Compounds > Rhynchophylline
Page last updated: 2024-11-10

Rhynchophylline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID5281408
CHEMBL ID519266
CHEBI ID70069
SCHEMBL ID2047380

Synonyms (32)

Synonym
nsc 21731
corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (7-beta,16e,20-alpha)-
mitrinermine
rhynchophyllin
rhynocophylline
nsc-21731
mitrinermin
C09236
bdbm50251393
chebi:70069 ,
CHEMBL519266 ,
methyl (e)-2-[(3r,6'r,7's,8'as)-6'-ethyl-2-oxospiro[1h-indole-3,1'-3,5,6,7,8,8a-hexahydro-2h-indolizine]-7'-yl]-3-methoxyprop-2-enoate
unii-46bq79vj8d
46bq79vj8d ,
S9400
corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (7.beta.,16e,20.alpha.)
rhynchophylline [mi]
rhynchophylline (constituent of cat's claw) [dsc]
CS-3807
SCHEMBL2047380
HY-N0387
R0105
mfcd00221748
AKOS037514819
Q7321711
HMS3887A03
CCG-268460
spiro[3h-indole-3,1'(5'h)-indolizine]-7'-acetic acid,6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-a-(methoxymethylene)-2-oxo-,methyl ester, (ae,1'r,6'r,7's,8'as)-
DTXSID70878612 ,
dtxcid001016656
rhynchophylline (constituent of cat's claw)
corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (7beta,16e,20alpha)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
indolizines
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC50 (µMol)773.00000.00091.901410.0000AID422445
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
5-hydroxytryptamine receptor 1AHomo sapiens (human)EC50 (µMol)10.30000.00010.25718.0000AID1617782
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (37)

Processvia Protein(s)Taxonomy
behavioral fear response5-hydroxytryptamine receptor 1AHomo sapiens (human)
G protein-coupled receptor signaling pathway5-hydroxytryptamine receptor 1AHomo sapiens (human)
adenylate cyclase-inhibiting serotonin receptor signaling pathway5-hydroxytryptamine receptor 1AHomo sapiens (human)
serotonin receptor signaling pathway5-hydroxytryptamine receptor 1AHomo sapiens (human)
gamma-aminobutyric acid signaling pathway5-hydroxytryptamine receptor 1AHomo sapiens (human)
positive regulation of cell population proliferation5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of serotonin secretion5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of vasoconstriction5-hydroxytryptamine receptor 1AHomo sapiens (human)
exploration behavior5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of dopamine metabolic process5-hydroxytryptamine receptor 1AHomo sapiens (human)
serotonin metabolic process5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of hormone secretion5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of behavior5-hydroxytryptamine receptor 1AHomo sapiens (human)
chemical synaptic transmission5-hydroxytryptamine receptor 1AHomo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger5-hydroxytryptamine receptor 1AHomo sapiens (human)
regulation of heart rate by cardiac conductionPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
regulation of heart rate by hormonePotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
regulation of membrane potentialPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
positive regulation of DNA-templated transcriptionPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
potassium ion homeostasisPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
cardiac muscle contractionPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
regulation of membrane repolarizationPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
regulation of ventricular cardiac muscle cell membrane repolarizationPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
cellular response to xenobiotic stimulusPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
potassium ion transmembrane transportPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
ventricular cardiac muscle cell action potentialPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
membrane repolarizationPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
membrane depolarization during action potentialPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
membrane repolarization during action potentialPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
membrane repolarization during cardiac muscle cell action potentialPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
regulation of heart rate by cardiac conductionPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
potassium ion export across plasma membranePotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
membrane repolarization during ventricular cardiac muscle cell action potentialPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
regulation of potassium ion transmembrane transportPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
negative regulation of potassium ion transmembrane transportPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
positive regulation of potassium ion transmembrane transportPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
negative regulation of potassium ion export across plasma membranePotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
potassium ion import across plasma membranePotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (16)

