Assay ID | Title | Year | Journal | Article |
AID498481 | Inhibition of N-terminally truncated rat PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
AID306653 | Clearance in rat at 5 mg/kg, po or 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8
| Optimization of halopemide for phospholipase D2 inhibition. |
AID306654 | Cmax in rat at 5 mg/kg, po or 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8
| Optimization of halopemide for phospholipase D2 inhibition. |
AID306650 | Inhibition of PLD2 | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8
| Optimization of halopemide for phospholipase D2 inhibition. |
AID498477 | Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
AID306655 | AUC in rat at 5 mg/kg, po or 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8
| Optimization of halopemide for phospholipase D2 inhibition. |
AID306652 | Half life in rat at 5 mg/kg, po or 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8
| Optimization of halopemide for phospholipase D2 inhibition. |
AID498478 | Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
AID306656 | Oral bioavailability in rat at 5 mg/kg | 2007 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 17, Issue:8
| Optimization of halopemide for phospholipase D2 inhibition. |
AID498484 | Inhibition of human PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
AID498482 | Inhibition of human PLD2 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1799395 | PLD1 In Vitro Enzymatic Assay from Article 10.1038/nchembio.140: \\Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.\\ | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
AID1799396 | d.311 Enzymatic Inhibition Assay from Article 10.1038/nchembio.140: \\Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.\\ | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
AID1799398 | 293-PLD2 Cell-Based Assay from Article 10.1038/nchembio.140: \\Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.\\ | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
AID1800492 | PLD In Vitro Kinetic Assay from Article 10.1111/cbdd.12319: \\1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D.\\ | 2014 | Chemical biology & drug design, Sep, Volume: 84, Issue:3
| 1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D. |
AID1799399 | PLD2 In Vitro Enzymatic Assay from Article 10.1038/nchembio.140: \\Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.\\ | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
AID1799397 | Calu-1 Cell-Based Assay from Article 10.1038/nchembio.140: \\Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.\\ | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
AID1345285 | Human PLD2 (Hydrolases) | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
AID1345246 | Human PLD1 (Phosphatidylcholine-specific phospholipase D) | 2009 | Nature chemical biology, Feb, Volume: 5, Issue:2
| Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |