negative regulation of striated muscle tissue development

Definition

Target type: biologicalprocess

Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development. [GOC:go_curators]

Negative regulation of striated muscle tissue development involves a complex interplay of signaling pathways, transcription factors, and epigenetic modifications. It is essential for proper muscle formation and function, ensuring that muscle fibers develop at the appropriate time and place. Key aspects of this process include:

1. **Inhibition of Myogenic Transcription Factors:** Factors like MyoD, Myf5, and Myogenin are crucial for myoblast differentiation and fusion. Negative regulators like Myostatin and the microRNA miR-206 suppress the expression and activity of these factors, preventing premature or uncontrolled muscle growth.

2. **Suppression of Muscle Growth Factors:** Growth factors like IGF-1 and FGF are important for muscle hypertrophy. Factors like TGF-beta and DKK1 inhibit IGF-1 signaling, while BMPs can suppress FGF signaling, ultimately limiting muscle growth.

3. **Regulation of Muscle Cell Cycle:** Muscle development involves precise control of cell division. Negative regulators like p21 and p27 arrest the cell cycle at specific points, ensuring that myoblasts differentiate into muscle fibers rather than continuing to divide.

4. **Control of Muscle Fiber Type:** Muscle fibers can be classified into different types based on their contractile properties. Negative regulators influence the expression of genes that determine fiber type, ensuring that appropriate muscle fibers are formed for specific functions.

5. **Suppression of Muscle Regeneration:** Negative regulators play a role in limiting muscle regeneration after injury, preventing excessive muscle growth and scar tissue formation. This is important for maintaining normal muscle function.

6. **Epigenetic Modifications:** Changes in chromatin structure and DNA methylation influence gene expression, playing a role in the negative regulation of muscle development. For example, histone deacetylases (HDACs) can suppress the expression of myogenic genes, while DNA methyltransferases can silence genes involved in muscle growth.

These processes are finely tuned, ensuring that muscle development occurs in a controlled and regulated manner. Dysregulation of negative regulation can lead to various muscle disorders, including muscular dystrophies, muscle wasting, and congenital myopathies.'
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Proteins (2)

Compounds (37)