cnb 001 profile

ID Source	ID
PubMed CID	135440402
CHEMBL ID	258741
SCHEMBL ID	12995841
MeSH ID	M0522059

Synonym
828911-76-8
n-phenylpyrazole curcumin
CHEMBL258741 ,
AKOS015949244
bdbm50391730
4,4'-[(1-phenyl-1h-pyrazole-3,5-diyl)diethene-2,1-diyl]bis(2-methoxyphenol)
4-[(e)-2-[5-[(e)-2-(4-hydroxy-3-methoxy-phenyl)vinyl]-1-phenyl-pyrazol-3-yl]vinyl]-2-methoxy-phenol
S11433
cnb-001
phenol, 4,4'-((1-phenyl-1h-pyrazole-3,5-diyl)di-(1e)-2,1-ethenediyl)bis(2-methoxy-
unii-ts3085b7p8
ts3085b7p8 ,
1019110-87-2
phenol, 4-(2-(3-(2-(4-hydroxy-3-methoxyphenyl)ethenyl)-1-phenyl-1h-pyrazol-5-yl)ethenyl)-2-methoxy-
4,4'-(1e,1'e)-2,2'-(1-phenyl-1h-pyrazole-3,5-diyl)bis(ethene-2,1-diyl)bis(2-methoxyphenol)
SCHEMBL12995841
4,4'-(1e,1'e)-2,2'-(1-phenyl-1h-pyrazole-3,5-diyl)-bis(ethene-2,1-diyl)bis(2-methoxyphenol)
4,4'-((1-phenyl-1h-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol)
J-513952
(4z)-4-[(2z)-2-{5-[(e)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-1-phenyl-1,2-dihydro-3h-pyrazol-3-ylidene}ethylidene]-2-methoxycyclohexa-2,5-dien-1-one
DTXSID60732491
CS-W001650
4-[2-[3-[2-(4-hydroxy-3-methoxyphenyl)ethenyl]-1-phenyl-1h-pyrazol-5-yl]ethenyl]-2-methoxyphenol
4,4'-((1e,1'e)-(1-phenyl-1h-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol)
mfcd17019190
DS-20189
AMY15788
nsc-757929
nsc757929
Q27290224
4-[(e)-2-[5-[(e)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-2-phenylpyrazol-3-yl]ethenyl]-2-methoxyphenol
4,4-(1e,1e)-2,2-(1-phenyl-1h-pyrazole-3,5-diyl)bis(ethene-2,1-diyl)bis(2-methoxyphenol)

Protein Targets (3)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Amyloid-beta precursor protein	Homo sapiens (human)	IC50 (µMol)	8.8333	0.0005	3.8895	10.0000	AID1894193; AID1894195; AID1894196
Microtubule-associated protein tau	Homo sapiens (human)	IC50 (µMol)	103.0000	0.0690	1.9769	3.5000	AID1894197
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	IC50 (µMol)	70.2500	0.0000	1.6395	10.0000	AID687449; AID687450; AID687451; AID687453
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (145)