Processvia Protein(s)Taxonomy
G protein-coupled serotonin receptor activity5-hydroxytryptamine receptor 1AHomo sapiens (human)
protein binding5-hydroxytryptamine receptor 1AHomo sapiens (human)
receptor-receptor interaction5-hydroxytryptamine receptor 1AHomo sapiens (human)
neurotransmitter receptor activity5-hydroxytryptamine receptor 1AHomo sapiens (human)
serotonin binding5-hydroxytryptamine receptor 1AHomo sapiens (human)
transcription cis-regulatory region bindingPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
inward rectifier potassium channel activityPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
voltage-gated potassium channel activityPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
delayed rectifier potassium channel activityPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
protein bindingPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
ubiquitin protein ligase bindingPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
identical protein bindingPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
protein homodimerization activityPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
C3HC4-type RING finger domain bindingPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarizationPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
scaffold protein bindingPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (7)

Processvia Protein(s)Taxonomy
plasma membrane5-hydroxytryptamine receptor 1AHomo sapiens (human)
synapse5-hydroxytryptamine receptor 1AHomo sapiens (human)
plasma membrane5-hydroxytryptamine receptor 1AHomo sapiens (human)
dendrite5-hydroxytryptamine receptor 1AHomo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
cell surfacePotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
perinuclear region of cytoplasmPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
voltage-gated potassium channel complexPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
inward rectifier potassium channel complexPotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
plasma membranePotassium voltage-gated channel subfamily H member 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (40)

