neotuberostemonine profile

neotuberostemonine: from Stemona collinsae; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Stemona	genus	A plant genus of the family Stemonaceae. Members contain STILBENES and phenyl BENZOFURANS.[MeSH]	Stemonaceae	A small plant family of the order Liliales, subclass Liliidae, class Liliopsida (monocotyledons).[MeSH]

ID Source	ID
PubMed CID	11667940
CHEMBL ID	479493
CHEBI ID	69386
SCHEMBL ID	19197265
MeSH ID	M0442727

Synonym
chebi:69386 ,
neotuberostemonine
CHEMBL479493
143120-46-1
AC-34908
SCHEMBL19197265
AKOS032948153
Q27137725
HY-N3196
CS-0023550
(1s,3s,9r,10r,11r,14s,15r,16r)-10-ethyl-14-methyl-3-[(2s,4s)-4-methyl-5-oxooxolan-2-yl]-12-oxa-4-azatetracyclo[7.6.1.04,16.011,15]hexadecan-13-one
MS-26085
DTXSID501316122
E80776

Research Excerpts

Overview

Neotuberostemonine is a potent antitussive alkaloid extracted from Stemona tuberosa.

Excerpt	Reference	Relevance
"Neotuberostemonine (NTS) is an active compound isolated from Stemona tuberosa Lour."	( Neotuberostemonine inhibits osteoclastogenesis via blockade of NF-κB pathway. Lee, KY; Park, B; Yun, J, 2019)	2.68
"Neotuberostemonine is a potent antitussive alkaloid extracted from Stemona tuberosa. "	( Pharmacokinetics, biodistribution and excretion studies of neotuberostemonine, a major bioactive alkaloid of Stemona tuberosa. Han, D; Ou, L; Tong, Y; Wu, Y; Xu, X; Zhang, C; Zhang, M, 2016)	2.12

Pharmacokinetics

Excerpt	Reference	Relevance
" In this work, plasma pharmacokinetic and biodistribution characteristics of the three alkaloids after oral administration of Stemonae Radix are investigated using a rapid and sensitive UPLC-Q-TOF-HDMS method."	( Ultra-performance liquid-chromatography with tandem mass spectrometry performing pharmacokinetic and biodistribution studies of croomine, neotuberostemonine and tuberostemonine alkaloids absorbed in the rat plasma after oral administration of Stemonae Rad Dong, W; Sun, H; Wang, W; Wang, X; Zhang, A, 2012)	0.58
" The present study was aimed to investigate the pharmacokinetic parameters of neotuberostemonine by developing an ultra-high performance liquid chromatography-tandem mass spectrometry method."	( Pharmacokinetics, biodistribution and excretion studies of neotuberostemonine, a major bioactive alkaloid of Stemona tuberosa. Han, D; Ou, L; Tong, Y; Wu, Y; Xu, X; Zhang, C; Zhang, M, 2016)	0.91

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
alkaloid	Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (3)

Assay ID	Title	Year	Journal	Article
AID377037	Ex vivo inhibition of leukotriene formation in calcium ionophore activated human neutrophilic granulocyte at 50 uM by ELISA	2005	Journal of natural products, Jan, Volume: 68, Issue:1	Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species.
AID377748	Antitussive activity in ip dosed Dunkin-Hartley guinea pig assessed as inhibition of citric acid-induced cough administered 30 mins before citric acid challenge	2006	Journal of natural products, Jul, Volume: 69, Issue:7	Stemoninines from the roots of Stemona tuberosa.
AID377036	Ex vivo inhibition of leukotriene formation in calcium ionophore activated human neutrophilic granulocyte by ELISA	2005	Journal of natural products, Jan, Volume: 68, Issue:1	Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (40.00)	29.6817
2010's	8 (53.33)	24.3611
2020's	1 (6.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
citric acid, anhydrous Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.. citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.	2.05	1	tricarboxylic acid	antimicrobial agent; chelator; food acidity regulator; fundamental metabolite
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2.15	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
diphenhydramine hydrochloride Antitussive Agents: Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.. diphenhydramine hydrochloride : The hydrochloride salt of diphenhydramine.	2.96	4	hydrochloride; organoammonium salt	anti-allergic agent; antiemetic; antiparkinson drug; antipruritic drug; H1-receptor antagonist; local anaesthetic; muscarinic antagonist; sedative
maleimide [no description available]	2.01	1	dicarboximide; maleimides	EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
tocopherols [no description available]	2.15	1
zileuton [no description available]	2.02	1	1-benzothiophenes; ureas	anti-asthmatic drug; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; ferroptosis inhibitor; leukotriene antagonist; non-steroidal anti-inflammatory drug
delta-tocopherol [no description available]	2.15	1	tocopherol; vitamin E	food antioxidant; plant metabolite
tuberostemonine tuberostemonine: alkaloid from Stemona japonica with anthelmintic action; structure given in first source; an azapine	3.69	9	alkaloid	metabolite
stemonine stemonine: structure in first source	2.44	2
dihydropinosylvin dihydropinosylvin : A member of the class of resorcinols carrying an additional 2-phenylethyl substituent at position 5.	2.02	1	diphenylethane; resorcinols	EC 1.14.18.1 (tyrosinase) inhibitor; plant metabolite
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.02	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
croomine croomine: structure given in first source; isolated from Croomia japonica	8.15	5	alkaloid	metabolite
pinosylvin pinosylvin: phytoalexin found in pine and eucalyptus	2.02	1	pinosylvin
stemoninine stemoninine: an antitussive agent isolated from the roots of Stemona tuberosa; structure in first source	2.52	2
transforming growth factor beta Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.	2.6	1

Condition	Relationship Strength	Studies
Alveolitis, Fibrosing [description not available]	2.63	2
Pulmonary Fibrosis A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.	2.63	2
Cough A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.	2.48	2
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.03	1

neotuberostemonine

Description

Cross-References

Synonyms (14)

Research Excerpts

Overview

Pharmacokinetics

Roles (1)

Drug Classes (1)

Bioassays (3)

Research

Studies (15)

Study Types

neotuberostemonine

Description

Related Flora

Cross-References

Synonyms (14)

Research Excerpts

Overview

Pharmacokinetics

Roles (1)

Drug Classes (1)

Bioassays (3)

Research

Studies (15)

Study Types

Related Drugs (15)

Related Conditions (4)