Process	via Protein(s)	Taxonomy
regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
cognition	Amyloid-beta precursor protein	Homo sapiens (human)
G2/M transition of mitotic cell cycle	Amyloid-beta precursor protein	Homo sapiens (human)
microglial cell activation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of protein phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
suckling behavior	Amyloid-beta precursor protein	Homo sapiens (human)
astrocyte activation involved in immune response	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of translation	Amyloid-beta precursor protein	Homo sapiens (human)
protein phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
intracellular copper ion homeostasis	Amyloid-beta precursor protein	Homo sapiens (human)
endocytosis	Amyloid-beta precursor protein	Homo sapiens (human)
response to oxidative stress	Amyloid-beta precursor protein	Homo sapiens (human)
cell adhesion	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of epidermal growth factor-activated receptor activity	Amyloid-beta precursor protein	Homo sapiens (human)
Notch signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
axonogenesis	Amyloid-beta precursor protein	Homo sapiens (human)
learning or memory	Amyloid-beta precursor protein	Homo sapiens (human)
learning	Amyloid-beta precursor protein	Homo sapiens (human)
mating behavior	Amyloid-beta precursor protein	Homo sapiens (human)
locomotory behavior	Amyloid-beta precursor protein	Homo sapiens (human)
axo-dendritic transport	Amyloid-beta precursor protein	Homo sapiens (human)
cholesterol metabolic process	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of cell population proliferation	Amyloid-beta precursor protein	Homo sapiens (human)
adult locomotory behavior	Amyloid-beta precursor protein	Homo sapiens (human)
visual learning	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of peptidyl-threonine phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of G2/M transition of mitotic cell cycle	Amyloid-beta precursor protein	Homo sapiens (human)
microglia development	Amyloid-beta precursor protein	Homo sapiens (human)
axon midline choice point recognition	Amyloid-beta precursor protein	Homo sapiens (human)
neuron remodeling	Amyloid-beta precursor protein	Homo sapiens (human)
dendrite development	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of Wnt signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular matrix organization	Amyloid-beta precursor protein	Homo sapiens (human)
forebrain development	Amyloid-beta precursor protein	Homo sapiens (human)
neuron projection development	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of chemokine production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of interleukin-1 beta production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of interleukin-6 production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
ionotropic glutamate receptor signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of multicellular organism growth	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of neuron differentiation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of glycolytic process	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of mitotic cell cycle	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of JNK cascade	Amyloid-beta precursor protein	Homo sapiens (human)
astrocyte activation	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of long-term neuronal synaptic plasticity	Amyloid-beta precursor protein	Homo sapiens (human)
collateral sprouting in absence of injury	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of inflammatory response	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of peptidyl-tyrosine phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of synapse structure or activity	Amyloid-beta precursor protein	Homo sapiens (human)
synapse organization	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of calcium-mediated signaling	Amyloid-beta precursor protein	Homo sapiens (human)
neuromuscular process controlling balance	Amyloid-beta precursor protein	Homo sapiens (human)
synaptic assembly at neuromuscular junction	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of protein metabolic process	Amyloid-beta precursor protein	Homo sapiens (human)
neuron apoptotic process	Amyloid-beta precursor protein	Homo sapiens (human)
smooth endoplasmic reticulum calcium ion homeostasis	Amyloid-beta precursor protein	Homo sapiens (human)
neuron cellular homeostasis	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Amyloid-beta precursor protein	Homo sapiens (human)
response to interleukin-1	Amyloid-beta precursor protein	Homo sapiens (human)
modulation of excitatory postsynaptic potential	Amyloid-beta precursor protein	Homo sapiens (human)
NMDA selective glutamate receptor signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of spontaneous synaptic transmission	Amyloid-beta precursor protein	Homo sapiens (human)
cytosolic mRNA polyadenylation	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of long-term synaptic potentiation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of long-term synaptic potentiation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	Amyloid-beta precursor protein	Homo sapiens (human)
cellular response to amyloid-beta	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of presynapse assembly	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of amyloid fibril formation	Amyloid-beta precursor protein	Homo sapiens (human)
amyloid fibril formation	Amyloid-beta precursor protein	Homo sapiens (human)
neuron projection maintenance	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of T cell migration	Amyloid-beta precursor protein	Homo sapiens (human)
central nervous system development	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of autophagy	Microtubule-associated protein tau	Homo sapiens (human)
microtubule cytoskeleton organization	Microtubule-associated protein tau	Homo sapiens (human)
microglial cell activation	Microtubule-associated protein tau	Homo sapiens (human)
internal protein amino acid acetylation	Microtubule-associated protein tau	Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic process	Microtubule-associated protein tau	Homo sapiens (human)
