irisflorentin: bioactive substance isolated from Rhizoma Belamcandae; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 170569 |
| CHEMBL ID | 487216 |
| CHEBI ID | 81410 |
| MeSH ID | M0571935 |
| Synonym |
|---|
| irisflorentin |
| 41743-73-1 |
| C17958 |
| chebi:81410 , |
| CHEMBL487216 |
| 5,3',4',5'-tetramethoxy-6,7-methylenedioxyisoflavone |
| LMPK12050419 |
| 9-methoxy-7-(3,4,5-trimethoxyphenyl)-[1,3]dioxolo[4,5-g]chromen-8-one |
| 9-methoxy-7-(3,4,5-trimethoxyphenyl)-8h-1,3-dioxolo(4,5-g)(1)benzopyran-8-one |
| 8h-1,3-dioxolo(4,5-g)(1)benzopyran-8-one, 9-methoxy-7-(3,4,5-trimethoxyphenyl)- |
| S9053 |
| FT-0688295 |
| AKOS015896764 |
| AC-34062 |
| Q-100469 |
| 9-methoxy-7-(3,4,5-trimethoxyphenyl)-8h-1,3-dioxolo[4,5-g][1]benzopyran-8-one |
| DTXSID60194575 |
| 9-methoxy-7-(3,4,5-trimethoxyphenyl)-8h-[1,3]dioxolo[4,5-g]chromen-8-one |
| Q27155343 |
| mfcd02183467 |
| HY-N0268 |
| CS-0008287 |
| CCG-268476 |
| AS-56483 |
| irisfloretin |
| I1063 |
Irisflorentin is an isoflavone component derived from the roots of Belamcanda chinensis (L.) DC.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Irisflorentin is an isoflavone component derived from the roots of Belamcanda chinensis (L.) DC. " | ( Irisflorentin modifies properties of mouse bone marrow-derived dendritic cells and reduces the allergic contact hypersensitivity responses. Chan, TM; Chen, YM; Chiu, SC; Fu, RH; Ho, YC; Hung, HS; Lin, HL; Lin, SZ; Liu, SP; Shyu, WC; Tsai, CH; Tsai, CW; Tsai, RT; Wang, YC, 2015) | 3.3 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " This method was successfully applied to a pharmacokinetic study of the three isoflavones after oral administration of Rhizoma Belamcandae extract to rats." | ( Simultaneous determination of tectorigenin, irigenin and irisflorentin in rat plasma and urine by UHPLC-MS/MS: application to pharmacokinetics. Gu, Y; Wang, R; Wang, XJ; Yang, WJ; Zhang, WD, 2011) | 0.61 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The metabolites were identified by ultra-high performance liquid chromatography combined with quadrupole/orbitrap tandem mass spectrometry." | ( Characterization of the metabolites of irisflorentin by using ultra-high performance liquid chromatography combined with quadrupole/orbitrap tandem mass spectrometry. Qiao, GX; Zhang, X; Zhao, GF; Zhao, SF, 2021) | 0.89 |
| Class | Description |
|---|---|
| 4'-methoxyisoflavones | Any methoxyisoflavone which has a methoxy group at the 4-position of the phenyl substituent. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID377457 | Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID377458 | Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID377456 | Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID377455 | Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID338974 | Inhibition of cow milk xanthine oxidase at 50 ug/mL | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (22.22) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (12.50%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (87.50%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||