiens (human)
zinc ion binding	Estrogen receptor beta	Homo sapiens (human)
enzyme binding	Estrogen receptor beta	Homo sapiens (human)
nuclear estrogen receptor activity	Estrogen receptor beta	Homo sapiens (human)
estrogen response element binding	Estrogen receptor beta	Homo sapiens (human)
receptor antagonist activity	Estrogen receptor beta	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (15)

Process	via Protein(s)	Taxonomy
nucleus	Estrogen receptor	Homo sapiens (human)
nucleoplasm	Estrogen receptor	Homo sapiens (human)
transcription regulator complex	Estrogen receptor	Homo sapiens (human)
cytoplasm	Estrogen receptor	Homo sapiens (human)
Golgi apparatus	Estrogen receptor	Homo sapiens (human)
cytosol	Estrogen receptor	Homo sapiens (human)
plasma membrane	Estrogen receptor	Homo sapiens (human)
membrane	Estrogen receptor	Homo sapiens (human)
chromatin	Estrogen receptor	Homo sapiens (human)
euchromatin	Estrogen receptor	Homo sapiens (human)
protein-containing complex	Estrogen receptor	Homo sapiens (human)
nucleus	Estrogen receptor	Homo sapiens (human)
endoplasmic reticulum	Aromatase	Homo sapiens (human)
endoplasmic reticulum membrane	Aromatase	Homo sapiens (human)
membrane	Aromatase	Homo sapiens (human)
endoplasmic reticulum	Aromatase	Homo sapiens (human)
nucleus	Estrogen receptor beta	Homo sapiens (human)
nucleoplasm	Estrogen receptor beta	Homo sapiens (human)
mitochondrion	Estrogen receptor beta	Homo sapiens (human)
intracellular membrane-bounded organelle	Estrogen receptor beta	Homo sapiens (human)
chromatin	Estrogen receptor beta	Homo sapiens (human)
nucleus	Estrogen receptor beta	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (17)