DNA damage response	Microtubule-associated protein tau	Homo sapiens (human)
cell-cell signaling	Microtubule-associated protein tau	Homo sapiens (human)
memory	Microtubule-associated protein tau	Homo sapiens (human)
response to lead ion	Microtubule-associated protein tau	Homo sapiens (human)
negative regulation of gene expression	Microtubule-associated protein tau	Homo sapiens (human)
negative regulation of mitochondrial membrane potential	Microtubule-associated protein tau	Homo sapiens (human)
rRNA metabolic process	Microtubule-associated protein tau	Homo sapiens (human)
axonal transport of mitochondrion	Microtubule-associated protein tau	Homo sapiens (human)
central nervous system neuron development	Microtubule-associated protein tau	Homo sapiens (human)
regulation of microtubule polymerization or depolymerization	Microtubule-associated protein tau	Homo sapiens (human)
regulation of microtubule polymerization	Microtubule-associated protein tau	Homo sapiens (human)
positive regulation of microtubule polymerization	Microtubule-associated protein tau	Homo sapiens (human)
cytoplasmic microtubule organization	Microtubule-associated protein tau	Homo sapiens (human)
neuron projection development	Microtubule-associated protein tau	Homo sapiens (human)
positive regulation of superoxide anion generation	Microtubule-associated protein tau	Homo sapiens (human)
regulation of chromosome organization	Microtubule-associated protein tau	Homo sapiens (human)
negative regulation of kinase activity	Microtubule-associated protein tau	Homo sapiens (human)
stress granule assembly	Microtubule-associated protein tau	Homo sapiens (human)
cellular response to heat	Microtubule-associated protein tau	Homo sapiens (human)
cellular response to reactive oxygen species	Microtubule-associated protein tau	Homo sapiens (human)
positive regulation of axon extension	Microtubule-associated protein tau	Homo sapiens (human)
microtubule polymerization	Microtubule-associated protein tau	Homo sapiens (human)
astrocyte activation	Microtubule-associated protein tau	Homo sapiens (human)
regulation of synaptic plasticity	Microtubule-associated protein tau	Homo sapiens (human)
intracellular distribution of mitochondria	Microtubule-associated protein tau	Homo sapiens (human)
generation of neurons	Microtubule-associated protein tau	Homo sapiens (human)
synapse organization	Microtubule-associated protein tau	Homo sapiens (human)
regulation of calcium-mediated signaling	Microtubule-associated protein tau	Homo sapiens (human)
protein polymerization	Microtubule-associated protein tau	Homo sapiens (human)
axon development	Microtubule-associated protein tau	Homo sapiens (human)
regulation of microtubule cytoskeleton organization	Microtubule-associated protein tau	Homo sapiens (human)
plus-end-directed organelle transport along microtubule	Microtubule-associated protein tau	Homo sapiens (human)
regulation of mitochondrial fission	Microtubule-associated protein tau	Homo sapiens (human)
negative regulation of mitochondrial fission	Microtubule-associated protein tau	Homo sapiens (human)
supramolecular fiber organization	Microtubule-associated protein tau	Homo sapiens (human)
axonal transport	Microtubule-associated protein tau	Homo sapiens (human)
regulation of cellular response to heat	Microtubule-associated protein tau	Homo sapiens (human)
regulation of long-term synaptic depression	Microtubule-associated protein tau	Homo sapiens (human)
positive regulation of protein localization to synapse	Microtubule-associated protein tau	Homo sapiens (human)
neurofibrillary tangle assembly	Microtubule-associated protein tau	Homo sapiens (human)
negative regulation of establishment of protein localization to mitochondrion	Microtubule-associated protein tau	Homo sapiens (human)
positive regulation of protein localization	Microtubule-associated protein tau	Homo sapiens (human)
negative regulation of tubulin deacetylation	Microtubule-associated protein tau	Homo sapiens (human)
positive regulation of diacylglycerol kinase activity	Microtubule-associated protein tau	Homo sapiens (human)
amyloid fibril formation	Microtubule-associated protein tau	Homo sapiens (human)
cellular response to nerve growth factor stimulus	Microtubule-associated protein tau	Homo sapiens (human)
cellular response to brain-derived neurotrophic factor stimulus	Microtubule-associated protein tau	Homo sapiens (human)
G1/S transition of mitotic cell cycle	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
response to ischemia	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
protein phosphorylation	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
calcium ion transport	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic process	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
peptidyl-serine phosphorylation	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
cellular response to interferon-beta	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
angiotensin-activated signaling pathway	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
positive regulation of receptor signaling pathway via JAK-STAT	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
protein autophosphorylation	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
regulation of neurotransmitter secretion	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
regulation of neuronal synaptic plasticity	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
negative regulation of hydrolase activity	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
positive regulation of calcium ion transport	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
dendritic spine development	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
cellular response to type II interferon	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic process	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
peptidyl-threonine autophosphorylation	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
regulation of endocannabinoid signaling pathway	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
regulation of neuron migration	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (42)