Assay IDTitleYearJournalArticle
AID422094Inactivation of Kv channel in +30 mV-stimulated mouse N2A cells assessed as decay time constant of inactivated K+ current at 30 uM via bath application measured after 3 mins (Rvb=1567 +/- 104 ms)2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422443Inactivation of Kv1.2 channel expressed in -70 mV-activated HEK293 cells followed by further 10 mV pulse stimulation assessed as reduction in half maximal activation potential (RVb= -0.1 +/- 2.2 mV)2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422433Inactivation of Kv channel in +30 mV-stimulated mouse N2A cells assessed as decay time constant of inactivated K+ current at 30 uM applied extracellularly (Rvb=1970 +/- 101 ms)2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422441Steady state inactivation of Kv potassium channel in -70 mV-activated mouse N2A cells followed by further 10 mV pulse stimulation assessed as change in slope factor potential at 30 uM (RVb= 16.1 +/- 1.1 no_unit)2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422444Inhibition of Kv1.2 channel expressed in -70 mV-activated HEK293 cells followed by further 10 mV pulse stimulation assessed as slope factor (RVb= 16.3 +/- 1.8 no_unit)2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422435Inactivation of open state of Kv channel in depolarized mouse N2A cells assessed as change in +30 mV-stimulated peak current at 30 uM treated 4 mins before voltage stimulation relative to control2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422434Inhibition of Kv channel in depolarized mouse N2A cells assessed as inhibition of +30 mV-triggered steady state potassium current flow2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID1862316Inhibition of HEWL fibril-induced toxicity in human HEK cells assessed as cell viability by MTT assay ( Rvb = 55.2 +/- 7.2%)2022European journal of medicinal chemistry, Oct-05, Volume: 240Regioselective pyrrolizidine bis-spirooxindoles as efficient anti-amyloidogenic agents.
AID422089Steady state inactivation of Kv potassium channel in 10 second long prepulse-activated mouse N2A cells followed by further +70 mV pulse stimulation assessed as reduction in half maximal activation potential at 30 uM (RVb=20.9 +/- 2.1 mV)2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422098Inactivation of Kv channel in +30 mV-activated mouse N2A cells followed by further +30 mV pulse stimulation assessed as peak K+ current recovery at 30 uM2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422438Inhibition of Kv potassium channel in mouse N2A assessed as blockade of channel pore at 10 uM in presence of 140 mM intracellular potassium ion2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422087Steady state inactivation of Kv potassium channel in -70 mV-activated mouse N2A cells followed by further 10 mV pulse stimulation assessed as reduction in half maximal activation potential at 30 uM applied intracellularly (RVb= 10.8 +/- 2.4 mV)2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422445Inhibition of human ERG channel2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422095Inactivation of open state of Kv channel in +30 mV-stimulated mouse N2A cells assessed as peak K+ current recovery at 30 uM treated 4 mins before voltage stimulation followed by restimulation with +30 mV pulse every 20 seconds measured after compound wash2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422439Inhibition of Kv potassium channel-induced current in mouse N2A cells assessed as left shift of activation curve2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422091Inactivation of Kv channel in +30 mV-stimulated mouse N2A cells assessed as decay time constant of inactivated K+ current at 30 uM applied extracellularly measured after compound washout (Rvb=1970 +/- 101 ms)2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422093Inactivation of Kv channel in +30 mV-stimulated mouse N2A cells assessed as decay time constant of inactivated K+ current at 30 uM applied via intracellular dialysis measured after 11 mins (Rvb=1567 +/- 104 ms)2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID1617782Agonist activity at human 5HT1A receptor expressed in CHOK1 cells incubated for 16 hrs followed by forskolin-stimulation and measured after 2 hrs by dual-glo luciferase reporter gene assay2019Journal of natural products, 12-27, Volume: 82, Issue:12
Uncarialins A-I, Monoterpenoid Indole Alkaloids from
AID422088Steady state inactivation of Kv potassium channel in -70 mV-activated mouse N2A cells followed by further 10 mV pulse stimulation assessed as activation slope factor at 30 uM applied intracellularly2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422092Inactivation of Kv channel in +30 mV-stimulated mouse N2A cells assessed as peak K+ current recovery at 30 uM applied extracellularly measured after compound washout (Rvb=1970 +/- 101 ms)2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID340408Inhibition of LPS-stimulated NO release in rat cortical microglial cells assessed as nitrite accumulation at 10 ug/ml after 48 hrs relative to LPS2008Journal of natural products, Jul, Volume: 71, Issue:7
Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia.
AID422437Inhibition of Kv potassium channel in mouse N2A assessed as blockade of channel pore at 30 uM in presence of 70 mM intracellular potassium ion2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID340406Inhibition of NO release in rat cortical microglial cells2008Journal of natural products, Jul, Volume: 71, Issue:7
Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia.
AID1862312Inhibition of Hen egg white lysozyme fibril formation by Thioflavin T spectroscopic assay relative to control2022European journal of medicinal chemistry, Oct-05, Volume: 240Regioselective pyrrolizidine bis-spirooxindoles as efficient anti-amyloidogenic agents.
AID568588Vasodilatory activity in Sprague-Dawley rat thoracic aorta smooth muscle assessed as inhibition of KCL-induced vasoconstriction2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.
AID568587Vasodilatory activity in Sprague-Dawley rat thoracic aorta smooth muscle assessed as inhibition of phenylephrine-induced vasoconstriction2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.