Assay ID	Title	Year	Journal	Article
AID484870	Displacement of [3H]17-beta-estradiol from human recombinant full length ERbeta	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	New estrogenic compounds isolated from Broussonetia kazinoki.
AID484861	Up-regulation of progesterone receptor gene expression in human MCF7 cells at 10 uM after 24 hrs by RT-PCR analysis	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	New estrogenic compounds isolated from Broussonetia kazinoki.
AID484872	Displacement of [3H]17-beta-estradiol from human recombinant full length ERbeta relative to estradiol	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	New estrogenic compounds isolated from Broussonetia kazinoki.
AID357965	Inhibition of aromatase from human placental microsomes	2001	Journal of natural products, Oct, Volume: 64, Issue:10	Aromatase inhibitors from Broussonetia papyrifera.
AID484862	Up-regulation of pS2 gene expression in human MCF7 cells at 10 uM after 24 hrs by RT-PCR analysis	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	New estrogenic compounds isolated from Broussonetia kazinoki.
AID657041	Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate preincubated for 15 mins prior substrate addition measured after 15 mins by spectrophotometry	2012	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8	A new pancreatic lipase inhibitor from Broussonetia kanzinoki.
AID484865	Transactivation of human recombinant ERbeta expressed in african green monkey CV1 cells co-expressing ERE-Luc after 24 hrs by luciferase reporter gene assay	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	New estrogenic compounds isolated from Broussonetia kazinoki.
AID484867	Transactivation of human recombinant ERbeta expressed in african green monkey CV1 cells co-expressing ERE-Luc after 24 hrs by luciferase reporter gene assay in presence of ER antagonist ICI 182780	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	New estrogenic compounds isolated from Broussonetia kazinoki.
AID484868	Transactivation of human recombinant ERalpha expressed in african green monkey CV1 cells co-expressing ERE-Luc after 24 hrs by luciferase reporter gene assay	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	New estrogenic compounds isolated from Broussonetia kazinoki.
AID484871	Displacement of [3H]17-beta-estradiol from human recombinant full length ERalpha relative to estradiol	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	New estrogenic compounds isolated from Broussonetia kazinoki.
AID468347	Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides.
AID484866	Transactivation of human recombinant ERalpha expressed in african green monkey CV1 cells co-expressing ERE-Luc after 24 hrs by luciferase reporter gene assay in presence of ER antagonist ICI 182780	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	New estrogenic compounds isolated from Broussonetia kazinoki.
AID484873	Selectivity ratio of IC50 for human recombinant full length ERbeta to IC50 for human recombinant full length ERalpha	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	New estrogenic compounds isolated from Broussonetia kazinoki.
AID484869	Displacement of [3H]17-beta-estradiol from human recombinant full length ERalpha	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	New estrogenic compounds isolated from Broussonetia kazinoki.
AID484863	Down-regulation of ERalpha mRNA expression in human MCF7 cells at 10 uM after 24 hrs by RT-PCR analysis	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	New estrogenic compounds isolated from Broussonetia kazinoki.
AID484864	Down-regulation of ERalpha mRNA expression in human MCF7 cells at 10 uM after 24 hrs by SDS PAGE and immunoblot analysis	2010	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12	New estrogenic compounds isolated from Broussonetia kazinoki.
AID657039	Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate at 100 uM preincubated for 15 mins prior substrate addition measured after 15 mins by spectrophotometry	2012	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8	A new pancreatic lipase inhibitor from Broussonetia kanzinoki.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (42.86)	29.6817
2010's	3 (42.86)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
aminoglutethimide Aminoglutethimide: An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.. aminoglutethimide : A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.	2	1	dicarboximide; piperidones; substituted aniline	adrenergic agent; anticonvulsant; antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor
loliolide loliolide: RN given refers to (6S-cis)-isomer	2	1	benzofurans	metabolite
aromadedrin aromadedrin: inhibits protein kinase C; the dihydro makes it a flavone rather than a flavonol. (+)-dihydrokaempferol : A tetrahydroxyflavanone having hydroxy groupa at the 3-, 4'-, 5- and 7-positions.	2	1	4'-hydroxyflavanones; dihydroflavonols; secondary alpha-hydroxy ketone; tetrahydroxyflavanone	metabolite
moracin m moracin M: has been isolated from Morus alba L.; structure in first source	2	1	benzofurans
marmesin marmesin: RN given refers to (S)-isomer; nodakenetin is the (R)-isomer	2	1	marmesin
naringenin (S)-naringenin : The (S)-enantiomer of naringenin.	2	1	(2S)-flavan-4-one; naringenin	expectorant; plant metabolite
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	2.46	2
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.43	2	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
isoliquiritigenin [no description available]	2.05	1	chalcones	antineoplastic agent; biological pigment; EC 1.14.18.1 (tyrosinase) inhibitor; GABA modulator; geroprotector; metabolite; NMDA receptor antagonist
orlistat Orlistat: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.. orlistat : A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.	2.07	1	beta-lactone; carboxylic ester; formamides; L-leucine derivative	anti-obesity agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor
isobavachalcone isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.	2	1	chalcones; polyphenol	antibacterial agent; metabolite; platelet aggregation inhibitor
broussonin b broussonin B: structure in first source	2.76	3
Isolicoflavonol [no description available]	2	1	flavones
3-deoxysappanchalcone 3-deoxysappanchalcone: Anti-allergic from the roots and heartwood of Caesalpinia sappan; structure in first source. 2'-O-methylisoliquiritigenin : A member of the class of chalcones that is isoliquiritigenin in which one of the hydroxy groups at position 2' is replaced by a methoxy group.	2.05	1	chalcones; monomethoxybenzene; phenols	metabolite
broussochalcone a broussochalcone A: RN given for (E)-isomer; inhibits neutrophil respiratory burst; structure in first source	2	1
bavachalcone bavachalcone: structure in first source	2	1	chalcones
nyasol nyasol: from roots Asparagus africanus; structure given in first source	7.75	3	1,3-bis(p-hydroxyphenyl)pentane-1,4-diene	plant metabolite
morachalcone a morachalcone A: tyrosinase inhibitor from the wood of Artocarpus heterophyllus; structure in first source	2	1	chalcones
2,4,2',4'-Tetrahydroxychalcone [no description available]	2	1	chalcones
bavachin bavachin: from Psoralea corylifolia (Leguminosae), has osteoblastic proliferation stimulating activity; do not confuse with bavachinin	2	1
mulberrofuran g mulberrofuran G: from Mulberry tree; Diels-Alder type adduct; structure given in first source	2	1
phytoestrogens Phytoestrogens: Compounds derived from plants, primarily ISOFLAVONES that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.	2.05	1

Condition	Relationship Strength	Studies
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2	1
Carcinoma, Non-Small Cell Lung [description not available]	2.41	1
Cancer of Lung [description not available]	2.41	1
Angiogenesis, Pathologic [description not available]	2.41	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.41	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.41	1
Anasarca [description not available]	2.1	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.1	1

broussonin a

Description

Cross-References

Synonyms (15)

Research Excerpts

Treatment

Protein Targets (4)

Inhibition Measurements

Activation Measurements

Biological Processes (57)

Molecular Functions (36)

Ceullar Components (15)

Bioassays (17)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.47

Study Types

broussonin a

Description

Related Flora

Cross-References

Synonyms (15)

Research Excerpts

Treatment

Protein Targets (4)

Inhibition Measurements

Activation Measurements

Biological Processes (57)

Molecular Functions (36)

Ceullar Components (15)

Bioassays (17)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.47

Study Types

Related Drugs (22)

Related Conditions (8)