Process	via Protein(s)	Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Amyloid-beta precursor protein	Homo sapiens (human)
DNA binding	Amyloid-beta precursor protein	Homo sapiens (human)
serine-type endopeptidase inhibitor activity	Amyloid-beta precursor protein	Homo sapiens (human)
signaling receptor binding	Amyloid-beta precursor protein	Homo sapiens (human)
protein binding	Amyloid-beta precursor protein	Homo sapiens (human)
heparin binding	Amyloid-beta precursor protein	Homo sapiens (human)
enzyme binding	Amyloid-beta precursor protein	Homo sapiens (human)
identical protein binding	Amyloid-beta precursor protein	Homo sapiens (human)
transition metal ion binding	Amyloid-beta precursor protein	Homo sapiens (human)
receptor ligand activity	Amyloid-beta precursor protein	Homo sapiens (human)
PTB domain binding	Amyloid-beta precursor protein	Homo sapiens (human)
protein serine/threonine kinase binding	Amyloid-beta precursor protein	Homo sapiens (human)
signaling receptor activator activity	Amyloid-beta precursor protein	Homo sapiens (human)
DNA binding	Microtubule-associated protein tau	Homo sapiens (human)
minor groove of adenine-thymine-rich DNA binding	Microtubule-associated protein tau	Homo sapiens (human)
double-stranded DNA binding	Microtubule-associated protein tau	Homo sapiens (human)
single-stranded DNA binding	Microtubule-associated protein tau	Homo sapiens (human)
RNA binding	Microtubule-associated protein tau	Homo sapiens (human)
actin binding	Microtubule-associated protein tau	Homo sapiens (human)
protein binding	Microtubule-associated protein tau	Homo sapiens (human)
microtubule binding	Microtubule-associated protein tau	Homo sapiens (human)
SH3 domain binding	Microtubule-associated protein tau	Homo sapiens (human)
enzyme binding	Microtubule-associated protein tau	Homo sapiens (human)
protein kinase binding	Microtubule-associated protein tau	Homo sapiens (human)
protein-macromolecule adaptor activity	Microtubule-associated protein tau	Homo sapiens (human)
apolipoprotein binding	Microtubule-associated protein tau	Homo sapiens (human)
dynactin binding	Microtubule-associated protein tau	Homo sapiens (human)
phosphatidylinositol binding	Microtubule-associated protein tau	Homo sapiens (human)
identical protein binding	Microtubule-associated protein tau	Homo sapiens (human)
sequence-specific DNA binding	Microtubule-associated protein tau	Homo sapiens (human)
protein-folding chaperone binding	Microtubule-associated protein tau	Homo sapiens (human)
protein phosphatase 2A binding	Microtubule-associated protein tau	Homo sapiens (human)
Hsp90 protein binding	Microtubule-associated protein tau	Homo sapiens (human)
lipoprotein particle binding	Microtubule-associated protein tau	Homo sapiens (human)
histone-dependent DNA binding	Microtubule-associated protein tau	Homo sapiens (human)
microtubule lateral binding	Microtubule-associated protein tau	Homo sapiens (human)
phosphatidylinositol bisphosphate binding	Microtubule-associated protein tau	Homo sapiens (human)
protein serine/threonine kinase activity	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
calmodulin-dependent protein kinase activity	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
protein binding	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
calmodulin binding	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
ATP binding	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
kinase activity	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
glutamate receptor binding	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
identical protein binding	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
protein homodimerization activity	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
metal ion binding	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
protein serine kinase activity	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (62)