AID340409Inhibition of LPS-stimulated NO release in rat cortical microglial cells assessed as nitrite accumulation after 48 hrs2008Journal of natural products, Jul, Volume: 71, Issue:7
Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia.
AID422440Steady state inactivation of Kv potassium channel in -70 mV-activated mouse N2A cells followed by further 10 mV pulse stimulation assessed as reduction in half maximal activation potential at 30 uM (RVb= 10.8 +/- 2.4 mV)2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422436Inactivation of open state of Kv channels in depolarized mouse N2A cells assessed as reduction of +30 mV-stimulated peak current magnitude at 30 uM treated 4 mins before voltage stimulation followed by restimulation with +30 mV pulse every 20 seconds meas2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID422097Inhibition of Kv potassium channel in +10 to +70 mV-stimulated mouse N2A cells at 10 uM2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID1488475Inhibition of recombinant human ACE at 100 uM using Mca-R-P-PG-F-S-A-F-K(Dnp)-OH as substrate measured every 2 mins for 8 mins by fluorescence assay2017Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16
Discovery of a potent angiotensin converting enzyme inhibitor via virtual screening.
AID568585Cytotoxicity against human HL60 cells after 48 hrs by MTT assay2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.
AID422090Steady state inactivation of Kv potassium channel in 10 sec long prepulse-activated mouse N2A cells followed by further +70 mV pulse stimulation assessed as change in slope factor potential at 30 uM (Rvb=6.4 +/- 1.1 no_unit)2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID340407Inhibition of LPS-stimulated NO release in rat cortical microglial cells assessed as nitrite accumulation at 1 ug/ml after 48 hrs relative to LPS2008Journal of natural products, Jul, Volume: 71, Issue:7
Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia.
AID568586Cytotoxicity against human SW480 cells after 48 hrs by MTT assay2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla.
AID340405Cell viability of rat cortical microglial cells after 48 hrs by MTT assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia.
AID340404Cell viability of LPS-stimulated rat cortical microglial cells after 48 hrs by MTT assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia.
AID422096Inhibition of Kv potassium channel in +10 to +70 mV-stimulated mouse N2A cells at 30 uM2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
AID340410Inhibition of LPS-stimulated NO release in rat cortical microglial cells assessed as nitrite accumulation at 100 ug/ml after 48 hrs relative to LPS2008Journal of natural products, Jul, Volume: 71, Issue:7
Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia.
AID422442Inactivation of Kv1.2 channel expressed in + 30 mV-stimulated HEK293 cells assessed as decay time constant of inactivated K+ current at 100 uM applied extracellularly (Rvb =2703 +/- 633 ms)2009Journal of natural products, May-22, Volume: 72, Issue:5
Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.20 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.72 (4.65)
Search Engine Demand Index44.85 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (35.20)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
vanillin
Vanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).		2.1510benzaldehydes;
monomethoxybenzene;
phenols		anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		2.0610aromatic ether;
nitrile;
polyether;
tertiary amino compound
captopril
Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.. captopril : A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.		2.1510alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
epigallocatechin gallate
epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.		2.6320flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
artemisinin
(+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.		2.1510organic peroxide;
sesquiterpene lactone		antimalarial;
plant metabolite
tetrahydroalstonine
tetrahydroalstonine : A heteropentacyclic compound that is (20alpha)-16,17-didehydro-18-oxayohimban which is substituted at position 16 by a methoxycarbonyl group and at position 19 by a methyl group. It is a metabolite found in several plant species.		2.2110methyl ester;
organic heteropentacyclic compound;
yohimban alkaloid		plant metabolite
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		2.0410resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
rhapontin
rhapontin: constituent of rhubarb rhizome		2.1510rhaponticinangiogenesis inhibitor;
anti-allergic agent;
anti-inflammatory agent;
antilipemic drug;
antineoplastic agent;
apoptosis inducer;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
hypoglycemic agent;
neuroprotective agent;
plant metabolite
isorhyncophylline
[no description available]		3.0340indolizinesmetabolite
polydatin
trans-piceid : A stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue.		2.1510beta-D-glucoside;
monosaccharide derivative;
polyphenol;
stilbenoid		anti-arrhythmia drug;
antioxidant;
geroprotector;
hepatoprotective agent;
metabolite;
nephroprotective agent;
potassium channel modulator
licochalcone a
licochalcone A: has both anti-inflammatory and antineoplastic activities; structure given in first source; isolated from root of Glycyrrhiza inflata; RN given refers to (E)-isomer		2.1510chalcones
corynoxine b
corynoxine B: structure in first source		2.0610indolizinesmetabolite
vincosamide
vincosamide: isolated from Anthocephalus cadamba; structure in first source		2.2110monoterpenoid indole alkaloid
strictosamide
strictosamide: from Sarcocephalus latifolius; structure in first source		2.2110beta-carbolines
corynoxine
corynoxine: structure in first source		2.0610indolizinesmetabolite
corynoxeine
corynoxeine: active principles of Uncariae Ramulus et Uncus; structure given in first source for ((7beta,16E,20alpha)-isomer) and ((16E,20alpha)-isomer); RN given refers to ((7beta,16E,20alpha)-isomer)		2.0410
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Confusional Senile Dementia
[description not available]		02.4110
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		02.4110