Any inhibitor of nonnucleoside hepatitis C virus polymerase.
ChEBI ID: 85180
| Member | Definition | Class |
|---|---|---|
| abt-333 | A member of the class of pyrimidone, which is (as the monohydrate of its sodium salt) in combination with ombitasvir, paritaprevir and ritonavir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver. | dasabuvir |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 178 (84.36) | 24.3611 |
| 2020's | 33 (15.64) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 46 (20.44%) | 5.53% |
| Reviews | 32 (14.22%) | 6.00% |
| Case Studies | 24 (10.67%) | 4.05% |
| Observational | 18 (8.00%) | 0.25% |
| Other | 105 (46.67%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 5.0119 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Protein cereblon | Homo sapiens (human) | IC50 | 15.6000 | 1 | 1 |
| Protein cereblon | Homo sapiens (human) | Ki | 4.7100 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| RNA-directed RNA polymerase | EC50 | 0.0018 | 1 | 1 |