Process	via Protein(s)	Taxonomy
extracellular space	Amyloid-beta precursor protein	Homo sapiens (human)
dendrite	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular region	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular space	Amyloid-beta precursor protein	Homo sapiens (human)
nuclear envelope lumen	Amyloid-beta precursor protein	Homo sapiens (human)
cytoplasm	Amyloid-beta precursor protein	Homo sapiens (human)
mitochondrial inner membrane	Amyloid-beta precursor protein	Homo sapiens (human)
endosome	Amyloid-beta precursor protein	Homo sapiens (human)
early endosome	Amyloid-beta precursor protein	Homo sapiens (human)
endoplasmic reticulum	Amyloid-beta precursor protein	Homo sapiens (human)
endoplasmic reticulum lumen	Amyloid-beta precursor protein	Homo sapiens (human)
smooth endoplasmic reticulum	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi apparatus	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi lumen	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi-associated vesicle	Amyloid-beta precursor protein	Homo sapiens (human)
cytosol	Amyloid-beta precursor protein	Homo sapiens (human)
plasma membrane	Amyloid-beta precursor protein	Homo sapiens (human)
clathrin-coated pit	Amyloid-beta precursor protein	Homo sapiens (human)
cell-cell junction	Amyloid-beta precursor protein	Homo sapiens (human)
synaptic vesicle	Amyloid-beta precursor protein	Homo sapiens (human)
cell surface	Amyloid-beta precursor protein	Homo sapiens (human)
membrane	Amyloid-beta precursor protein	Homo sapiens (human)
COPII-coated ER to Golgi transport vesicle	Amyloid-beta precursor protein	Homo sapiens (human)
axon	Amyloid-beta precursor protein	Homo sapiens (human)
growth cone	Amyloid-beta precursor protein	Homo sapiens (human)
platelet alpha granule lumen	Amyloid-beta precursor protein	Homo sapiens (human)
neuromuscular junction	Amyloid-beta precursor protein	Homo sapiens (human)
endosome lumen	Amyloid-beta precursor protein	Homo sapiens (human)
trans-Golgi network membrane	Amyloid-beta precursor protein	Homo sapiens (human)
ciliary rootlet	Amyloid-beta precursor protein	Homo sapiens (human)
dendritic spine	Amyloid-beta precursor protein	Homo sapiens (human)
dendritic shaft	Amyloid-beta precursor protein	Homo sapiens (human)
perikaryon	Amyloid-beta precursor protein	Homo sapiens (human)
membrane raft	Amyloid-beta precursor protein	Homo sapiens (human)
apical part of cell	Amyloid-beta precursor protein	Homo sapiens (human)
synapse	Amyloid-beta precursor protein	Homo sapiens (human)
perinuclear region of cytoplasm	Amyloid-beta precursor protein	Homo sapiens (human)
presynaptic active zone	Amyloid-beta precursor protein	Homo sapiens (human)
spindle midzone	Amyloid-beta precursor protein	Homo sapiens (human)
recycling endosome	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular exosome	Amyloid-beta precursor protein	Homo sapiens (human)
receptor complex	Amyloid-beta precursor protein	Homo sapiens (human)
early endosome	Amyloid-beta precursor protein	Homo sapiens (human)
membrane raft	Amyloid-beta precursor protein	Homo sapiens (human)
cell surface	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi apparatus	Amyloid-beta precursor protein	Homo sapiens (human)
plasma membrane	Amyloid-beta precursor protein	Homo sapiens (human)
microtubule	Microtubule-associated protein tau	Homo sapiens (human)
membrane	Microtubule-associated protein tau	Homo sapiens (human)
extracellular region	Microtubule-associated protein tau	Homo sapiens (human)
nucleus	Microtubule-associated protein tau	Homo sapiens (human)
cytoplasm	Microtubule-associated protein tau	Homo sapiens (human)
mitochondrion	Microtubule-associated protein tau	Homo sapiens (human)
cytosol	Microtubule-associated protein tau	Homo sapiens (human)
plasma membrane	Microtubule-associated protein tau	Homo sapiens (human)
microtubule cytoskeleton	Microtubule-associated protein tau	Homo sapiens (human)
nuclear speck	Microtubule-associated protein tau	Homo sapiens (human)
axon	Microtubule-associated protein tau	Homo sapiens (human)
dendrite	Microtubule-associated protein tau	Homo sapiens (human)
growth cone	Microtubule-associated protein tau	Homo sapiens (human)
axolemma	Microtubule-associated protein tau	Homo sapiens (human)
nuclear periphery	Microtubule-associated protein tau	Homo sapiens (human)
cytoplasmic ribonucleoprotein granule	Microtubule-associated protein tau	Homo sapiens (human)
somatodendritic compartment	Microtubule-associated protein tau	Homo sapiens (human)
neuronal cell body	Microtubule-associated protein tau	Homo sapiens (human)
dendritic spine	Microtubule-associated protein tau	Homo sapiens (human)
cell body	Microtubule-associated protein tau	Homo sapiens (human)
main axon	Microtubule-associated protein tau	Homo sapiens (human)
membrane raft	Microtubule-associated protein tau	Homo sapiens (human)
glial cell projection	Microtubule-associated protein tau	Homo sapiens (human)
neurofibrillary tangle	Microtubule-associated protein tau	Homo sapiens (human)
axon cytoplasm	Microtubule-associated protein tau	Homo sapiens (human)
tubulin complex	Microtubule-associated protein tau	Homo sapiens (human)
neuron projection	Microtubule-associated protein tau	Homo sapiens (human)
nucleus	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
nucleoplasm	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
mitochondrion	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
cytosol	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
postsynaptic density	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
endocytic vesicle membrane	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
dendritic spine	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
calcium- and calmodulin-dependent protein kinase complex	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
neuron projection	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
cytoplasm	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (20)

Assay ID	Title	Year	Journal	Article
AID687454	Inhibition of Albino Wistar rat CaMK2 in postsynaptic density fraction using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in presence of EGTA	2012	Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20	Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
AID1894198	Inhibition of tau depolymerization (unknown origin) transfected in H4 cells incubated for 20 to 24 hrs by LPECL assay	2021	European journal of medicinal chemistry, Mar-15, Volume: 214	Amyloid-β and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review.
AID687396	Inhibition of Albino Wistar rat CaMK2 autophosphorylation at Thr286 in brain cytosolic fraction using [gamma32P]ATP incubated for 30 secs prior to ATP addition measured after 30 secs	2012	Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20	Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
AID1894196	Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assay	2021	European journal of medicinal chemistry, Mar-15, Volume: 214	Amyloid-β and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review.
AID323181	Antimalarial activity against chloroquine-resistant Plasmodium falciparum MP14	2008	Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6	Synthesis and exploration of novel curcumin analogues as anti-malarial agents.
AID687450	Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in presence of EGTA	2012	Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20	Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
AID515080	Antimycobacterial activity against Mycobacterium tuberculosis H37Ra after 24 hrs by microtiter alamar blue assay	2010	European journal of medicinal chemistry, Oct, Volume: 45, Issue:10	Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity.
AID1894197	Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assay	2021	European journal of medicinal chemistry, Mar-15, Volume: 214	Amyloid-β and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review.
AID323180	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCK2	2008	Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6	Synthesis and exploration of novel curcumin analogues as anti-malarial agents.
AID687446	Inhibition of Albino Wistar rat CaMK2 in brain cytosolic fraction using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min	2012	Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20	Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
AID687455	Inhibition of Albino Wistar rat CaMK2 autophosphorylation at Thr286 in postsynaptic density fraction using [gamma32P]ATP incubated for 30 secs prior to ATP addition measured after 30 secs	2012	Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20	Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
AID687449	Inhibition of alphaCaMK2 autophosphorylation at Thr286 using [gamma32P]ATP incubated for 30 secs prior to ATP addition measured after 30 secs	2012	Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20	Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
AID687445	Inhibition of Albino Wistar rat CaMK2 in brain cytosolic fraction using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in presence of EGTA	2012	Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20	Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
AID1894194	Inhibition of amyloid beta 38 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assay	2021	European journal of medicinal chemistry, Mar-15, Volume: 214	Amyloid-β and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review.
AID687453	Inhibition of alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min	2012	Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20	Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
AID539297	Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced toxicity at 1 uM after 24 hrs by MTT assay in presence of GW-9662	2010	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23	N,N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA): peroxisome proliferator-activated receptor (PPAR-γ) agonists with neuroprotective properties.
AID1894195	Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assay	2021	European journal of medicinal chemistry, Mar-15, Volume: 214	Amyloid-β and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review.
AID687395	Inhibition of Albino Wistar rat CaMK2 in postsynaptic density fraction using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min	2012	Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20	Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
AID1894193	Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assay	2021	European journal of medicinal chemistry, Mar-15, Volume: 214	Amyloid-β and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review.
AID687451	Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min	2012	Bioorganic & medicinal chemistry, Oct-15, Volume: 20, Issue:20	Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	1 (20.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (20.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
isoniazid Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).	2.05	1	carbohydrazide	antitubercular agent; drug allergen
troglitazone Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.	2.05	1	chromanes; thiazolidinone	anticoagulant; anticonvulsant; antineoplastic agent; antioxidant; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; hypoglycemic agent; platelet aggregation inhibitor; vasodilator agent
kanamycin a Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.	2.05	1	kanamycins	bacterial metabolite
methylene blue Methylene Blue: A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.. methylene blue : An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.	3.41	1	organic chloride salt	acid-base indicator; antidepressant; antimalarial; antimicrobial agent; antioxidant; cardioprotective agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 4.6.1.2 (guanylate cyclase) inhibitor; fluorochrome; histological dye; neuroprotective agent; physical tracer
tetrahydrocurcumin tetrahydrocurcumin : A beta-diketone that is curcumin in which both of the double bonds have been reduced to single bonds.	2.05	1	beta-diketone; diarylheptanoid; polyphenol	metabolite
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	3.41	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
gw9662 2-chloro-5-nitrobenzanilide: pretreatment of peroxisome proliferator activated receptors with GW9662 results in the irreversible loss of ligand binding	2.05	1	benzamides
curcumin Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.	3.41	1	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger
gingerenone a gingerenone A: has antineoplastic activity; isolated from Zingiber officinale; structure in first source	2.05	1	diarylheptanoid
bisdemethoxycurcumin curcumin III: structure in first source. bisdemethoxycurcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups.	2.47	2	beta-diketone; diarylheptanoid; enone; polyphenol	EC 3.2.1.1 (alpha-amylase) inhibitor; metabolite
hexahydrocurcumin hexahydrocurcumin: from Zingiber officinale; structure in first source	2.05	1	diarylheptanoid
tetrahydroxycurcumin [no description available]	2.05	1	beta-diketone; catechols; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; neuroprotective agent; plant metabolite
diacetylcurcumin diacetylcurcumin: structure in first source	2.45	2
dimethoxycurcumin dimethoxycurcumin: has antineoplsatic activity; structure in first source	2.45	2
1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one: from Curcuma longa; structure in first source	2.05	1	diarylheptanoid
rifampin Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)	2.05	1	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor
hydrazinocurcumin hydrazinocurcumin: structure in first source. hydrazinocurcumin : A pyrazole obtained by cyclocodensation of the two carbonyl groups of curcumin with hydrazine.	4.1	4	aromatic ether; olefinic compound; polyphenol; pyrazoles	angiogenesis modulating agent; antineoplastic agent; EC 2.3.1.48 (histone acetyltransferase) inhibitor; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor

Condition	Relationship Strength	Studies
Koch's Disease [description not available]	2.05	1
Tuberculosis Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.	2.05	1
Acute Confusional Senile Dementia [description not available]	3.23	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	3.23	1

cnb 001

Cross-References

Synonyms (32)

Protein Targets (3)

Inhibition Measurements

Other Measurements

Biological Processes (145)

Molecular Functions (42)

Ceullar Components (62)

Bioassays (20)

Research

Studies (5)

Study Types

cnb 001

Cross-References

Synonyms (32)

Protein Targets (3)

Inhibition Measurements

Other Measurements

Biological Processes (145)

Molecular Functions (42)

Ceullar Components (62)

Bioassays (20)

Research

Studies (5)

Study Types

Related Drugs (17)

Related Conditions (4)